PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FRAT1	0	LTBP4	6	two hybrid	Wang J (2011)	1
MAP3K1	4	FRAT1	0	affinity chromatography technology, affinity chromatography technology	Loke J (2014), Loke J (2014)	2
FRAT1	0	GPRASP2	0	two hybrid	Wang J (2011)	1
FRAT1	0	PLSCR1	0	two hybrid	Wang J (2011)	1
FRAT1	0	LMAN2	0	two hybrid	Wang J (2011)	1
FRAT1	0	RABEP2	0	two hybrid	Wang J (2011)	1
DVL1	5	PSMA3	1	two hybrid	Wang J (2011)	1
FRAT1	0	PSMA3	1	two hybrid	Wang J (2011)	1
KRAS	1	PSMA3	1	two hybrid	Rolland T (2014)	1
GSK3B	1	MAP3K1	4	affinity chromatography technology, pull down	Kim JW (2003), Kim JW (2003)	2
GSK3B	1	FRAT1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Hein MY (2015)	3
FRAT1	0	LAMC3	9	two hybrid	Wang J (2011)	1
FRAT1	0	DVL1	5	affinity chromatography technology	Li L (1999)	1
FRAT1	0	KRT18	2	two hybrid	Wang J (2011)	1
FRAT1	0	KRAS	1	affinity chromatography technology	Hein MY (2015)	1
FRAT1	0	PIAS1	4	affinity chromatography technology	Hein MY (2015)	1
GSK3A	1	FRAT1	0	affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Hein MY (2015)	2
GRN	2	KRT18	2	two hybrid	Wang J (2011)	1
FRAT1	0	TDRD7	2	two hybrid	Wang J (2011)	1
MAP3K1	4	RABEP2	0	enzymatic study	Charlaftis N (2014)	1
FRAT1	0	GRN	2	two hybrid	Wang J (2011)	1
FRAT1	0	KCNK5	3	two hybrid	Wang J (2011)	1
PIAS1	4	GSK3B	1	affinity chromatography technology, enzymatic study	Coon TA (2015), Coon TA (2015)	2