PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CALM1	0	SQSTM1	0	pull down	Shen X (2005)	1
TRIM13	1	CALM1	0	affinity chromatography technology, affinity chromatography technology	Lerner M (2007), Lerner M (2007)	2
CALM1	0	AKT1	1	pull down, affinity chromatography technology	Shen X (2005), Shen X (2005)	2
IKBKG	0	ARHGDIA	3	pull down	Kim HJ (2014)	1
EVC2	5	TRIM13	1	bioid	Gupta GD (2015)	1
TMEM17	0	TRIM13	1	bioid	Gupta GD (2015)	1
LRRN2	2	TRIM13	1	affinity chromatography technology	Huttlin EL (2017)	1
TRIM13	1	SQSTM1	0	affinity chromatography technology	Tomar D (2011)	1
TCTN3	2	TRIM13	1	bioid	Gupta GD (2015)	1
TRIM13	1	VCP	6	affinity chromatography technology, affinity chromatography technology	Lerner M (2007), Lerner M (2007)	2
TCTN2	2	ATP2A2	7	bioid	Gupta GD (2015)	1
IKBKG	0	AKT1	1	pull down, affinity chromatography technology	Fenner BJ (2010), Hou Y (2010)	2
TRIM13	1	DDOST	0	affinity chromatography technology, affinity chromatography technology	Lerner M (2007), Lerner M (2007)	2
TRIM13	1	TRIM13	1	enzymatic study, enzymatic study	Lerner M (2007), Joo HM (2011)	2
TRIM13	1	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Tomar D (2014), Tomar D (2014)	2
PTPRN	3	TRIM13	1	affinity chromatography technology	Li X (2016)	1
AKT1	1	TRIM13	1	affinity chromatography technology, enzymatic study	Joo HM (2011), Joo HM (2011)	2
TCTN2	2	TRIM13	1	bioid	Gupta GD (2015)	1
TRIM13	1	GMCL1	0	two hybrid	Rolland T (2014)	1
TRAF6	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sanz L (2000), Sanz L (2000), Nakamura K (2010), Kim JY (2009), Seibenhener ML (2004), Feng Y (2005), Martin P (2006), Martin P (2006), Geetha T (2012), Geetha T (2012), Linares JF (2013), Linares JF (2011), Linares JF (2015), Schimmack G (2017), Tsai WT (2016)	15
TRIM13	1	ATP2A2	7	affinity chromatography technology, affinity chromatography technology	Lerner M (2007), Lerner M (2007)	2
TRIM13	1	NPLOC4	4	affinity chromatography technology	Huttlin EL (2017)	1
TMEM216	0	CKAP4	0	bioid	Gupta GD (2015)	1
TRIM13	1	ELOVL2	2	affinity chromatography technology	Huttlin EL (2017)	1
CTDNEP1	1	ATP2A2	7	affinity chromatography technology	St-Denis N (2016)	1
TEX28	0	TRIM13	1	affinity chromatography technology	Huttlin EL (2017)	1
TMEM216	0	TRIM13	1	bioid	Gupta GD (2015)	1
MDM2	2	TRIM13	1	affinity chromatography technology, enzymatic study	Joo HM (2011), Joo HM (2011)	2
TCTN3	2	CKAP4	0	bioid	Gupta GD (2015)	1
TRIM13	1	ZFYVE1	1	imaging technique	Tomar D (2011)	1
TRIM13	1	ARHGDIA	3	two hybrid	Vinayagam A (2011)	1
IKBKG	0	TRAF6	0	pull down, pull down, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Lamothe B (2008), Windheim M (2008), Lamothe B (2007), Gautheron J (2010), Gautheron J (2010), Hinz M (2010), Sebban-Benin H (2007), Zotti T (2014), Sun L (2004), Emmerich CH (2013), Zhou L (2014), Chen J (2015), Kim EK (2017), Medunjanin S (2016), Xing J (2016), Bal E (2017), Bal E (2017)	17
MDM2	2	ATP2A2	7	unspecified method	Nicholson J (2014)	1
TRIM13	1	ROBO2	2	two hybrid	Vinayagam A (2011)	1
EVC2	5	CKAP4	0	bioid	Gupta GD (2015)	1
TRIM13	1	UBE2D2	0	pull down	Lerner M (2007)	1
NPLOC4	4	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Lass A (2008), Ballar P (2007), Alexandru G (2008), Alexandru G (2008), Fernandez-Saiz V (2010), Noguchi M (2005), Bruderer RM (2004), Bruderer RM (2004), Lee JJ (2013), Erzurumlu Y (2013), Raman M (2015), Raman M (2015), Mountassif D (2015), Wang T (2016), Guo X (2017)	15
CACNA1C	8	VCP	6	affinity chromatography technology	Altier C (2011)	1
TRAF6	0	TRIM13	1	affinity chromatography technology	Huang B (2017)	1
MDM2	2	AKT1	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique	Lin HK (2002), Ogawara Y (2002), Zhou BP (2001), Zhou BP (2001), Kim CK (2011), Kim CK (2011), Zhu QS (2011), Milne D (2004), Deep G (2008), Deep G (2008), Chen TC (2014)	11
FAM234B	0	TRIM13	1	affinity chromatography technology	Huttlin EL (2017)	1
PTPRN	3	DDOST	0	bioid	St-Denis N (2016)	1
CACNA1C	8	TRIM13	1	affinity chromatography technology	Altier C (2011)	1
TRAF6	0	VCP	6	affinity chromatography technology	Ewing RM (2007)	1
TCTN3	2	ATP2A2	7	bioid	Gupta GD (2015)	1
TCTN2	2	DDOST	0	bioid	Gupta GD (2015)	1
TRAF6	0	AKT1	1	enzymatic study, affinity chromatography technology, affinity chromatography technology	Yang WL (2009), Mitra S (2011), Mitra S (2011)	3
TCTN2	2	TCTN3	2	affinity chromatography technology	Boldt K (2016)	1
AKT1	1	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Vandermoere F (2006), Vandermoere F (2006), Vandermoere F (2006), Klein JB (2005), Klein JB (2005), Klein JB (2005), Yu CC (2013), Yu CC (2013)	8
TMEM17	0	SQSTM1	0	bioid	Gupta GD (2015)	1
CTDNEP1	1	TRIM13	1	bioid	St-Denis N (2016)	1
IKBKG	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Martin P (2006), Zotti T (2014)	2
TMEM17	0	CKAP4	0	bioid	Gupta GD (2015)	1
TCTN2	2	CKAP4	0	bioid	Gupta GD (2015)	1
CALM1	0	CACNA1C	8	x-ray crystallography	Fallon JL (2005)	1
TRIM13	1	CKAP4	0	affinity chromatography technology	Huttlin EL (2017)	1
SQSTM1	0	UBE2D2	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Peng H (2017), Peng H (2017), Peng H (2017), Peng H (2017), Peng H (2017)	5
VCP	6	MDM2	2	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Okoro DR (2013)	2
UBE2D2	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
KIR3DL2	1	TRIM13	1	affinity chromatography technology	Huttlin EL (2017)	1
MDM2	2	UBE2D2	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Iyappan S (2010), Dou H (2012), Brenkman AB (2008), Fang S (2000), Szypowska AA (2011), Okamoto K (2009), Busso CS (2009), Maguire M (2008), Sehat B (2008), Uldrijan S (2007), Yang Y (2005), Jin Y (2004), Roxburgh P (2012), Shloush J (2011), Rinaldo C (2007), Cheng Q (2009), Amson R (2011), Li X (2009), David Y (2011), Sosin AM (2012), Schumacher FR (2013), Bista M (2013), Mikawa T (2014), Lohrum MA (2001), Fang S (2001), Saville MK (2004), Rodriguez MS (1999), Auger KR (2005), Wu PY (2003), Wu H (2015), Yamauchi T (2014), Nomura K (2017), Kurokawa M (2013)	33
TCTN3	2	DDOST	0	bioid	Gupta GD (2015)	1
COMMD10	0	TRIM13	1	affinity chromatography technology	Huttlin EL (2017)	1