Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
CHRM3 1131 TOLTERODINE TARTRATE CHEMBL1722209 antagonist ChemblInteractions
CHRM3 1131 PROPANTHELINE BROMIDE CHEMBL1240 antagonist ChemblInteractions
CHRM3 1131 METHIXENE CHEMBL1201342 antagonist TdgClinicalTrial, TEND, DrugBank 17139284, 17016423
CHRM3 1131 OXYPHENCYCLIMINE CHEMBL1495 antagonist TEND, TdgClinicalTrial, DrugBank 17139284, 17016423, 3247303, 1426023
CHRM3 1131 PROPIOMAZINE CHEMBL1201210 antagonist TdgClinicalTrial, TEND, DrugBank 17139284, 17016423
CHRM3 1131 TROPICAMIDE CHEMBL1200604 antagonist GuideToPharmacologyInteractions, ChemblInteractions, DrugBank 17594079
CHRM3 1131 BROMPHENIRAMINE CHEMBL811 antagonist DrugBank 10212017
CHRM3 1131 DIPHENIDOL CHEMBL936 antagonist TdgClinicalTrial, TEND, DrugBank 1863523, 17139284, 17016423, 12185001, 10530931
CHRM3 1131 METHACHOLINE CHEMBL978 agonist DrugBank 20347047, 20888332, 19460789, 19951374
CHRM3 1131 ACLIDINIUM CHEMBL1194325 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, DrugBank
CHRM3 1131 ACETYLCHOLINE CHEMBL667 agonist GuideToPharmacologyInteractions
CHRM3 1131 FURTRETHONIUM CHEMBL2110739 agonist GuideToPharmacologyInteractions
CHRM3 1131 CHEMBL99521 CHEMBL99521 agonist GuideToPharmacologyInteractions
CHRM3 1131 CHEMBL74300 CHEMBL74300 agonist GuideToPharmacologyInteractions
CHRM3 1131 BRUCINE CHEMBL501756 allosteric modulator GuideToPharmacologyInteractions
CHRM3 1131 STRYCHNINE CHEMBL227934 allosteric modulator GuideToPharmacologyInteractions
CHRM3 1131 CHEMBL2206331 CHEMBL2206331 allosteric modulator GuideToPharmacologyInteractions
CHRM3 1131 VINCAMINE CHEMBL1165342 allosteric modulator GuideToPharmacologyInteractions
CHRM3 1131 CHEMBL1256845 CHEMBL1256845 allosteric modulator GuideToPharmacologyInteractions
CHRM3 1131 AMITRIPTYLINE CHEMBL629 antagonist GuideToPharmacologyInteractions
CHRM3 1131 BENZTROPINE MESYLATE CHEMBL1200383 antagonist GuideToPharmacologyInteractions
CHRM3 1131 CHEMBL580785 CHEMBL580785 antagonist GuideToPharmacologyInteractions
CHRM3 1131 HEXOCYCLIUM CHEMBL1201325 antagonist GuideToPharmacologyInteractions
CHRM3 1131 HIMBACINE CHEMBL277642 antagonist GuideToPharmacologyInteractions
CHRM3 1131 SOLIFENACIN CHEMBL1734 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, TEND, TTD
CHRM3 1131 QUINUCLIDINYL BENZILATE CHEMBL12980 antagonist GuideToPharmacologyInteractions
CHRM3 1131 TIOTROPIUM (CHEMBL1900528) CHEMBL1900528 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, TEND
CHRM3 1131 PROMETHAZINE CHEMBL643 TdgClinicalTrial, TEND
CHRM3 1131 Tarafenacin CHEMBL1779046 antagonist TdgClinicalTrial, ChemblInteractions
CHRM3 1131 SOLIFENACIN SUCCINATE CHEMBL1200803 antagonist ChemblInteractions
CHRM3 1131 METHACHOLINE CHLORIDE CHEMBL1200764 agonist ChemblInteractions
CHRM3 1131 ACETYLCHOLINE CHLORIDE CHEMBL1184 agonist ChemblInteractions
CHRM3 1131 CARBACHOL (CHEMBL14) CHEMBL14 agonist ChemblInteractions
CHRM3 1131 CEVIMELINE HYDROCHLORIDE CHEMBL2218917 agonist ChemblInteractions
CHRM3 1131 THIETHYLPERAZINE CHEMBL1378 TdgClinicalTrial, TEND
CHRM3 1131 HOMATROPINE METHYLBROMIDE CHEMBL1200851 TdgClinicalTrial, TEND
CHRM3 1131 OXYBUTYNIN CHLORIDE CHEMBL1133 antagonist ChemblInteractions
CHRM3 1131 ISOPROPAMIDE IODIDE CHEMBL1200347 antagonist ChemblInteractions
CHRM3 1131 FESOTERODINE FUMARATE CHEMBL1201765 antagonist ChemblInteractions
CHRM3 1131 CYCLOPENTOLATE HYDROCHLORIDE CHEMBL1200473 antagonist ChemblInteractions
CHRM3 1131 AZD8683 CHEMBL3545222 antagonist ChemblInteractions
CHRM3 1131 TRIDIHEXETHYL CHLORIDE CHEMBL1200771 antagonist ChemblInteractions
CHRM3 1131 ARIPIPRAZOLE CHEMBL1112 antagonist DrugBank 17848919
CHRM3 1131 OLANZAPINE CHEMBL715 antagonist TdgClinicalTrial, TEND, DrugBank 10227113, 17848919
CHRM3 1131 LOXAPINE CHEMBL831 binder DrugBank
CHRM3 1131 TRIDIHEXETHYL CHEMBL1201354 antagonist TdgClinicalTrial, TEND, DrugBank 17139284, 17016423
CHRM3 1131 ANISOTROPINE METHYLBROMIDE CHEMBL1578 antagonist TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 17139284, 17016423, 4555460
CHRM3 1131 DIPHEMANIL METHYLSULFATE CHEMBL1200880 antagonist TdgClinicalTrial, ChemblInteractions, TEND, DrugBank, TTD 11752352, 17139284, 17016423
CHRM3 1131 BENZQUINAMIDE CHEMBL1201250 antagonist TdgClinicalTrial, TEND, DrugBank 17139284, 17016423
CHRM3 1131 LEVOMEPROMAZINE CHEMBL1764 antagonist TdgClinicalTrial, TEND, DrugBank 2870716, 2899826
CHRM3 1131 FESOTERODINE CHEMBL1201764 antagonist TdgClinicalTrial, TEND, DrugBank 11752352, 12076307
CHRM3 1131 ARECOLINE CHEMBL7303 agonist GuideToPharmacologyInteractions
CHRM3 1131 BETHANECHOL CHEMBL1482 agonist GuideToPharmacologyInteractions
CHRM3 1131 OXOTREMORINE CHEMBL7634 agonist GuideToPharmacologyInteractions
CHRM3 1131 MILAMELINE CHEMBL151938 agonist GuideToPharmacologyInteractions
CHRM3 1131 XANOMELINE CHEMBL21536 agonist GuideToPharmacologyInteractions
CHRM3 1131 VINBURNINE CHEMBL1892145 allosteric modulator GuideToPharmacologyInteractions
CHRM3 1131 CLIDINIUM CHEMBL620 antagonist GuideToPharmacologyInteractions
CHRM3 1131 IPRATROPIUM CHEMBL1621597 antagonist GuideToPharmacologyInteractions
CHRM3 1131 OXYBUTYNIN CHEMBL1231 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, TTD
CHRM3 1131 COENZYME_A CHEMBL1213327 antagonist GuideToPharmacologyInteractions
CHRM3 1131 CHEMBL1233686 CHEMBL1233686 antagonist GuideToPharmacologyInteractions
CHRM3 1131 Afacifenacin CHEMBL3545165 antagonist ChemblInteractions
CHRM3 1131 ACLIDINIUM BROMIDE CHEMBL551466 antagonist ChemblInteractions, TTD
CHRM3 1131 PILOCARPINE HYDROCHLORIDE CHEMBL1200330 agonist ChemblInteractions
CHRM3 1131 DICYCLOMINE HYDROCHLORIDE CHEMBL1200479 antagonist ChemblInteractions
CHRM3 1131 BETHANECHOL CHLORIDE CHEMBL1768 agonist ChemblInteractions
CHRM3 1131 OXYPHENCYCLIMINE HYDROCHLORIDE CHEMBL1200891 antagonist ChemblInteractions
CHRM3 1131 GLYCOPYRROLATE BROMIDE CHEMBL1201027 antagonist ChemblInteractions
CHRM3 1131 CLIDINIUM BROMIDE CHEMBL1200950 antagonist ChemblInteractions
CHRM3 1131 OXYPHENONIUM BROMIDE CHEMBL1200906 antagonist ChemblInteractions
CHRM3 1131 TERFENADINE CHEMBL17157 antagonist DrugBank 10212017
CHRM3 1131 PROCYCLIDINE CHEMBL86715 antagonist DrugBank 20624420, 1426023
CHRM3 1131 GLYCOPYRROLATE CHEMBL1201335 antagonist GuideToPharmacologyInteractions, DrugBank 10385241
CHRM3 1131 TOLTERODINE CHEMBL1382 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, TEND, DrugBank, TTD 14769832, 11752352, 11193006, 19168050
CHRM3 1131 PILOCARPINE CHEMBL550 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, DrugBank 19498041, 18824613
CHRM3 1131 CHLORPROTHIXENE CHEMBL908 antagonist DrugBank 7855217
CHRM3 1131 ISOPROPAMIDE CHEMBL1201232 antagonist DrugBank 29133, 3580704
CHRM3 1131 MEPENZOLATE CHEMBL524004 antagonist DrugBank 7122991, 7623487, 2791613
CHRM3 1131 5-METHYLFURMETHIODIDE CHEMBL1316369 agonist GuideToPharmacologyInteractions
CHRM3 1131 ERIBAXABAN CHEMBL476186 agonist GuideToPharmacologyInteractions
CHRM3 1131 CHEMBL130715 CHEMBL130715 agonist GuideToPharmacologyInteractions
CHRM3 1131 SABCOMELINE CHEMBL134641 agonist GuideToPharmacologyInteractions
CHRM3 1131 CHEMBL139677 CHEMBL139677 allosteric modulator GuideToPharmacologyInteractions
CHRM3 1131 CHEMBL523685 CHEMBL523685 allosteric modulator GuideToPharmacologyInteractions
CHRM3 1131 4-DAMP CHEMBL76897 antagonist GuideToPharmacologyInteractions
CHRM3 1131 BIPERIDEN (CHEMBL1101) CHEMBL1101 antagonist GuideToPharmacologyInteractions
CHRM3 1131 DICYCLOMINE CHEMBL1123 antagonist GuideToPharmacologyInteractions
CHRM3 1131 HYDROCHLORIC ACID CHEMBL1231821 antagonist GuideToPharmacologyInteractions
CHRM3 1131 OTENZEPAD CHEMBL17045 antagonist GuideToPharmacologyInteractions
CHRM3 1131 PIRENZEPINE CHEMBL9967 antagonist GuideToPharmacologyInteractions
CHRM3 1131 PROPANTHELINE CHEMBL1180725 antagonist GuideToPharmacologyInteractions
CHRM3 1131 CHEMBL1628667 CHEMBL1628667 antagonist GuideToPharmacologyInteractions
CHRM3 1131 LAS190792 CHEMBL3545272 antagonist ChemblInteractions
CHRM3 1131 TIOTROPIUM BROMIDE CHEMBL3545181 antagonist ChemblInteractions, TTD
CHRM3 1131 SUXAMETHONIUM CHEMBL703 antagonist TTD
CHRM3 1131 CEVIMELINE CHEMBL168815 TdgClinicalTrial, TEND
CHRM3 1131 HEXOCYCLIUM METHYLSULFATE CHEMBL1626570 antagonist ChemblInteractions
CHRM3 1131 ATROPINE SULFATE CHEMBL2146146 antagonist ChemblInteractions
CHRM3 1131 DARIFENACIN HYDROBROMIDE CHEMBL1200935 antagonist ChemblInteractions
CHRM3 1131 DOXEPIN CHEMBL1628227 TdgClinicalTrial
CHRM3 1131 METHSCOPOLAMINE BROMIDE CHEMBL1201024 antagonist ChemblInteractions
CHRM3 1131 TROSPIUM CHLORIDE CHEMBL3084748 antagonist ChemblInteractions
CHRM3 1131 ASM-024 CHEMBL3707249 antagonist ChemblInteractions
CHRM3 1131 DAROTROPIUM BROMIDE CHEMBL2103803 antagonist ChemblInteractions
CHRM3 1131 DARIFENACIN CHEMBL1346 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, TEND, DrugBank, TTD 11752352, 18046909, 20395537, 19416629
CHRM3 1131 CLOZAPINE CHEMBL42 antagonist DrugBank 17848919
CHRM3 1131 PROMAZINE CHEMBL564 antagonist TdgClinicalTrial, TEND, DrugBank 17139284, 17016423
CHRM3 1131 UMECLIDINIUM CHEMBL1187833 antagonist GuideToPharmacologyInteractions, DrugBank 23435542
CHRM3 1131 ARECAIDINE PROPARGYL ESTER CHEMBL128365 agonist GuideToPharmacologyInteractions
CHRM3 1131 ALCURONIUM CHEMBL1180293 allosteric modulator GuideToPharmacologyInteractions
CHRM3 1131 CHEMBL343796 CHEMBL343796 allosteric modulator GuideToPharmacologyInteractions
CHRM3 1131 CHEMBL343357 CHEMBL343357 allosteric modulator GuideToPharmacologyInteractions
CHRM3 1131 CHEMBL279453 CHEMBL279453 antagonist GuideToPharmacologyInteractions
CHRM3 1131 ATROPINE CHEMBL517712 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND
CHRM3 1131 DOTHIEPIN (CHEMBL1492500) CHEMBL1492500 antagonist GuideToPharmacologyInteractions
CHRM3 1131 CHEMBL1256682 CHEMBL1256682 antagonist GuideToPharmacologyInteractions
CHRM3 1131 METHOCTRAMINE CHEMBL27673 antagonist GuideToPharmacologyInteractions
CHRM3 1131 TRIPITRAMINE CHEMBL265256 antagonist GuideToPharmacologyInteractions
CHRM3 1131 REVATROPATE CHEMBL2105235 antagonist TTD
CHRM3 1131 UMECLIDINIUM BROMIDE CHEMBL523299 antagonist ChemblInteractions
CHRM3 1131 BATEFENTEROL CHEMBL3039518 antagonist TdgClinicalTrial, ChemblInteractions
CHRM3 1131 MEPENZOLATE BROMIDE CHEMBL1724 antagonist ChemblInteractions
CHRM3 1131 IPRATROPIUM BROMIDE HYDRATE CHEMBL2134724 antagonist ChemblInteractions
CHRM3 1131 HYOSCYAMINE CHEMBL1331216 antagonist DrugBank 11495349
CHRM3 1131 SCOPOLAMINE CHEMBL1187846 antagonist GuideToPharmacologyInteractions, DrugBank 18045203
CHRM3 1131 ITOPRIDE CHEMBL2107457 DrugBank 17300287
CHRM3 1131 MIVACURIUM CHEMBL1182833 antagonist DrugBank 19020136
CHRM3 1131 PIPECURONIUM CHEMBL1201206 antagonist DrugBank 12426786

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
CHRM3 rs2165870 AA dexamethasone efficacy not stated Authors looked at dexamethasone and acustimulation as preventative of PONV in patients with low Apfel scores. Relative Risk Reductions were greater for AA genotypes than AG+GG but authors compared each genotype to untreated rather than between genotypes. RRR 30% for Dexamethasone for AA, 19% for AG/GG, 30% for Acustimulation for AA, 26% for AG/GG, 86% for both treatments for AA and 53% for AG/GG. Genotype AA is associated with increased response to dexamethasone in people with Postoperative Nausea and Vomiting as compared to genotypes AG + GG. 29935595 1449566589