Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
CCR5 1234 GUANINE CHEMBL219568 agonist GuideToPharmacologyInteractions
CCR5 1234 BICARBONATE CHEMBL1161632 agonist GuideToPharmacologyInteractions
CCR5 1234 APLAVIROC CHEMBL1255794 antagonist GuideToPharmacologyInteractions
CCR5 1234 APLAVIROC HYDROCHLORIDE CHEMBL1668019 antagonist ChemblInteractions
CCR5 1234 VICRIVIROC MALEATE CHEMBL2107384 antagonist ChemblInteractions
CCR5 1234 CHEMBL78535 CHEMBL78535 binder TTD
CCR5 1234 GUANIDINO ACETATE CHEMBL281593 agonist GuideToPharmacologyInteractions
CCR5 1234 AZD5672 CHEMBL1951914 antagonist GuideToPharmacologyInteractions, ChemblInteractions, TTD
CCR5 1234 CHEMBL207004 CHEMBL207004 binder TTD
CCR5 1234 CHEMBL41275 CHEMBL41275 antagonist TTD
CCR5 1234 GLYCERIN CHEMBL692 agonist GuideToPharmacologyInteractions
CCR5 1234 ENOXAPARIN CHEMBL1201685 agonist GuideToPharmacologyInteractions
CCR5 1234 ANCRIVIROC (CHEMBL2107311) CHEMBL2107311 antagonist GuideToPharmacologyInteractions
CCR5 1234 CENICRIVIROC CHEMBL2110727 antagonist GuideToPharmacologyInteractions, ChemblInteractions
CCR5 1234 INCB-9471 CHEMBL1688243 antagonist ChemblInteractions, DrugBank, TTD
CCR5 1234 CHEMBL518924 CHEMBL518924 DrugBank
CCR5 1234 PF-04634817 CHEMBL3545032 antagonist ChemblInteractions
CCR5 1234 PRO-140 CHEMBL2109343 antagonist, antibody TdgClinicalTrial, ChemblInteractions, TTD
CCR5 1234 GLATIRAMER ACETATE CHEMBL1201507 PharmGKB
CCR5 1234 CHEMBL1196395 CHEMBL1196395 antagonist GuideToPharmacologyInteractions
CCR5 1234 MARAVIROC CHEMBL1201187 antagonist PharmGKB, TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, DrugBank, TTD 17139284, 17016423, 16298345, 11752352, 19098484, 19692476
CCR5 1234 VICRIVIROC CHEMBL82301 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, TTD
CCR5 1234 PHENPROCOUMON CHEMBL16694 antagonist GuideToPharmacologyInteractions

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
CCR5 rs333 del glatiramer acetate efficacy yes Significant only when also combined with the HLA-DRB1*15 allele and rs1800469 allele A. Risk of not responding to the drug was significantly increased in individuals carrying this allele combination. This risk was further increased in individuals with the HLA-DRB1*15-rs1800469 A-rs333 del-rs1012335 G allele combination. Allele del is associated with decreased response to glatiramer acetate in people with Multiple Sclerosis as compared to allele GTCAGTATCAATTCTGGAAGAATTTCCAGACA. 22111603 827823538