PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PTK2	2	JAK2	1	affinity chromatography technology, affinity chromatography technology	Zhu T (1998), Ryu H (2000)	2
PTK2	2	CCR5	1	affinity chromatography technology	Cicala C (1999)	1
AFP	1	CCR5	1	affinity chromatography technology	Atemezem A (2002)	1
STAT5B	3	JAK2	1	affinity chromatography technology, two hybrid, enzymatic study	Barahmand-Pour F (1998), Fujitani Y (1997), Varghese LN (2014)	3
CD4	1	CXCR4	0	affinity chromatography technology, affinity chromatography technology	Xiao X (2000), Markovic I (2004)	2
PTK2	2	STAT3	0	affinity chromatography technology, imaging technique	Ryu H (2000), Chen TC (2014)	2
PTK2	2	CXCR4	0	affinity chromatography technology	Wang J (2001)	1
CCR5	1	IL24	0	two hybrid	Wang J (2011)	1
STAT5B	3	STAT3	0	imaging technique	Chen TC (2014)	1
CCR5	1	ETV5	0	two hybrid	Wang J (2011)	1
JAK2	1	STAT3	0	affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Ram PA (1997), Manea A (2010), Andl CD (2004), Kamakura S (2004), He K (2013), Kucia-Tran JA (2016), M L (2016)	7
6349	0	CCR5	1	pull down, pull down	Miyakawa T (2002), Struyf S (2001)	2
CCR5	1	JAK2	1	affinity chromatography technology	Wong M (2001)	1
STAT3	0	PIK3R2	3	two hybrid	Grossmann A (2015)	1
CCR5	1	PSMA5	0	two hybrid, affinity chromatography technology	Fernandis AZ (2002), Fernandis AZ (2002)	2
CXCR4	0	CCR5	1	pull down	Agrawal L (2002)	1
CCR5	1	STAT3	0	affinity chromatography technology	Mellado M (2001)	1
CCL3	0	CCR5	1	pull down	Navenot JM (2001)	1
CCL5	1	CCR5	1	affinity chromatography technology, pull down, pull down	Slimani H (2003), Struyf S (2001), Proudfoot AE (2001)	3
CXCR4	0	JAK2	1	affinity chromatography technology	Vila-Coro AJ (1999)	1
CCR5	1	PIK3R2	3	affinity chromatography technology	Mellado M (2001)	1
CD4	1	CCR5	1	affinity chromatography technology	Xiao X (2000)	1
CCR5	1	STAT5B	3	affinity chromatography technology	Mellado M (2001)	1
CCR5	1	ARRB1	2	pull down	Huttenrauch F (2002)	1
CCR5	1	CST9L	0	two hybrid	Wang J (2011)	1
ARRB1	2	PIK3R2	3	affinity chromatography technology, two hybrid	Xiao K (2007), Wang J (2011)	2
CCR5	1	CTBP2	7	two hybrid	Wang J (2011)	1