PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRIM23	3	TRAIP	0	two hybrid	Woodsmith J (2012)	1
RNF2	1	RNF114	0	affinity chromatography technology	Cao Q (2014)	1
UBE2U	0	BARD1	4	two hybrid	van Wijk SJ (2009)	1
UBE2U	0	RNF139	4	two hybrid	van Wijk SJ (2009)	1
UBE2U	0	TRIM5	4	two hybrid	Markson G (2009)	1
RBCK1	0	PML	7	imaging technique	Tatematsu K (2005)	1
UBE2U	0	RNF181	0	two hybrid	van Wijk SJ (2009)	1
UBE2U	0	TRIM65	1	two hybrid	van Wijk SJ (2009)	1
UBE2U	0	RNF150	2	two hybrid	van Wijk SJ (2009)	1
UBE2U	0	TRIM74	0	two hybrid	Markson G (2009)	1
UBE2U	0	RNF17	6	two hybrid	van Wijk SJ (2009)	1
UBE2U	0	CGRRF1	0	two hybrid	van Wijk SJ (2009)	1
TRIM24	1	PML	7	affinity chromatography technology	Zhong S (1999)	1
UBE2U	0	MKRN3	2	two hybrid	Markson G (2009)	1
UBE2U	0	RNF114	0	two hybrid	van Wijk SJ (2009)	1
UBE2U	0	KAT6A	19	two hybrid	van Wijk SJ (2009)	1
UBE2U	0	TRIM37	7	two hybrid	van Wijk SJ (2009)	1
TRAIP	0	RNF114	0	two hybrid	Woodsmith J (2012)	1
PCGF6	0	TRIM28	1	affinity chromatography technology	Hauri S (2016)	1
RNF2	1	TRIM27	2	affinity chromatography technology	Hein MY (2015)	1
TRIM63	0	TRIM54	1	two hybrid, pull down	Centner T (2001), Centner T (2001)	2
MKRN3	2	TRIM23	3	two hybrid	Woodsmith J (2012)	1
UBE2U	0	MID2	1	two hybrid	van Wijk SJ (2009)	1
UBE2U	0	TRIM38	3	two hybrid	van Wijk SJ (2009)	1
PCGF1	1	RNF2	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gearhart MD (2006), Gearhart MD (2006), Gao Z (2012), Gao Z (2012), Gao Z (2012), Gao Z (2012), Woodsmith J (2012), Woodsmith J (2012), Cao Q (2014), Hein MY (2015), Taherbhoy AM (2015), Taherbhoy AM (2015), Oliviero G (2015), Oliviero G (2015), Hauri S (2016), Hauri S (2016)	16
PCGF1	1	RNF125	0	two hybrid	Woodsmith J (2012)	1
TRIM24	1	RNF181	0	two hybrid	Woodsmith J (2012)	1
UBE2U	0	TRIM68	2	two hybrid	van Wijk SJ (2009)	1
UBE2U	0	PCGF2	3	two hybrid	van Wijk SJ (2009)	1
RNF166	0	RNF41	2	two hybrid	Woodsmith J (2012)	1
RNF2	1	TRIM24	1	affinity chromatography technology	Cao Q (2014)	1
UBE2U	0	ZSWIM2	1	two hybrid	van Wijk SJ (2009)	1
MDM2	2	TRIM28	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang C (2005), Wang C (2005), Wang C (2005), Gilmore-Hebert M (2010), Okamoto K (2006), Okamoto K (2006), Okamoto K (2006)	7
UBE2U	0	TRIM34	1	two hybrid	van Wijk SJ (2009)	1
MDM2	2	RNF2	1	affinity chromatography technology, affinity chromatography technology	Wen W (2013), Wen W (2013)	2
UBE2U	0	TRIM15	0	two hybrid	Markson G (2009)	1
RBCK1	0	PCGF2	3	two hybrid	Woodsmith J (2012)	1
MID2	1	TRIM54	1	two hybrid	Rolland T (2014)	1
VPS28	2	MVB12A	0	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
TRIM32	2	VPS11	3	two hybrid	Woodsmith J (2012)	1
TRIM34	1	MKRN3	2	two hybrid	Woodsmith J (2012)	1
UBE2U	0	RNF26	2	two hybrid	van Wijk SJ (2009)	1
UBE2U	0	PCGF6	0	two hybrid	Markson G (2009)	1
UBE2U	0	RNF14	2	two hybrid	van Wijk SJ (2009)	1
TRIM32	2	RNF41	2	two hybrid	Woodsmith J (2012)	1
RBCK1	0	TRIM65	1	two hybrid	Woodsmith J (2012)	1
UBE2U	0	DZIP3	6	two hybrid	Markson G (2009)	1
UBE2U	0	RNFT1	0	two hybrid	van Wijk SJ (2009)	1
RNF181	0	VPS11	3	two hybrid	Woodsmith J (2012)	1
TRIM27	2	MDM2	2	affinity chromatography technology, enzymatic study	Chu Y (2011), Chu Y (2011)	2
MDM2	2	RNF10	0	two hybrid	Woodsmith J (2012)	1
UBE2U	0	TRIM47	2	two hybrid	van Wijk SJ (2009)	1
ANAPC11	0	TRIM65	1	two hybrid	Woodsmith J (2012)	1
UBE2U	0	RBCK1	0	two hybrid	Markson G (2009)	1
TRIM27	2	VPS28	2	two hybrid	Rolland T (2014)	1
UBE2U	0	RNF125	0	two hybrid	Markson G (2009)	1
UBE2U	0	RNF25	1	two hybrid	van Wijk SJ (2009)	1
TRIM27	2	MID2	1	two hybrid	Rolland T (2014)	1
GOLGA2	2	VPS28	2	two hybrid	Rolland T (2014)	1
TRIM28	1	TRIM23	3	biochemical	Reymond A (2001)	1
MDM2	2	TRIM23	3	two hybrid	Woodsmith J (2012)	1
UBE2U	0	VPS11	3	two hybrid	Markson G (2009)	1
TRIM32	2	MID2	1	two hybrid	Reymond A (2001)	1
UBE2U	0	RNF5	0	two hybrid	van Wijk SJ (2009)	1
TRIM46	3	RNF125	0	two hybrid	Woodsmith J (2012)	1
UBE2U	0	RNF170	1	two hybrid	van Wijk SJ (2009)	1
UBE2U	0	TRIM63	0	two hybrid	van Wijk SJ (2009)	1
TRIM32	2	TRIM27	2	two hybrid, two hybrid	Reymond A (2001), Woodsmith J (2012)	2
UBE2U	0	RNF41	2	two hybrid	van Wijk SJ (2009)	1
UBE2U	0	VPS28	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM65	1	MKRN3	2	two hybrid	Woodsmith J (2012)	1
TRIM28	1	TRIM24	1	fluorescent resonance energy transfe	Germain-Desprez D (2003)	1
UBE2U	0	MIB2	7	two hybrid	van Wijk SJ (2009)	1
TRIM35	1	TRIM5	4	pull down	Li X (2006)	1
UBE2U	0	RNF144B	0	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
TRIM5	4	MKRN3	2	two hybrid	Woodsmith J (2012)	1
MDM2	2	MKRN3	2	two hybrid	Woodsmith J (2012)	1
UBE2U	0	SYVN1	2	two hybrid	van Wijk SJ (2009)	1
RNF125	0	PML	7	two hybrid	Woodsmith J (2012)	1
UBE2U	0	TRIM54	1	two hybrid	van Wijk SJ (2009)	1
UBE2U	0	TRIM23	3	two hybrid	Markson G (2009)	1
UBE2U	0	DTX1	2	two hybrid	van Wijk SJ (2009)	1
UBE2U	0	PCGF1	1	two hybrid	van Wijk SJ (2009)	1
UBE2U	0	TRIM35	1	two hybrid	van Wijk SJ (2009)	1
PML	7	MDM2	2	affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bernardi R (2004), Bernardi R (2004), Zhu H (2003), Zhu H (2003), Kurki S (2003), Kurki S (2003), Wei X (2003), Wei X (2003), Wu Q (2009), Chu Y (2011), Yang Q (2013), Yang Q (2013), Bursac S (2012)	13
TRIM27	2	TRIM23	3	two hybrid, two hybrid	Reymond A (2001), Woodsmith J (2012)	2
RNF166	0	RNF114	0	affinity chromatography technology	Huttlin EL (2017)	1
KAT6A	19	PML	7	affinity chromatography technology, far western blotting	Rokudai S (2013), Rokudai S (2013)	2
UBE2U	0	TRIM32	2	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
UBE2U	0	MIB1	5	two hybrid	van Wijk SJ (2009)	1
TRIM27	2	PML	7	affinity chromatography technology	Cao T (1998)	1
UBE2U	0	RNF10	0	two hybrid	Markson G (2009)	1
UBE2U	0	TRAIP	0	two hybrid	van Wijk SJ (2009)	1
UBE2U	0	MVB12A	0	affinity chromatography technology	Huttlin EL (2017)	1
RBCK1	0	RNF181	0	two hybrid	Woodsmith J (2012)	1
RNF2	1	TRIM28	1	affinity chromatography technology	Cao Q (2014)	1
UBE2U	0	PML	7	two hybrid	van Wijk SJ (2009)	1
TRIM34	1	TRIM5	4	two hybrid, two hybrid	Zhang F (2006), Woodsmith J (2012)	2
UBE2U	0	TRIM2	1	two hybrid	van Wijk SJ (2009)	1
VPS41	3	VPS11	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), van der Kant R (2015), Huttlin EL (2017), Hunter MR (2017)	4
GOLGA2	2	UBE2U	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
RNF2	1	PCGF6	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Trojer P (2011), Gao Z (2012), Gao Z (2012), Gao Z (2012), Akasaka T (2002), Akasaka T (2002), Akasaka T (2002), Woodsmith J (2012), Cao Q (2014), Hein MY (2015), Taherbhoy AM (2015), Taherbhoy AM (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	15
UBE2U	0	MUL1	1	two hybrid	van Wijk SJ (2009)	1
TRIM2	1	TRIM3	2	affinity chromatography technology	Huttlin EL (2017)	1
RNF25	1	TRIM27	2	two hybrid	Woodsmith J (2012)	1
UBE2U	0	TRIM28	1	two hybrid	van Wijk SJ (2009)	1
TRIM32	2	TRIM23	3	two hybrid	Reymond A (2001)	1
UBE2U	0	RNF113B	1	two hybrid	van Wijk SJ (2009)	1
UBE2U	0	TRIM24	1	two hybrid	van Wijk SJ (2009)	1
TRIM5	4	TRIM32	2	two hybrid	Woodsmith J (2012)	1
RNF166	0	MKRN3	2	two hybrid	Woodsmith J (2012)	1
UBE2U	0	PJA1	1	two hybrid	van Wijk SJ (2009)	1
UBE2U	0	TRIM27	2	two hybrid	Markson G (2009)	1
UBE2U	0	VPS41	3	two hybrid	van Wijk SJ (2009)	1
UBE2U	0	ANAPC11	0	two hybrid	van Wijk SJ (2009)	1
BARD1	4	GOLGA2	2	two hybrid	Rolland T (2014)	1
UBE2U	0	TRIM3	2	two hybrid	van Wijk SJ (2009)	1
GOLGA2	2	MID2	1	two hybrid	Rolland T (2014)	1
UBE2U	0	TRIM46	3	two hybrid	Markson G (2009)	1
UBE2U	0	CADPS2	0	two hybrid	van Wijk SJ (2009)	1
UBE2U	0	RNF11	0	two hybrid	van Wijk SJ (2009)	1
PCGF2	3	RNF2	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Elderkin S (2007), Elderkin S (2007), Maertens GN (2009), Gao Z (2012), Gao Z (2012), Gao Z (2012), Endoh M (2012), Woodsmith J (2012), Woodsmith J (2012), Cao Q (2014), Taherbhoy AM (2015), Taherbhoy AM (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	15
UBE2U	0	RNF2	1	two hybrid	van Wijk SJ (2009)	1
UBE2U	0	RNF166	0	two hybrid	van Wijk SJ (2009)	1
UBE2U	0	MDM2	2	two hybrid	van Wijk SJ (2009)	1
RNF166	0	VPS11	3	affinity chromatography technology	Huttlin EL (2015)	1
UBE2U	0	RNF113A	0	two hybrid	van Wijk SJ (2009)	1
VPS28	2	TRIM54	1	two hybrid	Rolland T (2014)	1
UBE2U	0	BFAR	0	two hybrid	van Wijk SJ (2009)	1