PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ECSIT	3	EXOC6	1	two hybrid	Soler-Lopez M (2011)	1
RIN3	2	CYP2C8	3	two hybrid	Grossmann A (2015)	1
MAST1	9	APOE	1	two hybrid	Soler-Lopez M (2011)	1
A2M	8	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	APOE	1	two hybrid	Soler-Lopez M (2011)	1
A2M	8	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	CYP2C8	3	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	CYP2C8	3	two hybrid	Soler-Lopez M (2011)	1
IFIT3	1	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	PSEN1	11	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	CYP2C8	3	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	BLMH	0	two hybrid	Soler-Lopez M (2011)	1
APOE	1	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	DNAJB1	1	two hybrid	Soler-Lopez M (2011)	1
A2M	8	IFIT3	1	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	IFIT3	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	BLMH	0	two hybrid	Soler-Lopez M (2011)	1
IFIT3	1	APOE	1	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	CYP2C8	3	two hybrid	Soler-Lopez M (2011)	1
CYP2C8	3	PGRMC1	1	affinity chromatography technology	Szczesna-Skorupa E (2011)	1
CYP2C8	3	BLMH	0	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	DNAJB1	1	two hybrid	Soler-Lopez M (2011)	1
CYP2C8	3	APOE	1	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	EXOC6	1	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	PSEN1	11	two hybrid, affinity chromatography technology, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011), Soler-Lopez M (2011)	3
MAST1	9	A2M	8	two hybrid	Soler-Lopez M (2011)	1
CYP2C8	3	DNAJB1	1	two hybrid	Soler-Lopez M (2011)	1
A2M	8	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
CYP2C8	3	CYP2C8	3	x-ray crystallography, pull down	Schoch GA (2004), Schoch GA (2004)	2
RNF32	0	EXOC6	1	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
CYP2C8	3	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
A2M	8	DNAJB1	1	two hybrid	Soler-Lopez M (2011)	1
A2M	8	APOE	1	affinity chromatography technology, pull down, two hybrid	Krimbou L (1998), Krimbou L (1998), Soler-Lopez M (2011)	3
PSEN1	11	APOE	1	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	APOE	1	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
RNF32	0	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	LONP1	9	two hybrid	Soler-Lopez M (2011)	1
CYP2C8	3	EXOC6	1	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	BLMH	0	two hybrid	Soler-Lopez M (2011)	1
MAST1	9	IFIT3	1	two hybrid	Soler-Lopez M (2011)	1
A2M	8	CYP2C8	3	two hybrid	Soler-Lopez M (2011)	1
CYP2C8	3	IFIT3	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	IFIT3	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	MAST1	9	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	LONP1	9	two hybrid	Soler-Lopez M (2011)	1