PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DCN	0	LONP2	0	affinity chromatography technology	Huttlin EL (2015)	1
DCN	0	ZBTB33	1	affinity chromatography technology	Huttlin EL (2015)	1
TGFB1	2	DCN	0	pull down, pull down, pull down	Hildebrand A (1994), Schoenherr E (1998), Takeuchi Y (1994)	3
SFTPD	2	DCN	0	pull down	Nadesalingam J (2003)	1
EGFR	5	AHSG	0	affinity chromatography technology	Yao Z (2017)	1
TNF	0	DCN	0	pull down	Tufvesson E (2002)	1
DCN	0	COL6A1	2	pull down	Bidanset DJ (1992)	1
ELN	1	DCN	0	pull down	Reinboth B (2002)	1
DCN	0	CHSY1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MET	7	DCN	0	affinity chromatography technology, pull down	Goldoni S (2009), Goldoni S (2009)	2
DCN	0	PLAT	2	affinity chromatography technology	Huttlin EL (2015)	1
TGFB2	2	DCN	0	pull down	Schoenherr E (1998)	1
COL14A1	5	DCN	0	pull down	Ehnis T (1997)	1
DCN	0	FLNA	10	pull down	Yoshida K (2002)	1
DCN	0	KLHL17	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DCN	0	EGFR	5	two hybrid, pull down, pull down	Santra M (2002), Santra M (2002), Iozzo RV (1999)	3
PLA2G2A	1	DCN	0	pull down	Sartipy P (2000)	1
BRCA1	7	FLNA	10	affinity chromatography technology, affinity chromatography technology	Woods NT (2012), Ertych N (2016)	2
DCN	0	AHSG	0	pull down	Sugars RV (2002)	1
BRCA1	7	DCN	0	two hybrid	Woods NT (2012)	1
C1QA	0	DCN	0	pull down	Krumdieck R (1992)	1
EGFR	5	MET	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li J (2013), Li L (2015), Liu X (2011)	3