PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EWSR1	2	ACE	6	bioid	Elzi DJ (2014)	1
ACE	6	BDKRB2	0	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Chen Z (2006), Chen Z (2006), Chen Z (2006)	3
AGT	3	EWSR1	2	two hybrid	Rual JF (2005)	1
ACE	6	AGT	3	enzymatic study, enzymatic study, x-ray crystallography	Donoghue M (2000), Rice GI (2004), Masuyer G (2012)	3
ACE	6	CSNK2A1	15	affinity chromatography technology, unspecified method	Kohlstedt K (2006), Kohlstedt K (2006)	2
ACE	6	ACTB	8	affinity chromatography technology	Kohlstedt K (2006)	1
ACE	6	MYH9	19	affinity chromatography technology, unspecified method, affinity chromatography technology	Kohlstedt K (2006), Kohlstedt K (2006), Kohlstedt K (2006)	3
MYH9	19	ACTB	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kohlstedt K (2006), Hein MY (2015), Chiu HC (2012)	3
LMNA	2	CSNK2A1	15	affinity chromatography technology	Depreux FF (2015)	1
LMNA	2	ACE	6	bioid	Roux KJ (2012)	1
MYH9	19	CSNK2A1	15	affinity chromatography technology, enzymatic study	Kohlstedt K (2006), Kohlstedt K (2006)	2