PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DLX2	0	MSX2	1	pull down, pull down	Zhang H (1997), Zhang H (1997)	2
XRCC6	3	MSX2	1	affinity chromatography technology	Willis DM (2002)	1
MSX1	0	HOXC8	0	pull down	Zhang H (1997)	1
XRCC6	3	DLX2	0	pull down	Schild-Poulter C (2001)	1
AVP	0	DLX2	0	two hybrid	Corominas R (2014)	1
DLX2	0	DLX2	0	pull down	Zhang H (1997)	1
MSX2	1	MSX1	0	pull down, pull down, two hybrid	Zhang H (1997), Zhang H (1997), Zhang H (1997)	3
DLX2	0	GRN	2	two hybrid	Rolland T (2014)	1
TSPOAP1	9	DLX2	0	two hybrid	Corominas R (2014)	1
MVP	1	TSPOAP1	9	two hybrid	Corominas R (2014)	1
DLX5	0	MSX2	1	pull down, pull down	Zhang H (1997), Zhang H (1997)	2
DLX2	0	HOXC8	0	pull down	Zhang H (1997)	1
DLX5	0	DLX2	0	pull down, pull down	Zhang H (1997), Zhang H (1997)	2
PRKN	1	XRCC6	3	affinity chromatography technology	Zanon A (2013)	1
DLX2	0	MSX1	0	pull down, pull down, two hybrid	Zhang H (1997), Zhang H (1997), Zhang H (1997)	3
PRKN	1	DLX2	0	two hybrid	Corominas R (2014)	1
MVP	1	DLX2	0	two hybrid	Corominas R (2014)	1
DLX2	0	PIK3R1	6	two hybrid	Wang J (2011)	1
DGCR6	0	DLX2	0	two hybrid	Corominas R (2014)	1
DLX5	0	MSX1	0	pull down, pull down	Zhang H (1997), Zhang H (1997)	2
DLX5	0	HOXC8	0	pull down	Zhang H (1997)	1