PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MCM2	3	TARDBP	4	affinity chromatography technology	Drissi R (2015)	1
NTRK1	1	ZNF598	6	affinity chromatography technology	Emdal KB (2015)	1
ATG101	1	DSC1	2	affinity chromatography technology	Behrends C (2010)	1
TUBG1	2	DSP	8	affinity chromatography technology	Fogeron ML (2013)	1
PKP2	4	JUP	7	affinity chromatography technology, two hybrid	Chen X (2002), Chen X (2002)	2
USP1	4	DSG1	1	affinity chromatography technology	Sowa ME (2009)	1
PRKAB1	0	DSC1	2	affinity chromatography technology	Behrends C (2010)	1
CDK2	0	JUP	7	affinity chromatography technology	Neganova I (2011)	1
CYLD	2	JUP	7	affinity chromatography technology	Elliott PR (2016)	1
PKP3	4	DSP	8	two hybrid	Bonne S (2003)	1
TUBG1	2	DSC1	2	affinity chromatography technology	Fogeron ML (2013)	1
UCHL5	1	DSP	8	pull down	Fang Y (2011)	1
ZNF598	6	DSC1	2	affinity chromatography technology	Garzia A (2017)	1
UBXN1	0	DSC1	2	affinity chromatography technology	Raman M (2015)	1
ZNF598	6	DSP	8	affinity chromatography technology	Garzia A (2017)	1
USP1	4	DSC1	2	affinity chromatography technology	Sowa ME (2009)	1
CYLD	2	DSG1	1	affinity chromatography technology	Elliott PR (2016)	1
CDK2	0	CDC20	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), So J (2015), Craney A (2016), Huttlin EL (2017)	4
CDK2	0	DSP	8	affinity chromatography technology	Neganova I (2011)	1
MCM5	1	JUP	7	affinity chromatography technology	Drissi R (2015)	1
MCM2	3	DSP	8	affinity chromatography technology	Drissi R (2015)	1
USP1	4	JUP	7	affinity chromatography technology	Sowa ME (2009)	1
MAPK7	1	JUP	7	affinity chromatography technology	Varjosalo M (2013)	1
DSC1	2	DSP	8	pull down	Smith EA (1998)	1
DLD	1	DSC1	2	affinity chromatography technology	Malty RH (2017)	1
CEP76	1	DSC1	2	affinity chromatography technology	Fogeron ML (2013)	1
MCM5	1	DSP	8	affinity chromatography technology	Drissi R (2015)	1
PKP1	2	DSC1	2	two hybrid	Cheng X (2004)	1
CYLD	2	TARDBP	4	affinity chromatography technology	Elliott PR (2016)	1
CYLD	2	PKP1	2	affinity chromatography technology	Elliott PR (2016)	1
MCM2	3	PLK1	0	affinity chromatography technology	Boldt K (2016)	1
NTRK1	1	DLD	1	affinity chromatography technology	Emdal KB (2015)	1
MCM2	3	JUP	7	affinity chromatography technology	Drissi R (2015)	1
TUBG1	2	PKP1	2	affinity chromatography technology	Fogeron ML (2013)	1
NTRK1	1	TUBG1	2	affinity chromatography technology	Emdal KB (2015)	1
DLD	1	DSP	8	affinity chromatography technology	Malty RH (2017)	1
PKP2	4	DSG1	1	affinity chromatography technology, two hybrid	Chen X (2002), Chen X (2002)	2
NTRK1	1	MCM5	1	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	DSP	8	affinity chromatography technology	Emdal KB (2015)	1
CFTR	5	DSP	8	affinity chromatography technology	Pankow S (2015)	1
CYLD	2	NF2	1	affinity chromatography technology	Elliott PR (2016)	1
ZNF598	6	DSG1	1	affinity chromatography technology	Garzia A (2017)	1
NTRK1	1	MCM2	3	affinity chromatography technology	Emdal KB (2015)	1
CEP57	0	DSC1	2	affinity chromatography technology	Fogeron ML (2013)	1
CFTR	5	UBXN1	0	affinity chromatography technology	Pankow S (2015)	1
PLK1	0	TUBG1	2	affinity chromatography technology	Feng Y (1999)	1
DSP	8	JUP	7	affinity chromatography technology, affinity chromatography technology, two hybrid	Kowalczyk AP (1998), Kowalczyk AP (1997), Kowalczyk AP (1997)	3
TARDBP	4	DSC1	2	affinity chromatography technology	Freibaum BD (2010)	1
CFTR	5	TARDBP	4	affinity chromatography technology	Pankow S (2015)	1
MCM5	1	DSC1	2	affinity chromatography technology	Drissi R (2015)	1
TARDBP	4	DSP	8	affinity chromatography technology	Freibaum BD (2010)	1
PKP3	4	DSG1	1	two hybrid, affinity chromatography technology	Bonne S (2003), Bonne S (2003)	2
NF2	1	DSC1	2	affinity chromatography technology	Zhou L (2015)	1
CFTR	5	DSC1	2	affinity chromatography technology	Pankow S (2015)	1
NTRK1	1	MAPK7	1	affinity chromatography technology	Emdal KB (2015)	1
CDC20	1	PLK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Sedgwick GG (2012), Hyun SY (2013), Hyun SY (2013), Hyun SY (2013), Jia L (2016)	5
UBASH3B	4	CRK	0	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009)	2
PKP2	4	DSC1	2	two hybrid	Chen X (2002)	1
MCM2	3	DSG1	1	affinity chromatography technology	Drissi R (2015)	1
TARDBP	4	JUP	7	affinity chromatography technology	Freibaum BD (2010)	1
NTRK1	1	UCHL5	1	affinity chromatography technology	Emdal KB (2015)	1
DSC1	2	DSG2	8	pull down, affinity chromatography technology	Chitaev NA (1997), Chitaev NA (1997)	2
MCM2	3	PKP1	2	affinity chromatography technology	Drissi R (2015)	1
CDK2	0	MCM2	3	enzymatic study, affinity chromatography technology	Montagnoli A (2006), Neganova I (2011)	2
JUP	7	DSC1	2	two hybrid	Cheng X (2004)	1
NTRK1	1	PLK1	0	affinity chromatography technology	Emdal KB (2015)	1
ZNF598	6	JUP	7	affinity chromatography technology	Garzia A (2017)	1
TARDBP	4	PKP1	2	affinity chromatography technology	Freibaum BD (2010)	1
DSG1	1	DSC1	2	pull down	Smith EA (1998)	1
CDC20	1	DSC1	2	affinity chromatography technology	Fogeron ML (2013)	1
PKP3	4	DSG2	8	two hybrid, affinity chromatography technology	Bonne S (2003), Bonne S (2003)	2
DSG2	8	JUP	7	affinity chromatography technology, affinity chromatography technology, pull down	Bannon LJ (2001), Wahl JK3rd (2000), Ozawa M (1995)	3
CFTR	5	MCM2	3	affinity chromatography technology	Pankow S (2015)	1
PKP3	4	JUP	7	two hybrid	Bonne S (2003)	1
CDK2	0	DSG1	1	affinity chromatography technology	Neganova I (2011)	1
CRK	0	DSC1	2	affinity chromatography technology	Brehme M (2009)	1
MCM2	3	DSC1	2	affinity chromatography technology	Drissi R (2015)	1
PKP1	2	DSP	8	pull down, affinity chromatography technology	Hofmann I (2000), Hofmann I (2000)	2
PLK1	0	DSC1	2	affinity chromatography technology	Hein MY (2015)	1
NTRK1	1	JUP	7	affinity chromatography technology	Emdal KB (2015)	1
CYLD	2	MCM5	1	affinity chromatography technology	Elliott PR (2016)	1
CEP76	1	DSG1	1	affinity chromatography technology	Fogeron ML (2013)	1
UBASH3B	4	DSC1	2	affinity chromatography technology	Brehme M (2009)	1
PKP2	4	DSG2	8	affinity chromatography technology	Chen X (2002)	1
DSG1	1	PKP1	2	pull down	Smith EA (1998)	1
NTRK1	1	CDK2	0	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	TARDBP	4	affinity chromatography technology	Emdal KB (2015)	1
UCHL5	1	PKP1	2	pull down	Fang Y (2011)	1
DLD	1	JUP	7	affinity chromatography technology	Malty RH (2017)	1
UCHL5	1	DSC1	2	pull down	Fang Y (2011)	1
PKP3	4	DSC1	2	two hybrid	Bonne S (2003)	1
CDC20	1	TUBG1	2	affinity chromatography technology	Kim AH (2009)	1
MCM2	3	UBXN1	0	affinity chromatography technology	Drissi R (2015)	1
NTRK1	1	DSC1	2	affinity chromatography technology	Emdal KB (2015)	1
USP1	4	PKP1	2	affinity chromatography technology	Sowa ME (2009)	1
PKP2	4	DSP	8	affinity chromatography technology, two hybrid	Chen X (2002), Chen X (2002)	2
GOSR1	1	PKP1	2	affinity chromatography technology	Behrends C (2010)	1
DSG1	1	JUP	7	pull down	Smith EA (1998)	1
UBXN1	0	DSG1	1	affinity chromatography technology	Raman M (2015)	1
CYLD	2	DSP	8	affinity chromatography technology	Elliott PR (2016)	1
MCM5	1	DSG1	1	affinity chromatography technology	Drissi R (2015)	1
NTRK1	1	DSG1	1	affinity chromatography technology	Emdal KB (2015)	1
TUBG1	2	DSG1	1	affinity chromatography technology	Fogeron ML (2013)	1
MAPK7	1	DSG1	1	affinity chromatography technology	Varjosalo M (2013)	1
UBXN1	0	JUP	7	affinity chromatography technology	Raman M (2015)	1
PLK1	0	DSG1	1	affinity chromatography technology	Hein MY (2015)	1
MCM5	1	MCM2	3	two hybrid, two hybrid, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Kneissl M (2003), Kneissl M (2003), DaFonseca CJ (2001), Havugimana PC (2012), Ramachandran N (2004), Wan C (2015), Drissi R (2015), Drissi R (2015), Huang J (2013), Lossaint G (2013)	10
GOSR1	1	DSC1	2	affinity chromatography technology	Behrends C (2010)	1
CDK2	0	TUBG1	2	biochemical	Nishimura T (2005)	1
CDK2	0	DSC1	2	affinity chromatography technology	Neganova I (2011)	1
CYLD	2	PLK1	0	affinity chromatography technology, affinity chromatography technology	Stegmeier F (2007), Stegmeier F (2007)	2
MAPK7	1	DSC1	2	affinity chromatography technology	Varjosalo M (2013)	1
CYLD	2	DSC1	2	affinity chromatography technology	Elliott PR (2016)	1