PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SRC	2	FYN	1	unspecified method, affinity chromatography technology, affinity chromatography technology	Pirozzi G (1997), Chen Y (2009), Huttlin EL (2017)	3
EPHA3	5	ILKAP	2	two hybrid	Yao Z (2017)	1
EFNA5	1	EPHA7	2	affinity chromatography technology, affinity chromatography technology	Janis LS (1999), Huttlin EL (2017)	2
LRRIQ1	5	EPHA7	2	affinity chromatography technology	Huttlin EL (2017)	1
TMEM231	1	EPHA3	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBXO7	1	EPHA3	5	enzymatic study	Teixeira FR (2016)	1
EPHA7	2	STYX	1	two hybrid	Yao Z (2017)	1
SRPK1	2	EPHA3	5	enzymatic study	Varjosalo M (2013)	1
EPHA3	5	DUSP21	0	two hybrid	Yao Z (2017)	1
CDKN2A	1	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Zhang Y (2003), Zhang Y (2003), Rizos H (2003), Zhang Y (1998), Zhang Y (1998), Li L (2010), Li L (2010), Kamijo T (1998), Stott FJ (1998), Ivanov AA (2017)	10
EPHA3	5	TP53	0	pull down	Jiang T (2004)	1
EPHA7	2	DUSP18	0	two hybrid	Yao Z (2017)	1
LRRIQ1	5	EPHA3	5	affinity chromatography technology	Huttlin EL (2017)	1
HLA-DRA	2	EPHA3	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EFNB2	0	EFNB1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CEACAM21	1	EPHA3	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TP53	0	SLAMF1	2	genetic interference	Xie L (2013)	1
EPHA3	5	MTMR11	2	two hybrid	Yao Z (2017)	1
CDKN2A	1	EPHA3	5	pull down	Souza-Rodrigues E (2007)	1
SRC	2	EFNB1	0	enzymatic study	Holland SJ (1996)	1
CEACAM21	1	EFNB1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SRPK1	2	TP53	0	two hybrid, pull down, affinity chromatography technology	Peidis P (2011), Peidis P (2011), Peidis P (2011)	3
ABL1	9	CRK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, two hybrid, enzymatic study	Brehme M (2009), Brehme M (2009), Brehme M (2009), Peterson ME (2008), Yoshida K (2005), Chen C (2008), Feller SM (1994), Feller SM (1994), Bai RY (1998), Ren J (2002)	10
CRK	0	TP53	0	two hybrid	Grossmann A (2015)	1
EFNA5	1	SRC	2	pull down	Kressler D (2007)	1
ABL1	9	EPHA3	5	pull down	Yu HH (2001)	1
FAM118B	0	EPHA3	5	affinity chromatography technology	Huttlin EL (2017)	1
SLAMF1	2	EPHA3	5	affinity chromatography technology	Huttlin EL (2017)	1
FYN	1	SLAMF1	2	pull down	Chan B (2003)	1
EPHA3	5	EFNA3	0	pull down	Lackmann M (1997)	1
SRC	2	TP53	0	enzymatic study	Huang YF (2014)	1
ABL1	9	TP53	0	pull down	Nie Y (2000)	1
EPHA3	5	CTDSP2	1	two hybrid	Yao Z (2017)	1
ABL1	9	SRC	2	pull down	Yu HH (2001)	1
EPHA3	5	DUSP18	0	two hybrid	Yao Z (2017)	1
EFNA5	1	EPHA3	5	pull down, pull down, biochemical	Kozlosky CJ (1997), Lackmann M (1997), Lackmann M (1997)	3
EPHA3	5	RBM18	0	two hybrid	Wang J (2011)	1
EPHA3	5	STYX	1	two hybrid	Yao Z (2017)	1
FBXO7	1	ABL1	9	enzymatic study	Teixeira FR (2016)	1
EPHA3	5	EFNB2	0	pull down, pull down	Cerretti DP (1995), Lackmann M (1997)	2
FBXO7	1	ILKAP	2	enzymatic study	Teixeira FR (2016)	1
EFNA3	0	EPHA7	2	affinity chromatography technology	Janis LS (1999)	1
SRC	2	EPHA3	5	pull down	Zisch AH (1998)	1
EPHA3	5	EFNA4	1	pull down	Lackmann M (1997)	1
CRK	0	EPHA3	5	affinity chromatography technology	Lawrenson ID (2002)	1
LRRIQ1	5	FYN	1	affinity chromatography technology	Huttlin EL (2017)	1
EPHA7	2	EPHA3	5	affinity chromatography technology	Huttlin EL (2017)	1
CEACAM21	1	SRC	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EPHA3	5	EFNB1	0	pull down	Lackmann M (1997)	1
EPHA3	5	7179	0	two hybrid	Yao Z (2017)	1
FBXO7	1	STYX	1	enzymatic study	Teixeira FR (2016)	1
TMEM231	1	EPHA7	2	affinity chromatography technology	Huttlin EL (2015)	1
CRK	0	SRC	2	affinity chromatography technology, affinity chromatography technology	Hsia DA (2003), Garcia-Guzman M (2000)	2
EPHA3	5	EFNA1	0	pull down	Lackmann M (1997)	1
FYN	1	EPHA3	5	pull down	Zisch AH (1998)	1