PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
USP11	3	UBC	7	enzymatic study, pull down, pull down	Faesen AC (2011), Zhang X (2017), Kwasna D (2018)	3
USP11	3	OTUD1	3	affinity chromatography technology	Sowa ME (2009)	1
OTUD1	3	FLNB	11	affinity chromatography technology	Sowa ME (2009)	1
OTUD1	3	TP53	0	affinity chromatography technology, affinity chromatography technology	Piao S (2017), Piao S (2017)	2
RAD23A	1	UBC	7	pull down, pull down, x-ray crystallography, pull down, x-ray crystallography, affinity chromatography technology, pull down, pull down, unspecified method, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, pull down, x-ray crystallography, pull down, pull down	Kang Y (2006), Sims JJ (2009), Kang Y (2007), Kang Y (2007), Wang Q (2003), Scanlon TC (2009), Raasi S (2003), Sokratous K (2012), Varadan R (2005), Fenner BJ (2009), Raasi S (2005), Massey LK (2004), Chen L (2006), Nathan JA (2013), Nathan JA (2013), Jung J (2014), Goh AM (2008), Castaneda CA (2013), Nakasone MA (2013), Lai MY (2012), Kristariyanto YA (2015), Zhang X (2017)	22
OTUD1	3	RIPK1	2	enzymatic study	Mevissen TE (2013)	1
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
TP53	0	FLNA	10	affinity chromatography technology	Horikawa I (2014)	1
FLNA	10	FLNB	11	two hybrid, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Sheen VL (2002), Sheen VL (2002), Havugimana PC (2012), Wan C (2015), Hein MY (2015)	5
OTUD1	3	UBC	7	enzymatic study, pull down	Mevissen TE (2013), Kwasna D (2018)	2
RAD23A	1	RAD23B	1	biochemical, affinity chromatography technology	van der Spek PJ (1996), Hsieh HC (2005)	2
USP11	3	TP53	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Sowa ME (2009), Ke JY (2014), Ke JY (2014)	3
XPO1	8	RIPK1	2	affinity chromatography technology	Kirli K (2015)	1
FLNB	11	FLNC	8	biochemical	Kristensen AR (2012)	1
OTUD1	3	FLNC	8	affinity chromatography technology	Sowa ME (2009)	1
XPO1	8	OTUD1	3	affinity chromatography technology	Kirli K (2015)	1
OTUD1	3	RAD23A	1	affinity chromatography technology	Sowa ME (2009)	1
RAD23A	1	TP53	0	affinity chromatography technology, affinity chromatography technology	Brignone C (2004), Hsieh HC (2005)	2
UBC	7	RAD23B	1	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Ryu KS (2003), Chen L (2006), Nathan JA (2013), Nathan JA (2013), Nakayasu ES (2013), Nakayasu ES (2013), Kristariyanto YA (2015), Zhang X (2017)	9
OTUD1	3	FLNA	10	affinity chromatography technology	Sowa ME (2009)	1
OTUD1	3	RAD23B	1	affinity chromatography technology	Sowa ME (2009)	1
RIPK1	2	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao L (2015), Ding Z (2015), Varfolomeev E (2015)	3