PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HUWE1	22	PSMC5	4	affinity chromatography technology	Thompson JW (2014)	1
MRAS	0	RALGDS	4	two hybrid, pull down	Kimmelman A (1997), Ehrhardt GR (1999)	2
RHOU	0	MRAS	0	pull down	Dart AE (2015)	1
MRAS	0	RAPGEF5	1	affinity chromatography technology, pull down	Rebhun JF (2000), Rebhun JF (2000)	2
RAF1	3	SHOC2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li W (2000), Li W (2000), Jang ER (2014), Jang ER (2015)	4
RAPGEF6	6	MRAS	0	pull down	Gao X (2001)	1
MRAS	0	BRAF	12	affinity chromatography technology	Kimmelman AC (2002)	1
MRAS	0	PKLR	0	affinity chromatography technology	Huttlin EL (2017)	1
PSMC5	4	MRAS	0	affinity chromatography technology	Jang ER (2015)	1
SHOC2	4	PSMC5	4	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Jang ER (2015), Jang ER (2015), Jang ER (2015), Jang ER (2015)	4
BRAF	12	RAF1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Weber CK (2001), Weber CK (2001), Kilili GK (2010), Chen C (2008), Chen C (2008), Lito P (2012), Huttlin EL (2017)	7
RAF1	3	MRAS	0	pull down, affinity chromatography technology	Ehrhardt GR (1999), Jang ER (2014)	2
SHOC2	4	HUWE1	22	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jang ER (2014), Jang ER (2014), Jang ER (2014), Jang ER (2014), Jang ER (2015), Jang ER (2015)	6
MRAS	0	SHOC2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jang ER (2014), Jang ER (2015), Jang ER (2015)	3
MRAS	0	ELOC	0	two hybrid	Wang J (2011)	1
RASSF5	2	MRAS	0	pull down, affinity chromatography technology	Ortiz-Vega S (2002), Ortiz-Vega S (2002)	2
RAF1	3	HUWE1	22	affinity chromatography technology	Jang ER (2014)	1
MRAS	0	HUWE1	22	affinity chromatography technology	Jang ER (2014)	1