PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
XYLT2	3	FOXJ1	0	affinity chromatography technology	Boldt K (2016)	1
CDK20	0	RHOT1	0	affinity chromatography technology	Wang Q (2017)	1
CDK20	0	PPP5C	2	pull down	Fu Z (2006)	1
MAK	3	ICK	1	affinity chromatography technology	Boldt K (2016)	1
CDK20	0	CDK12	3	affinity chromatography technology	Varjosalo M (2013)	1
CDK20	0	84163	0	two hybrid	Qiu H (2008)	1
CDK7	0	POLR2B	3	enzymatic study	Cujec TP (1997)	1
CDK2	0	EEF2	11	affinity chromatography technology	Neganova I (2011)	1
CDK20	0	LBR	1	affinity chromatography technology	Wang Q (2017)	1
PSMC6	0	PSMB2	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
CDK20	0	AHSA1	0	affinity chromatography technology	Wang Q (2017)	1
CDK20	0	RBBP4	3	affinity chromatography technology	Varjosalo M (2013)	1
SLC9A6	1	CDK20	0	affinity chromatography technology	Huttlin EL (2017)	1
CDK7	0	CDK2	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Drapkin R (1996), Cheng A (2005), Xu X (1999), Higashi H (1996), Aprelikova O (1995), Moisan A (2004), Larochelle S (2012), Larochelle S (2006), Larochelle S (2006), Garrett S (2001), Garrett S (2001), Lolli G (2004), Varjosalo M (2013), So J (2015)	14
FKBP8	1	PSMD1	2	affinity chromatography technology	Nakagawa T (2007)	1
CDK20	0	CCNH	3	two hybrid, affinity chromatography technology	Qiu H (2008), Qiu H (2008)	2
CDK20	0	ICK	1	affinity chromatography technology, enzymatic study	Fu Z (2006), Fu Z (2006)	2
CDK20	0	NPEPPS	3	affinity chromatography technology	Wang Q (2017)	1
CDK7	0	CCNH	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down	Maekelae TP (1994), Maekelae TP (1994), Maekelae TP (1994), Maekelae TP (1994), Yee A (1995), Garber ME (2000), Garber ME (2000), Jeronimo C (2007), Reardon JT (1996), Liu J (1997), Cujec TP (1997), Epie N (2005), Bockstaele L (2006), Tassan JP (1995), Chen D (1999), Havugimana PC (2012), Poterszman A (1997), Nguyen VT (2001), Garrett S (2001), Pinhero R (2004), Varjosalo M (2013), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Luo J (2015)	25
CDK20	0	PSMC6	0	affinity chromatography technology	Varjosalo M (2013)	1
CFAP20	0	CDK20	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
CDK2	0	NPEPPS	3	affinity chromatography technology	Neganova I (2011)	1
CDK7	0	CDK20	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDK20	0	PSMB5	3	affinity chromatography technology	Varjosalo M (2013)	1
CDK20	0	HDAC1	4	affinity chromatography technology	Boldt K (2016)	1
RFX3	7	CFAP20	0	affinity chromatography technology	Boldt K (2016)	1
PSMC6	0	PSMD1	2	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
FOXJ1	0	RFX3	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017), Boldt K (2016)	3
CDK20	0	NTPCR	2	affinity chromatography technology	Varjosalo M (2013)	1
PSMB2	0	PSMD1	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
CDK20	0	POLR2B	3	affinity chromatography technology	Varjosalo M (2013)	1
CDK2	0	PSMC6	0	affinity chromatography technology	Neganova I (2011)	1
CDK20	0	CDK2	0	enzymatic study	Liu Y (2004)	1
PSMB5	3	PSMD1	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
CDK20	0	XYLT2	3	affinity chromatography technology	Boldt K (2016)	1
HAX1	1	CDK20	0	affinity chromatography technology	Huttlin EL (2017)	1
CCNH	3	POLR2B	3	enzymatic study	Cujec TP (1997)	1
PSMB2	0	PSMB5	3	two hybrid, biochemical, biochemical, biochemical, affinity chromatography technology	Fricke B (2007), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	5
RFX3	7	CDK20	0	affinity chromatography technology	Boldt K (2016)	1
CDK20	0	PSMB2	0	affinity chromatography technology	Varjosalo M (2013)	1
AHSA1	0	ATP1A1	9	affinity chromatography technology	Wolfgeher D (2015)	1
CDK20	0	ATP1A1	9	affinity chromatography technology	Varjosalo M (2013)	1
XYLT2	3	HDAC1	4	affinity chromatography technology	Boldt K (2016)	1
CDK20	0	PANK4	3	two hybrid	Qiu H (2008)	1
CDK20	0	RAF1	3	affinity chromatography technology	Varjosalo M (2013)	1
ICK	1	PSMC6	0	affinity chromatography technology	Varjosalo M (2013)	1
RFX3	7	XYLT2	3	affinity chromatography technology	Boldt K (2016)	1
CDK2	0	SMC1A	15	affinity chromatography technology	Neganova I (2011)	1
CDK20	0	PSMD1	2	affinity chromatography technology	Varjosalo M (2013)	1
CDK20	0	SMC1A	15	affinity chromatography technology	Varjosalo M (2013)	1
AHSA1	0	PPP5C	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014)	4
CDK12	3	PSMD1	2	genetic interference	Horlbeck MA (2018)	1
FKBP8	1	PSMB2	0	affinity chromatography technology	Nakagawa T (2007)	1
CDK20	0	CSNK2B	5	two hybrid, affinity chromatography technology	Qiu H (2008), Qiu H (2008)	2
HDAC1	4	FOXJ1	0	affinity chromatography technology	Boldt K (2016)	1
CCNH	3	CDK2	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xu X (1999), Higashi H (1996), Garrett S (2001), Lolli G (2004), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	7
CDK5	0	CDK20	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAK	3	CDK20	0	affinity chromatography technology	Wang LY (2012)	1
HDAC1	4	CSNK2B	5	affinity chromatography technology	Joshi P (2013)	1
CDK20	0	EEF2	11	affinity chromatography technology	Varjosalo M (2013)	1
CDK20	0	ZNF146	1	affinity chromatography technology	Varjosalo M (2013)	1
FOXJ1	0	CFAP20	0	affinity chromatography technology, affinity chromatography technology	Li X (2015), Boldt K (2016)	2
STUB1	4	PSMD1	2	affinity chromatography technology	Arndt V (2005)	1
CCNH	3	CSNK2B	5	two hybrid	Wang J (2011)	1
CDK20	0	NOP58	3	affinity chromatography technology	Varjosalo M (2013)	1
CDK20	0	KEAP1	0	affinity chromatography technology, affinity chromatography technology	Wang Q (2017), Wang Q (2017)	2
PSMC6	0	PSMB5	3	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
CDK20	0	NDUFS3	0	affinity chromatography technology	Wang Q (2017)	1
ACMSD	0	CDK20	0	affinity chromatography technology	Huttlin EL (2017)	1
CDK20	0	FKBP8	1	affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Wang Q (2017)	2
CDK20	0	MAGED2	1	affinity chromatography technology	Varjosalo M (2013)	1
RAF1	3	STUB1	4	affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study	Dogan T (2008), Dogan T (2008), Alberti S (2004), Westhoff B (2005), Dreiseidler M (2012)	5
CDK20	0	FANCD2	3	affinity chromatography technology	Varjosalo M (2013)	1
CDK20	0	STUB1	4	affinity chromatography technology	Varjosalo M (2013)	1
RBBP4	3	HDAC1	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2003), Yao YL (2003), Nicolas E (2001), Nicolas E (2001), Grozinger CM (1999), You A (2001), Hassig CA (1997), Hassig CA (1997), Ng HH (1999), Zhang Y (1999), Zhang Y (2002), Hassig CA (1998), Zhang Y (1997), Banach-Orlowska M (2009), Pflum MK (2001), Pflum MK (2001), Skowyra D (2001), Humphrey GW (2001), Zhang Y (1998), Zhang Y (1998), Sun JM (2007), Sun JM (2007), Karwowska-Desaulniers P (2007), Terhune SS (2010), Xue Y (1998), Xue Y (1998), Cui S (2011), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016)	35
CDK20	0	ERC1	0	affinity chromatography technology	Varjosalo M (2013)	1
CDK5	0	STUB1	4	affinity chromatography technology	Kim C (2016)	1
RAF1	3	KEAP1	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
FKBP8	1	PSMC6	0	affinity chromatography technology	Nakagawa T (2007)	1
FKBP8	1	PSMB5	3	affinity chromatography technology	Nakagawa T (2007)	1
KEAP1	0	EEF2	11	affinity chromatography technology	Lu K (2017)	1
FOXJ1	0	CDK20	0	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
ICK	1	PSMD1	2	affinity chromatography technology	Varjosalo M (2013)	1
CDK2	0	ATP1A1	9	affinity chromatography technology	Neganova I (2011)	1
CDK20	0	TRAFD1	2	affinity chromatography technology	Varjosalo M (2013)	1
RFX3	7	HDAC1	4	affinity chromatography technology	Boldt K (2016)	1
CDK20	0	CDC42EP1	1	affinity chromatography technology	Wang Q (2017)	1