PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NR5A1	1	CREBBP	29	pull down	Ito M (2000)	1
ELAVL1	0	ALYREF	0	affinity chromatography technology	Abdelmohsen K (2009)	1
NR5A1	1	CTNNB1	30	two hybrid, pull down	Mizusaki H (2003), Mizusaki H (2003)	2
CTNNB1	30	SP1	0	affinity chromatography technology	Ponce E (2014)	1
CTNNB1	30	CREBBP	29	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ma H (2005), Sustmann C (2008), Taurin S (2006), Zhao Y (2016), Benoit YD (2017)	5
ALYREF	0	THOC2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Masuda S (2005), Masuda S (2005), Cheng H (2006), Cheng H (2006), Cheng H (2006), Cheng H (2006), Chi B (2013), Chi B (2013), Hein MY (2015)	9
THOC2	4	EIF4A3	1	affinity chromatography technology	Hein MY (2015)	1
DDX39B	1	NR5A1	1	affinity chromatography technology	Cheng H (2006)	1
ELAVL1	0	TRERF1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
TRAPPC2	0	NR5A1	1	affinity chromatography technology, two hybrid	Jeyabalan J (2010), Jeyabalan J (2010)	2
CREBBP	29	GTF2B	1	pull down, pull down	Tini M (2002), Fan S (2002)	2
KRAS	1	UBE2I	0	genetic interference	Luo J (2009)	1
BARD1	4	NR5A1	1	affinity chromatography technology, affinity chromatography technology	Lu Y (2011), Lu Y (2011)	2
NR5A1	1	TRERF1	1	pull down, affinity chromatography technology, two hybrid	Gizard F (2002), Gizard F (2002), Gizard F (2002)	3
NR5A1	1	CXXC1	3	two hybrid	Ravasi T (2010)	1
ELAVL1	0	CREBBP	29	affinity chromatography technology	Abdelmohsen K (2009)	1
ALYREF	0	NR5A1	1	affinity chromatography technology	Cheng H (2006)	1
UBE2I	0	CREBBP	29	affinity chromatography technology, pull down, enzymatic study, two hybrid	Hsieh YL (2013), Hsieh YL (2013), Hsieh YL (2013), Liu ST (2012)	4
CREBBP	29	NCOA1	6	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, pull down	Sheppard HM (2001), Sheppard HM (2001), Sheppard HM (2001), Wu RC (2002), Torchia J (1997), Torchia J (1997), Matsuda S (2004), DiRenzo J (2000), Nakuci E (2006), Ruas JL (2005), Huang SM (2002)	11
DDX39B	1	THOC2	4	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Masuda S (2005), Masuda S (2005), Masuda S (2005), Cheng H (2006), Cheng H (2006), Cheng H (2006), Cheng H (2006), Havugimana PC (2012), Chi B (2013), Chi B (2013), Hein MY (2015)	11
KRAS	1	NR5A1	1	genetic interference	Luo J (2009)	1
EIF4A3	1	ALYREF	0	affinity chromatography technology	Singh G (2012)	1
UBE2I	0	EDF1	0	enzymatic study	Jakobs A (2007)	1
TRAPPC2	0	PITX1	2	affinity chromatography technology, two hybrid	Jeyabalan J (2010), Jeyabalan J (2010)	2
NR5A1	1	NR0B1	2	pull down, two hybrid, pull down, pull down, two hybrid	Lopez D (2001), Lopez D (2001), Sugawara T (2001), Park YY (2004), Rolland T (2014)	5
JUN	0	EDF1	0	affinity chromatography technology, pull down	Miotto B (2006), Miotto B (2006)	2
ELAVL1	0	TRAPPC2	0	affinity chromatography technology	Abdelmohsen K (2009)	1
SP1	0	NR5A1	1	pull down, two hybrid	Sugawara T (2000), Sugawara T (2000)	2
EIF4A3	1	NR5A1	1	affinity chromatography technology	Cheng H (2006)	1
UBE2I	0	SOX9	2	enzymatic study	Ogawa H (2009)	1
ELAVL1	0	NRIP1	4	affinity chromatography technology	Abdelmohsen K (2009)	1
JUN	0	GTF2B	1	pull down, pull down	Franklin CC (1995), Franklin CC (1995)	2
NRIP1	4	JUN	0	pull down	Teyssier C (2003)	1
GTF2B	1	NR5A1	1	pull down	Li LA (1999)	1
CREBBP	29	SP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goto T (2006), Leclerc GJ (2010), Chuang JY (2012), Guo W (2014)	4
NR5A1	1	ZNF653	0	two hybrid, pull down	Borud B (2003), Borud B (2003)	2
UBE2I	0	NR5A1	1	enzymatic study	Ogawa H (2009)	1
BARD1	4	DDX39B	1	two hybrid	Woods NT (2012)	1
CREBBP	29	TRERF1	1	pull down, affinity chromatography technology	Gizard F (2001), Gizard F (2001)	2
ALYREF	0	UBE2I	0	biochemical	Havugimana PC (2012)	1
NCOA1	6	GTF2B	1	pull down	Takeshita A (1996)	1
NR5A1	1	NCOA1	6	two hybrid	Crawford PA (1997)	1
RAD54L2	5	UBE2I	0	two hybrid	Domanskyi A (2006)	1
ELAVL1	0	NR5A1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
NRIP1	4	NR0B1	2	two hybrid, pull down	Sugawara T (2001), Sugawara T (2001)	2
ALYREF	0	DDX39B	1	pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Pryor A (2004), Masuda S (2005), Masuda S (2005), Masuda S (2005), Cheng H (2006), Cheng H (2006), Cheng H (2006), Cheng H (2006), Thomas M (2011), Havugimana PC (2012), Chi B (2013), Chi B (2013), Chi B (2013), Chi B (2013)	14
ELAVL1	0	BARD1	4	affinity chromatography technology	Abdelmohsen K (2009)	1
GATA4	4	SP1	0	affinity chromatography technology, pull down, pull down	Flueck CE (2004), Flueck CE (2004), Ito H (2011)	3
NR5A1	1	GATA4	4	pull down	Tremblay JJ (1999)	1
ELAVL1	0	KRAS	1	affinity chromatography technology	Abdelmohsen K (2009)	1
NR5A1	1	RAD54L2	5	affinity chromatography technology, affinity chromatography technology, pull down	Ogawa H (2009), Ogawa H (2009), Ogawa H (2009)	3
JUN	0	UBE2I	0	two hybrid, enzymatic study	Goettlicher M (1996), Muller S (2000)	2
CTNNB1	30	ELAVL1	0	pull down	Kim I (2012)	1
SP1	0	JUN	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Kardassis D (1999), Hung JJ (2006), Chen BK (2007), Chen BK (2007), Chen BK (2007)	5
SOX9	2	NR5A1	1	two hybrid, pull down, affinity chromatography technology	De Santa Barbara P (1998), De Santa Barbara P (1998), De Santa Barbara P (1998)	3
KRAS	1	EIF4A3	1	genetic interference	Luo J (2009)	1
NR5A1	1	PITX1	2	pull down	Tremblay JJ (1999)	1
EDF1	0	NR5A1	1	affinity chromatography technology	Kabe Y (1999)	1
NR5A1	1	NRIP1	4	two hybrid, two hybrid, pull down, pull down	Mellgren G (2003), Sugawara T (2001), Mellgren G (2003), Sugawara T (2001)	4
NR5A1	1	NCK2	2	two hybrid	Rolland T (2014)	1
CREBBP	29	JUN	0	pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, far western blotting	Sano Y (1998), Sano Y (1998), Merika M (1998), Duyndam MC (1999), Johnson J (2007), Yamaguchi K (2005), Tsai LN (2008), Arias J (1994)	8
JUN	0	NR5A1	1	pull down	Li LA (1999)	1
ELAVL1	0	DDX39B	1	affinity chromatography technology	Abdelmohsen K (2009)	1
THOC2	4	NR5A1	1	affinity chromatography technology	Cheng H (2006)	1
NCOA1	6	JUN	0	pull down, pull down, two hybrid, pull down	Lee SK (1999), Lee SK (2000), Lee SK (1998), Lee SK (1998)	4