Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
GABRB1 2560 TEMAZEPAM CHEMBL967 potentiator, positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 18384456, 20138190
GABRB1 2560 PRAZEPAM CHEMBL969 potentiator, positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 7773620
GABRB1 2560 CLORAZEPATE DIPOTASSIUM CHEMBL2096631 positive allosteric modulator ChemblInteractions
GABRB1 2560 MEPROBAMATE CHEMBL979 agonist ChemblInteractions
GABRB1 2560 ALPRAZOLAM CHEMBL661 positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND
GABRB1 2560 TALBUTAL CHEMBL1200802 positive allosteric modulator ChemblInteractions
GABRB1 2560 ETHCHLORVYNOL CHEMBL591 ChemblInteractions
GABRB1 2560 METHYPRYLON CHEMBL1200790 positive allosteric modulator ChemblInteractions
GABRB1 2560 PROPOFOL CHEMBL526 positive allosteric modulator ChemblInteractions
GABRB1 2560 THIAMYLAL SODIUM CHEMBL1201065 positive allosteric modulator ChemblInteractions
GABRB1 2560 ETOMIDATE CHEMBL681 ChemblInteractions
GABRB1 2560 ISOFLURANE CHEMBL1256 positive allosteric modulator ChemblInteractions
GABRB1 2560 TRICLOFOS SODIUM CHEMBL1200789 ChemblInteractions
GABRB1 2560 ZOLPIDEM TARTRATE CHEMBL1723343 positive allosteric modulator ChemblInteractions
GABRB1 2560 PF-06372865 CHEMBL3707402 agonist ChemblInteractions
GABRB1 2560 CLORAZEPIC ACID CHEMBL1213252 TdgClinicalTrial, TEND
GABRB1 2560 FLURAZEPAM CHEMBL968 TdgClinicalTrial, TEND
GABRB1 2560 THIOPENTAL SODIUM CHEMBL738 positive allosteric modulator ChemblInteractions
GABRB1 2560 DESFLURANE CHEMBL1200733 positive allosteric modulator ChemblInteractions
GABRB1 2560 ADINAZOLAM CHEMBL328250 potentiator TdgClinicalTrial, TEND, DrugBank 6148400, 6320036
GABRB1 2560 OXAZEPAM CHEMBL568 potentiator, positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 18384456, 11752090
GABRB1 2560 TRIAZOLAM CHEMBL646 potentiator, positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 18384456, 11752090
GABRB1 2560 PICROTOXIN CHEMBL1908342 channel blocker GuideToPharmacologyInteractions
GABRB1 2560 BROMAZEPAM CHEMBL277062 potentiator TdgClinicalTrial, TEND, DrugBank 18384456
GABRB1 2560 KETAZOLAM CHEMBL2104356 potentiator DrugBank 18384456, 11752090, 15009644, 2874815
GABRB1 2560 CINOLAZEPAM CHEMBL2104926 potentiator TdgClinicalTrial, TEND, DrugBank 7849137
GABRB1 2560 CLOBAZAM CHEMBL70418 positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND
GABRB1 2560 LORAZEPAM CHEMBL580 positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND
GABRB1 2560 METHOHEXITAL SODIUM CHEMBL30219 positive allosteric modulator ChemblInteractions
GABRB1 2560 MIDAZOLAM HYDROCHLORIDE CHEMBL1200420 positive allosteric modulator ChemblInteractions
GABRB1 2560 PRIMIDONE CHEMBL856 positive allosteric modulator ChemblInteractions
GABRB1 2560 SECOBARBITAL SODIUM CHEMBL1200903 positive allosteric modulator ChemblInteractions
GABRB1 2560 FLUMAZENIL CHEMBL407 ChemblInteractions
GABRB1 2560 CLONAZEPAM CHEMBL452 positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND
GABRB1 2560 SEVOFLURANE CHEMBL1200694 positive allosteric modulator ChemblInteractions
GABRB1 2560 FLURAZEPAM HYDROCHLORIDE CHEMBL1200602 positive allosteric modulator ChemblInteractions
GABRB1 2560 TOPIRAMATE CHEMBL220492 ChemblInteractions
GABRB1 2560 ZALEPLON CHEMBL1521 positive allosteric modulator ChemblInteractions
GABRB1 2560 OCINAPLON CHEMBL2105199 TdgClinicalTrial
GABRB1 2560 LINDANE CHEMBL15891 antagonist DrugBank 20600211, 17139284, 17016423, 7885191, 8841090, 7566682, 10592235, 12614680, 9530529, 14635176, 12645305
GABRB1 2560 HALAZEPAM CHEMBL970 potentiator, positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 2867566, 6738302
GABRB1 2560 DIAZEPAM CHEMBL12 potentiator, positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 18384456, 11752090
GABRB1 2560 CLOTIAZEPAM CHEMBL1697737 potentiator TdgClinicalTrial, TEND, DrugBank 18855614
GABRB1 2560 FLUDIAZEPAM CHEMBL13291 potentiator TdgClinicalTrial, TEND, DrugBank 2857046
GABRB1 2560 NITRAZEPAM CHEMBL13209 potentiator TdgClinicalTrial, TEND, DrugBank 18384456, 11752090
GABRB1 2560 CHLORDIAZEPOXIDE HYDROCHLORIDE CHEMBL1200703 positive allosteric modulator ChemblInteractions
GABRB1 2560 BUTABARBITAL SODIUM CHEMBL1200982 positive allosteric modulator ChemblInteractions
GABRB1 2560 ACAMPROSATE CALCIUM CHEMBL2068724 ChemblInteractions
GABRB1 2560 ENFLURANE CHEMBL1257 ChemblInteractions
GABRB1 2560 PENTOBARBITAL CHEMBL448 positive allosteric modulator ChemblInteractions
GABRB1 2560 HALOTHANE CHEMBL931 positive allosteric modulator ChemblInteractions
GABRB1 2560 PENTOBARBITAL SODIUM CHEMBL971 positive allosteric modulator ChemblInteractions
GABRB1 2560 ESZOPICLONE CHEMBL1522 positive allosteric modulator ChemblInteractions
GABRB1 2560 CHLORDIAZEPOXIDE CHEMBL451 positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND
GABRB1 2560 GLUTETHIMIDE CHEMBL1102 ChemblInteractions
GABRB1 2560 METHARBITAL CHEMBL450 positive allosteric modulator ChemblInteractions
GABRB1 2560 GABOXADOL CHEMBL312443 agonist TdgClinicalTrial, ChemblInteractions
GABRB1 2560 ESTAZOLAM CHEMBL285674 potentiator, positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 2889803, 639854
GABRB1 2560 T-BUTYLBICYCLOPHOSPHOROTHIONATE CHEMBL485673 channel blocker GuideToPharmacologyInteractions
GABRB1 2560 QUAZEPAM CHEMBL1200472 potentiator, positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 3017690, 2892106
GABRB1 2560 ADIPIPLON CHEMBL2103791 TdgClinicalTrial
GABRB1 2560 METHOXYFLURANE CHEMBL1341 ChemblInteractions
GABRB1 2560 BUTALBITAL CHEMBL454 positive allosteric modulator ChemblInteractions
GABRB1 2560 MIDAZOLAM CHEMBL655 TdgClinicalTrial, TEND
GABRB1 2560 ETAZOLATE CHEMBL356388 TdgClinicalTrial

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
GABRB1 rs4627835 T antipsychotics dosage yes Associated allele was not explicitly stated so assumed the minor allele for the annotation. Significance was for dosage as measured by percentage of maximum dose and chlorpromazine equivalent dose. Allele T is associated with increased dose of antipsychotics in people with schizoaffective disorder and Schizophrenia as compared to allele A. 26780210 1447678861
GABRB1 rs16860087 A antipsychotics dosage yes Associated allele was not explicitly stated so assumed the minor allele for the annotation. Significance was for dosage as measured by percentage of maximum dose and chlorpromazine equivalent dose. Allele A is associated with increased dose of antipsychotics in people with schizoaffective disorder and Schizophrenia as compared to allele C. 26780210 1447678850