PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PYGO1	0	PRMT6	2	two hybrid	Weimann M (2013)	1
LENG8	2	PRMT6	2	two hybrid	Weimann M (2013)	1
PYGO1	0	SPTBN1	6	two hybrid	Bandyopadhyay S (2010)	1
PYGO1	0	BCL9	6	pull down, x-ray crystallography	Townsley FM (2004), Fiedler M (2008)	2
PYGO1	0	UBR5	13	affinity chromatography technology	Flack JE (2017)	1
PYGO1	0	CARM1	0	two hybrid	Weimann M (2013)	1
PYGO1	0	LENG8	2	two hybrid	Bandyopadhyay S (2010)	1