Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
PTPN22	rs2476601	A	adalimumab	efficacy	no		Allele A is not associated with response to adalimumab, etanercept, infliximab or Tumor necrosis factor alpha (TNF-alpha) inhibitors in people with Arthritis, Rheumatoid as compared to allele G.	23007924	981417521
PTPN22	rs2476601	GG	rituximab	efficacy	no	No significant association was seen between genotype and whether a patient was a "responder" or a "non-responder". "Responders" had a post-rituximab disease activity score (DAS28) of lower than 5.1 and a DAS28 variation between baseline and post-treatment higher than 0.6. Please note alleles have been complemented to the plus chromosomal strand.	Genotype GG is not associated with response to rituximab in people with Arthritis, Rheumatoid as compared to genotypes AA + AG.	22129793	982047084
PTPN22	rs2476601	AA + AG	leflunomide	toxicity	no	Over the first 12 months of leflunomide treatment, there was no statistically significant relationship between carrying the T allele and cessation of leflunomide treatment due to side effects. Please note that alleles have been complemented to the plus chromosomal strand.	Genotypes AA + AG is not associated with discontinuation of leflunomide in people with Arthritis, Rheumatoid as compared to genotype GG.	25040563	1445296386
PTPN22	rs2476601	A	Tumor necrosis factor alpha	efficacy	no	using either the absolute change in DAS28 or the proportion of good responders and non-responders as outcomes.	Allele A is not associated with decreased response to Tumor necrosis factor alpha (TNF-alpha) inhibitors in people with Arthritis, Rheumatoid as compared to allele G.	25834819	1444702654
PTPN22	rs2476601	AA + AG	leflunomide	efficacy	no	Over the first 12 months of leflunomide treatment, there was no statistically significant relationship between carrying the T allele and change in 28-joint Disease Activity Score (DAS28; used to assess clinical response). Please note that alleles have been complemented to the plus chromosomal strand.	Genotypes AA + AG is not associated with response to leflunomide in people with Arthritis, Rheumatoid as compared to genotype GG.	25040563	1445296375