PPI network (data source: BioGrid)

Symbol A GeneA coding DNM count Symbol B GeneB coding DNM count Interaction detection method Publication Evidence
PTPN22 3 GLUD1 2 affinity chromatography technology Li X (2016) 1
PTPN22 3 MIB1 5 bioid St-Denis N (2016) 1
CD3E 0 LCK 0 affinity chromatography technology, affinity chromatography technology Munoz P (2003), Munoz P (2003) 2
PTPN22 3 CD247 1 affinity chromatography technology Wu J (2006) 1
MED4 2 CCDC138 2 bioid, affinity chromatography technology Lambert JP (2015), Lambert JP (2015) 2
MED4 2 KIAA0753 1 bioid, bioid Lambert JP (2015), Gupta GD (2015) 2
PTPN22 3 GRB2 2 affinity chromatography technology Hill RJ (2002) 1
PTPN22 3 SFXN4 3 affinity chromatography technology Li X (2016) 1
PTPN22 3 PIBF1 2 bioid St-Denis N (2016) 1
GRB2 2 VCP 6 two hybrid, affinity chromatography technology Grossmann A (2015), Grossmann A (2015) 2
NDUFA9 1 NDUFB10 0 biochemical, affinity chromatography technology Wan C (2015), Guarani V (2014) 2
PTPN22 3 KIF7 3 bioid St-Denis N (2016) 1
PTPN22 3 ACAD8 0 affinity chromatography technology Li X (2016) 1
PTPN22 3 CALU 4 affinity chromatography technology Li X (2016) 1
PTPN22 3 PTPN22 3 affinity chromatography technology, affinity chromatography technology Cohen S (1999), Li X (2016) 2
VCP 6 PRKAR2A 0 affinity chromatography technology Yu CC (2013) 1
CSK 3 CD3E 0 pull down Catipovic B (1996) 1
PTPN22 3 PRKAR2A 0 affinity chromatography technology Li X (2016) 1
EGFR 5 CBL 7 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study Ettenberg SA (1999), Tvorogov D (2002), Pennock S (2008), Umebayashi K (2008), Ng C (2008), Ng C (2008), Povlsen GK (2008), Khan EM (2008), Su X (2007), Shtiegman K (2007), Han W (2006), Visser GD (2005), Tsacoumangos A (2005), Prasad NK (2005), Gur G (2004), Kowanetz K (2004), Feshchenko EA (2004), Wu WJ (2003), Schmidt MH (2003), Bao J (2003), Rubin C (2003), Waterman H (1999), Bonaccorsi L (2007), Dey N (2011), Miraoui H (2010), Guo HB (2009), Tong J (2009), Tong J (2009), Sun Q (2010), Sanada F (2009), Rafiq K (2011), Ravid T (2004), Ravid T (2004), Duan L (2011), Duan L (2011), Haglund K (2005), Oksvold MP (2003), Oksvold MP (2003), Gui A (2012), Yang S (2006), de Melker AA (2004), Crovello CS (1998), Graus-Porta D (1997), Oksvold MP (2001), Raguz J (2007), de Melker AA (2004), Thien CB (2001), Kassenbrock CK (2004), Tarcic G (2009), Schroeder B (2012), Adachi S (2009), Shen F (2007), Mitsushima M (2006), Choi JH (2003), Burke P (2001), Tanaka S (1995), Meisner H (1995), Meisner H (1995), Kumar EA (2012), Tong J (2008), Dou H (2012), Levkowitz G (1999), Levkowitz G (1999), Bode AM (2009), Thomas C (2012), Meijer IM (2013), Chang CC (2012), Chang CC (2012), Smith CJ (2013), Gan Y (2010), Scott RP (2005), Fukazawa T (1996), Fukazawa T (1996), Fukazawa T (1996), Wang L (2013), Hong SY (2013), Sigismund S (2013), Sigismund S (2013), Sigismund S (2013), Meisner H (1997), Odintsova E (2013), Kondratov KA (2010), He Z (2014), Tong J (2014), Balaji K (2012), Kiuchi T (2014), Zhang B (2005), Waterman H (1999), Ha Thi HT (2015), Yao S (2015), Kortuem F (2015), Igloi Z (2015), Song F (2016), Song F (2016), Lin TY (2017), Conte A (2017) 96
CBL 7 GRB2 2 affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Jain SK (1997), Liu SK (1998), Ettenberg SA (1999), Wong A (2002), Wong A (2002), Robertson H (1997), Donovan JA (1994), Park RK (1999), Erdreich-Epstein A (1999), Gesbert F (1998), Gesbert F (1998), Gesbert F (1998), Husson H (1997), Saci A (2002), Odai H (1997), Ng C (2008), Khan EM (2008), Bandyopadhyay S (2010), Jiang X (2003), Waterman H (2002), Miraoui H (2010), Ravid T (2004), Ingham RJ (1996), Erdreich-Epstein A (1997), Rellahan BL (2003), Izadi KD (1998), Wang Y (1999), Chu J (1998), Bonita DP (1997), Boussiotis VA (1997), Meisner H (1995), Meisner H (1995), Barber DL (1997), Shishido T (2000), Bartkiewicz M (1999), Buday L (1996), Tarcic G (2009), Belleudi F (2007), Brizzi MF (1996), Brenner B (2001), Donovan JA (1996), Donovan JA (1996), Donovan JA (1996), Gaston I (2004), Gaston I (2004), Tsygankov AY (1996), Tsygankov AY (1996), Hunter S (1997), Jain SK (1997), Levkowitz G (1996), Liu YC (1997), Odai H (1995), Odai H (1995), Meisner H (1995), Huang JY (2000), Panchamoorthy G (1996), Panchamoorthy G (1996), Yokouchi M (1997), Oda A (1996), Fukazawa T (1995), Fukazawa T (1995), Selbach M (2006), Brehme M (2009), Brehme M (2009), Fukazawa T (1995), Cerboni C (1998), Cerboni C (1998), Fixman ED (1997), Anderson SM (1997), Houtman JC (2006), Brizzi MF (1996), Scott RP (2005), Scott RP (2005), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Umehara H (2002), Taipale M (2014), Taipale M (2014), Grossmann A (2015), Grossmann A (2015), Igloi Z (2015), Huttlin EL (2017) 83
MED4 2 PIBF1 2 bioid Lambert JP (2015) 1
EGFR 5 GRB2 2 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Schulze WX (2006), Blagoev B (2003), Oneyama C (2002), Wong L (1999), Okutani T (1994), Okutani T (1994), Okutani T (1994), Tortora G (1997), Daly RJ (1996), Buday L (1994), Lowenstein EJ (1992), Lowenstein EJ (1992), Braverman LE (1999), Khan EM (2008), Bonaccorsi L (2007), Miraoui H (2010), Tong J (2009), Severe N (2011), Takahashi Y (1999), Tarcic G (2009), Thien CB (1997), Burke P (2001), Katayama H (1999), Meisner H (1995), Kurada BR (2009), Tong J (2008), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Sigismund S (2013), Foerster S (2013), Bisson N (2011), Gotoh N (1994), Wu SL (2006), Wu SL (2006), Tong J (2014), Oksvold MP (2001), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Song F (2016), Song F (2016), Ueno H (1995), Ueno H (1995), Ueno H (1995), Prigent SA (1996), Kapoor GS (2010), Kapoor GS (2010), Okamura T (2009) 51
KIF7 3 PIBF1 2 affinity chromatography technology Hein MY (2015) 1
PTPN22 3 PSTPIP2 2 affinity chromatography technology, affinity chromatography technology St-Denis N (2016), Li X (2016) 2
PTPN22 3 LCK 0 affinity chromatography technology, affinity chromatography technology Wu J (2006), Wu J (2006) 2
PTPN22 3 ACTA1 1 affinity chromatography technology Wu J (2006) 1
CLK1 1 PTPN22 3 enzymatic study Lipp JJ (2015) 1
PTPN22 3 SLC25A19 0 affinity chromatography technology Li X (2016) 1
GRB2 2 PSTPIP2 2 affinity chromatography technology, affinity chromatography technology Brehme M (2009), Bisson N (2011) 2
CEP131 9 PIBF1 2 affinity chromatography technology Boldt K (2016) 1
MED4 2 CEP131 9 bioid Lambert JP (2015) 1
SSX2IP 0 PIBF1 2 bioid Gupta GD (2015) 1
PTPN22 3 VCP 6 affinity chromatography technology Wu J (2006) 1
VCP 6 CSK 3 affinity chromatography technology Yu CC (2013) 1
MED4 2 MIB1 5 bioid Lambert JP (2015) 1
PTPN22 3 MAD2L1BP 0 affinity chromatography technology Li X (2016) 1
PTPN22 3 CSK 3 bioid, affinity chromatography technology St-Denis N (2016), Li X (2016) 2
KIAA0753 1 KIF7 3 bioid Gupta GD (2015) 1
CBL 7 ZAP70 5 affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, x-ray crystallography Lupher ML (1996), Meng W (1999), Wang HY (2001), Rao N (2000), Lupher ML (1997), Okabe S (2006), Zhang Z (1999), Lupher ML (1996), Dou H (2012), Dou H (2012), Gabrielsen M (2017) 11
VAV1 2 EGFR 5 affinity chromatography technology, unspecified method, two hybrid, protein complementation assay Moores SL (2000), Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014) 4
VAV1 2 ZAP70 5 pull down, affinity chromatography technology Katzav S (1994), Huby RD (1995) 2
MED4 2 KIF7 3 bioid Lambert JP (2015) 1
KIAA0753 1 CEP131 9 bioid, bioid Firat-Karalar EN (2014), Gupta GD (2015) 2
PTPN22 3 RCN1 0 affinity chromatography technology Li X (2016) 1
PTPN22 3 CBL 7 affinity chromatography technology Cohen S (1999) 1
RCN1 0 CALR 1 biochemical Wan C (2015) 1
SSX2IP 0 CEP131 9 affinity chromatography technology, bioid Gupta GD (2015), Gupta GD (2015) 2
SSX2IP 0 TBC1D31 2 bioid Gupta GD (2015) 1
VCP 6 RCN1 0 biochemical Wan C (2015) 1
EGFR 5 CSK 3 affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology Schulze WX (2006), Tong J (2014), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014) 5
LCK 0 LZTS2 4 two hybrid Rolland T (2014) 1
VCP 6 CALR 1 biochemical Wan C (2015) 1
SSX2IP 0 KIAA0753 1 bioid, bioid Gupta GD (2015), Gupta GD (2015) 2
SRPK2 1 CLK1 1 enzymatic study Varjosalo M (2013) 1
LZTS2 4 KIF7 3 affinity chromatography technology Huttlin EL (2017) 1
KIAA0753 1 CCDC138 2 bioid, bioid Firat-Karalar EN (2014), Gupta GD (2015) 2
ACTA1 1 SPTA1 10 affinity chromatography technology, affinity chromatography technology Sridharan DM (2006), Sridharan DM (2006) 2
LZTS2 4 CEP131 9 affinity chromatography technology Huttlin EL (2017) 1
CBL 7 SPTA1 10 affinity chromatography technology Brehme M (2009) 1
CBL 7 VAV1 2 affinity chromatography technology, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Marengere LE (1997), Marengere LE (1997), Marengere LE (1997), Marengere LE (1997), Bertagnolo V (2001), Miura-Shimura Y (2003), Simmons A (2005), Shen M (2009), Shen M (2009), Lottin-Divoux S (2006), Lottin-Divoux S (2006), Peterson ME (2008) 12
SSX2IP 0 MIB1 5 affinity chromatography technology Gupta GD (2015) 1
LCK 0 ZAP70 5 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Pelosi M (1999), Thome M (1995), Lupher ML (1996) 3
VAV1 2 GRB2 2 affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology Song JS (1996), Ye ZS (1994), Ye ZS (1994), Germani A (1999), Lee IS (1997) 5
PTPN22 3 CCDC138 2 bioid St-Denis N (2016) 1
EGFR 5 ZAP70 5 unspecified method, two hybrid, protein complementation assay, affinity chromatography technology Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014) 4
CD247 1 LCK 0 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Munoz P (2003), Munoz P (2003), Yang M (2015) 3
LZTS2 4 SSX2IP 0 affinity chromatography technology Huttlin EL (2017) 1
PTPN22 3 MED4 2 bioid St-Denis N (2016) 1
SRPK2 1 PTPN22 3 enzymatic study Lipp JJ (2015) 1
LCK 0 CBL 7 affinity chromatography technology, pull down, pull down, affinity chromatography technology Rao N (2002), Tsygankov AY (1996), Reedquist KA (1996), Nervi S (2005) 4
PTPN22 3 SDF4 1 affinity chromatography technology Li X (2016) 1
PTPN22 3 NDUFB10 0 affinity chromatography technology Li X (2016) 1
PTPN22 3 CEP131 9 bioid St-Denis N (2016) 1
SSX2IP 0 RCN1 0 affinity chromatography technology Gupta GD (2015) 1
MAIP1 0 SLC25A19 0 affinity chromatography technology Floyd BJ (2016) 1
CSK 3 ZAP70 5 pull down Catipovic B (1996) 1
PTPN22 3 ZAP70 5 affinity chromatography technology, affinity chromatography technology Wu J (2006), Wu J (2006) 2
GRB2 2 LZTS2 4 two hybrid Rolland T (2014) 1
PTPN22 3 VAV1 2 affinity chromatography technology Wu J (2006) 1
MED4 2 TBC1D31 2 bioid Lambert JP (2015) 1
CD247 1 ZAP70 5 affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology Mustelin T (1995), Wang HY (2001), La Face DM (1997), Huang H (2010), Huang H (2010), Hubert P (1996), Yang M (2015) 7
SSX2IP 0 CCDC138 2 affinity chromatography technology, bioid Gupta GD (2015), Gupta GD (2015) 2
KIF7 3 TBC1D31 2 affinity chromatography technology Hein MY (2015) 1
ZAP70 5 CD3E 0 pull down, affinity chromatography technology Bu JY (1995), Hubert P (1996) 2
HSPB1 2 CALR 1 two hybrid, affinity chromatography technology Katsogiannou M (2014), Katsogiannou M (2014) 2
EGFR 5 PTPN22 3 two hybrid, protein complementation assay, affinity chromatography technology Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014) 3
SSX2IP 0 KIF7 3 bioid, affinity chromatography technology Gupta GD (2015), Hein MY (2015) 2
PTPN22 3 KIAA0753 1 bioid St-Denis N (2016) 1
PTPN22 3 CD3E 0 affinity chromatography technology, affinity chromatography technology Wu J (2006), Wu J (2006) 2
EGFR 5 NDUFA9 1 affinity chromatography technology Tong J (2014) 1
PTPN22 3 AKR7A2 1 affinity chromatography technology Li X (2016) 1
CD3E 0 CD247 1 affinity chromatography technology, affinity chromatography technology, imaging technique Munoz P (2003), Munoz P (2003), Chen TC (2014) 3
PTPN22 3 CALR 1 affinity chromatography technology Li X (2016) 1
PTPN22 3 MAIP1 0 affinity chromatography technology Li X (2016) 1
MAIP1 0 SFXN4 3 affinity chromatography technology Floyd BJ (2016) 1
CALU 4 EGFR 5 biochemical Havugimana PC (2012) 1
MED4 2 SSX2IP 0 bioid Lambert JP (2015) 1
CBL 7 CD247 1 affinity chromatography technology, affinity chromatography technology Wang HY (2001), Wang HY (2001) 2
PTPN22 3 EIF3E 1 affinity chromatography technology Li X (2016) 1
PTPN22 3 LZTS2 4 bioid St-Denis N (2016) 1
KIAA0753 1 TBC1D31 2 bioid Gupta GD (2015) 1
PTPN22 3 NDUFA9 1 affinity chromatography technology Li X (2016) 1
ZAP70 5 GRB2 2 affinity chromatography technology, affinity chromatography technology Nel AE (1995), Jin HS (2013) 2
VCP 6 HSPB1 2 affinity chromatography technology Yu CC (2013) 1
VCP 6 CALU 4 biochemical Wan C (2015) 1
CALU 4 CALR 1 biochemical Wan C (2015) 1
KIAA0753 1 PIBF1 2 bioid, bioid Firat-Karalar EN (2014), Gupta GD (2015) 2
EGFR 5 HSPB1 2 affinity chromatography technology Li J (2013) 1
PTPN22 3 SCO2 0 affinity chromatography technology Li X (2016) 1
PTPN22 3 SSX2IP 0 bioid St-Denis N (2016) 1
EGFR 5 CALR 1 affinity chromatography technology Tong J (2014) 1
PTPN22 3 HAX1 1 affinity chromatography technology Li X (2016) 1
PTPN22 3 HSPB1 2 affinity chromatography technology Li X (2016) 1
CBL 7 ACTA1 1 affinity chromatography technology Valiya Veettil M (2011) 1
CBL 7 CSK 3 affinity chromatography technology, affinity chromatography technology Sanjay A (2001), Brehme M (2009) 2
PTPN22 3 RPS19BP1 0 affinity chromatography technology Li X (2016) 1
PTPN22 3 TBC1D31 2 bioid St-Denis N (2016) 1
CSK 3 CD247 1 pull down, affinity chromatography technology Catipovic B (1996), Catipovic B (1996) 2
PTPN22 3 SPTA1 10 affinity chromatography technology Wu J (2006) 1
GRB2 2 CSK 3 affinity chromatography technology Bisson N (2011) 1
KIF7 3 CEP131 9 affinity chromatography technology Hein MY (2015) 1
CEP131 9 MIB1 5 affinity chromatography technology, pull down Villumsen BH (2013), Villumsen BH (2013) 2