PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GCKR	1	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study	Park JM (2015), Park JM (2015), Park JM (2015)	3
GCKR	1	SIRT2	1	affinity chromatography technology	Park JM (2015)	1
SIRT2	1	EP300	36	enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Black JC (2008), Han Y (2008), Han Y (2008), Han Y (2008), Delvecchio M (2013)	5
GCKR	1	GCK	2	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Shiota C (1999), Park JM (2015), Park JM (2015), Park JM (2015), Rees MG (2012)	5
CDKN1A	1	EP300	36	pull down, affinity chromatography technology	Cazzalini O (2008), Cazzalini O (2008)	2
EP300	36	TRAF2	1	two hybrid	Wang J (2011)	1
TRAF2	1	GCKR	1	pull down	Shi CS (2003)	1
CDKN1A	1	GCKR	1	two hybrid	Wang J (2011)	1