PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ANAPC1	1	ANAPC5	2	biochemical, biochemical, affinity chromatography technology, biochemical	Sumara I (2000), Havugimana PC (2012), Vodermaier HC (2003), Wan C (2015)	4
AURKA	1	LATS2	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, fluorescent resonance energy transfe	Yabuta N (2011), Toji S (2004), Toji S (2004), Toji S (2004), Toji S (2004), Ivanov AA (2017)	6
AMOT	6	NF2	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Li Y (2015), Li Y (2015), Hauri S (2013), Zhou L (2015)	5
AMOT	6	YAP1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Wang C (2012), Wang C (2012), Adler JJ (2013), Couzens AL (2013), Adler JJ (2013), Chan SW (2013), Dai X (2013), Hauri S (2013)	9
YWHAG	5	YAP1	0	affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Jin J (2004), Couzens AL (2013), Hauri S (2013), Enzo E (2015), Ivanov AA (2017)	5
YAP1	0	NF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Hauri S (2013), Enzo E (2015)	3
USP9X	15	CTNNB1	30	affinity chromatography technology, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology	Taya S (1999), Taya S (1999), Taya S (1999), Murray RZ (2004), Yang B (2016), Yang B (2016)	6
LATS2	1	AMOT	6	affinity chromatography technology, bioid, enzymatic study, enzymatic study, enzymatic study	Couzens AL (2013), Couzens AL (2013), Adler JJ (2013), Chan SW (2013), Dai X (2013)	5
AURKA	1	CTNNB1	30	affinity chromatography technology	Hein MY (2015)	1
AMOT	6	CTNNB1	30	bioid	Couzens AL (2013)	1
LATS2	1	LATS2	1	bioid, fluorescent resonance energy transfe, pull down, enzymatic study, fluorescent resonance energy transfe	Couzens AL (2013), Mo XL (2015), Mo XL (2015), Rashidian J (2015), Ivanov AA (2017)	5
YAP1	0	AJUBA	2	affinity chromatography technology	Enzo E (2015)	1
USP9X	15	AMOTL2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim M (2016), Kim M (2016), Toloczko A (2017), Zhu C (2018)	4
LATS2	1	AJUBA	2	two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Abe Y (2006), Abe Y (2006), Abe Y (2006), Abe Y (2006), Das Thakur M (2010)	5
USP9X	15	AMOT	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Thanh Nguyen H (2016), Thanh Nguyen H (2016), Toloczko A (2017)	3
YAP1	0	CTNNB1	30	affinity chromatography technology	Boldt K (2016)	1
AMOTL2	5	NF2	1	affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Zhou L (2015)	2
LATS2	1	CTNNB1	30	bioid, affinity chromatography technology, affinity chromatography technology, pull down	Couzens AL (2013), Li J (2013), Li J (2013), Li J (2013)	4
USP9X	15	YAP1	0	biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kim M (2016), Kim M (2016)	3
LATS2	1	USP9X	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Toloczko A (2017), Toloczko A (2017), Toloczko A (2017), Zhu C (2018), Zhu C (2018), Zhu C (2018)	7
LATS2	1	ANAPC1	1	affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Couzens AL (2013), Couzens AL (2013), Zhu C (2018), Zhu C (2018), Zhu C (2018), Zhu C (2018)	6
MOB1B	0	MOB1A	2	affinity chromatography technology, affinity chromatography technology	Hauri S (2013), Huttlin EL (2017)	2
MOB1B	0	LATS2	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down, bioid, affinity chromatography technology	Chow A (2010), Chow A (2010), Bao Y (2009), Bao Y (2009), Couzens AL (2013), Huttlin EL (2017)	6
LATS2	1	ANAPC5	2	affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Couzens AL (2013), Zhu C (2018), Zhu C (2018)	4
LATS2	1	AMOTL2	5	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Paramasivam M (2011), Paramasivam M (2011), Couzens AL (2013), Kim M (2016), Kim M (2016)	5
AMOT	6	AMOTL2	5	affinity chromatography technology, bioid	Wells CD (2006), Couzens AL (2013)	2
AURKA	1	USP9X	15	affinity chromatography technology	Fogeron ML (2013)	1
LATS2	1	YWHAG	5	affinity chromatography technology, affinity chromatography technology, enzymatic study, fluorescent resonance energy transfe	Okada N (2011), Okada N (2011), Okada N (2011), Ivanov AA (2017)	4
AMOTL2	5	YAP1	0	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Paramasivam M (2011), Couzens AL (2013), Couzens AL (2013), Hauri S (2013), Kim M (2016), Enzo E (2015)	6
MOB1A	2	AMOT	6	bioid	Couzens AL (2013)	1
NF2	1	AURKA	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YWHAG	5	AMOT	6	affinity chromatography technology	Adler JJ (2013)	1
PPP1R13B	9	LATS2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Vigneron AM (2010), Vigneron AM (2010), Aylon Y (2010), Aylon Y (2010), Couzens AL (2013)	5
LATS2	1	YAP1	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, fluorescent resonance energy transfe, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, fluorescent resonance energy transfe, enzymatic study	Ikeda M (2009), Zhang J (2008), Zhang J (2008), Vigneron AM (2010), Vigneron AM (2010), Bao Y (2009), Kawahara M (2008), Paramasivam M (2011), Aylon Y (2010), Oka T (2008), Yu FX (2012), Mo XL (2015), Rashidian J (2015), Kim M (2016), Enzo E (2015), Si Y (2017), Ivanov AA (2017), Zhu C (2018)	18
NF2	1	LATS2	1	x-ray crystallography, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Li Y (2015), Yin F (2013), Ivanov AA (2017), Zhu C (2018)	4
MOB1A	2	LATS2	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chow A (2010), Chow A (2010), Kohler RS (2010), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Couzens AL (2013), Suzuki H (2013), Hoa L (2016), Zhu C (2018)	10