PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GRIK2	4	PICK1	2	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Hirbec H (2003), Hirbec H (2003), Hirbec H (2003), Laezza F (2008)	4
GRIA1	5	PICK1	2	pull down	Hirbec H (2002)	1
GRIK2	4	GRIP1	1	pull down	Hirbec H (2003)	1
GRIA2	4	SDCBP	0	pull down	Hirbec H (2002)	1
PRKN	1	GRIK2	4	affinity chromatography technology	Maraschi A (2014)	1
GRIK2	4	DLG3	1	affinity chromatography technology	Garcia EP (1998)	1
GRIA1	5	GRID2	5	affinity chromatography technology, affinity chromatography technology	Kohda K (2003), Kohda K (2003)	2
DLG4	11	GRIA2	4	affinity chromatography technology	Fukata Y (2006)	1
PRKN	1	PICK1	2	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Joch M (2007), Joch M (2007), Joch M (2007), Joch M (2007)	4
GRIK5	5	DLG3	1	affinity chromatography technology	Garcia EP (1998)	1
GRIA2	4	GRID2	5	affinity chromatography technology	Kohda K (2003)	1
HNRNPL	3	CALCOCO1	2	affinity chromatography technology	Fei T (2017)	1
GRIA1	5	GRIP1	1	pull down	Hirbec H (2002)	1
GRIA1	5	SDCBP	0	pull down	Hirbec H (2002)	1
GRIP1	1	GRIA2	4	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hirbec H (2002), Hirbec H (2002), Correia SS (2008), Chan CB (2011), Chan CB (2011)	5
GRIK2	4	GRIK5	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wenthold RJ (1994), Ripellino JA (1998), Valluru L (2005)	3
GRIK5	5	DLG4	11	affinity chromatography technology, affinity chromatography technology, pull down	Mehta S (2001), Garcia EP (1998), Garcia EP (1998)	3
PICK1	2	GRIA2	4	two hybrid, pull down, pull down	Hirbec H (2002), Hirbec H (2002), Dutta P (2014)	3
GRIK2	4	GRIA1	5	affinity chromatography technology	Wenthold RJ (1994)	1
TRIM25	5	HNRNPL	3	affinity chromatography technology	Choudhury NR (2017)	1
HNRNPL	3	PRKN	1	affinity chromatography technology	Fei T (2017)	1
GRIK2	4	SDCBP	0	two hybrid, pull down, affinity chromatography technology	Hirbec H (2003), Hirbec H (2003), Hirbec H (2003)	3
GRIK2	4	GRIA2	4	affinity chromatography technology	Wenthold RJ (1994)	1
GRIA1	5	GRIA2	4	affinity chromatography technology, affinity chromatography technology	Leuschner WD (1999), Correia SS (2008)	2
DLG3	1	DLG4	11	two hybrid, pull down	Masuko N (1999), Masuko N (1999)	2
HNRNPL	3	DLG1	2	affinity chromatography technology	Fei T (2017)	1
GRIK2	4	TRIM25	5	two hybrid	Wang J (2011)	1
DLG1	2	GRIK2	4	affinity chromatography technology, affinity chromatography technology	Mehta S (2001), Garcia EP (1998)	2
GRIK2	4	DLG4	11	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Hirbec H (2003), Hirbec H (2003), Mehta S (2001), Garcia EP (1998), Garcia EP (1998), Piserchio A (2002)	6
DLG3	1	DLG1	2	affinity chromatography technology	Hein MY (2015)	1
PRKN	1	DLG4	11	affinity chromatography technology	Fallon L (2002)	1
CALCOCO1	2	GRIK2	4	two hybrid	Wang J (2011)	1
PRKN	1	DLG1	2	imaging technique	Chen TC (2014)	1
GRIK2	4	GRID2	5	affinity chromatography technology, affinity chromatography technology	Kohda K (2003), Kohda K (2003)	2
GRIK5	5	GRID2	5	affinity chromatography technology	Kohda K (2003)	1
HNRNPL	3	GRIK2	4	affinity chromatography technology	Fei T (2017)	1
DLG1	2	GRIA1	5	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Gardoni F (2003), Leonard AS (1998), Leonard AS (1998), Sans N (2001)	4