Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
GRIN2A 2903 AZD8108 CHEMBL3707355 antagonist ChemblInteractions
GRIN2A 2903 DEXTROMETHORPHAN HYDROBROMIDE MONOHYDRATE CHEMBL1256818 antagonist ChemblInteractions
GRIN2A 2903 MEMANTINE CHEMBL807 TEND
GRIN2A 2903 D-ASPARTATE CHEMBL29757 agonist GuideToPharmacologyInteractions
GRIN2A 2903 ASPARTIC ACID CHEMBL274323 agonist GuideToPharmacologyInteractions
GRIN2A 2903 CHEMBL280828 CHEMBL280828 agonist GuideToPharmacologyInteractions
GRIN2A 2903 CHEMBL273636 CHEMBL273636 antagonist GuideToPharmacologyInteractions
GRIN2A 2903 SELFOTEL CHEMBL39664 antagonist GuideToPharmacologyInteractions
GRIN2A 2903 MODAFINIL CHEMBL1373 antagonist GuideToPharmacologyInteractions
GRIN2A 2903 CHEMBL191838 CHEMBL191838 antagonist GuideToPharmacologyInteractions
GRIN2A 2903 PHENCYCLIDINE CHEMBL275528 channel blocker GuideToPharmacologyInteractions
GRIN2A 2903 AV-101 CHEMBL3545351 antagonist ChemblInteractions
GRIN2A 2903 ESKETAMINE CHEMBL395091 ChemblInteractions
GRIN2A 2903 DEXTROMETHORPHAN POLISTIREX CHEMBL1201461 antagonist ChemblInteractions
GRIN2A 2903 MEMANTINE HYDROCHLORIDE CHEMBL1699 ChemblInteractions
GRIN2A 2903 LANICEMINE CHEMBL2107647 blocker ChemblInteractions
GRIN2A 2903 ACAMPROSATE CALCIUM CHEMBL2068724 antagonist ChemblInteractions
GRIN2A 2903 HALOTHANE CHEMBL931 antagonist DrugBank 8968191
GRIN2A 2903 (D)-SERINE CHEMBL285123 agonist GuideToPharmacologyInteractions
GRIN2A 2903 N-METHYL-D-ASPARTIC ACID (NMDA) CHEMBL291278 agonist GuideToPharmacologyInteractions
GRIN2A 2903 CGP-37849 CHEMBL29811 antagonist GuideToPharmacologyInteractions
GRIN2A 2903 CHEMBL31741 CHEMBL31741 antagonist GuideToPharmacologyInteractions
GRIN2A 2903 DIZOCILPINE CHEMBL284237 channel blocker GuideToPharmacologyInteractions
GRIN2A 2903 MAGNESIUM CHEMBL2146125 channel blocker GuideToPharmacologyInteractions
GRIN2A 2903 NEBOGLAMINE CHEMBL1255840 positive allosteric modulator ChemblInteractions
GRIN2A 2903 CNS-5161 CHEMBL41306 blocker ChemblInteractions
GRIN2A 2903 ESKETAMINE HYDROCHLORIDE CHEMBL2364609 ChemblInteractions
GRIN2A 2903 KETAMINE HYDROCHLORIDE CHEMBL1714 ChemblInteractions
GRIN2A 2903 GW468816 CHEMBL1207366 antagonist ChemblInteractions
GRIN2A 2903 FELBAMATE CHEMBL1094 antagonist ChemblInteractions, TEND, DrugBank 11752352
GRIN2A 2903 L-GLUTAMATE CHEMBL575060 DrugBank 8886398, 17139284, 17016423, 12068077, 11080203
GRIN2A 2903 GLYCINE CHEMBL773 agonist, antagonist GuideToPharmacologyInteractions, DrugBank, TTD 11752352, 17405869, 17360906, 17403555, 17513636, 17646495
GRIN2A 2903 CHEMBL2333945 CHEMBL2333945 allosteric modulator GuideToPharmacologyInteractions
GRIN2A 2903 CONANTOKIN G CHEMBL525025 antagonist GuideToPharmacologyInteractions
GRIN2A 2903 TENOCYCLIDINE CHEMBL279676 antagonist DrugBank 17157509, 2538766
GRIN2A 2903 DELUCEMINE CHEMBL2110814 antagonist ChemblInteractions
GRIN2A 2903 NRX-1074 CHEMBL3545230 partial agonist ChemblInteractions
GRIN2A 2903 ORPHENADRINE CITRATE CHEMBL1200395 antagonist ChemblInteractions
GRIN2A 2903 RALFINAMIDE CHEMBL2107771 antagonist ChemblInteractions
GRIN2A 2903 CHEMBL140784 CHEMBL140784 agonist GuideToPharmacologyInteractions
GRIN2A 2903 CHEMBL50267 CHEMBL50267 antagonist GuideToPharmacologyInteractions
GRIN2A 2903 CHEMBL287327 CHEMBL287327 antagonist GuideToPharmacologyInteractions
GRIN2A 2903 CHEMBL173031 CHEMBL173031 antagonist GuideToPharmacologyInteractions
GRIN2A 2903 MESORIDAZINE CHEMBL1088 antagonist GuideToPharmacologyInteractions
GRIN2A 2903 CHEMBL22304 CHEMBL22304 antagonist GuideToPharmacologyInteractions
GRIN2A 2903 AMANTADINE HYDROCHLORIDE CHEMBL1569 antagonist, channel blocker GuideToPharmacologyInteractions, ChemblInteractions
GRIN2A 2903 KETAMINE CHEMBL742 channel blocker GuideToPharmacologyInteractions
GRIN2A 2903 CHEMBL1184349 CHEMBL1184349 channel blocker GuideToPharmacologyInteractions
GRIN2A 2903 RAPASTINEL CHEMBL3544917 partial agonist ChemblInteractions
GRIN2A 2903 Indantadol CHEMBL3707400 antagonist ChemblInteractions
GRIN2A 2903 ORPHENADRINE (CHLORIDE) CHEMBL1201023 antagonist ChemblInteractions
GRIN2A 2903 NERAMEXANE MESYLATE CHEMBL2106798 antagonist ChemblInteractions
GRIN2A 2903 ACETYLCYSTEINE CHEMBL600 activator DrugBank 12183209

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
GRIN2A rs2229193 CC methylphenidate efficacy yes Alleles given as A and G. These data combine an 8-week open label trial with a 2-year clinical trial prospective study. Efficacy was evaluated as change in symptom severity compared to the baseline using the Korean version of the ADHD rating scale-IV (ADHD-RS). Genotype CC is not associated with response to methylphenidate in children with Attention Deficit Disorder with Hyperactivity as compared to genotype CT. 27624150 1448262090