PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SRC	2	FYN	1	unspecified method, affinity chromatography technology, affinity chromatography technology	Pirozzi G (1997), Chen Y (2009), Huttlin EL (2017)	3
AKT1	1	GRIN2A	13	two hybrid	Arroyo R (2015)	1
PTK2B	6	FYN	1	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Ganju RK (1997), Katagiri T (2000), Qian D (1997), Qian D (1997), Marie-Cardine A (1999)	5
GRIN2A	13	DLG3	1	two hybrid, affinity chromatography technology, pull down	Irie M (1997), Lim IA (2002), Lim IA (2002)	3
DLG3	1	DLGAP1	6	two hybrid	Takeuchi M (1997)	1
NEDD4	2	PTK2B	6	affinity chromatography technology	Verma N (2017)	1
AKT1	1	SRC	2	imaging technique, affinity chromatography technology	Chen TC (2014), Lee J (2013)	2
FYN	1	GRIN1	13	enzymatic study	Wechsler A (1998)	1
DLG1	2	DLGAP1	6	two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, two hybrid, two hybrid, far western blotting	Takeuchi M (1997), Satoh K (1997), Satoh K (1997), Satoh K (1997), Wu H (2000), Wu H (2000), Kim E (1997), Kim E (1997)	8
GRIN2A	13	DLG2	4	two hybrid	Irie M (1997)	1
SRC	2	PTK2B	6	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Keely SJ (2000), Kumar S (1999), Dikic I (1996), Dikic I (1996), Bruzzaniti A (2009)	5
NEDD4	2	GRIN2A	13	pull down	Gautam V (2013)	1
SRC	2	GRIN2A	13	affinity chromatography technology, pull down, affinity chromatography technology	Ma J (2003), Takagi N (1999), Takagi N (1999)	3
GRIN3B	2	GRIN1	13	affinity chromatography technology	Matsuda K (2002)	1
GRIN2A	13	DLG4	11	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, far western blotting, affinity chromatography technology	Hou XY (2002), Hou XY (2002), Irie M (1997), Irie M (1997), Satoh K (1997), Sans N (2000), Lim IA (2002), Lim IA (2002), Niethammer M (1996), Niethammer M (1996), Papadakis M (2004)	11
DLG4	11	PTK2B	6	affinity chromatography technology, pull down	Seabold GK (2003), Seabold GK (2003)	2
GRIN1	13	SPTAN1	9	biochemical, pull down	Wechsler A (1998), Wechsler A (1998)	2
DLG3	1	PTK2B	6	affinity chromatography technology, affinity chromatography technology, pull down	Seabold GK (2003), Seabold GK (2003), Seabold GK (2003)	3
PTPN4	0	GRIN2A	13	affinity chromatography technology	Hironaka K (2000)	1
GRIN2A	13	PTK2B	6	affinity chromatography technology, affinity chromatography technology	Seabold GK (2003), Liu Y (2001)	2
DLGAP1	6	DLG4	11	affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, far western blotting, affinity chromatography technology, affinity chromatography technology	Naisbitt S (2000), Takeuchi M (1997), Takeuchi M (1997), Satoh K (1997), Satoh K (1997), Boeckers TM (1999), Wu H (2000), Kim E (1997), Kim E (1997), Kim E (1997), Kim E (1997)	11
NEDD4	2	SRC	2	affinity chromatography technology, pull down, enzymatic study	Persaud A (2014), Persaud A (2014), Persaud A (2014)	3
DLG3	1	DLG4	11	two hybrid, pull down	Masuko N (1999), Masuko N (1999)	2
DLGAP1	6	DLG2	4	affinity chromatography technology	Naisbitt S (2000)	1
NEDD4	2	FYN	1	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
GRIN2A	13	SPTAN1	9	biochemical, pull down	Wechsler A (1998), Wechsler A (1998)	2
DLGAP1	6	GRIN2A	13	affinity chromatography technology	Satoh K (1997)	1
DLG3	1	DLG1	2	affinity chromatography technology	Hein MY (2015)	1
GRIN3B	2	GRIN2A	13	affinity chromatography technology	Matsuda K (2002)	1
DLG2	4	DLG4	11	affinity chromatography technology	Hsueh YP (1997)	1
GRIN1	13	GRIN2A	13	affinity chromatography technology, affinity chromatography technology	Al-Hallaq RA (2002), Papadakis M (2004)	2
NEDD4	2	AKT1	1	enzymatic study, enzymatic study, affinity chromatography technology	Persaud A (2009), Fan CD (2013), Fan CD (2013)	3
FYN	1	DLG4	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tezuka T (1999), Hou XY (2002), Hou XY (2002)	3
FYN	1	GRIN2A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Ma J (2003), Tezuka T (1999), Hou XY (2002), Hou XY (2002), Takagi N (1999), Takagi N (1999)	6
GRIN2A	13	DLG1	2	affinity chromatography technology, pull down, two hybrid	Gardoni F (2003), Gardoni F (2003), Niethammer M (1996)	3