PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CDH1	4	TRIM25	5	bioid	Guo Z (2014)	1
TRIM25	5	JUP	7	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
CDH1	4	CTNNA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Kinch MS (1995), Oneyama C (2002), Navarro P (1993), Takahashi K (1997), Schmeiser K (1999), Catimel B (2005), Guo Z (2014)	7
CTNNA3	3	AMER1	0	affinity chromatography technology	Huttlin EL (2017)	1
CTNNA3	3	PRKAA2	1	affinity chromatography technology	Huttlin EL (2017)	1
CTNNA3	3	CDH24	3	affinity chromatography technology	Huttlin EL (2017)	1
APC	5	CTNNB1	30	affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, unspecified method, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Su LK (1993), Su LK (1993), Kucerova D (2001), Tickenbrock L (2003), Davies G (2001), Ryo A (2001), Homma MK (2002), Tickenbrock L (2003), Davies G (2001), Satoh K (1997), Eklof Spink K (2001), Eklof Spink K (2001), Sierra J (2006), Choi J (2004), Huang X (2009), Brocardo MG (2011), Xing Y (2004), Xing Y (2004), Xing Y (2004), Hamada F (2004), Hamada F (2004), Schneikert J (2013), Hsi LC (1999), Hein MY (2015), Hein MY (2015), Chen TC (2014), Kuslansky Y (2016), Novellasdemunt L (2017), Novellasdemunt L (2017)	29
TRIM25	5	OSBPL1A	1	affinity chromatography technology	Choudhury NR (2017)	1
APC	5	AMER1	0	affinity chromatography technology	Hein MY (2015)	1
CTNNA3	3	CDH12	0	affinity chromatography technology	Huttlin EL (2017)	1
CTNNA3	3	VMA21	0	affinity chromatography technology	Huttlin EL (2017)	1
CDH3	3	CTNNA1	7	biochemical, affinity chromatography technology, affinity chromatography technology	Klingelhoefer J (2000), Klingelhoefer J (2000), Schmeiser K (1999)	3
CTNNA3	3	OSBPL1A	1	affinity chromatography technology	Huttlin EL (2017)	1
CTNNA3	3	CDH2	4	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	CTNNB1	30	affinity chromatography technology	Choudhury NR (2017)	1
CTNNA3	3	CDH10	1	affinity chromatography technology	Huttlin EL (2017)	1
CDH1	4	JUP	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Kinch MS (1995), Hazan RB (1998), Shibata T (1994), Hinck L (1994), Knudsen KA (1992), Geng F (2012), Guo Z (2014)	7
CTNNA3	3	EPS8	1	two hybrid	Wang J (2011)	1
TRIM25	5	CTNNA3	3	affinity chromatography technology	Choudhury NR (2017)	1
CTNNBIP1	1	CTNNA1	7	affinity chromatography technology	Huttlin EL (2017)	1
CTNNB1	30	CTNND1	4	affinity chromatography technology, affinity chromatography technology	Hazan RB (1998), Kucerova D (2001)	2
JUP	7	CTNNBIP1	1	two hybrid, affinity chromatography technology	Rual JF (2005), Ewing RM (2007)	2
CTNNB1	30	JUP	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Hazan RB (1998), Kucerova D (2001), Hein MY (2015), Chen TC (2014)	4
CDH2	4	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Straub BK (2003), Wahl JK (2003), Fischer L (2002), Sadot E (2002), Chung FZ (2014), Boscher C (2008)	6
CTNNA3	3	CDH3	3	affinity chromatography technology	Huttlin EL (2017)	1
CDH4	0	CDH2	4	affinity chromatography technology	Shan WS (2000)	1
JUP	7	APC	5	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	Shibata T (1994), Daniel JM (1995), Bandyopadhyay S (2010), Hein MY (2015), Chen TC (2014)	5
CTNNA3	3	CTNND1	4	affinity chromatography technology	Huttlin EL (2017)	1
CDH2	4	CTNND1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Straub BK (2003), Wahl JK (2003), Ishiyama N (2010)	3
CTNNA3	3	CTNNBIP1	1	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	CTNNA1	7	affinity chromatography technology	Choudhury NR (2017)	1
CDH3	3	CTNNB1	30	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Klingelhoefer J (2000), Klingelhoefer J (2000), Schmeiser K (1999), Ribeiro AS (2013)	4
CDH10	1	JUP	7	two hybrid	Corominas R (2014)	1
RELL1	0	ATP5B	0	affinity chromatography technology	Huttlin EL (2017)	1
CDH1	4	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Davies G (2001), Kucerova D (2001), Oyama T (1994), Hazan RB (1997), Kinch MS (1995), Jiang MC (2002), Hazan RB (1998), Bonvini P (2001), Li Y (1998), Wendeler MW (2004), Shibata T (2003), Piedra J (2003), Oneyama C (2002), Navarro P (1993), Takahashi K (1997), Dobrosotskaya IY (2000), Dobrosotskaya IY (2000), Geng L (2000), Shibamoto S (1995), Rao RK (2002), Rao RK (2002), Huber AH (2001), Schmeiser K (1999), Pai R (2008), Tu LC (2007), Tu LC (2007), Smyth D (2012), Xue B (2005), Xue B (2005), Catimel B (2005), Huang Z (2012), Yan HX (2006), Yan HX (2006), Figueiredo J (2013), Ponce E (2014), Ponce E (2014), Ponce E (2014), Ribeiro AS (2013), Pinheiro H (2012), Geng F (2012), Lee HK (2007), Guo Z (2014)	42
PKP4	5	CDH2	4	two hybrid	Hatzfeld M (2003)	1
EHMT2	4	CTNNA3	3	affinity chromatography technology	Waaijers S (2013)	1
TRIM25	5	PKP4	5	affinity chromatography technology	Choudhury NR (2017)	1
CTNNBIP1	1	APC	5	affinity chromatography technology	Huttlin EL (2017)	1
CTNNA3	3	APC	5	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	RELL1	0	affinity chromatography technology	Choudhury NR (2017)	1
CDH3	3	JUP	7	affinity chromatography technology, biochemical	Klingelhoefer J (2000), Klingelhoefer J (2000)	2
CTNNA3	3	TPD52	0	affinity chromatography technology	Huttlin EL (2017)	1
CDH1	4	CTNND1	4	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, bioid	Daniel JM (1995), Daniel JM (1995), Ireton RC (2002), Kinch MS (1995), Hazan RB (1998), Bonne S (2003), Piedra J (2003), Piedra J (2003), Shibamoto S (1995), Shibamoto S (1995), Ohkubo T (1999), Ohkubo T (1999), Ishiyama N (2010), Ishiyama N (2010), Ishiyama N (2010), Chen Y (2009), Smyth D (2012), Del Valle-Perez B (2011), Figueiredo J (2013), Ribeiro AS (2013), Pinheiro H (2012), Guo Z (2014)	22
CTNNA3	3	GIMAP8	7	affinity chromatography technology	Huttlin EL (2017)	1
CTNNA3	3	FAM162A	0	affinity chromatography technology	Huttlin EL (2017)	1
CDH1	4	ARVCF	5	bioid	Guo Z (2014)	1
CTNNB1	30	CTNNA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down	Oyama T (1994), Roe S (1998), Piedra J (2003), Aberle H (1994), Reuver SM (1998), Selbach M (2006), Tian Q (2004), Wan C (2015), Hein MY (2015), Ji H (2009), Ji H (2009)	11
CTNNB1	30	CDH10	1	affinity chromatography technology, affinity chromatography technology	Shimoyama Y (2000), Hein MY (2015)	2
CTNNA3	3	ARVCF	5	affinity chromatography technology	Huttlin EL (2017)	1
CTNNA3	3	PKP4	5	affinity chromatography technology	Huttlin EL (2017)	1
CDH2	4	CTNNA1	7	affinity chromatography technology, affinity chromatography technology, biochemical	Straub BK (2003), Wahl JK (2003), Havugimana PC (2012)	3
CTNNA3	3	CDH4	0	affinity chromatography technology	Huttlin EL (2017)	1
CTNNA3	3	CDH1	4	affinity chromatography technology	Huttlin EL (2017)	1
CTNNBIP1	1	CTNNB1	30	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Tago K (2000), Selbach M (2006), Daniels DL (2002), Chen Y (2016), Huttlin EL (2017)	6
SPRY2	4	CTNNA3	3	affinity chromatography technology	Waaijers S (2013)	1
CDH1	4	TPD52	0	bioid	Guo Z (2014)	1
CTNNA3	3	ATP5B	0	affinity chromatography technology	Huttlin EL (2017)	1
CDH2	4	JUP	7	affinity chromatography technology, affinity chromatography technology, biochemical	Straub BK (2003), Sacco PA (1995), Havugimana PC (2012)	3
CTNNA3	3	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Janssens B (2001), Waaijers S (2013), Chen TC (2014), Huttlin EL (2017)	4
CTNND1	4	CDH3	3	affinity chromatography technology, affinity chromatography technology	Reynolds AB (1996), Ribeiro AS (2013)	2
CTNNA3	3	BLZF1	0	affinity chromatography technology	Huttlin EL (2017)	1
PKP4	5	CDH1	4	two hybrid, bioid	Hatzfeld M (2003), Guo Z (2014)	2
JUP	7	CTNNA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, biochemical, biochemical, imaging technique	Roe S (1998), Roe S (1998), Sacco PA (1995), Obama H (1997), Bandyopadhyay S (2010), Havugimana PC (2012), Wan C (2015), Chen TC (2014)	8
CTNNA3	3	CTNNA1	7	affinity chromatography technology	Waaijers S (2013)	1
CTNNA3	3	JUP	7	affinity chromatography technology, affinity chromatography technology	Waaijers S (2013), Waaijers S (2013)	2
APC	5	TRIM25	5	two hybrid	Arroyo R (2015)	1
CDH3	3	CDH1	4	affinity chromatography technology, affinity chromatography technology, biochemical	Klingelhoefer J (2000), Klingelhoefer J (2000), Klingelhoefer J (2000)	3
CTNNA3	3	MYCBP2	11	affinity chromatography technology	Huttlin EL (2017)	1
APC	5	CTNNA1	7	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology	Su LK (1993), Daniel JM (1995), Bandyopadhyay S (2010), Hein MY (2015), Chen TC (2014), Novellasdemunt L (2017)	6
CDH1	4	RELL1	0	bioid	Guo Z (2014)	1
CTNNA3	3	RELL1	0	affinity chromatography technology	Huttlin EL (2017)	1
CTNNA1	7	CTNND1	4	affinity chromatography technology	Daniel JM (1995)	1
AMER1	0	CTNNB1	30	pull down, affinity chromatography technology	Major MB (2007), Hein MY (2015)	2