Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
GSK3B 2932 ALSTERPAULLONE CHEMBL50894 inhibitor GuideToPharmacologyInteractions, DrugBank 17139284, 17016423, 10592235
GSK3B 2932 CHEMBL524266 CHEMBL524266 inhibitor GuideToPharmacologyInteractions, DrugBank 10592235
GSK3B 2932 CHEMBL284861 CHEMBL284861 inhibitor GuideToPharmacologyInteractions
GSK3B 2932 CHEMBL359482 CHEMBL359482 inhibitor GuideToPharmacologyInteractions
GSK3B 2932 ISOGRANULATIMIDE CHEMBL413188 inhibitor GuideToPharmacologyInteractions
GSK3B 2932 RGB-286638 CHEMBL3545083 inhibitor GuideToPharmacologyInteractions
GSK3B 2932 Tideglusib CHEMBL3545157 inhibitor TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions
GSK3B 2932 A-443654 CHEMBL379300 DrugBank 10592235
GSK3B 2932 AZD-1080 CHEMBL1969664 inhibitor GuideToPharmacologyInteractions, ChemblInteractions
GSK3B 2932 QUINOXALINE1 CHEMBL259389 inhibitor GuideToPharmacologyInteractions
GSK3B 2932 CHEMBL156987 CHEMBL156987 DrugBank 17139284, 17016423, 10592235
GSK3B 2932 CHEMBL259850 CHEMBL259850 DrugBank 17139284, 17016423, 10592235
GSK3B 2932 STAUROSPORINE CHEMBL388978 DrugBank 17139284, 17016423
GSK3B 2932 CHEMBL1230989 CHEMBL1230989 DrugBank 17139284, 17016423
GSK3B 2932 CHEMBL428462 CHEMBL428462 DrugBank 10592235
GSK3B 2932 CHEMBL227381 CHEMBL227381 DrugBank 10592235
GSK3B 2932 FLUOXETINE CHEMBL41 PharmGKB
GSK3B 2932 CHEMBL1236539 CHEMBL1236539 inhibitor GuideToPharmacologyInteractions
GSK3B 2932 CHIR-99021 CHEMBL412142 inhibitor GuideToPharmacologyInteractions
GSK3B 2932 CHEMBL311228 CHEMBL311228 inhibitor GuideToPharmacologyInteractions
GSK3B 2932 CHEMBL1082552 CHEMBL1082552 inhibitor GuideToPharmacologyInteractions, DrugBank 17139284, 17016423, 10592235
GSK3B 2932 KENPAULLONE CHEMBL296586 inhibitor GuideToPharmacologyInteractions
GSK3B 2932 SB-216763 CHEMBL102714 inhibitor GuideToPharmacologyInteractions
GSK3B 2932 CHEMBL322970 CHEMBL322970 inhibitor GuideToPharmacologyInteractions
GSK3B 2932 CHEMBL405759 CHEMBL405759 inhibitor GuideToPharmacologyInteractions
GSK3B 2932 CHEMBL456218 CHEMBL456218 DrugBank 10592235
GSK3B 2932 CHEMBL428963 CHEMBL428963 DrugBank 10592235
GSK3B 2932 LITHIUM CITRATE HYDRATE CHEMBL2103738 inhibitor ChemblInteractions
GSK3B 2932 LITHIUM CARBONATE CHEMBL1200826 inhibitor ChemblInteractions
GSK3B 2932 AT-9283 CHEMBL495727 inhibitor TALC
GSK3B 2932 BX-795 CHEMBL577784 inhibitor GuideToPharmacologyInteractions
GSK3B 2932 LY-2090314 CHEMBL362558 inhibitor GuideToPharmacologyInteractions, ChemblInteractions
GSK3B 2932 CHEMBL1082152 CHEMBL1082152 DrugBank 17139284, 17016423, 10592235
GSK3B 2932 CHEMBL259833 CHEMBL259833 DrugBank 10592235
GSK3B 2932 ENZASTAURIN CHEMBL300138 inhibitor TTD

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
GSK3B rs3732361 A methotrexate metabolism/PK yes Concentrations refers to area on the concentration at 48 hrs Allele A is associated with increased concentrations of methotrexate in children with Osteosarcoma as compared to allele G. 27566582 1449188881
GSK3B rs334558 GG citalopram efficacy yes Genotype GG is associated with increased response to citalopram and fluoxetine in people with Depressive Disorder, Major as compared to allele A. 18195729 769171579
GSK3B rs334558 G lithium efficacy not stated This is from a review article which does not give all the details. It does not state exactly how the alleles were compared. Allele G is associated with increased response to lithium in people with Bipolar Disorder as compared to allele A. 21047205 699639264
GSK3B rs3755557 A lithium efficacy not stated This is from a review article which does not give all the details. It says that no association was found between the SNP and lithium response, but it does not state exactly how the alleles were compared. Allele A is not associated with response to lithium in people with Bipolar Disorder as compared to allele T. 21047205 699639267
GSK3B rs6438552 GG lithium efficacy yes This result is for the combination of GG at this SNP with rs2071427 TT. People with this genotype combination had a 75% chance of being in the Li-responsive group. People with rs2071427 CC/rs6438552 AA had a 44% response rate. Those with 2 or 3 favorable alleles had responses on a gradient between these two results. Genotype GG is associated with increased response to lithium in people with Bipolar Disorder. 21781277 827784991
GSK3B rs6438552 GG lithium efficacy no Authors say not significant. Genotype GG is associated with increased response to lithium in people with Bipolar Disorder. 21781277 827784981
GSK3B rs334558 G lithium efficacy not stated This is from a review article which does not give all the details. It says that in this population, no association was found between the SNP and lithium response, but it does not state exactly how the alleles were compared. Allele G is not associated with response to lithium in people with Bipolar Disorder as compared to allele A. 21047205 699639266