PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
IRF2BP1	4	IRF2BPL	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Yeung KT (2011), Yeung KT (2011)	3
CSNK2A1	15	MDM2	2	enzymatic study, enzymatic study	Goetz C (1999), Hjerrild M (2001)	2
NFKB1	2	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Deng WG (2003), Deng WG (2003), Furia B (2002), Wang H (2010), Wang H (2010), Sen GS (2011), Hassa PO (2003), Hassa PO (2003), Deng WG (2003)	9
KAT2A	1	RELA	1	affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Mao X (2009), Mao X (2009), Mao X (2009), Ivanov AA (2017)	4
ATG7	2	PPP3CB	1	biochemical	Kristensen AR (2012)	1
IRF2	7	APP	1	pull down	Olah J (2011)	1
MDM2	2	KAT2B	2	pull down, affinity chromatography technology, genetic interference, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Jin Y (2002), Jin Y (2002), Jin Y (2002), Jin Y (2004), Jin Y (2004), Jung CR (2010), Morgan JE (2017)	7
IRF8	4	IRF2	7	affinity chromatography technology	Sharf R (1995)	1
IRF2	7	FAM208B	4	affinity chromatography technology	Huttlin EL (2017)	1
FOXK1	5	AP5Z1	7	affinity chromatography technology	Li X (2015)	1
IRF1	0	IRF2	7	pull down	Tooze RM (2006)	1
HCFC1	4	HCFC2	1	biochemical, affinity chromatography technology	Yokoyama A (2004), Huttlin EL (2017)	2
HSP90AA1	7	APP	1	affinity chromatography technology	Kumar P (2007)	1
IRF2	7	PPP3CA	3	affinity chromatography technology	Li S (2011)	1
IRF2	7	IRF2BP2	0	affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Li S (2011), Childs KS (2003), Childs KS (2003), Childs KS (2003), Huttlin EL (2017)	5
IRF2	7	PPP3CB	1	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
IRF1	0	HSP90AA1	7	affinity chromatography technology	Gao B (2013)	1
IRF2	7	HCFC1	4	affinity chromatography technology	Li S (2011)	1
NFKB1	2	RELA	1	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, imaging technique, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Palvimo JJ (1996), Dhar SK (2006), Williams SA (2006), Williams SA (2006), Hassa PO (2005), Hassa PO (2005), Sasaki CY (2005), Jeon YJ (2010), Urban MB (1991), Beauchef G (2012), Ryo A (2003), Burstein E (2005), Beinke S (2002), Sharif-Askari E (2010), Mifflin RC (2002), Nie M (2003), Nehra R (2010), Wang J (2011), Mellits KH (1993), Gallois C (1998), Milanovic M (2013), Milanovic M (2013), Kwon JH (2003), Cimen I (2011), Saha RN (2007), Wi SM (2014), Wi SM (2014), Hochrainer K (2012), Longoni N (2013), Li X (2015)	31
PRDM1	5	IRF1	0	imaging technique	Barnes NA (2009)	1
PRDM1	5	IRF2	7	imaging technique, genetic interference	Barnes NA (2009), Ma Y (2017)	2
EP300	36	KAT2B	2	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kiernan R (2003), Kim JH (2011), Lee M (2010), Santos-Rosa H (2003), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996), Mizuguchi Y (2012)	8
IRF2	7	BRD7	2	two hybrid, pull down	Staal A (2000), Staal A (2000)	2
IRF8	4	IRF1	0	two hybrid, affinity chromatography technology, pull down	Schaper F (1998), Sharf R (1995), Kautz B (2001)	3
RELA	1	IRF8	4	pull down	Drew PD (1995)	1
ATG7	2	EP300	36	affinity chromatography technology, affinity chromatography technology	Lee IH (2009), Lee IH (2009)	2
NFKB1	2	IRF2	7	pull down	Drew PD (1995)	1
CSNK2A1	15	RELA	1	affinity chromatography technology, enzymatic study	Wang D (2000), Wang D (2000)	2
MDM2	2	RELA	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Wang J (2011), Heyne K (2013), Heyne K (2013), Heyne K (2013)	4
IRF1	0	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Deng WG (2003), Deng WG (2003), Dornan D (2004), Gao B (2013), Burysek L (1999)	5
FOXK1	5	FOXK2	9	affinity chromatography technology	Li X (2015)	1
IRF2	7	AP5Z1	7	affinity chromatography technology	Li S (2011)	1
PRKACA	2	HSP90AA1	7	affinity chromatography technology	Varjosalo M (2013)	1
IRF2	7	CTSS	0	affinity chromatography technology	Huttlin EL (2017)	1
IRF2	7	FOXK2	9	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Li S (2011), Li S (2011), Li X (2015), Huttlin EL (2017)	4
HSP90AA1	7	PRDM1	5	affinity chromatography technology	Taipale M (2012)	1
IRF2	7	EP300	36	affinity chromatography technology, enzymatic study, pull down	Masumi A (2001), Masumi A (2001), Masumi A (2001)	3
IRF2	7	MDM2	2	affinity chromatography technology, enzymatic study, unspecified method	Pettersson S (2009), Pettersson S (2009), Nicholson J (2014)	3
IRF1	0	MDM2	2	affinity chromatography technology, pull down, enzymatic study, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology	Landre V (2013), Landre V (2013), Landre V (2013), Landre V (2013), Wevers BA (2014), Nicholson J (2014), Remoli AL (2016)	7
IRF1	0	HCFC1	4	affinity chromatography technology	Li S (2011)	1
IRF2BPL	5	IRF2BP2	0	biochemical, affinity chromatography technology, affinity chromatography technology	Wan C (2015), Yeung KT (2011), Yeung KT (2011)	3
RELA	1	IRF2	7	pull down	Drew PD (1995)	1
HCFC1	4	HSP90AA1	7	affinity chromatography technology	Wysocka J (2003)	1
IRF2BP1	4	IRF2BP2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Yeung KT (2011), Yeung KT (2011)	3
IRF1	0	KAT2A	1	pull down	Masumi A (1999)	1
CSNK2A1	15	IRF2	7	enzymatic study	Birnbaum MJ (1997)	1
IRF2	7	IRF2BPL	5	affinity chromatography technology, affinity chromatography technology	Li S (2011), Huttlin EL (2017)	2
IRF2	7	KAT2B	2	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down	Masumi A (2001), Masumi A (2001), Masumi A (2001), Masumi A (1999), Masumi A (1999)	5
HSP90AA1	7	IRF2	7	affinity chromatography technology	Taipale M (2012)	1
PRKACA	2	RELA	1	enzymatic study, enzymatic study	Manna SK (2010), Vermeulen L (2003)	2
PRKACA	2	IRF2	7	enzymatic study	Birnbaum MJ (1997)	1
IRF2	7	FOXK1	5	affinity chromatography technology, pull down, affinity chromatography technology	Li S (2011), Li S (2011), Huttlin EL (2017)	3
ATG7	2	APP	1	pull down	Olah J (2011)	1
CSNK2A1	15	APP	1	pull down	Olah J (2011)	1
HSP90AA1	7	NCL	1	biochemical	Havugimana PC (2012)	1
MDM2	2	HSP90AA1	7	affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, biochemical, unspecified method, affinity chromatography technology	Lu TL (2010), Burch L (2004), Burch L (2004), Burch L (2004), Burch L (2004), Burch LR (2004), Okoro DR (2013)	7
IRF2	7	ATG7	2	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
IRF2	7	IRF2BP1	4	affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Li S (2011), Childs KS (2003), Childs KS (2003), Childs KS (2003), Huttlin EL (2017)	5
IRF2	7	NCL	1	affinity chromatography technology, affinity chromatography technology	Masumi A (2006), Masumi A (2006)	2
NFKB1	2	IRF8	4	pull down	Drew PD (1995)	1
EP300	36	RELA	1	enzymatic study, two hybrid, affinity chromatography technology, genetic interference, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kiernan R (2003), Gerritsen ME (1997), Gerritsen ME (1997), Gerritsen ME (1997), Gerritsen ME (1997), Hiroi M (2003), Nicot C (2001), Kim RH (2001), Hassa PO (2008), Hassa PO (2008), Hu J (2004), Naeaer AM (1999), Lee IT (2010), Nehra R (2010), Hsu HC (2007), Hsu HC (2007), Saha RN (2007), Saha RN (2007), Hassa PO (2003), Hassa PO (2003), Mendonca DB (2011), Chen W (2008), Chen LF (2002), OHara A (2014), Lu Y (2013), Lu Y (2013), Ren YB (2015), Chen LF (2005), Chen LF (2005), Chen LF (2005), Deng WG (2003)	31
IRF1	0	KAT2B	2	pull down, pull down, affinity chromatography technology	Masumi A (1999), Masumi A (1999), Gao B (2013)	3
FOXK1	5	HCFC1	4	affinity chromatography technology	Okino Y (2015)	1
CSNK2A1	15	NCL	1	enzymatic study, biochemical	Zhang M (2011), Wan C (2015)	2
IRF2	7	HCFC2	1	affinity chromatography technology, affinity chromatography technology	Li S (2011), Huttlin EL (2017)	2
FOXK2	9	HCFC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down	Okino Y (2015), Li X (2015), Ji Z (2014), Ji Z (2014), Ji Z (2014)	5
MDM2	2	APP	1	pull down	Miyamoto-Sato E (2010)	1
IRF2	7	KAT2A	1	pull down	Masumi A (1999)	1
BRD7	2	EP300	36	affinity chromatography technology	Drost J (2010)	1
HSP90AA1	7	CSNK2A1	15	pull down, enzymatic study, enzymatic study, affinity chromatography technology	Miyata Y (1995), Muller P (2012), Zhang M (2011), Woo SH (2009)	4
EP300	36	MDM2	2	pull down, affinity chromatography technology, biochemical, pull down, pull down, enzymatic study, affinity chromatography technology, biochemical, enzymatic study	Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Matt T (2004), Wang X (2004), Gillotin S (2010), Kobet E (2000), Nihira NT (2017)	9
FKBP7	2	IRF2	7	two hybrid	Wang J (2011)	1
NCL	1	MDM2	2	affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Saxena A (2006), Bhatt P (2011), Bhatt P (2011), Miyamoto-Sato E (2010), Okoro DR (2013), Saxena A (2006), Saxena A (2006)	7