PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CASK	18	ABLIM1	3	affinity chromatography technology	So J (2015)	1
DLG1	2	APBA1	6	affinity chromatography technology	Leonoudakis D (2004)	1
SNTB2	4	DMD	6	unspecified method, affinity chromatography technology, affinity chromatography technology	Ahn AH (1996), Johnson EK (2012), Huttlin EL (2017)	3
KCNJ12	0	MPP6	3	affinity chromatography technology	Leonoudakis D (2004)	1
KCNJ12	0	SNTB1	1	affinity chromatography technology	Leonoudakis D (2004)	1
LIN7B	0	CASK	18	affinity chromatography technology	Leonoudakis D (2004)	1
KCNJ12	0	CASK	18	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004)	3
KCNJ12	0	DLG2	4	affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004)	2
KCNJ12	0	DMD	6	affinity chromatography technology	Leonoudakis D (2004)	1
LIN7C	0	LIN7B	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KCNJ12	0	ABLIM1	3	affinity chromatography technology	Leonoudakis D (2004)	1
SNTA1	1	DMD	6	unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ahn AH (1996), Yang B (1995), Gee SH (1998), Lyssand JS (2008), Huttlin EL (2017)	5
LIN7C	0	CASK	18	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), So J (2015), Huttlin EL (2015), Huttlin EL (2017)	4
KCNJ12	0	SNTB2	4	affinity chromatography technology	Leonoudakis D (2004)	1
LIN7C	0	APBA1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Huttlin EL (2015), Huttlin EL (2017)	3
KCNJ12	0	DLG3	1	affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004)	2
KCNJ12	0	LIN7C	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004)	4
KCNJ12	0	DTNA	4	affinity chromatography technology	Leonoudakis D (2004)	1
DMD	6	MPP6	3	affinity chromatography technology	Huttlin EL (2017)	1
CASK	18	SNTB2	4	affinity chromatography technology	So J (2015)	1
MPP6	3	LIN7A	1	pull down, affinity chromatography technology	Tseng TC (2001), Hauri S (2013)	2
LIN7A	1	SNTB2	4	affinity chromatography technology	Hauri S (2013)	1
KCNJ12	0	LIN7A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004)	4
CASK	18	DLG4	11	affinity chromatography technology, two hybrid	Chetkovich DM (2002), Chetkovich DM (2002)	2
DLG3	1	DLG4	11	two hybrid, pull down	Masuko N (1999), Masuko N (1999)	2
DLG1	2	LIN7A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Hauri S (2013)	3
DLG1	2	LIN7C	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Huttlin EL (2015), Huttlin EL (2017)	4
SNTB1	1	DMD	6	pull down, pull down, affinity chromatography technology	Ahn AH (1995), Ahn AH (1995), Huttlin EL (2017)	3
KCNJ12	0	LIN7B	0	affinity chromatography technology, affinity chromatography technology, pull down	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004)	3
DLG4	11	LIN7A	1	pull down	Jo K (1999)	1
LIN7B	0	DLG4	11	affinity chromatography technology	Jo K (1999)	1
KCNJ12	0	SNTA1	1	affinity chromatography technology	Leonoudakis D (2004)	1
LIN7C	0	ABLIM1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DLG3	1	DLG1	2	affinity chromatography technology	Hein MY (2015)	1
LIN7A	1	CASK	18	affinity chromatography technology, two hybrid, affinity chromatography technology	Leonoudakis D (2004), Rolland T (2014), Hauri S (2013)	3
DLG2	4	DLG4	11	affinity chromatography technology	Hsueh YP (1997)	1
LIN7C	0	MPP6	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KCNJ12	0	APBA1	6	affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004)	2
LIN7B	0	APBA1	6	affinity chromatography technology	Leonoudakis D (2004)	1
DLG1	2	CASK	18	affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Chetkovich DM (2002), Nix SL (2000), Nix SL (2000), Nix SL (2000), Nix SL (2000), So J (2015)	8
APBA1	6	CASK	18	pull down	Borg JP (1999)	1
KCNJ12	0	DLG4	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004)	3
DTNA	4	DMD	6	two hybrid, pull down, far western blotting, affinity chromatography technology	Sadoulet-Puccio HM (1997), Sadoulet-Puccio HM (1997), Tommasi di Vignano A (2000), Huttlin EL (2017)	4
KCNJ12	0	DLG1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2004), Leonoudakis D (2001), Leonoudakis D (2001)	6
DTNA	4	SNTA1	1	pull down, affinity chromatography technology	Sadoulet-Puccio HM (1997), Lyssand JS (2008)	2