Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
KRAS 3845 LONAFARNIB CHEMBL298734 inhibitor GuideToPharmacologyInteractions
KRAS 3845 PALBOCICLIB CHEMBL189963 OncoKB, CKB, CGI, CIViC 26658964, 1291017, 22805291, 15483017, 25787767, 26515496, 25609064, 15542782, 20736363, 26028255, 15801831, 25801412, 23934108, 26728409, 24908424, 26837474, 20609353, 23200175, 24746704, 25792301, 27167191, 26369631
KRAS 3845 VANDETANIB CHEMBL24828 ClearityFoundationBiomarkers
KRAS 3845 SORAFENIB CHEMBL1336 CKB, CGI 25363205, 26743856, 27480147, 23224737, 25294897, 23629727, 26307133
KRAS 3845 NIVOLUMAB CHEMBL2108738 CIViC 28525386
KRAS 3845 INK-128 CHEMBL3545056 CKB 26272063, 26574479
KRAS 3845 DEMCIZUMAB CHEMBL2109384 CKB 26855149
KRAS 3845 AZD-5363 CHEMBL2178577 CKB 19755509, 24088382
KRAS 3845 AMG-337 CHEMBL3545212 CKB 26432108, 27196782
KRAS 3845 SUNITINIB CHEMBL535 CKB 23455880, 26864210
KRAS 3845 BUPARLISIB CHEMBL2017974 CKB 22159814, 26715098, 26098748, 24576621
KRAS 3845 CRIZOTINIB CHEMBL601719 CKB 26432108, 27338794, 25232318
KRAS 3845 PF-04691502 CHEMBL1234354 CKB 21750219, 26725216
KRAS 3845 GEDATOLISIB CHEMBL592445 CKB 25673820, 21325073, 25688157, 24042735, 12068308, 23012248, 17314276
KRAS 3845 LINSITINIB CHEMBL1091644 CKB 26725216
KRAS 3845 NECITUMUMAB CHEMBL1743047 CKB 26766738
KRAS 3845 DANUSERTIB CHEMBL402548 CKB 26725216
KRAS 3845 MLN-2480 CHEMBL3348923 CKB
KRAS 3845 BAY-1125976 CHEMBL3545049 CKB 27699769
KRAS 3845 TRAMETINIB CHEMBL2103875 ClearityFoundationBiomarkers, OncoKB, CKB, CGI, CIViC 24915778, 22169769, 24685132, 27876675, 26644315, 22805291, 15483017, 25787767, 26515496, 25609064, 15542782, 20736363, 26028255, 15801831, 25801412, 23934108, 26728409, 24908424, 26837474, 20609353, 23200175, 24746704, 25792301, 26369631, 27312529, 27338794, 26343583, 27659046, 27556948, 25665005, 28179366, 26882569, 26582713, 27222538, 26324075
KRAS 3845 BINIMETINIB CHEMBL3187723 ClearityFoundationBiomarkers, OncoKB, CKB, CIViC 27167191, 27422710, 26206338, 28152546, 25167228, 27556948, 22805291, 15483017, 25787767, 26515496, 25609064, 15542782, 20736363, 26028255, 15801831, 25801412, 23934108, 26728409, 24908424, 26837474, 20609353, 23200175, 24746704, 25792301
KRAS 3845 Ribociclib CHEMBL3545110 OncoKB 22805291, 15483017, 25787767, 26515496, 25609064, 15542782, 20736363, 26028255, 15801831, 25801412, 23934108, 26728409, 24908424, 26837474, 20609353, 23200175, 24746704, 25792301
KRAS 3845 COBIMETINIB CHEMBL2146883 ClearityFoundationBiomarkers, OncoKB, CKB 23934108, 22805291, 15483017, 25787767, 26515496, 25609064, 15542782, 20736363, 26028255, 15801831, 22084396
KRAS 3845 ATEZOLIZUMAB CHEMBL3707227 OncoKB, CKB, CIViC 22805291, 15483017, 25787767, 26515496, 25609064, 15542782, 20736363, 26028255, 15801831, 28525386
KRAS 3845 SELUMETINIB CHEMBL1614701 inhibitor ClearityFoundationBiomarkers, OncoKB, CKB, CGI, CIViC, MyCancerGenomeClinicalTrial 25801412, 23934108, 22805291, 26728409, 24908424, 26837474, 20609353, 23200175, 15542782, 24746704, 25792301, 15801831, 26125448, 22392911, 25199829, 21985784, 28492898, 19029981, 25322874, 26666244, 27422710, 26676756, 26232337, 26272063, 22952903, 22271687, 24939055, 27655129, 26725216, 24935174, 27480147, 26351322, 27231576, 27556948, 27312529, 26438159, 27222538, 25870145
KRAS 3845 ABEMACICLIB CHEMBL3301610 OncoKB, CKB, CGI, CIViC 25801412, 23934108, 22805291, 26728409, 24908424, 26837474, 20609353, 23200175, 15542782, 24746704, 25792301, 15801831, 26658964, 1291017, 27217383
KRAS 3845 EVEROLIMUS CHEMBL1908360 ClearityFoundationBiomarkers, CKB 20664174, 20664172, 26725216, 22662154, 23629727
KRAS 3845 PD-0325901 CHEMBL507361 ClearityFoundationBiomarkers, CKB, CIViC 20570890, 26272063, 22684718, 25673820, 21516509, 26267534, 23934108, 26037647, 27556948, 26582713, 21325073
KRAS 3845 GEMCITABINE CHEMBL888 CKB, CGI, CIViC 26228206, 27167172, 26156229, 26091808, 27975152, 26540314, 21862683, 24915778
KRAS 3845 AFATINIB CHEMBL1173655 CKB, CIViC 24685132, 26341921, 27338794, 25870145
KRAS 3845 AZD-5438 CHEMBL488436 CIViC 26881434
KRAS 3845 IRINOTECAN CHEMBL481 CKB 25322874, 25567130, 26341920, 24798549, 25714871, 23209031, 21325073, 16707468, 24042735
KRAS 3845 PA-799 CHEMBL1684984 CKB 21558396, 22159814
KRAS 3845 VEMURAFENIB CHEMBL1229517 CKB 27312529
KRAS 3845 SARACATINIB CHEMBL217092 CKB 27231123, 26725216
KRAS 3845 LY-294002 CHEMBL98350 CKB 22871572
KRAS 3845 AZD-8055 CHEMBL1801204 CKB 24791855, 22271687, 26725216
KRAS 3845 RIGOSERTIB CHEMBL1241855 CKB 27104980, 26091808
KRAS 3845 JNJ-42756493 CHEMBL3545376 CKB 28341788
KRAS 3845 CUDC-907 CHEMBL3545052 CKB 19490892, 22693356, 20570890, 19165201
KRAS 3845 OXALIPLATIN CHEMBL414804 CKB 21468686, 26341920, 26540314, 23209813
KRAS 3845 CHEMBL376408 CHEMBL376408 CKB 21468686
KRAS 3845 BAY-1082439 CHEMBL3545245 CKB
KRAS 3845 RALIMETINIB CHEMBL2364626 CKB 26725216
KRAS 3845 FLUOROURACIL CHEMBL185 CKB 26341920
KRAS 3845 SALIRASIB CHEMBL23293 CKB 21847063
KRAS 3845 Ro-4987655 CHEMBL1614766 CKB 24947927, 26438159
KRAS 3845 RIDAFOROLIMUS CHEMBL2103839 CKB 26725216
KRAS 3845 CHEMBL589258 CHEMBL589258 CKB 20371716
KRAS 3845 CAPECITABINE CHEMBL1773 CKB
KRAS 3845 LENALIDOMIDE CHEMBL848 CKB 27458141
KRAS 3845 OSIMERTINIB CHEMBL3353410 CKB 27252416, 25870145
KRAS 3845 FARNESYL DIPHOSPHATE CHEMBL69330 DrugBank 10592235
KRAS 3845 CETUXIMAB CHEMBL1201577 PharmGKB, ClearityFoundationBiomarkers, OncoKB, CKB, CGI, CIViC, DoCM 25605843, 25877855, 28404754, 21228335, 20619739, 18316791, 20921465, 24024839, 20921462, 24739896, 19339720, 15269313, 15677699, 17470858, 23177514, 28006059, 16618717, 18946061, 18202412, 20978259, 26371285, 26812186, 20956938, 22586653, 28275037, 22722830, 25673644, 19603018, 20570890, 25666295, 26666244, 27312529, 26341921, 25838391, 26715098, 24304820, 27002107, 25714871, 19064407, 28632865, 27458141, 28280091, 28179366, 2278970, 12460918, 24558511, 22407852, 26623049, 16361624, 22392911, 19773371, 16434492, 18794081, 19255327, 17384584, 25157968, 19114683, 22734028, 23406027, 19018267, 21975775, 23182985, 19075190, 19679400, 21398618, 3122217
KRAS 3845 ERLOTINIB CHEMBL553 ClearityFoundationBiomarkers, OncoKB, CKB, CIViC 15696205, 21862683, 23313110, 19794967, 21969500, 25801412, 23934108, 22805291, 26728409, 24908424, 26837474, 20609353, 23200175, 15542782, 24746704, 25792301, 15801831, 27659046, 27480147, 16043828, 18626007
KRAS 3845 TEMSIROLIMUS CHEMBL1201182 ClearityFoundationBiomarkers, CKB 26725216, 27016228, 21216929
KRAS 3845 GEFITINIB CHEMBL939 ClearityFoundationBiomarkers, CKB, CIViC 27338794, 15696205, 25870145, 23313110, 19794967
KRAS 3845 PIMASERTIB CHEMBL2107832 ClearityFoundationBiomarkers, CKB 26228206, 23629727
KRAS 3845 CARBOPLATIN CHEMBL1351 CKB, CIViC 22139083, 25637314, 27998224, 16043828, 21216929, 26307133
KRAS 3845 AZD-8186 CHEMBL3545424 CKB, CIViC 26725216
KRAS 3845 TEPROTUMUMAB CHEMBL1743079 CIViC 21985784
KRAS 3845 BEVACIZUMAB CHEMBL1201583 CKB, CIViC 25363205, 23828442, 28632865, 21216929
KRAS 3845 PILARALISIB (CHEMBL3218575) CHEMBL3218575 CKB 25637314, 21216929
KRAS 3845 VX-970 CHEMBL3545202 CKB 28363999
KRAS 3845 MK-2206 CHEMBL1079175 CKB 26676756, 22025163, 26725216, 25931518, 27480147
KRAS 3845 METFORMIN CHEMBL1431 CKB 24077915, 23877793
KRAS 3845 SIROLIMUS CHEMBL413 CKB 26144316, 26882569
KRAS 3845 DABRAFENIB CHEMBL2028663 CKB 27312529
KRAS 3845 ALPELISIB CHEMBL2396661 CKB 27312529, 24608574, 27602501, 27659046
KRAS 3845 PICTILISIB CHEMBL521851 CKB 22952903, 26725216, 22084396, 22693356, 19165201
KRAS 3845 TAK-733 CHEMBL1615025 CKB 26439693
KRAS 3845 SONOLISIB CHEMBL411907 CKB 18493606
KRAS 3845 CHEMBL56543 CHEMBL56543 CKB 22159814
KRAS 3845 DS-7423 CHEMBL3545248 CKB 24504419
KRAS 3845 PANOBINOSTAT CHEMBL483254 CKB 19490892, 22693356, 26725216
KRAS 3845 CI-1040 CHEMBL105442 CKB 19372556, 19018267
KRAS 3845 NILOTINIB CHEMBL255863 CKB 26725216
KRAS 3845 Panulisib CHEMBL3545322 CKB
KRAS 3845 BENZONATATE CHEMBL1374379 CKB 26725216
KRAS 3845 Ulixertinib CHEMBL3545022 CKB 26725216
KRAS 3845 BI-2536 CHEMBL513909 CKB 26597303
KRAS 3845 VENETOCLAX CHEMBL3137309 CKB 27974663
KRAS 3845 PANITUMUMAB CHEMBL1201827 PharmGKB, ClearityFoundationBiomarkers, OncoKB, CKB, CGI, CIViC, DoCM 21228335, 20619739, 18316791, 20921465, 24024839, 20921462, 24739896, 19339720, 15269313, 15677699, 17470858, 23177514, 25242168, 21170960, 28275037, 26644315, 26341920, 19064407, 24919569, 23625191, 26540314, 28404754, 2278970, 12460918, 24558511, 22407852, 26623049, 16361624, 22392911, 19773371, 16434492, 18794081, 26371285, 19255327, 17384584, 25157968, 16618717, 19114683, 22734028, 23406027, 19018267, 26812186, 21975775, 23182985, 19075190, 19679400, 21398618, 3122217, 20978259
KRAS 3845 GDC-0994 CHEMBL3544964 OncoKB 22805291, 15483017
KRAS 3845 REGORAFENIB CHEMBL1946170 inhibitor OncoKB, CKB, CGI, MyCancerGenomeClinicalTrial 20921462, 24739896, 20921465, 19339720, 15269313, 15677699, 17470858, 23177514, 25242168, 21170960, 25838391, 27004155, 23629727
KRAS 3845 DOCETAXEL CHEMBL92 OncoKB, CKB, CGI, CIViC 25801412, 23934108, 22805291, 26728409, 24908424, 26837474, 20609353, 23200175, 15542782, 24746704, 25792301, 15801831, 26125448, 28492898, 27876675
KRAS 3845 CABOZANTINIB CHEMBL2105717 OncoKB, CKB 25242168, 23177514, 21170960, 27525386
KRAS 3845 IMATINIB CHEMBL941 CGI
KRAS 3845 CHEMBL387187 CHEMBL387187 CIViC 27037411, 26739882
KRAS 3845 DACTOLISIB CHEMBL1879463 CKB, CIViC 22392911, 19029981, 26206338, 26232337, 26272063, 22662154, 23475782, 24939055, 25673820, 23629727
KRAS 3845 PACLITAXEL CHEMBL428647 CKB, CIViC 22139083, 16043828, 21216929, 26307133
KRAS 3845 DASATINIB CHEMBL1421 CKB, CIViC 20956938, 26855149, 27231123, 28280091, 26725216, 27222538
KRAS 3845 ENCORAFENIB CHEMBL3301612 CKB, CIViC 25673644, 27312529
KRAS 3845 OLAPARIB CHEMBL521686 CKB 28363999
KRAS 3845 AZD-1775 CHEMBL1976040 CKB 28652249, 24791855, 27998224
KRAS 3845 NERATINIB CHEMBL180022 CKB 26243863, 26725216
KRAS 3845 NAVITOCLAX CHEMBL443684 CKB 26725216, 25665005, 27659046
KRAS 3845 DEGUELIN CHEMBL393417 CKB 20811676, 24978597
KRAS 3845 VOXTALISIB CHEMBL3545366 CKB 24634413
KRAS 3845 Poziotinib CHEMBL3545154 CKB 21306821
KRAS 3845 BGB-283 CHEMBL3545246 CKB
KRAS 3845 MIDOSTAURIN CHEMBL608533 CKB 26725216
KRAS 3845 INK-1117 CHEMBL3545055 CKB
KRAS 3845 IPATASERTIB CHEMBL2177390 CKB 26725216
KRAS 3845 ROMIDEPSIN CHEMBL1213490 CKB
KRAS 3845 VOLASERTIB CHEMBL1233528 CKB 26597303
KRAS 3845 IRX-4204 CHEMBL75133 CKB
KRAS 3845 OSI-027 CHEMBL3120215 CKB 26725216, 21673091
KRAS 3845 BMS-754807 CHEMBL575448 CKB 26725216
KRAS 3845 2-ACETYL FURANONAPTHOQUINONE CHEMBL64130 CKB
KRAS 3845 CHEMBL392068 CHEMBL392068 CKB 26855149
KRAS 3845 CC-223 CHEMBL3545151 CKB 25855786, 24978597
KRAS 3845 LY-3009120 CHEMBL3545195 CKB 26343583
KRAS 3845 TRASTUZUMAB CHEMBL1201585 CKB, CGI 26243863, 27108243
KRAS 3845 CHIR-265 CHEMBL558752 CIViC 25199829
KRAS 3845 FASUDIL CHEMBL38380 CKB 22541434
KRAS 3845 A-443654 CHEMBL379300 CKB 24978597, 24569089
KRAS 3845 PF-00477736 CHEMBL3545137 CKB 26140595
KRAS 3845 INFIGRATINIB CHEMBL1852688 CKB 27338794
KRAS 3845 DINACICLIB CHEMBL2103840 CKB 25931518, 27550941
KRAS 3845 IXABEPILONE CHEMBL1201752 CKB 26864210
KRAS 3845 RILOTUMUMAB CHEMBL1743063 CKB 24919569
KRAS 3845 CHEMBL217354 CHEMBL217354 CKB 25665005
KRAS 3845 CHEMBL428462 CHEMBL428462 CKB 24978597, 20423992
KRAS 3845 CAMPTOTHECIN CHEMBL65 CKB 25688157, 24042735
KRAS 3845 PEMETREXED (CHEMBL1201258) CHEMBL1201258 CKB, CIViC 27876675
KRAS 3845 COPANLISIB CHEMBL3218576 CKB 24170767
KRAS 3845 APITOLISIB CHEMBL1922094 CKB 21998291, 25673820
KRAS 3845 TASELISIB CHEMBL2387080 CKB 28331003
KRAS 3845 CHEMBL1231206 CHEMBL1231206 CKB 26140595
KRAS 3845 IMGATUZUMAB CHEMBL2109389 CKB 23209031
KRAS 3845 PHENFORMIN CHEMBL170988 CKB 26574479
KRAS 3845 PAZOPANIB CHEMBL477772 CKB 26324075
KRAS 3845 DECITABINE CHEMBL1201129 CGI, CIViC 25968887
KRAS 3845 PONATINIB CHEMBL1171837 CKB, CGI 27338794
KRAS 3845 CHEMBL525191 CHEMBL525191 CKB 19276360
KRAS 3845 SAR-125844 CHEMBL3545325 CKB 25504634
KRAS 3845 AT-13148 CHEMBL3544960 CKB 22781553
KRAS 3845 RAMUCIRUMAB CHEMBL1743062 CKB 25877855
KRAS 3845 AZD-4547 CHEMBL3184679 CKB 27338794
KRAS 3845 LAPATINIB CHEMBL554 CKB, CGI 27108243
KRAS 3845 PEMBROLIZUMAB CHEMBL3137343 CKB, CIViC 28451792, 28039262
KRAS 3845 Refametinib CHEMBL2138601 CKB 25294897, 27975152, 26582713
KRAS 3845 NVP-AUY922 CHEMBL252164 CKB 26832792
KRAS 3845 BORTEZOMIB CHEMBL325041 CKB 22541434
KRAS 3845 CANDICIDIN CHEMBL1200647 CKB 26839307
KRAS 3845 ANILINOQUINAZOLINE1 CHEMBL382590 CKB 26842935
KRAS 3845 CHEMBL458997 CHEMBL458997 CKB 26090892

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
KRAS rs61764370 AC + CC cetuximab efficacy no In the results section the uncorrected p value listed looks good but when looking at Table 3 can see the corrected p value is not significant and authors state result is not significant. Genotypes AC + CC is not associated with response to cetuximab or panitumumab in people with Colorectal Neoplasms as compared to genotype AA. 25210463 1446909124
KRAS rs112445441 T cetuximab efficacy no Allele complemented to plus chromosomal strand. For patients with G13D, cetuximab did not appear to provide a clinically relevant benefit. Allele T is not associated with increased response to cetuximab in people with Colorectal Neoplasms. 26371285 1447519253
KRAS rs61764370 C cetuximab efficacy no Meta-analysis with 5 studies. The authors did not provide the exact number of patients but stated that "the median number of patients per analysis was 110 (range 50 - 740)". Most definitions of response were variations of the RECIST criteria. Please note that alleles have been complemented to the plus chromosomal strand. Allele C is not associated with response to cetuximab or panitumumab in people with Colorectal Neoplasms as compared to allele A. 27897268 1449165394
KRAS rs61764370 AC capecitabine efficacy yes C allele carriers (there were no homozygotes) had a statistically significantly higher rate of complete response (CR) after neoadjuvant therapy and a trend for better 5-year progression-free survival (PFS) and overall survival. Both CR and survival outcomes were independent of the use of cetuximab. Patients received neoadjuvant CAPOX followed by chemoradiotherapy, surgery and adjuvant CAPOX plus or minus cetuximab Genotype AC is associated with increased response to capecitabine, cetuximab and oxaliplatin in people with Rectal Neoplasms as compared to genotype AA. 26162609 1446908428