PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
KRAS	1	PNPLA4	0	genetic interference, genetic interference	Vizeacoumar FJ (2013), Luo J (2009)	2
PIK3CA	8	ARAF	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
KRAS	1	RAF1	3	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, genetic interference, affinity chromatography technology, fluorescent resonance energy transfe	Li W (2000), Kiyono M (2000), Sui X (2009), Lito P (2012), Rajalingam K (2005), Zhu J (2005), Blaukat A (2000), So J (2015), Ji H (2016), Hart T (2015), Wang T (2017), Saito T (2004), Ivanov AA (2017)	13
RAF1	3	BCL2	0	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang HG (1996), Wang HG (1996), Wang HG (1996), Jin S (2005), Jin S (2005), Mazzocca A (2003)	6
BRAF	12	MAPK1	1	enzymatic study, genetic interference, enzymatic study	Ren JG (2008), Hart T (2015), Smith BD (2015)	3
MAPK1	1	KRAS	1	affinity chromatography technology, genetic interference	Blaukat A (2000), Hart T (2015)	2
KRAS	1	EEF1A1	0	two hybrid, genetic interference	Vinayagam A (2011), Luo J (2009)	2
MAPK1	1	RAF1	3	affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Lin YL (2000), Dougherty MK (2005), Zhu J (2005), Blaukat A (2000), Wang J (2009), Wang J (2009), Wang J (2009)	7
CALM1	0	RAF1	3	affinity chromatography technology	Villalonga P (2001)	1
RAF1	3	SHOC2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li W (2000), Li W (2000), Jang ER (2014), Jang ER (2015)	4
ARAF	0	KRAS	1	two hybrid, affinity chromatography technology, fluorescent resonance energy transfe	Rolland T (2014), So J (2015), Ivanov AA (2017)	3
KRAS	1	SHOC2	4	two hybrid, genetic interference	Li W (2000), Wang T (2017)	2
KRAS	1	DIRAS3	0	genetic interference, two hybrid	Vizeacoumar FJ (2013), Arroyo R (2015)	2
KRAS	1	KRAS	1	genetic interference, fluorescent resonance energy transfe	Luo J (2009), Zhao L (2016)	2
SERPINB5	0	EEF1A1	0	two hybrid	Blacque OE (2002)	1
KRAS	1	GATAD2A	3	genetic interference, affinity chromatography technology	Luo J (2009), Hein MY (2015)	2
BRAF	12	PIK3CA	8	genetic interference	Shen JP (2017)	1
KRAS	1	THOC1	1	genetic interference, genetic interference	Vizeacoumar FJ (2013), Luo J (2009)	2
PIK3CG	3	KRAS	1	pull down, affinity chromatography technology	Rubio I (1999), Rubio I (1999)	2
BRAF	12	KRAS	1	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Huttlin EL (2017), Eisenhardt AE (2016), Ivanov AA (2017)	3
BRAF	12	RAF1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Weber CK (2001), Weber CK (2001), Kilili GK (2010), Chen C (2008), Chen C (2008), Lito P (2012), Huttlin EL (2017)	7
BRAF	12	ARAF	0	affinity chromatography technology, imaging technique, affinity chromatography technology, fluorescent resonance energy transfe	Gloeckner CJ (2007), Chen TC (2014), Huttlin EL (2017), Ivanov AA (2017)	4
KRAS	1	RASSF2	2	affinity chromatography technology, pull down	Vos MD (2003), Vos MD (2003)	2
HNRNPC	0	KRAS	1	two hybrid, genetic interference	Rual JF (2005), Luo J (2009)	2
BCL2	0	KRAS	1	affinity chromatography technology, affinity chromatography technology	Wang X (2009), Wang X (2009)	2
KRAS	1	PIK3CA	8	two hybrid, genetic interference	Li W (2000), Hart T (2015)	2
DIRAS3	0	RAP1GDS1	0	affinity chromatography technology	Huttlin EL (2015)	1
KRAS	1	RALGDS	4	two hybrid, two hybrid, pull down, two hybrid	Li W (2000), Spaargaren M (1994), Spaargaren M (1994), Wang J (2011)	4
CALM1	0	KRAS	1	affinity chromatography technology, pull down, pull down, two hybrid	Villalonga P (2001), Villalonga P (2001), Sidhu RS (2003), Sidhu RS (2003)	4
MAPK1	1	BCL2	0	enzymatic study, affinity chromatography technology	Tamura Y (2004), Tamura Y (2004)	2
RAP1GDS1	0	KRAS	1	two hybrid, affinity chromatography technology	Vikis HG (2002), Berg TJ (2010)	2
EEF1A1	0	RAF1	3	affinity chromatography technology, affinity chromatography technology, imaging technique	Lamberti A (2007), Lamberti A (2007), Lamberti A (2007)	3
KRAS	1	SERPINB5	0	genetic interference, two hybrid	Luo J (2009), Arroyo R (2015)	2