PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SHC1	0	AP2M1	5	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Li J (2013)	2
CUL5	1	HNRNPU	12	affinity chromatography technology	Bennett EJ (2010)	1
CBL	7	KRT3	0	affinity chromatography technology	Brehme M (2009)	1
CUL5	1	KRT3	0	affinity chromatography technology	Bennett EJ (2010)	1
EGFR	5	AP2M1	5	protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deribe YL (2009), Foerster S (2013), Li J (2013), Tong J (2014), Li J (2013)	5
AP2M1	5	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
CUL5	1	COPS5	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010)	2
TRAF6	0	KRT3	0	affinity chromatography technology	Yu J (2016)	1
ITGAV	7	CBL	7	affinity chromatography technology	Elsegood CL (2006)	1
SIRT6	2	KRT3	0	affinity chromatography technology	Simeoni F (2013)	1
SHC1	0	KRT14	2	affinity chromatography technology	Brehme M (2009)	1
KRT14	2	KRT3	0	biochemical	Havugimana PC (2012)	1
COPS5	0	KRT3	0	affinity chromatography technology	Bennett EJ (2010)	1
AP2M1	5	KRT3	0	affinity chromatography technology	Brehme M (2009)	1
AP2M1	5	KRT14	2	affinity chromatography technology	Brehme M (2009)	1
EGFR	5	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ettenberg SA (1999), Tvorogov D (2002), Pennock S (2008), Umebayashi K (2008), Ng C (2008), Ng C (2008), Povlsen GK (2008), Khan EM (2008), Su X (2007), Shtiegman K (2007), Han W (2006), Visser GD (2005), Tsacoumangos A (2005), Prasad NK (2005), Gur G (2004), Kowanetz K (2004), Feshchenko EA (2004), Wu WJ (2003), Schmidt MH (2003), Bao J (2003), Rubin C (2003), Waterman H (1999), Bonaccorsi L (2007), Dey N (2011), Miraoui H (2010), Guo HB (2009), Tong J (2009), Tong J (2009), Sun Q (2010), Sanada F (2009), Rafiq K (2011), Ravid T (2004), Ravid T (2004), Duan L (2011), Duan L (2011), Haglund K (2005), Oksvold MP (2003), Oksvold MP (2003), Gui A (2012), Yang S (2006), de Melker AA (2004), Crovello CS (1998), Graus-Porta D (1997), Oksvold MP (2001), Raguz J (2007), de Melker AA (2004), Thien CB (2001), Kassenbrock CK (2004), Tarcic G (2009), Schroeder B (2012), Adachi S (2009), Shen F (2007), Mitsushima M (2006), Choi JH (2003), Burke P (2001), Tanaka S (1995), Meisner H (1995), Meisner H (1995), Kumar EA (2012), Tong J (2008), Dou H (2012), Levkowitz G (1999), Levkowitz G (1999), Bode AM (2009), Thomas C (2012), Meijer IM (2013), Chang CC (2012), Chang CC (2012), Smith CJ (2013), Gan Y (2010), Scott RP (2005), Fukazawa T (1996), Fukazawa T (1996), Fukazawa T (1996), Wang L (2013), Hong SY (2013), Sigismund S (2013), Sigismund S (2013), Sigismund S (2013), Meisner H (1997), Odintsova E (2013), Kondratov KA (2010), He Z (2014), Tong J (2014), Balaji K (2012), Kiuchi T (2014), Zhang B (2005), Waterman H (1999), Ha Thi HT (2015), Yao S (2015), Kortuem F (2015), Igloi Z (2015), Song F (2016), Song F (2016), Lin TY (2017), Conte A (2017)	96
TRAF6	0	KRT5	1	affinity chromatography technology	Yu J (2016)	1
KRT14	2	KRT5	1	biochemical	Havugimana PC (2012)	1
INPPL1	6	KRT14	2	affinity chromatography technology	Brehme M (2009)	1
CBL	7	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
EPS15	1	AP2M1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Li J (2013), Huttlin EL (2015), Huttlin EL (2017)	5
SHC1	0	HNRNPU	12	affinity chromatography technology	Li J (2013)	1
INPPL1	6	KRT3	0	affinity chromatography technology	Brehme M (2009)	1
CRK	0	INPPL1	6	affinity chromatography technology	Brehme M (2009)	1
EPS15	1	CRK	0	far western blotting, pull down, affinity chromatography technology, affinity chromatography technology	Schumacher C (1995), Schumacher C (1995), Brehme M (2009), Brehme M (2009)	4
INPPL1	6	HNRNPU	12	affinity chromatography technology	Brehme M (2009)	1
EGFR	5	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Schulze WX (2006), Sakaguchi K (1998), Tong J (2009), Crovello CS (1998), Graus-Porta D (1997), Oksvold MP (2001), Burke P (2001), Katayama H (1999), Tong J (2008), Zhang L (1999), Levkowitz G (1999), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Foerster S (2013), Gotoh N (1994), Tong J (2014), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Li J (2013), Li J (2013), Prigent SA (1996), Prigent SA (1996), Grosse R (2000), Yao Z (2017), Wills MK (2014), Wills MK (2014), Kapoor GS (2010)	29
EGFR	5	KRT5	1	affinity chromatography technology	Yao Z (2017)	1
TRAF6	0	CUL5	1	affinity chromatography technology, pull down, affinity chromatography technology	Zhu Z (2016), Zhu Z (2016), Zhu Z (2017)	3
SHC1	0	KRT3	0	affinity chromatography technology	Brehme M (2009)	1
HNRNPU	12	HP1BP3	2	affinity chromatography technology	Hein MY (2015)	1
EGFR	5	INPPL1	6	affinity chromatography technology, affinity chromatography technology	Pesesse X (2001), Sanada F (2009)	2
EPS15	1	KRT3	0	affinity chromatography technology	Brehme M (2009)	1
AP2M1	5	CRK	0	affinity chromatography technology	Brehme M (2009)	1
HNRNPU	12	KRT3	0	biochemical	Havugimana PC (2012)	1
CUL5	1	KRT5	1	affinity chromatography technology	Bennett EJ (2010)	1
CRK	0	KRT14	2	affinity chromatography technology	Brehme M (2009)	1
CRK	0	KRT3	0	affinity chromatography technology	Brehme M (2009)	1
CBL	7	KRT14	2	affinity chromatography technology	Brehme M (2009)	1
CBL	7	SHC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park RK (1999), Gesbert F (1998), Erdreich-Epstein A (1997), Wang Y (1999), Brehme M (2009), Brehme M (2009), Cerboni C (1998), Brizzi MF (1996), Fukazawa T (1996)	9
SHC1	0	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
EGFR	5	CRK	0	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid, protein complementation assay, affinity chromatography technology	Schulze WX (2006), Hashimoto Y (1998), Hashimoto Y (1998), Katayama H (1999), Ota S (1998), Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	9
INPPL1	6	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
ITGAV	7	KRT3	0	biochemical	Havugimana PC (2012)	1
EGFR	5	KRT3	0	affinity chromatography technology	Yao Z (2017)	1
HNRNPU	12	KRT14	2	biochemical	Havugimana PC (2012)	1
EPS15	1	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
CBL	7	INPPL1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vandenbroere I (2003), Prasad NK (2005), De Schutter J (2009), De Schutter J (2009), Brehme M (2009)	5
CUL5	1	HP1BP3	2	affinity chromatography technology	Bennett EJ (2010)	1
SHC1	0	INPPL1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wisniewski D (1999), Wisniewski D (1999), Pesesse X (2001), Habib T (1998), Brehme M (2009), Brehme M (2009)	6
CRK	0	KRT5	1	affinity chromatography technology	Brehme M (2009)	1
SHC1	0	CRK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Ota S (1998), Larsson H (1999)	4
EPS15	1	KRT14	2	affinity chromatography technology	Brehme M (2009)	1
COPS5	0	KRT14	2	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	HNRNPU	12	affinity chromatography technology	Bennett EJ (2010)	1
KRT3	0	KRT5	1	biochemical	Havugimana PC (2012)	1
ITGAV	7	SHC1	0	affinity chromatography technology	Lee DY (2010)	1
SKA3	3	KRT3	0	affinity chromatography technology	Hein MY (2015)	1
CUL5	1	KRT14	2	affinity chromatography technology	Bennett EJ (2010)	1
CRK	0	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, two hybrid	Gesbert F (1998), Husson H (1997), Ingham RJ (1996), Ingham RJ (1996), Delehanty LL (2003), Garcia-Guzman M (2000), Garcia-Guzman M (2000), Barber DL (1997), Buday L (1996), Sawasdikosol S (1996), Sawasdikosol S (1996), Thien CB (1997), van Leeuwen JE (1999), Ribon V (1996), Lottin-Divoux S (2006), Reedquist KA (1996), Brehme M (2009), Brehme M (2009), Ota S (1998), Peterson ME (2008), Liu BA (2012), Fukazawa T (1996), Umehara H (2002), Grossmann A (2015)	24
HP1BP3	2	KRT3	0	biochemical	Havugimana PC (2012)	1
COPS5	0	KRT5	1	affinity chromatography technology	Bennett EJ (2010)	1
EPS15	1	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	van Delft S (1997), Sigismund S (2005), Bertelsen V (2011), Parachoniak CA (2009), Parachoniak CA (2009), Hoeller D (2006)	6
COPS5	0	SKA3	3	genetic interference	Horlbeck MA (2018)	1