Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
LPL 4023 CARBON, ACTIVATED CHEMBL2108847 DrugBank
LPL 4023 ACARBOSE CHEMBL1566 NCI 8886823
LPL 4023 INOSITOL CHEMBL1222251 NCI 8063863
LPL 4023 FENOFIBRATE CHEMBL672 PharmGKB
LPL 4023 ORLISTAT CHEMBL175247 TdgClinicalTrial
LPL 4023 GEMFIBROZIL CHEMBL457 activator TTD
LPL 4023 HYDROGEN PEROXIDE CHEMBL71595 NCI 8732780
LPL 4023 LABETALOL CHEMBL429 NCI 4050551
LPL 4023 ISOTRETINOIN CHEMBL547 NCI 2931603
LPL 4023 RESERPINE CHEMBL772 NCI 7282227
LPL 4023 CLOFIBRATE CHEMBL565 activator TTD
LPL 4023 FOLIC ACID CHEMBL1622 NCI 6732760
LPL 4023 RETINYL ACETATE CHEMBL486193 NCI 16716627
LPL 4023 TYLOXAPOL CHEMBL1201548 inhibitor DrugBank 16839786, 1493594, 9406449
LPL 4023 DEXTRAN SULFATE SODIUM CHEMBL2108952 NCI 7920442
LPL 4023 MIFEPRISTONE CHEMBL1276308 NCI 7627771
LPL 4023 DIAZOXIDE CHEMBL181 NCI 14499880
LPL 4023 ASPARAGINASE CHEMBL2108989 NCI 9264396
LPL 4023 EDARAVONE CHEMBL290916 NCI 8895065
LPL 4023 LOVASTATIN CHEMBL503 NCI 8663292
LPL 4023 NADOLOL CHEMBL649 NCI 1681747
LPL 4023 TRIAMCINOLONE CHEMBL1451 NCI 4077022

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
LPL rs320 GG fenofibrate efficacy yes Response was measured as the percentage of triglyceride lowering. Genotype GG is associated with decreased response to fenofibrate in people with Hypertriglyceridemia as compared to genotypes GT + TT. 19207029 769170844
LPL rs1801177 A fenofibrate efficacy no No association between the variant and risk of exhibiting residual hypertriglyceridemia (post-treatment triglyceride levels > 2.0 mmol/l) or risk of exhibiting plasma total cholesterol (TC)/high density lipoprotein cholesterol (HDL-C) ratio greater than 5 after 3 months of treatment was seen. Multivariate logistic regression model included age, gender, presence of the ApoE2 allele, presence of type 2 diabetes, body mass index (BMI) and pre-treatment triglyceride levels. When TC/HDL-C ratio was studied, the model included the ratio before fenofibrate treatment along with the other covariates. Allele A is not associated with response to fenofibrate in people with Hypertriglyceridemia as compared to allele G. 12042669 982036545
LPL rs328 GG pravastatin efficacy yes as measured by decreases in total cholesterol. Genotype GG is associated with increased response to pravastatin as compared to genotypes CC + CG. 16103896 982045665