PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CALR	1	APP	1	affinity chromatography technology, imaging technique	Johnson RJ (2001), Chen TC (2014)	2
LPL	3	VLDLR	3	pull down	Argraves KM (1995)	1
LPL	3	APP	1	pull down	Olah J (2011)	1
LPL	3	LUC7L2	0	two hybrid	Stelzl U (2005)	1
RPL18A	0	LPL	3	two hybrid	Stelzl U (2005)	1
CUL3	17	EMD	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	LUC7L2	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	LPL	3	affinity chromatography technology	Bennett EJ (2010)	1
CCND1	1	LPL	3	two hybrid	Wang J (2011)	1
LPL	3	LRP1	25	pull down, pull down, pull down	Williams SE (1994), Nykjaer A (1994), Chappell DA (1992)	3
LPL	3	COPS6	0	two hybrid	Stelzl U (2005)	1
PTPN4	0	LPL	3	two hybrid	Stelzl U (2005)	1
LUC7L2	0	APP	1	pull down	Olah J (2011)	1
LRP1	25	APP	1	affinity chromatography technology	Lakshmana MK (2009)	1
APP	1	LRP2	13	pull down	Hammad SM (1997)	1
PLK1	0	LPL	3	affinity chromatography technology	Svendsen JM (2009)	1
ASCC2	3	LPL	3	two hybrid	Stelzl U (2005)	1
CUL3	17	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
COPS6	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	6
LUC7L2	0	CEP126	0	two hybrid	Stelzl U (2005)	1
LUC7L2	0	RPL18A	0	biochemical	Havugimana PC (2012)	1
TSC22D2	2	LPL	3	two hybrid	Li Q (2016)	1
LRP1	25	CALR	1	affinity chromatography technology	Orlando RA (2004)	1
PLK1	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
LPL	3	CEP126	0	two hybrid	Stelzl U (2005)	1
EMD	0	COPS6	0	two hybrid	Stelzl U (2005)	1
LPL	3	LPL	3	pull down	Zhang L (2003)	1
LPL	3	UBE2Z	0	two hybrid	Stelzl U (2005)	1
LRP2	13	LPL	3	pull down	Kounnas MZ (1993)	1
LPL	3	CALR	1	affinity chromatography technology	Zhang L (2003)	1
EMD	0	LPL	3	two hybrid	Wilkinson FL (2003)	1
LPL	3	LMF1	1	affinity chromatography technology	Doolittle MH (2009)	1