Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
ARRB2	rs7208257	C	opioids	dosage	no	Variant had no significant association with opioid dose in the development sample.	Allele C is not associated with dose of opioids in people with Pain as compared to allele T.	21398039	1449715034
ARRB2	rs3786047	A	opioids	dosage	no	Variant had no significant association with opioid dose in either the development sample or the validation sample.	Allele A is not associated with dose of opioids in people with Pain as compared to allele G.	21398039	1449715027
ARRB2	rs4790693	C	opioids	dosage	no	Variant had no significant association with opioid dose in either the development sample or the validation sample.	Allele C is not associated with dose of opioids in people with Pain as compared to allele T.	21398039	1449715020
ARRB2	rs2271167	A	opioids	dosage	no	Variant had no significant association with opioid dose in either the development sample or the validation sample.	Allele A is not associated with dose of opioids in people with Pain as compared to allele G.	21398039	1449715048
ARRB2	rs1045280	C	opioids	dosage	no	Variant had no significant association with opioid dose in either the development sample or the validation sample.	Allele C is not associated with dose of opioids in people with Pain as compared to allele T.	21398039	1449715041
ARRB2	rs2036657	A	nicotine	efficacy	no	Bivariate analysis found no significant association in abstinence rates between the genotype groups at the end of nicotine replacement therapy treatment or 6 months after completing treatment.	Allele A is not associated with response to nicotine in people with Tobacco Use Disorder as compared to allele G.	17978999	1450811492
ARRB2	rs1045280	C	nicotine	efficacy	no	Bivariate and multivariate analyses found no significant association in abstinence rates between the genotype groups at the end of nicotine replacement therapy treatment or 6 months after completing treatment.	Allele C is not associated with response to nicotine in people with Tobacco Use Disorder as compared to allele T.	17978999	1450811473
ARRB2	rs2036657	A	opioids	dosage	no	Variant had no significant association with opioid dose in either the development sample or the validation sample.	Allele A is not associated with dose of opioids in people with Pain as compared to allele G.	21398039	1449715055
ARRB2	rs3786047	A	nicotine	efficacy	no	Bivariate analysis found no significant association in abstinence rates between the genotype groups at the end of nicotine replacement therapy treatment or 6 months after completing treatment.	Allele A is not associated with response to nicotine in people with Tobacco Use Disorder as compared to allele G.	17978999	1450811485