PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ARRB2	5	CTNNA1	7	affinity chromatography technology, imaging technique	Xiao K (2007), Chen TC (2014)	2
FBL	1	NOLC1	2	biochemical, affinity chromatography technology, biochemical	Havugimana PC (2012), Huttlin EL (2015), Wan C (2015)	3
CSNK2A1	15	MDM2	2	enzymatic study, enzymatic study	Goetz C (1999), Hjerrild M (2001)	2
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
GPR55	1	ARRB2	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPK10	0	ARRB2	5	affinity chromatography technology, unspecified method	Miller WE (2001), Li X (2009)	2
ARRB1	2	MAPK9	3	two hybrid, two hybrid	Wang J (2011), Rolland T (2014)	2
ARRB2	5	LIMK1	3	pull down, affinity chromatography technology	Zoudilova M (2007), Zoudilova M (2007)	2
ADRB2	0	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Nabhan JF (2010), Han SO (2012)	2
NEDD4	2	MAP3K5	1	enzymatic study	Persaud A (2009)	1
TCOF1	1	NOLC1	2	affinity chromatography technology, affinity chromatography technology, genetic interference	Werner A (2015), Werner A (2015), Horlbeck MA (2018)	3
HGS	5	ITCH	1	affinity chromatography technology, affinity chromatography technology	Marchese A (2003), OConnor HF (2015)	2
ARRB2	5	YWHAQ	0	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
EGFR	5	AKT1	1	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
SRC	2	MAPK3	4	affinity chromatography technology	Lee J (2013)	1
MAPK10	0	ARRB1	2	affinity chromatography technology, unspecified method	Miller WE (2001), Li X (2009)	2
MAPK1	1	ARRB1	2	enzymatic study	Lin FT (1999)	1
YWHAQ	0	HSPA8	4	affinity chromatography technology	Jin J (2004)	1
ARRB1	2	MAP3K1	4	affinity chromatography technology	Xiao K (2007)	1
ARRB2	5	MAP2K4	3	affinity chromatography technology, unspecified method	McDonald PH (2000), Li X (2009)	2
ARRDC3	0	ARRB2	5	affinity chromatography technology, affinity chromatography technology	Shea FF (2012), Han SO (2012)	2
NEDD4	2	HGS	5	enzymatic study, affinity chromatography technology, affinity chromatography technology	Katz M (2002), Sun Y (2013), Tan X (2015)	3
EGFR	5	ITCH	1	affinity chromatography technology	Tong J (2014)	1
TCOF1	1	CSNK2A1	15	affinity chromatography technology	Werner A (2015)	1
MDM2	2	ARRB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Wang P (2003), Shenoy SK (2008), Girnita L (2005), Girnita L (2005), Nogues L (2011), Shenoy SK (2001), Ahmed MR (2011)	7
TRAF6	0	SRC	2	affinity chromatography technology, pull down	Wong BR (1999), Liu A (2012)	2
ARRB2	5	HGS	5	affinity chromatography technology, affinity chromatography technology	Han SO (2012), Malik R (2010)	2
ARRB2	5	FBL	1	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Xiao K (2007)	2
FBL	1	NCL	1	affinity chromatography technology	Padilla PI (2008)	1
SRC	2	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, two hybrid	Olayioye MA (1999), Keely SJ (2000), Sato K (2000), Lee CW (2007), Jaganathan S (2011), Jaganathan S (2011), Lee IT (2010), Hitosugi T (2007), Chang CC (2012), Chang CC (2012), Tung WH (2011), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Yao Z (2017)	15
MDM2	2	PKM	1	pull down, affinity chromatography technology, pull down, enzymatic study	Miyamoto-Sato E (2010), Riscal R (2016), Riscal R (2016), Riscal R (2016)	4
AKT1	1	PTGDS	0	two hybrid	Arroyo R (2015)	1
YWHAQ	0	NOLC1	2	pull down	Meek SE (2004)	1
MAP2K4	3	ITCH	1	affinity chromatography technology, pull down, enzymatic study	Ahn YH (2009), Ahn YH (2009), Ahn YH (2009)	3
MDM2	2	UBC	7	pull down, enzymatic study, enzymatic study	Higashitsuji H (2005), Luo J (2013), Poyurovsky MV (2007)	3
PRKCB	4	EGFR	5	enzymatic study	Khaled Z (1995)	1
ARRB2	5	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Y (2006), Wang Y (2006), Xiao N (2015)	3
ARRB2	5	CFL1	0	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Zoudilova M (2007)	2
ARRB2	5	ZRANB2	0	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
ADRB2	0	CALM3	0	affinity chromatography technology	Roy SJ (2013)	1
MAPK9	3	MAPK10	0	affinity chromatography technology	Varjosalo M (2013)	1
NFKBIA	0	SRC	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AGTR1	4	ARRB1	2	affinity chromatography technology	Barnes WG (2005)	1
AKT1	1	PPM1A	1	imaging technique	Chen TC (2014)	1
MAPK3	4	ARRB1	2	enzymatic study	Lin FT (1999)	1
TRAF6	0	MAP3K5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nishitoh H (1998), Hoeflich KP (1999), Mochida Y (2000), Fujino G (2007), Fujino G (2007)	5
CHUK	5	TRAF6	0	affinity chromatography technology	Kishida S (2005)	1
ARRB1	2	RALGDS	4	affinity chromatography technology, affinity chromatography technology	Bhattacharya M (2002), Bhattacharya M (2002)	2
CSNK2A1	15	AKT1	1	enzymatic study	Di Maira G (2005)	1
ARRB1	2	FLNA	10	affinity chromatography technology	Xiao K (2007)	1
HGS	5	HSPA8	4	pull down	Pridgeon JW (2009)	1
ARRB1	2	CTTN	1	affinity chromatography technology	Xiao K (2007)	1
NEDD4	2	UBC	7	x-ray crystallography, pull down, unspecified method, enzymatic study, x-ray crystallography, enzymatic study, pull down, pull down	Maspero E (2011), Maspero E (2011), Ernst A (2013), Maspero E (2013), Mari S (2014), Mari S (2014), Mari S (2014), Kathman SG (2015)	8
CHUK	5	SRC	2	affinity chromatography technology, affinity chromatography technology	Huang WC (2003), Funakoshi-Tago M (2005)	2
ARRB2	5	MAP3K1	4	affinity chromatography technology, imaging technique	Xiao K (2007), Chen TC (2014)	2
ARRB1	2	PDE4D	4	affinity chromatography technology, two hybrid	Li X (2009), Bolger GB (2003)	2
AKT1	1	SRC	2	imaging technique, affinity chromatography technology	Chen TC (2014), Lee J (2013)	2
ADRB2	0	USP33	1	affinity chromatography technology	Han SO (2012)	1
ADRB2	0	SRC	2	affinity chromatography technology	Cao W (2000)	1
MAP2K4	3	MAPK9	3	two hybrid, affinity chromatography technology, pull down	Vinayagam A (2011), Li Y (2012), Ho DT (2003)	3
ARRB1	2	CFL1	0	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Zoudilova M (2007)	2
ARRB1	2	MAP3K5	1	affinity chromatography technology, affinity chromatography technology, unspecified method	Zhang Z (2009), Li X (2009), Li X (2009)	3
MAPK9	3	ARRB2	5	two hybrid, two hybrid	Venkatesan K (2009), Rolland T (2014)	2
ARRB1	2	HSPA8	4	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
SRC	2	CFL1	0	enzymatic study	Yoo Y (2010)	1
ADRB2	0	ARRDC3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down	Nabhan JF (2010), Shea FF (2012), Qi S (2014), Patwari P (2011), Shea FF (2012), Tian X (2016), Tian X (2016), Tian X (2016)	8
UBC	7	MAP2K4	3	pull down	Zhang X (2017)	1
ARRB2	5	NCL	1	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
AKT1	1	TCOF1	1	affinity chromatography technology	Hein MY (2015)	1
MAPK1	1	PDE4D	4	enzymatic study	Li X (2010)	1
MAP2K4	3	MAP3K5	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Ryoo K (2004), Song JJ (2004), Kim EK (2007), Zhang H (2004)	4
ARRB2	5	USP33	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology	Berthouze M (2009), Shenoy SK (2009), Shenoy SK (2009), Shenoy SK (2014), Shenoy SK (2014), Shenoy SK (2009), Shenoy SK (2009), Shenoy SK (2009), Liu H (2016)	9
ARRB2	5	ITCH	1	affinity chromatography technology, affinity chromatography technology, pull down	Shenoy SK (2008), Bhandari D (2007), Bhandari D (2007)	3
ARRB2	5	RALGDS	4	two hybrid, affinity chromatography technology, affinity chromatography technology	Bhattacharya M (2002), Bhattacharya M (2002), Bhattacharya M (2002)	3
FLNA	10	GSN	3	affinity chromatography technology	Hein MY (2015)	1
ARRB2	5	NOLC1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Xiao K (2007), Xiao K (2007), Werner A (2015), Huttlin EL (2017)	5
ARRB1	2	UBC	7	affinity chromatography technology	Xiao K (2007)	1
ARRB2	5	CTTN	1	affinity chromatography technology, imaging technique	Xiao K (2007), Chen TC (2014)	2
ARRB2	5	CHUK	5	affinity chromatography technology, imaging technique	Xiao K (2007), Chen TC (2014)	2
MAP2K4	3	MAPK1	1	pull down	Ho DT (2003)	1
MAPK1	1	CSNK2A1	15	enzymatic study, affinity chromatography technology, pull down	Ji H (2009), Ji H (2009), Ji H (2009)	3
CSNK2A1	15	CHUK	5	enzymatic study	Heilker R (1999)	1
GSN	3	ITCH	1	affinity chromatography technology	Abedini MR (2014)	1
MAPK9	3	AKT1	1	enzymatic study	Xiao L (2010)	1
MDM2	2	NEDD4	2	unspecified method, enzymatic study, affinity chromatography technology	Burch LR (2004), Xu C (2014), Xu C (2014)	3
MAPK1	1	MAP3K1	4	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study	Karandikar M (2000), Karandikar M (2000), Gallagher ED (2004), Tu Z (2003), Loke J (2014)	5
SLC9A5	4	ARRB2	5	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Szabo EZ (2005), Szabo EZ (2005), Szabo EZ (2005), Szabo EZ (2005)	4
EGFR	5	IGF1R	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Morgillo F (2006), Riedemann J (2007), Riedemann J (2007)	3
ARRB2	5	ARRB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Xiao K (2007), Xiao K (2007), Huttlin EL (2017)	4
EGFR	5	ARRB2	5	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
ARRB1	2	PKM	1	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
EGFR	5	AP2B1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Tong J (2014), Li J (2013)	3
ARRB2	5	CSNK2A1	15	affinity chromatography technology, enzymatic study	Xiao K (2007), Kim YM (2002)	2
MDM2	2	PDE4D	4	affinity chromatography technology, affinity chromatography technology, enzymatic study	Li X (2009), Li X (2009), Li X (2009)	3
PKM	1	MAPK1	1	affinity chromatography technology, pull down, enzymatic study	Yang W (2012), Yang W (2012), Yang W (2012)	3
ARRB2	5	SRC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rosano L (2009), Luan B (2009), Kim YM (2002), Lee J (2013)	4
EGFR	5	PPM1A	1	affinity chromatography technology, two hybrid	Yao Z (2017), Yao Z (2017)	2
AKT1	1	ARRB2	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Beaulieu JM (2008), Beaulieu JM (2008), Lodeiro M (2009), Luan B (2009)	4
ARRDC3	0	ARRB1	2	affinity chromatography technology	Shea FF (2012)	1
IGF1R	5	ARRB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Broussas M (2009), Girnita L (2005), Girnita L (2005), Zheng H (2012)	4
HSPA8	4	UBC	7	two hybrid	Stelzl U (2005)	1
ARRB2	5	TCOF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Xiao K (2007), Xiao K (2007), Werner A (2015)	4
MDM2	2	YWHAQ	0	affinity chromatography technology, pull down, affinity chromatography technology	Pereg Y (2006), Wang B (2010), Wang B (2010)	3
PKM	1	PRKN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study	Liu K (2016), Liu K (2016), Liu K (2016), Liu K (2016), Liu K (2016), Liu K (2016)	6
ARRB1	2	ZRANB2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Xiao K (2007), Xiao K (2007)	3
ITCH	1	UBC	7	enzymatic study, unspecified method, enzymatic study, enzymatic study	Sheng Y (2012), Ernst A (2013), Maspero E (2013), Kristariyanto YA (2015)	4
AGTR1	4	MAPK1	1	affinity chromatography technology	Luttrell LM (2001)	1
CYTH2	2	ARRB1	2	affinity chromatography technology, pull down	Claing A (2001), Claing A (2001)	2
EGFR	5	MAP2K4	3	affinity chromatography technology	Tong J (2014)	1
ARRB2	5	PDE4D	4	affinity chromatography technology, affinity chromatography technology, two hybrid	Xiao K (2007), Bolger GB (2003), Bolger GB (2003)	3
MDM2	2	NOLC1	2	enzymatic study	Guo Z (2013)	1
ARRB2	5	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Shenoy SK (2008), Han SO (2012)	2
YWHAQ	0	PKM	1	pull down	Meek SE (2004)	1
ARRB2	5	MAPK3	4	affinity chromatography technology, imaging technique	Tohgo A (2003), Chen TC (2014)	2
YWHAQ	0	CFL1	0	pull down	Meek SE (2004)	1
SRC	2	MDM2	2	unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Batuello CN (2015), Batuello CN (2015), Batuello CN (2015), Batuello CN (2015), Batuello CN (2015)	5
LIMK1	3	CFL1	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Foletta VC (2003), Maekawa M (1999), Yang X (2004), Talukder AH (2006), Zoudilova M (2007)	5
ARRB1	2	PPM1B	2	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
ARRB1	2	NFKBIA	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Witherow DS (2004), Witherow DS (2004), Witherow DS (2004), Gao H (2004), Gao H (2004)	5
EGFR	5	NCL	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liccardi G (2014), Yao Z (2017), Goldshmit Y (2014)	3
EGFR	5	ARRB1	2	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
EGFR	5	YWHAQ	0	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
ARRB1	2	NEDD4	2	affinity chromatography technology	Shenoy SK (2008)	1
YWHAQ	0	NCL	1	pull down	Meek SE (2004)	1
ARRB2	5	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid, two hybrid, affinity chromatography technology	Wang P (2003), Wang P (2003), Wang P (2003), Shenoy SK (2008), Shenoy SK (2001), Ahmed MR (2011), Yin C (2011), Yin C (2011), Yin C (2011), Girnita L (2005), Girnita L (2005), Nogues L (2011), Boularan C (2007), Boularan C (2007), Wang J (2011), Shenoy SK (2001), Zheng M (2015)	17
ARRB1	2	PPM1A	1	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
STK38	0	MAP3K1	4	affinity chromatography technology, affinity chromatography technology	Enomoto A (2008), Enomoto A (2008)	2
MAP3K1	4	CHUK	5	enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Lee FS (1998), Nemoto S (1998), Nemoto S (1998), Li Q (2006)	4
ARRB1	2	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Wang Y (2006), Wang Y (2006)	2
ARRB1	2	TCOF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Xiao K (2007), Xiao K (2007), Werner A (2015), Huttlin EL (2017)	5
ADRB2	0	ITCH	1	affinity chromatography technology	Shea FF (2012)	1
CTNNA1	7	CTTN	1	biochemical	Kristensen AR (2012)	1
MAPK3	4	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Wang J (2009), Wang J (2009), Wan C (2015), Hu B (2006)	6
IGF1R	5	NEDD4	2	affinity chromatography technology, enzymatic study, affinity chromatography technology	Vecchione A (2003), Sehat B (2008), Broussas M (2009)	3
ARRB1	2	YWHAQ	0	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
FLNA	10	AP2B1	3	affinity chromatography technology	Hein MY (2015)	1
FLNA	10	CTTN	1	affinity chromatography technology	Hein MY (2015)	1
ARRB2	5	PTGDS	0	two hybrid, pull down, affinity chromatography technology, pull down	Mathurin K (2011), Mathurin K (2011), Mathurin K (2011), Mathurin K (2011)	4
ARRB1	2	IGF1R	5	affinity chromatography technology, affinity chromatography technology	Girnita L (2005), Girnita L (2005)	2
CHUK	5	NFKBIA	0	enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology	DiDonato JA (1997), Cohen L (1998), Woronicz JD (1997), Ninomiya-Tsuji J (1999), Burke JR (2002), Wu ZH (2010), Tong KM (2008), Singhirunnusorn P (2005), Heilker R (1999), Huang TT (2002), Lee FS (1998), Kim KS (2002), Cappello C (2007), Hong S (2007), Morrison BH (2007), Zandi E (1998), Li Q (2006), Manna SK (2010), Li XH (2001), Poyet JL (2001), Zhang W (2010), Bauer JA (2007), Chan H (2005), Munzert G (2002), Stehlik C (2002), Shambharkar PB (2007), Cui J (2010), Li Q (2006), Bernier M (2006), Mitsuhashi S (2008), Hayashi T (2007), Niu J (2013), Dan HC (2008), Criollo A (2010), Kim Y (2002), Huttlin EL (2015), Liu D (2014), Zhang H (2004), Aggarwal S (2006), Ninomiya-Tsuji J (2003), Huttlin EL (2017)	41
UBC	7	AP2B1	3	pull down	Zhang X (2017)	1
MAP3K1	4	MAPK3	4	enzymatic study, imaging technique	Loke J (2014), Chen TC (2014)	2
LIMK1	3	PRKN	1	affinity chromatography technology, affinity chromatography technology	Lim MK (2007), Lim MK (2007)	2
AGTR1	4	ARRB2	5	affinity chromatography technology, affinity chromatography technology	Luttrell LM (2001), Barnes WG (2005)	2
ARRB1	2	DRD4	3	affinity chromatography technology	Skieterska K (2016)	1
EGFR	5	PTGDS	0	protein complementation assay	Deribe YL (2009)	1
SRC	2	FLNA	10	two hybrid	Bandyopadhyay S (2010)	1
AKT1	1	HSPA8	4	affinity chromatography technology	Klein JB (2005)	1
UBC	7	NCL	1	affinity chromatography technology	Matsumoto M (2005)	1
PRKCB	4	CHUK	5	imaging technique	Chen TC (2014)	1
SLC9A5	4	ARRB1	2	affinity chromatography technology	Szabo EZ (2005)	1
ARRB1	2	ARR3	0	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Xiao K (2007)	2
MDM2	2	IGF1R	5	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Sehat B (2008), Sehat B (2008), Girnita L (2003), Girnita L (2003), Broussas M (2009), Chen TC (2014), Worrall C (2017)	7
ADRB2	0	FLNA	10	affinity chromatography technology	Roy SJ (2013)	1
ARRDC3	0	HGS	5	affinity chromatography technology	Han SO (2012)	1
YWHAQ	0	MAP3K5	1	pull down	Zhang H (2007)	1
EGFR	5	CFL1	0	protein complementation assay	Deribe YL (2009)	1
NEDD4	2	SRC	2	affinity chromatography technology, pull down, enzymatic study	Persaud A (2014), Persaud A (2014), Persaud A (2014)	3
ARRB2	5	PRKN	1	affinity chromatography technology, pull down	Ahmed MR (2011), Ahmed MR (2011)	2
ARRB2	5	CALM3	0	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
ARRB1	2	SRC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rosano L (2009), Rosano L (2009), Buchanan FG (2006), Buchanan FG (2006), Lee J (2013)	5
MDM2	2	AKT1	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique	Lin HK (2002), Ogawara Y (2002), Zhou BP (2001), Zhou BP (2001), Kim CK (2011), Kim CK (2011), Zhu QS (2011), Milne D (2004), Deep G (2008), Deep G (2008), Chen TC (2014)	11
ARRB2	5	AP2B1	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Laporte SA (1999), Kim YM (2002), Xiao K (2007), Wyatt D (2011)	4
ARRB2	5	UBC	7	affinity chromatography technology, fluorescent resonance energy transfe	Xiao K (2007), Dalrymple MB (2011)	2
EGFR	5	CTTN	1	affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2014), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	4
ARRDC3	0	NEDD4	2	affinity chromatography technology, imaging technique, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Nabhan JF (2010), Nabhan JF (2010), Qi S (2014), Qi S (2014), Qi S (2014), Huttlin EL (2017)	6
CFL1	0	PKM	1	biochemical	Wan C (2015)	1
MAPK3	4	RALGDS	4	imaging technique	Chen TC (2014)	1
AKT1	1	NFKBIA	0	affinity chromatography technology	Koul D (2001)	1
CYTH2	2	ARRB2	5	affinity chromatography technology, pull down	Claing A (2001), Claing A (2001)	2
ARRB2	5	PPM1A	1	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
PRKN	1	EGFR	5	affinity chromatography technology, affinity chromatography technology	Lin DC (2015), Lin DC (2015)	2
EGFR	5	HSPA8	4	protein complementation assay, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deribe YL (2009), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Li J (2013), Yao Z (2017)	8
USP33	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Yasunaga J (2011), Yasunaga J (2011)	2
MAP3K1	4	NFKBIA	0	enzymatic study	Tu Z (2003)	1
SRC	2	PDE4D	4	far western blotting	Beard MB (1999)	1
YWHAQ	0	MAP3K1	4	affinity chromatography technology	Sun BK (2011)	1
CSNK2A1	15	CTNNA1	7	enzymatic study, affinity chromatography technology	Ji H (2009), Ji H (2009)	2
GSN	3	SRC	2	affinity chromatography technology	Chellaiah MA (2001)	1
ARRB1	2	S100A9	0	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
MAPK9	3	PPM1A	1	biochemical	Wan C (2015)	1
ARRDC3	0	ITCH	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Shea FF (2012), Shea FF (2012), Huttlin EL (2017)	3
EGFR	5	PPM1B	2	two hybrid	Yao Z (2017)	1
ARRB1	2	PRKN	1	affinity chromatography technology, affinity chromatography technology, pull down	Ahmed MR (2011), Ahmed MR (2011), Ahmed MR (2011)	3
AKT1	1	CHUK	5	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Ozes ON (1999), Ozes ON (1999), Romashkova JA (1999), Lu Y (2005), Chen TC (2014), Takada Y (2005), Koul D (2001)	7
MDM2	2	ADRB2	0	enzymatic study	Shenoy SK (2001)	1
IGF1R	5	PPM1A	1	affinity chromatography technology, two hybrid	Yao Z (2017), Yao Z (2017)	2
EGFR	5	S100A9	0	affinity chromatography technology, affinity chromatography technology	Wu SL (2006), Wu SL (2006)	2
TRAF6	0	ITCH	1	affinity chromatography technology	Shembade N (2008)	1
ARRB2	5	AP3B2	3	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Kim YM (2002)	2
AKT1	1	PRKCB	4	two hybrid, enzymatic study	Arroyo R (2015), Wu D (2009)	2
TRAF6	0	AKT1	1	enzymatic study, affinity chromatography technology, affinity chromatography technology	Yang WL (2009), Mitra S (2011), Mitra S (2011)	3
EGFR	5	HGS	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Umebayashi K (2008), Morino C (2004), Meijer IM (2013), Sun Y (2013), Ali N (2013), Tan X (2015)	6
PRKCB	4	ARRB2	5	affinity chromatography technology, affinity chromatography technology	Zheng M (2015), Zheng M (2015)	2
ARRB2	5	NFKBIA	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Witherow DS (2004), Witherow DS (2004), Gao H (2004), Gao H (2004), Gao H (2004)	5
ARRB1	2	AKT1	1	affinity chromatography technology	Lodeiro M (2009)	1
PPM1A	1	PPM1B	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ARRB2	5	STK38	0	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
ARRB1	2	NCL	1	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
AKT1	1	MAP2K4	3	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Park HS (2002), Park HS (2002), Park HS (2002), Song JJ (2005), Song JJ (2005)	5
ADRB2	0	HGS	5	affinity chromatography technology	Shea FF (2012)	1
FLNA	10	CFL1	0	affinity chromatography technology	Hein MY (2015)	1
PRKN	1	UBC	7	enzymatic study, imaging technique, enzymatic study, fluorescent resonance energy transfe, pull down, pull down, pull down, pull down, x-ray crystallography, imaging technique, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, enzymatic study	Kondapalli C (2012), Kane LA (2014), Kane LA (2014), Koyano F (2014), Zheng X (2013), Shiba-Fukushima K (2014), Shiba-Fukushima K (2014), Kumar A (2015), Kumar A (2015), Okatsu K (2015), Okatsu K (2015), Okatsu K (2015), Yamano K (2015), Fiesel FC (2015), Ordureau A (2015), Kazlauskaite A (2015), Kazlauskaite A (2015), Kumar A (2017), Kliza K (2017)	19
HGS	5	UBC	7	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Mizuno E (2006), Raiborg C (2002), Raiborg C (2002), Nathan JA (2013), Nathan JA (2013), Bishop N (2002), Stuible M (2010), Oved S (2006), Hoeller D (2006), Kharitidi D (2015), Zhang X (2017)	11
ARRB1	2	MAP2K4	3	unspecified method	Li X (2009)	1
ARRB1	2	HGS	5	affinity chromatography technology, affinity chromatography technology	Malik R (2010), Han SO (2012)	2
SRC	2	MAPK1	1	affinity chromatography technology	Lee J (2013)	1
ARRB1	2	STK38	0	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
UBC	7	CSNK2A1	15	affinity chromatography technology	Matsumoto M (2005)	1
MDM2	2	GSN	3	affinity chromatography technology	Frum R (2007)	1
PPM1B	2	GSN	3	affinity chromatography technology	Ewing RM (2007)	1
EGFR	5	TCOF1	1	affinity chromatography technology	Yao Z (2017)	1
PRKN	1	HSPA8	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Imai Y (2002), Imai Y (2002), Imai Y (2003), Zanon A (2013)	4
ARRB2	5	MAP3K5	1	affinity chromatography technology, affinity chromatography technology, unspecified method	McDonald PH (2000), Zhang Z (2009), Li X (2009)	3
ARRB2	5	S100A9	0	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
CSNK2A1	15	NCL	1	enzymatic study, biochemical	Zhang M (2011), Wan C (2015)	2
EGFR	5	MAPK9	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
EGFR	5	FBL	1	affinity chromatography technology	Tong J (2014)	1
UBC	7	FBL	1	affinity chromatography technology	Matsumoto M (2005)	1
MAP3K1	4	MAP2K4	3	affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study	Cheng J (2000), Gallagher ED (2004), Ryoo K (2004), Ryoo K (2004), Tu Z (2003), Takekawa M (2005), Xia Y (1998), Xia Y (1998), Gallagher ED (2002), Xia Y (1998), Chen Z (2006), Ahn JS (2016)	12
SRC	2	CSNK2A1	15	affinity chromatography technology	Liang K (2010)	1
MAP2K4	3	MAPK10	0	enzymatic study, pull down, unspecified method	Ryoo K (2004), Ho DT (2003), Ho DT (2003)	3
UBC	7	CHUK	5	pull down	Zhang X (2017)	1
MDM2	2	ITCH	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kubo N (2010), Kubo N (2010), Wu H (2015), Wu H (2015)	4
CSNK2A1	15	ZRANB2	0	enzymatic study	Zhang M (2011)	1
ARRB1	2	CSNK2A1	15	affinity chromatography technology	Ewing RM (2007)	1
MAP3K1	4	HGS	5	enzymatic study	Charlaftis N (2014)	1
PRKN	1	MAPK1	1	affinity chromatography technology	Um JW (2012)	1
UBC	7	TCOF1	1	pull down	Zhang X (2017)	1
MDM2	2	HSPA8	4	affinity chromatography technology, affinity chromatography technology	Lu TL (2010), Okoro DR (2013)	2
ARRB2	5	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Shenoy SK (2005), Luttrell LM (2001), Xiao K (2007), Chen TC (2014)	4
ARRB1	2	LIMK1	3	pull down, affinity chromatography technology	Zoudilova M (2007), Zoudilova M (2007)	2
ARRB1	2	ITCH	1	affinity chromatography technology, affinity chromatography technology	Shenoy SK (2008), Bhandari D (2007)	2
ARRB2	5	FLNA	10	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Boularan C (2007)	2
ARRB1	2	CALM3	0	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
ADRB2	0	UBC	7	affinity chromatography technology	Roy SJ (2013)	1
NEDD4	2	AKT1	1	enzymatic study, enzymatic study, affinity chromatography technology	Persaud A (2009), Fan CD (2013), Fan CD (2013)	3
EGFR	5	CTNNA1	7	imaging technique, affinity chromatography technology	Chen TC (2014), Li J (2013)	2
MAP3K1	4	MAPK9	3	two hybrid, pull down	Gallagher ED (2004), Gallagher ED (2002)	2
ADRB2	0	ARRB2	5	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Kittanakom S (2014), Tian X (2016), Tian X (2016)	3
PPM1B	2	CHUK	5	affinity chromatography technology, affinity chromatography technology, imaging technique	Prajapati S (2004), Prajapati S (2004), Chen TC (2014)	3
ARRB1	2	GSN	3	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
USP33	1	ARRB1	2	affinity chromatography technology, affinity chromatography technology	Shenoy SK (2009), Shenoy SK (2009)	2
ARRB2	5	GSN	3	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
ARRB2	5	PPM1B	2	affinity chromatography technology, affinity chromatography technology, imaging technique	Xiao K (2007), Xiao K (2007), Chen TC (2014)	3
ARRB1	2	NOLC1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Xiao K (2007), Xiao K (2007), Werner A (2015), Huttlin EL (2017)	5
CSNK2A1	15	NOLC1	2	affinity chromatography technology, affinity chromatography technology	So J (2015), Werner A (2015)	2
DRD4	3	ARRB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rondou P (2010), Skieterska K (2016), Skieterska K (2016)	3
USP33	1	UBC	7	enzymatic study, pull down	Shenoy SK (2014), Kwasna D (2018)	2
NEDD4	2	EGFR	5	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
AKT1	1	MAP3K5	1	affinity chromatography technology, enzymatic study	Kim AH (2001), Kim AH (2001)	2
ARRB2	5	PKM	1	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
CSNK2A1	15	ITCH	1	enzymatic study	Morales B (2007)	1
ARRB2	5	ARR3	0	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Huttlin EL (2017)	2
EGFR	5	CSNK2A1	15	affinity chromatography technology	Tong J (2014)	1
ARRB2	5	HSPA8	4	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
NCL	1	MDM2	2	affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Saxena A (2006), Bhatt P (2011), Bhatt P (2011), Miyamoto-Sato E (2010), Okoro DR (2013), Saxena A (2006), Saxena A (2006)	7