PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SMURF1	4	MAP3K10	2	enzymatic study	Andrews PS (2010)	1
MAPK9	3	MAP3K10	2	enzymatic study	Phelan DR (2001)	1
MAPK14	0	MAPK1	1	affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology	Sanz-Moreno V (2003), Tanoue T (2001), Srivastav RK (2011), Chan PM (2008)	4
CDC42	3	MAPK9	3	imaging technique	Chen TC (2014)	1
HGS	5	MAP3K10	2	pull down	Pridgeon JW (2009)	1
YWHAE	0	MAPK14	0	biochemical	Wan C (2015)	1
CLTC	12	HGS	5	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Raiborg C (2001), Raiborg C (2001), Nakamura M (2006), Zlatic SA (2011)	4
MAP3K10	2	KIF3A	4	two hybrid, affinity chromatography technology	Nagata K (1998), Nagata K (1998)	2
MAP2K4	3	MAPK9	3	two hybrid, affinity chromatography technology, pull down	Vinayagam A (2011), Li Y (2012), Ho DT (2003)	3
MAP3K10	2	MAPK8IP2	5	affinity chromatography technology, pull down	Yasuda J (1999), Yasuda J (1999)	2
MAP3K10	2	KIF17	2	two hybrid	Nagata K (1998)	1
SMURF1	4	CLTC	12	affinity chromatography technology	Xie Y (2013)	1
MAPK9	3	MAPK8IP1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yasuda J (1999), Yasuda J (1999), Whitmarsh AJ (1998), Song JJ (2005), Huttlin EL (2017)	5
MAP2K4	3	MAPK1	1	pull down	Ho DT (2003)	1
MAP3K10	2	ABL2	4	two hybrid	Bandyopadhyay S (2010)	1
MAP3K10	2	HPCA	4	affinity chromatography technology	Nagata K (1998)	1
RAC1	7	CLTC	12	affinity chromatography technology	Visvikis O (2011)	1
MAP3K10	2	MAP3K10	2	enzymatic study	Phelan DR (2001)	1
MAPK9	3	MAPK8IP2	5	affinity chromatography technology, pull down, pull down	Yasuda J (1999), Yasuda J (1999), Yasuda J (1999)	3
MAP3K10	2	YWHAE	0	affinity chromatography technology	Nagata K (1998)	1
HTT	14	MAP3K10	2	affinity chromatography technology, affinity chromatography technology	Liu YF (2000), Liu YF (2000)	2
KIF3A	4	KIFAP3	1	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lolkema MP (2007), Wan C (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	6
MAP3K10	2	DNM1	21	pull down	Rasmussen RK (1998)	1
COPS2	5	MAP3K10	2	two hybrid, pull down, enzymatic study	Eckey M (2003), Eckey M (2003), Eckey M (2003)	3
MAP3K10	2	MAP3K21	4	two hybrid	Bandyopadhyay S (2010)	1
DLG4	11	HGS	5	two hybrid, affinity chromatography technology	Chetkovich DM (2002), Chetkovich DM (2002)	2
GARS	1	MAP3K10	2	two hybrid	Wang J (2011)	1
MAP3K10	2	KIFAP3	1	two hybrid, affinity chromatography technology	Nagata K (1998), Nagata K (1998)	2
MAP2K4	3	MAPK14	0	enzymatic study, affinity chromatography technology, pull down	Deacon K (1997), Xia Y (1998), Xia Y (1998)	3
NEUROD1	0	HTT	14	affinity chromatography technology	Marcora E (2003)	1
CDC42	3	KIF17	2	affinity chromatography technology	Hein MY (2015)	1
MAP3K10	2	MAPK8IP1	7	affinity chromatography technology, pull down	Yasuda J (1999), Yasuda J (1999)	2
MAP3K10	2	CLTC	12	affinity chromatography technology	Akbarzadeh S (2002)	1
MAPK14	0	MAP3K10	2	enzymatic study	Phelan DR (2001)	1
MAPK1	1	MAP3K10	2	enzymatic study	Phelan DR (2001)	1
MAPK8IP1	7	MAPK8IP2	5	affinity chromatography technology, pull down, affinity chromatography technology	Yasuda J (1999), Yasuda J (1999), Huttlin EL (2017)	3
CDC42	3	MAP3K10	2	two hybrid, pull down	Nagata K (1998), Nagata K (1998)	2
NEUROD1	0	MAP3K10	2	two hybrid, affinity chromatography technology, enzymatic study	Marcora E (2003), Marcora E (2003), Marcora E (2003)	3
MAP3K10	2	RAC1	7	pull down, two hybrid	Nagata K (1998), Nagata K (1998)	2
MAP3K10	2	MAP2K4	3	enzymatic study	Hirai S (1997)	1
DLG4	11	MAP3K10	2	affinity chromatography technology	Savinainen A (2001)	1