Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
NR3C2 4306 DROSPIRENONE CHEMBL1509 antagonist, binder TTD, TdgClinicalTrial, GuideToPharmacologyInteractions, DrugBank, ChemblInteractions 8922878, 7625729, 8732994, 11752352, 11024226
NR3C2 4306 CORTICOSTERONE CHEMBL110739 DrugBank 10592235
NR3C2 4306 HYDROCORTISONE CHEMBL389621 agonist GuideToPharmacologyInteractions
NR3C2 4306 DESOXYCORTICOSTERONE CHEMBL1498 agonist GuideToPharmacologyInteractions
NR3C2 4306 DEXAMETHASONE CHEMBL384467 agonist GuideToPharmacologyInteractions
NR3C2 4306 FINERENONE CHEMBL2181927 antagonist GuideToPharmacologyInteractions, ChemblInteractions
NR3C2 4306 SPIRONOLACTONE CHEMBL1393 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, DrugBank 11791081, 15947888, 11752352, 15554912, 15128471, 14978157, 15808807, 14664717
NR3C2 4306 ALDOSTERONE CHEMBL273453 agonist GuideToPharmacologyInteractions, DrugBank 17724138, 10592235, 9392437
NR3C2 4306 PREDNISOLONE CHEMBL131 agonist GuideToPharmacologyInteractions
NR3C2 4306 OXPRENOATE POTASSIUM CHEMBL2107003 antagonist GuideToPharmacologyInteractions
NR3C2 4306 MT-3995 CHEMBL3545392 antagonist ChemblInteractions
NR3C2 4306 LY2623091 CHEMBL3545275 antagonist ChemblInteractions
NR3C2 4306 EPLERENONE CHEMBL1095097 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, DrugBank 11752352, 14607457, 15554912, 14503934
NR3C2 4306 FLUDROCORTISONE CHEMBL1201388 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, TEND, TTD
NR3C2 4306 ONAPRISTONE CHEMBL1908373 antagonist GuideToPharmacologyInteractions
NR3C2 4306 PF-03882845 CHEMBL3545175 antagonist GuideToPharmacologyInteractions, ChemblInteractions
NR3C2 4306 DESOXYCORTICOSTERONE ACETATE CHEMBL1200542 agonist ChemblInteractions
NR3C2 4306 PROGESTERONE CHEMBL103 agonist, antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, DrugBank 8282004
NR3C2 4306 DESOXYCORTICOSTERONE PIVALATE CHEMBL1200592 agonist, binder TdgClinicalTrial, ChemblInteractions, TEND, DrugBank, TTD 6227474, 17139284, 17016423, 744157, 11752352
NR3C2 4306 XL550 CHEMBL3545393 antagonist ChemblInteractions, TTD
NR3C2 4306 FLUDROCORTISONE ACETATE CHEMBL1201010 agonist ChemblInteractions
NR3C2 4306 NIMODIPINE CHEMBL1428 antagonist GuideToPharmacologyInteractions, ChemblInteractions, DrugBank 18250364
NR3C2 4306 FELODIPINE CHEMBL1480 antagonist ChemblInteractions, DrugBank 18250364

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
NR3C2 rs5522 TT enalapril efficacy yes The reduction in diastolic blood pressure (DBP) was significantly greater in patients with the TT genotype compared to the CC+CT genotype (p=0.009). Reduction is systolic blood pressure (SBP) was NOT significantly different between genotypes. Multiple linear regression analysis showed that significant predictors of DBP were rs5522 genotype, baseline DBP and wait:hip ratio. Please note alleles have been complemented to the plus chromosomal strand. Genotype TT is associated with increased response to enalapril in people with Hypertension as compared to genotypes CC + CT. 24059494 1184226554
NR3C2 rs2070950 CC enalapril efficacy no The reduction in systolic or diastolic blood pressure (SBP or DBP) after enalapril treatment was not significantly different between genotypes. Multiple linear regression analysis showed that significant predictors of DBP were rs5522 genotype, baseline DBP and wait:hip ratio (not rs2070950 genotype). Please note alleles have been complemented to the plus chromosomal strand - the variant was described as G>C, here the variant C allele is complemented to G. Genotype CC is not associated with increased response to enalapril in people with Hypertension as compared to genotypes CG + GG. 24059494 1184228585