PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PTGES3	0	NR3C2	4	affinity chromatography technology	Freeman BC (2000)	1
UBE2I	0	EP300	36	enzymatic study, affinity chromatography technology	Girdwood D (2003), Bian XL (2017)	2
NR3C1	2	NRIP1	4	affinity chromatography technology, pull down, pull down, pull down, pull down, two hybrid, pull down	Tazawa H (2003), Tazawa H (2003), Zilliacus J (2001), Zilliacus J (2001), Subramaniam N (1999), Windahl SH (1999), Windahl SH (1999)	7
PPP5C	2	HSP90AA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Zeke T (2005), Silverstein AM (1997), Schuelke JP (2010), Gano JJ (2010), Cliff MJ (2006), Skarra DV (2011), Skarra DV (2011), Horibe T (2011), Taipale M (2014), Taipale M (2014), Hein MY (2015), Woo SH (2009), Woo SH (2009), Woodford MR (2016), St-Denis N (2016), Yadav L (2017), Yadav L (2017)	17
NR3C1	2	DNAJC7	2	affinity chromatography technology	Schuelke JP (2010)	1
NR3C1	2	CREBBP	29	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Almloef T (1998), Almloef T (1998), Fryer CJ (1998), Govindan MV (2010), Govindan MV (2010), Govindan MV (2010), Carruthers CW (2015)	7
EGLN3	0	PSMC5	4	affinity chromatography technology	Rodriguez J (2016)	1
RXRA	1	NCOA1	6	pull down, pull down, two hybrid, far western blotting, pull down, pull down, two hybrid, pull down, pull down, pull down, pull down, two hybrid, pull down	Jeyakumar M (1997), Yang W (2000), Shao G (2000), Shao G (2000), Mouchon A (1999), Herdick M (2000), Chan CM (2013), Kim HJ (1999), Flajollet S (2007), Monden T (1999), Kurtev V (2004), Osburn DL (2001), DiRenzo J (1997)	13
CREBBP	29	DAXX	5	two hybrid, affinity chromatography technology	Kuo HY (2005), Kuo HY (2005)	2
NR3C2	4	AIP	1	affinity chromatography technology	Schuelke JP (2010)	1
DAXX	5	SUMO1	0	two hybrid, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, pull down, pull down, x-ray crystallography, pull down, two hybrid, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, two hybrid, x-ray crystallography, two hybrid	Lin DY (2002), Ryu SW (2000), Ryu SW (2000), Ryu SW (2000), Escobar-Cabrera E (2011), Escobar-Cabrera E (2011), Naik MT (2011), Chang CC (2011), Chang CC (2011), Chen A (2006), Chen A (2006), Saul VV (2014), Ullmann R (2012), Lin DY (2006), Lin DY (2006), Ullmann R (2012), Ullmann R (2012), Lin DY (2006), Naik MT (2011), Li C (2017)	20
EGLN3	0	AIP	1	affinity chromatography technology	Rodriguez J (2016)	1
STUB1	4	NR3C1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Connell P (2001), Schuelke JP (2010), Mata-Greenwood E (2013), Connell P (2001)	4
EP300	36	RXRA	1	affinity chromatography technology, affinity chromatography technology	Zhao WX (2007), Zhao WX (2007)	2
EGLN3	0	PPP1CA	3	affinity chromatography technology	Rodriguez J (2016)	1
NR3C2	4	SUMO1	0	two hybrid	Tirard M (2007)	1
ACSL1	1	NR3C2	4	two hybrid	Wang J (2011)	1
EGLN3	0	ACSL1	1	affinity chromatography technology	Rodriguez J (2016)	1
CARNMT1	2	NR3C2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CAND1	2	HSP90AA1	7	affinity chromatography technology	Bennett EJ (2010)	1
RXRA	1	PSMC5	4	pull down, two hybrid	vom Baur E (1996), Choi HS (1996)	2
EP300	36	KAT2B	2	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kiernan R (2003), Kim JH (2011), Lee M (2010), Santos-Rosa H (2003), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996), Mizuguchi Y (2012)	8
NR3C2	4	RABAC1	0	two hybrid	Wang J (2011)	1
UBE2I	0	CREBBP	29	affinity chromatography technology, pull down, enzymatic study, two hybrid	Hsieh YL (2013), Hsieh YL (2013), Hsieh YL (2013), Liu ST (2012)	4
PTGES3	0	PPP5C	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schuelke JP (2010), Taipale M (2014), Taipale M (2014), Yadav L (2017)	4
HSP90AA1	7	NR3C2	4	affinity chromatography technology	Taipale M (2012)	1
CREBBP	29	NCOA1	6	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, pull down	Sheppard HM (2001), Sheppard HM (2001), Sheppard HM (2001), Wu RC (2002), Torchia J (1997), Torchia J (1997), Matsuda S (2004), DiRenzo J (2000), Nakuci E (2006), Ruas JL (2005), Huang SM (2002)	11
HSP90AA1	7	PPID	0	affinity chromatography technology, biochemical, pull down, affinity chromatography technology, pull down	Schuelke JP (2010), Park MS (2011), Shimamoto S (2010), Shimamoto S (2010), Graumann K (2000)	5
NR3C2	4	PSMC5	4	two hybrid	Albers M (2005)	1
EGLN3	0	PPP5C	2	affinity chromatography technology	Rodriguez J (2016)	1
UBE2I	0	NR3C1	2	enzymatic study	Ogawa H (2009)	1
CASP8AP2	3	SUMO1	0	affinity chromatography technology	Sun H (2012)	1
NR3C2	4	FKBP5	0	affinity chromatography technology	Schuelke JP (2010)	1
NR3C1	2	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Amat R (2007), Wang W (2012), Kino T (2002)	3
PTGES3	0	STUB1	4	affinity chromatography technology	Schuelke JP (2010)	1
PTGES3	0	DNAJC7	2	affinity chromatography technology	Schuelke JP (2010)	1
NR3C1	2	PPID	0	affinity chromatography technology	Schuelke JP (2010)	1
NR3C2	4	PPID	0	affinity chromatography technology	Schuelke JP (2010)	1
FKBP4	0	HSP90AA1	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology	Li J (2011), Esposito V (2012), Schuelke JP (2010), Gano JJ (2010), Skarra DV (2011), Shimamoto S (2010), Shimamoto S (2010), Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Graumann K (2000), Graumann K (2000), Sun L (2012), Huttlin EL (2017)	14
NR3C2	4	RXRA	1	two hybrid	Wang J (2011)	1
NR3C2	4	FAF1	1	two hybrid, affinity chromatography technology	Obradovic D (2004), Obradovic D (2004)	2
NRIP1	4	RXRA	1	pull down, pull down	Farooqui M (2003), LHorset F (1996)	2
TRIM24	1	NR3C2	4	pull down, pull down, affinity chromatography technology	Zennaro MC (2001), Thenot S (1997), Hellal-Levy C (2000)	3
NR3C2	4	CREBBP	29	affinity chromatography technology	Seo M (2015)	1
STUB1	4	HSP90AA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, enzymatic study, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down	Zhang L (2007), Zhang M (2005), Tateishi Y (2004), Tateishi Y (2004), Connell P (2001), Ko HS (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Stankiewicz M (2010), Graf C (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Zhou P (2003), Zhang M (2008), Grelle G (2006), Kim SA (2005), Arndt V (2005), Muller P (2012), Burch L (2004), Burch L (2004), Jang KW (2011), Schuelke JP (2010), Wang Q (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Gano JJ (2010), Skarra DV (2011), Yang SW (2013), Grelle G (2006), Grelle G (2006), Narayan V (2015)	36
NR3C2	4	NRIP1	4	affinity chromatography technology	Hellal-Levy C (2000)	1
NR3C1	2	DAXX	5	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, two hybrid, imaging technique, affinity chromatography technology	Lin DY (2003), Lin DY (2003), Lin DY (2003), Lin DY (2006), Lin DY (2006), Lin DY (2006), Lin DY (2006), Obradovic D (2004)	8
NR3C2	4	STUB1	4	affinity chromatography technology	Schuelke JP (2010)	1
HSP90AA1	7	PTGES3	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down	McLaughlin SH (2002), Mollapour M (2010), Kovacs JJ (2005), Giommarelli C (2010), Tsutsumi S (2012), Lee YT (2004), Schuelke JP (2010), Sarkar S (2012), Gano JJ (2010), Zelin E (2012), Obermann WM (1998), Wang J (2011), Weaver AJ (2000), Donze O (2001), Shimamura T (2012), Chan CT (2008), Chan CT (2008), Graumann K (2000), Martinez-Yamout MA (2006), Chadli A (2010), Woo SH (2009), Woo SH (2009), Woo SH (2009), Ni L (2010), Chadli A (2008), Picard D (2006), Wochnik GM (2004), Woodford MR (2016), Scholz GM (2001), McLaughlin SH (2006), Sun L (2012), Woodford MR (2016), Lepvrier E (2015)	33
PTGES3	0	NR3C1	2	affinity chromatography technology	Freeman BC (2000)	1
PTGES3	0	AIP	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Schuelke JP (2010), Taipale M (2014), Taipale M (2014), Kazlauskas A (2000)	4
NR3C2	4	FKBP4	0	affinity chromatography technology	Schuelke JP (2010)	1
NR3C1	2	SUMO1	0	affinity chromatography technology	Lin DY (2006)	1
FKBP4	0	PTGES3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Scholz GM (2001)	3
EGLN3	0	NR3C2	4	affinity chromatography technology	Rodriguez J (2016)	1
PPID	0	PTGES3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Scholz GM (2001)	3
EGLN3	0	CAND1	2	affinity chromatography technology	Rodriguez J (2016)	1
PPP1CA	3	NR3C2	4	affinity chromatography technology, affinity chromatography technology	Nagarajan S (2017), Nagarajan S (2017)	2
NR3C2	4	EP300	36	affinity chromatography technology	Seo M (2015)	1
AIP	1	HSP90AA1	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Li J (2011), Schuelke JP (2010), Taipale M (2014), Taipale M (2014), Kazlauskas A (2000)	5
NR3C1	2	NCOA1	6	pull down, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, bioid	Zilliacus J (2001), Kucera T (2002), Windahl SH (1999), Fryer CJ (1998), Needham M (2000), Li G (2006), Lempiaeinen JK (2017)	7
CREBBP	29	SUMO1	0	x-ray crystallography, pull down	Diehl C (2016), Diehl C (2016)	2
CAV1	0	NR3C2	4	affinity chromatography technology	Luo X (2017)	1
UBE2I	0	CASP8AP2	3	two hybrid, enzymatic study	Bandyopadhyay S (2010), Gocke CB (2005)	2
DNAJC7	2	STUB1	4	affinity chromatography technology	Hein MY (2015)	1
NR3C1	2	CASP8AP2	3	affinity chromatography technology	Obradovic D (2004)	1
NCOA1	6	TRIM24	1	affinity chromatography technology	Eng FC (1998)	1
EGLN3	0	STUB1	4	affinity chromatography technology	Rodriguez J (2016)	1
NR3C2	4	DNAJC7	2	affinity chromatography technology	Schuelke JP (2010)	1
TRIM24	1	RXRA	1	pull down, pull down, pull down	Thenot S (1997), Lee WY (2002), vom Baur E (1996)	3
CREBBP	29	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Crusselle-Davis VJ (2007), Dohda T (2004), Dohda T (2004)	3
NR3C1	2	PPP5C	2	affinity chromatography technology	Schuelke JP (2010)	1
NR3C2	4	PPP5C	2	affinity chromatography technology	Schuelke JP (2010)	1
PTGES3	0	FKBP5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schuelke JP (2010), Taipale M (2014), Taipale M (2014)	3
CREBBP	29	PSMC5	4	affinity chromatography technology	Koues OI (2008)	1
PROX1	0	EP300	36	two hybrid, affinity chromatography technology	Chen Q (2002), Chen Q (2002)	2
NR3C2	4	PROX1	0	two hybrid	Albers M (2005)	1
UBE2I	0	DAXX	5	two hybrid, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, two hybrid	Ryu SW (2000), Knipscheer P (2008), Hsieh YL (2013), Hsieh YL (2013), Hsieh YL (2013), Chang CC (2011), Lin DY (2006), Lin DY (2006)	8
NCOA1	6	KAT2B	2	pull down, two hybrid, affinity chromatography technology, two hybrid, pull down	Spencer TE (1997), Spencer TE (1997), Korzus E (1998), Korzus E (1998), Jenster G (1997)	5
NR3C2	4	CASP8AP2	3	two hybrid	Obradovic D (2004)	1
NR3C1	2	FKBP5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schuelke JP (2010), Taipale M (2014), Taipale M (2014)	3
CREBBP	29	KAT2B	2	pull down, biochemical, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Tini M (2002), Cho H (1998), Cho H (1998), Cho H (1998), Korzus E (1998), Korzus E (1998), Korzus E (1998), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996)	10
CAND1	2	NR3C2	4	affinity chromatography technology	Bennett EJ (2010)	1
HSP90AA1	7	CAV1	0	affinity chromatography technology	Ji Y (2007)	1
FKBP5	0	HSP90AA1	7	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Nair SC (1997), Nair SC (1997), Li J (2011), Schuelke JP (2010), Gano JJ (2010), Skarra DV (2011), Horibe T (2011), Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Graumann K (2000), Ni L (2010), Luo K (2017)	13
TRIM24	1	NR3C1	2	pull down	Thenot S (1997)	1
NR3C2	4	KAT2B	2	affinity chromatography technology	Seo M (2015)	1
NR3C2	4	NR3C1	2	pull down, two hybrid, affinity chromatography technology	Savory JG (2001), Savory JG (2001), Moraes LA (2005)	3
DAXX	5	STUB1	4	affinity chromatography technology, pull down	McDonough H (2009), McDonough H (2009)	2
FKBP4	0	NR3C1	2	pull down, affinity chromatography technology, affinity chromatography technology	Alnemri ES (1993), Schuelke JP (2010), Moraes LA (2005)	3
NR3C1	2	HSP90AA1	7	imaging technique, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, pull down	Jibard N (1999), Hulkko SM (2000), Kanelakis KC (2002), Hecht K (1997), de Castro M (1996), van den Berg JD (1996), Stancato LF (1996), Kovacs JJ (2005), Silverstein AM (1997), Gradin K (1994), Gano JJ (2010), Miyamoto-Sato E (2010), Mollapour M (2014), Moraes LA (2005), Wochnik GM (2004), Woodford MR (2016), Lievens S (2016), McGuire J (1994)	18
NCOA1	6	EP300	36	affinity chromatography technology, imaging technique, pull down, pull down	Matsuda S (2004), Wang F (2010), Kino T (2002), Nasrin N (2000)	4
NR3C2	4	UBE2I	0	two hybrid	Tirard M (2007)	1
EGLN3	0	DNAJC7	2	affinity chromatography technology	Rodriguez J (2016)	1
NR3C2	4	NCOA1	6	affinity chromatography technology, two hybrid	Hellal-Levy C (2000), Albers M (2005)	2
UBE2I	0	SUMO1	0	affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid, pull down, fluorescent resonance energy transfe, pull down, two hybrid, pull down, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Tatham MH (2003), Minty A (2000), Shen Z (1996), Song Y (2011), Knipscheer P (2007), Boutell C (2011), Gong L (1997), Gong L (1997), Hemelaar J (2004), Hecker CM (2006), Hecker CM (2006), Martin SF (2008), Everett RD (2014), Rolland T (2014), Zilio N (2013), Carbia-Nagashima A (2007), Knipscheer P (2007), Matic I (2008), Wan C (2015), Hein MY (2015)	21
EGLN3	0	CREBBP	29	affinity chromatography technology	Rodriguez J (2016)	1
PPP1CA	3	CAV1	0	affinity chromatography technology, affinity chromatography technology, pull down	Li L (2003), Li L (2003), Li L (2003)	3
HSP90AA1	7	DNAJC7	2	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down	Schuelke JP (2010), Gano JJ (2010), Brychzy A (2003), Brychzy A (2003)	4
UBE2I	0	RXRA	1	enzymatic study	Ogawa H (2009)	1
NR3C2	4	DAXX	5	two hybrid, affinity chromatography technology	Obradovic D (2004), Obradovic D (2004)	2