PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CCNA2	1	CREBBP	29	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NFYA	2	SPI1	1	pull down	Bemark M (1998)	1
JUN	0	APP	1	pull down	Miyamoto-Sato E (2010)	1
NFYC	0	SREBF2	5	two hybrid	Bandyopadhyay S (2010)	1
EP300	36	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pao GM (2000), Pao GM (2000), Pao GM (2000), Pao GM (2000), Fan S (2002), Fan S (2002), Ma Y (2010), Subbaramaiah K (2011), Subbaramaiah K (2012)	9
TAF6	4	TAF12	0	two hybrid	Bando M (1997)	1
NFYA	2	LASP1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SP1	0	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, two hybrid, imaging technique, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Gao J (2009), Goto T (2006), Hung JJ (2006), Hung JJ (2006), Hung JJ (2006), Choi HS (2002), Walker GE (2001), Kundu TK (2000), Suzuki T (2000), Suzuki T (2000), Wang X (2008), Wang X (2008), Wang X (2008), Chen YJ (2007), Chen YJ (2007), Azahri NS (2012), Azahri NS (2012), Li J (2013), Li J (2013), Wang SA (2014)	20
CREBBP	29	NFYB	2	affinity chromatography technology	Leclerc GJ (2010)	1
CREB1	1	TP53	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Giebler HA (2000), Giebler HA (2000), Giebler HA (2000), Okoshi R (2011), Borger DR (2006), Chen TC (2014)	6
NFYA	2	LUC7L2	0	two hybrid	Rolland T (2014)	1
HDAC1	4	ESR1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique	Kawai H (2003), Kawai H (2003), Varshochi R (2005), Varshochi R (2005), Kurtev V (2004), Liu XF (2004), Itoh Y (2007), Tarallo R (2011), Yoshimaru T (2013)	9
MOV10	6	NFYA	2	affinity chromatography technology	Castello A (2012)	1
LUC7L2	0	SHMT2	3	biochemical	Kristensen AR (2012)	1
MOV10	6	TES	1	affinity chromatography technology	Castello A (2012)	1
ATF2	1	CREB1	1	biochemical	Wan C (2015)	1
BRCA1	7	NFYA	2	affinity chromatography technology	Fan W (2002)	1
NFYA	2	APP	1	pull down	Olah J (2011)	1
TAF6	4	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
SRF	1	CREBBP	29	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Matsuzaki K (2003), Matsuzaki K (2003), Ramirez S (1997), Ramirez S (1997)	4
NFYA	2	SRF	1	two hybrid, pull down	Yamada K (1999), Yamada K (1999)	2
EP300	36	NFYB	2	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology	Uramoto H (2004), Uramoto H (2004), Li Q (1998), Faniello MC (1999), Faniello MC (1999)	5
TES	1	APP	1	affinity chromatography technology	Sala S (2017)	1
TP53	0	TAF6	4	pull down, affinity chromatography technology, affinity chromatography technology	Wilhelm E (2010), Wilhelm E (2010), Wilhelm E (2010)	3
HMGA1	0	ELF1	2	pull down	John S (1995)	1
NFYA	2	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Imbriano C (2005), Imbriano C (2005), Imbriano C (2005), Di Agostino S (2006), Di Agostino S (2006), Huang X (2013)	6
CCNA2	1	BRCA1	7	affinity chromatography technology, pull down	Ruffner H (1999), Wang H (1997)	2
JUN	0	CSNK2A1	15	pull down, far western blotting, enzymatic study	Yamaguchi Y (1998), Yamaguchi Y (1998), Uhle S (2003)	3
EP300	36	ESR1	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid, enzymatic study, affinity chromatography technology, enzymatic study, pull down, pull down	Fajas L (2002), Fan S (2002), Fan S (2002), Fan S (2002), Kang YK (2002), Kang YK (2002), Hao L (2010), Jin W (2008), Cui Y (2006), Dutertre M (2003), Dutertre M (2003), Shiozawa T (2003), Kim SH (2010), Ma Y (2010), Ma Y (2010), Fujita T (2003), Likhite VS (2004), Band AM (2011), Loven MA (2004), Nalvarte I (2010), Yi P (2015)	21
TAF11	0	TAF6	4	affinity chromatography technology	Gupta K (2017)	1
CREBBP	29	SREBF2	5	far western blotting, affinity chromatography technology, affinity chromatography technology	Oliner JD (1996), Oliner JD (1996), Nath S (2014)	3
NFYA	2	ATF6B	1	two hybrid	Yoshida H (2001)	1
LUC7L2	0	CSNK2A1	15	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SP1	0	NFYA	2	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Roder K (1999), Roder K (1999), Roder K (1999), Roder K (1999), Wang W (1999)	5
NXF1	0	CDC25A	2	affinity chromatography technology	Castello A (2012)	1
NFYA	2	CCNA2	1	pull down	Yun J (2003)	1
NFYA	2	IRGQ	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SP1	0	ESR1	0	imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Koslowski M (2009), Jin W (2008), Dong J (2006), Dong J (2006), Castet A (2006), He S (2005), He S (2005), Varshochi R (2005), Varshochi R (2005), Petz LN (2004), Li D (2007), Itoh Y (2007), Saville B (2000), Gibson LL (2005)	14
EP300	36	HDAC1	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Han Y (2008), Mayanil CS (2006), Simone C (2004), Simone C (2004), Simone C (2004), Liu Y (2012), Mizuguchi Y (2012)	7
CSNK2A1	15	SRF	1	enzymatic study	Marais RM (1992)	1
ACTN4	4	ESR1	0	affinity chromatography technology, pull down	Khurana S (2011), Khurana S (2011)	2
BRCA1	7	UBE2D2	0	two hybrid, two hybrid, x-ray crystallography, pull down	Dynek JN (2010), Christensen DE (2009), Christensen DE (2009), Christensen DE (2009)	4
HDAC1	4	SPI1	1	affinity chromatography technology, pull down, affinity chromatography technology	Suzuki M (2003), Suzuki M (2006), Kihara-Negishi F (2001)	3
CDK2	0	HMGA1	0	affinity chromatography technology	Neganova I (2011)	1
NXF1	0	SP1	0	affinity chromatography technology	Castello A (2012)	1
EP300	36	TP63	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Liao JM (2013), Liao JM (2013), MacPartlin M (2005), MacPartlin M (2005), MacPartlin M (2005), MacPartlin M (2005), MacPartlin M (2005), Restelli M (2015), Restelli M (2015)	9
TES	1	LASP1	1	affinity chromatography technology	Sala S (2017)	1
NFYC	0	NFYB	2	two hybrid, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology	Bandyopadhyay S (2010), Wang J (2011), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	5
NFYC	0	NFYA	2	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Bandyopadhyay S (2010), Yun J (2003), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	5
ESR1	0	CREBBP	29	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Sheppard HM (2001), Fan S (2002), Fan S (2002), Fan S (2002), Jin W (2008), Jaber BM (2004), Jaber BM (2004), Heery DM (1997), Ku TK (2007), Crowe DL (2006)	10
NFYA	2	TAF12	0	pull down	Frontini M (2002)	1
CSNK2A1	15	SPI1	1	enzymatic study	Mao C (1996)	1
CREBBP	29	HMGA1	0	two hybrid, enzymatic study	Nagpal S (1999), Munshi N (1998)	2
CDK2	0	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	4
ATF2	1	APP	1	pull down	Olah J (2011)	1
TAF11	0	TAF12	0	affinity chromatography technology	Gupta K (2017)	1
SHMT2	3	NFYA	2	affinity chromatography technology	Castello A (2012)	1
HMGA1	0	ATF2	1	pull down	Yie J (1999)	1
NFYA	2	ZHX1	1	two hybrid, pull down, two hybrid, pull down	Yamada K (1999), Yamada K (1999), Yamada K (1999), Yamada K (1999)	4
CREB1	1	EP300	36	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, far western blotting, pull down	Hussain MA (1999), Magenta A (2003), Subbaramaiah K (2011), Solomou EE (2001), Subbaramaiah K (2012), Tung WH (2011), Tung WH (2011), Lundblad JR (1995), Lundblad JR (1995)	9
ATF2	1	283458	0	affinity chromatography technology	Lau E (2012)	1
NFYA	2	ATF6	3	two hybrid	Yoshida H (2001)	1
CREB1	1	SREBF2	5	two hybrid	Bandyopadhyay S (2010)	1
NFYA	2	HMGA1	0	far western blotting	Currie RA (1997)	1
CDK2	0	TP53	0	enzymatic study, enzymatic study, imaging technique	Luciani MG (2000), Tsai CH (2009), Chen TC (2014)	3
NFYA	2	ME1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
APP	1	HMGA1	0	pull down	Virok DP (2011)	1
ESR1	0	NFYA	2	affinity chromatography technology	Han SJ (2016)	1
CDK2	0	NFYA	2	enzymatic study, pull down, affinity chromatography technology	Yun J (2003), Yun J (2003), Yun J (2003)	3
CREB1	1	POGZ	49	two hybrid	Bandyopadhyay S (2010)	1
CDK2	0	NFYC	0	affinity chromatography technology	Yun J (2003)	1
ACTN4	4	NFYA	2	affinity chromatography technology, affinity chromatography technology	Poch MT (2004), Poch MT (2004)	2
SP1	0	ELF1	2	pull down	Gunther M (2000)	1
LUC7L2	0	APP	1	pull down	Olah J (2011)	1
NFYC	0	POGZ	49	two hybrid	Bandyopadhyay S (2010)	1
CCNA2	1	EP300	36	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SHMT2	3	APP	1	pull down	Olah J (2011)	1
SRF	1	ATF6	3	two hybrid, pull down	Zhu C (1997), Zhu C (1997)	2
BRCA1	7	SP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Abramovitch S (2003), Maor S (2007), Maor S (2007), Abramovitch S (2003)	4
CSNK2A1	15	NXF1	0	enzymatic study	Zhang M (2011)	1
LUC7L2	0	MOV10	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CREB1	1	HMGA1	0	affinity chromatography technology	Li X (2015)	1
BRCA1	7	CREB1	1	genetic interference	Houvras Y (2000)	1
NFYA	2	283458	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SP1	0	SRF	1	pull down	Biesiada E (1999)	1
ATF6	3	SP1	0	genetic interference	Zhang D (2012)	1
TAF6	4	HDAC1	4	affinity chromatography technology	Nakamura T (2002)	1
NFYB	2	TAF6	4	pull down	Frontini M (2002)	1
NFYB	2	TAF11	0	pull down, pull down	Frontini M (2002), Frontini M (2002)	2
NFYA	2	HMGCS1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NFYC	0	ATF6	3	pull down, two hybrid	Yoshida H (2001), Bandyopadhyay S (2010)	2
TP63	0	NFYA	2	affinity chromatography technology	Ratovitski EA (2010)	1
NXF1	0	TES	1	affinity chromatography technology	Castello A (2012)	1
SPI1	1	JUN	0	pull down	Carrere S (1998)	1
CSNK2A1	15	BRCA1	7	pull down	OBrien KA (1999)	1
BRCA1	7	HDAC1	4	pull down	Yarden RI (1999)	1
TP53	0	EP300	36	pull down, genetic interference, pull down, enzymatic study, pull down, pull down, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, unspecified method, affinity chromatography technology, enzymatic study, unspecified method, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, unspecified method	An W (2004), Pastorcic M (2000), Livengood JA (2002), Livengood JA (2002), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Tang Y (2008), Wang H (2008), Valbuena A (2008), Shi D (2009), Vega FM (2004), Finlan L (2004), Groenroos E (2004), Zhao Y (2006), Roe JS (2006), Pedeux R (2005), Sekaric P (2007), Pan X (2009), Tang Y (2006), Sen GS (2011), Li Y (2012), Li Y (2012), Gillotin S (2010), Grossman SR (2003), Issaeva N (2004), Kitagawa M (2008), Sabbatini P (2002), Burge S (2009), Zilfou JT (2001), Issaeva N (2004), Issaeva N (2004), Feng H (2009), Feng H (2009), Lill NL (1997), Dornan D (2004), Dornan D (2004), Di Agostino S (2006), Wells M (2008), Fath DM (2006), Kobet E (2000), Costanzo A (2002), Kumazawa T (2011), Borger DR (2006), Cui D (2013), Borger DR (2006), Lee SJ (2013), Tang HY (2006), Lin C (2011), Choi WI (2014), Ding G (2013), Kim MK (2013), Ali A (2013), Wu G (2014), Mizuguchi Y (2012), Sinha S (2012), Sinha S (2012), Her YR (2013), Her YR (2013), Wu SY (2009), Wu SY (2009), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Gu W (1997), Teufel DP (2007), Mantovani F (2007), Mantovani F (2007), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), Dornan D (2003), MacPartlin M (2005), Mujtaba S (2004), Wang YH (2003), Chen H (1999), Tang Z (2013), Graczyk A (2013), Graczyk A (2013), Chan HM (2001), Thomas MC (2005), Miller Jenkins LM (2015), Miller Jenkins LM (2015), Koh DI (2014), Koh DI (2014), Koh DI (2014), Li H (2015), Chen LF (2005), Shi D (2016), Wright DG (2016), Zhang X (2016), Procopio MG (2015), Tong Q (2015)	95
ATF6	3	APP	1	pull down	Olah J (2011)	1
NFYA	2	PWP1	3	two hybrid	Ravasi T (2010)	1
CSNK2A1	15	HDAC1	4	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology	Pflum MK (2001), Cai R (2001), Sun JM (2007), Zhang M (2011), Joshi P (2013)	5
PWP1	3	APP	1	pull down	Olah J (2011)	1
BRCA1	7	JUN	0	affinity chromatography technology, pull down	Hu YF (2002), Hu YF (2002)	2
TP53	0	NFYB	2	affinity chromatography technology, affinity chromatography technology	Imbriano C (2005), Di Agostino S (2006)	2
SP1	0	POGZ	49	pull down	Gunther M (2000)	1
CDK2	0	ESR1	0	enzymatic study, affinity chromatography technology	Zhou W (2014), Zhou W (2014)	2
NFYA	2	HDAC1	4	affinity chromatography technology	Ahn J (2011)	1
CREB1	1	NFYA	2	affinity chromatography technology	Li X (2015)	1
CREBBP	29	CSNK2A1	15	pull down, far western blotting, affinity chromatography technology	Yamaguchi Y (1998), Yamaguchi Y (1998), Jung SY (2005)	3
NFYB	2	CCNA2	1	affinity chromatography technology	Yun J (2003)	1
NFYA	2	NFYB	2	pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, biochemical, affinity chromatography technology	Mantovani R (1994), Hu Q (2006), Imbriano C (2005), Yun J (2003), Rolland T (2014), Wan C (2015), Hein MY (2015)	7
TP53	0	SP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Borellini F (1993), Jin W (2008), Dhar SK (2006), Lagger G (2003), Lagger G (2003), Lagger G (2003), Lagger G (2003), Sengupta S (2005), Sengupta S (2005), Lin RK (2010), Kim HA (2011), Sawaya BE (1998), St Clair S (2004), Innocente SA (2005), Innocente SA (2005), Ohlsson C (1998), Kong X (2013), Bocangel D (2009), Bocangel D (2009)	19
JUN	0	HDAC1	4	affinity chromatography technology	Tenbrock K (2006)	1
CREBBP	29	SP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goto T (2006), Leclerc GJ (2010), Chuang JY (2012), Guo W (2014)	4
NXF1	0	NFYA	2	affinity chromatography technology	Castello A (2012)	1
CDC25A	2	CCNA2	1	affinity chromatography technology	Li X (2016)	1
NFYA	2	UBE2D2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CREBBP	29	NFYA	2	affinity chromatography technology, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
CREBBP	29	TP53	0	enzymatic study, pull down, genetic interference, pull down, enzymatic study, fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, imaging technique, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, affinity chromatography technology, unspecified method, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Ito A (2002), Livengood JA (2002), Livengood JA (2002), Giebler HA (2000), Tang Y (2008), Jenkins LM (2009), Shi D (2009), Zhao Y (2006), Saifudeen Z (2005), Scolnick DM (1997), Scolnick DM (1997), Gu W (1997), Gu W (1997), Matsuda S (2004), Pasqualucci L (2011), Lee SK (1999), Dai C (2011), Lee CW (2010), Ferreon JC (2009), Ruas JL (2010), Ruas JL (2010), Huang WC (2007), Huang WC (2007), Mujtaba S (2004), Mujtaba S (2004), Mujtaba S (2004), Mujtaba S (2004), Col E (2002), Jansma AL (2014), Jansma AL (2014), Krois AS (2016), Hasegawa K (2008), Huang X (2013), Huang X (2013), Piskacek M (2016)	35
APP	1	APPBP2	3	two hybrid, pull down, affinity chromatography technology	Zheng P (1998), Zheng P (1998), Briand S (2011)	3
BRCA1	7	MOV10	6	affinity chromatography technology	Ertych N (2016)	1
CDC25A	2	CDK2	0	pull down, enzymatic study, affinity chromatography technology	Xu X (1996), Cheng A (2005), Li X (2016)	3
JUN	0	ATF2	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Newell CL (1994), Newell CL (1994), Kara CJ (1990), Hai T (1991), Fuchs SY (1999), Reinke AW (2013), Reinke AW (2013), Miyamoto-Sato E (2010), Hayakawa J (2004), Hein MY (2015), Li X (2015), Huttlin EL (2017)	12
NXF1	0	POGZ	49	affinity chromatography technology	Castello A (2012)	1
SP1	0	CCNA2	1	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Wang CH (2006), Fojas de Borja P (2001), Haidweger E (2001), Haidweger E (2001)	4
NFYA	2	JUN	0	affinity chromatography technology, affinity chromatography technology	Faniello MC (2002), Ahn J (2011)	2
SREBF2	5	ATF6	3	pull down, affinity chromatography technology, affinity chromatography technology	Zeng L (2004), Zeng L (2004), Zeng L (2004)	3
LASP1	1	NXF1	0	biochemical	Wan C (2015)	1
ESR1	0	SHMT2	3	pull down	Nalvarte I (2010)	1
JUN	0	ESR1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Teyssier C (2001), Baron S (2007), Ruiz ML (2013), Ruiz ML (2013)	4
CREB1	1	ZHX1	1	two hybrid	Bandyopadhyay S (2010)	1
ATF2	1	CSNK2A1	15	pull down, far western blotting	Yamaguchi Y (1998), Yamaguchi Y (1998)	2
NFYA	2	ELF1	2	pull down	Bemark M (1998)	1
TP53	0	MOV10	6	affinity chromatography technology	Li X (2015)	1
CSNK2A1	15	ZHX1	1	two hybrid	Stelzl U (2005)	1
GTF2A1	1	NFYA	2	two hybrid	Rolland T (2014)	1
CDK2	0	SP1	0	enzymatic study	Fojas de Borja P (2001)	1
CSNK2A1	15	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, enzymatic study	Uhle S (2003), Fogeron ML (2013), Bhansali M (2014), Chen TC (2014), Walerych D (2004), Walerych D (2004)	6
TP53	0	ESR1	0	pull down, affinity chromatography technology, affinity chromatography technology	Liu G (2000), Duong V (2007), Saxena R (2016)	3
TES	1	ACTN4	4	affinity chromatography technology	Sala S (2017)	1
RPS6KA6	0	APP	1	pull down	Olah J (2011)	1
PWP1	3	TCAF1	1	affinity chromatography technology	Huttlin EL (2017)	1
NFYA	2	CHMP4A	1	affinity chromatography technology	Huttlin EL (2017)	1
CCNA2	1	TAF11	0	affinity chromatography technology	Hein MY (2015)	1
CREBBP	29	EP300	36	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Crusselle-Davis VJ (2007), Dohda T (2004), Dohda T (2004)	3
NFYC	0	TAF11	0	pull down, pull down	Frontini M (2002), Frontini M (2002)	2
CSNK2A1	15	APP	1	pull down	Olah J (2011)	1
EP300	36	SREBF2	5	far western blotting	Oliner JD (1996)	1
NFYA	2	EP300	36	affinity chromatography technology, affinity chromatography technology	Ahn J (2011), Di Agostino S (2006)	2
NFYC	0	TAF6	4	pull down	Frontini M (2002)	1
CREBBP	29	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, genetic interference, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Pao GM (2000), Pao GM (2000), Benezra M (2003), Fan S (2002), Fan S (2002), Neish AS (1998), Nakuci E (2006), Crowe DL (2006), Chai YL (1999)	9
MOV10	6	POGZ	49	affinity chromatography technology	Castello A (2012)	1
NFYA	2	TCAF1	1	two hybrid	Yu H (2011)	1
RPS6KA6	0	NFYA	2	biochemical	Havugimana PC (2012)	1
MOV10	6	ATF6B	1	affinity chromatography technology	Castello A (2012)	1
GTF2A1	1	TAF6	4	affinity chromatography technology	Jeronimo C (2007)	1
TAF11	0	APPBP2	3	two hybrid	Rolland T (2014)	1
CREB1	1	HDAC1	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Canettieri G (2003), Canettieri G (2003), Canettieri G (2003), Kim HC (2010)	4
GTF2A1	1	ME1	1	biochemical	Kristensen AR (2012)	1
HDAC1	4	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mayanil CS (2006), Chuang HC (2006), Chuang HC (2006)	3
NFYC	0	SP1	0	two hybrid	Bandyopadhyay S (2010)	1
BRCA1	7	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Abramovitch S (2004), Ouchi T (1998), Dong Y (2003), Dong Y (2003), Chai YL (1999), Chai YL (1999), Zhang H (1998), Dong Y (2003), Chen Y (2006), Quaresima B (2006), Zhang H (1998), Zhang H (1998), Mark WY (2005), Jin S (2009), Jiang J (2011), Rasti M (2015), Rasti M (2015)	17
ATF6	3	ATF6B	1	two hybrid	Yoshida H (2001)	1
NFYA	2	SERPINB1	0	affinity chromatography technology	Huttlin EL (2017)	1
CREB1	1	GTF2A1	1	two hybrid	Bandyopadhyay S (2010)	1
CDC25A	2	NFYA	2	two hybrid	Wang J (2011)	1
NFYA	2	FTO	1	affinity chromatography technology	Huttlin EL (2017)	1
NFYC	0	TAF12	0	pull down	Frontini M (2002)	1
NFYC	0	ATF6B	1	pull down	Yoshida H (2001)	1
NXF1	0	ATF6B	1	affinity chromatography technology	Castello A (2012)	1
NFYC	0	HDAC1	4	affinity chromatography technology	Kato T (2009)	1
TP53	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique	Ito A (2002), Wang C (2005), Dohi Y (2008), Jin W (2008), Lei Q (2006), Wu Y (2001), Wu Y (2001), Luo J (2000), Juan LJ (2000), Juan LJ (2000), Juan LJ (2000), Murphy M (1999), Insinga A (2004), Sun JM (2007), Yu XY (2010), Sinha S (2010), Sinha S (2010), Li Y (2012), Di Agostino S (2006), Pavithra L (2009), Pavithra L (2009), Luo J (2000), Chen TC (2014), Park EK (2015), Park EK (2015), Park EK (2015)	26
CREB1	1	ATF6	3	two hybrid	Bandyopadhyay S (2010)	1
APPBP2	3	LUC7L2	0	two hybrid	Rolland T (2014)	1
ATF2	1	SHMT2	3	affinity chromatography technology	Lau E (2012)	1
NFYA	2	EIF4EBP2	0	affinity chromatography technology	Huttlin EL (2017)	1
CCNA2	1	TAF6	4	affinity chromatography technology	Hein MY (2015)	1
NFYB	2	SP1	0	affinity chromatography technology	Leclerc GJ (2010)	1
TP53	0	ZHX1	1	two hybrid	Goehler H (2004)	1
TAF11	0	APP	1	pull down	Olah J (2011)	1
APPBP2	3	ZC3H10	1	two hybrid	Rolland T (2014)	1
CREB1	1	JUN	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Benbrook DM (1990), Li X (2015), Li X (2015)	3
CSNK2A1	15	NFYA	2	two hybrid	Rolland T (2014)	1
SP1	0	JUN	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Kardassis D (1999), Hung JJ (2006), Chen BK (2007), Chen BK (2007), Chen BK (2007)	5
HMGA1	0	JUN	0	pull down, two hybrid	Yie J (1999), Nagpal S (1999)	2
SREBF2	5	NFYA	2	two hybrid	Bandyopadhyay S (2010)	1
CCNA2	1	TP53	0	pull down	Luciani MG (2000)	1
NFYA	2	TAF6	4	pull down	Frontini M (2002)	1
TP53	0	TP63	0	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McDade SS (2011), Lu D (2013), Chae YS (2012), Chae YS (2012), Stindt MH (2015), Wei S (2014)	6
CREBBP	29	CREB1	1	affinity chromatography technology, two hybrid, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, fluorescent resonance energy transfe, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology, far western blotting, pull down, far western blotting, pull down, far western blotting, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shi Y (2004), Kim J (2005), Shimomura A (1996), Radhakrishnan I (1997), Radhakrishnan I (1997), Sano Y (1998), Sano Y (1998), Zor T (2002), Giebler HA (2000), Zhang Q (2000), Ernst P (2001), Ledo F (2002), Poon SL (2008), Best JL (2004), Best JL (2004), Chan EC (2010), Yang F (2006), Solomou EE (2001), Du K (1998), Venza I (2001), Lundblad JR (1995), Lundblad JR (1995), Arias J (1994), Chrivia JC (1993), Chrivia JC (1993), Shi Y (2004), Ramirez JA (2007), Sun HS (2003), Sun HS (2003), Wang Y (2016)	30
CREBBP	29	ATF2	1	pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Sano Y (1998), Sano Y (1998), Sano Y (1998), Sano Y (1998), Deb S (2006), Merika M (1998), Johnson J (2007), Venza I (2001)	8
CCNA2	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henneke G (2003), Naderi S (2005), Varshochi R (2005), Di Fiore B (2010), Mateo F (2009), Abbas T (2007), Schulman BA (1998), Datta NS (1998), Wu G (1997), Sebastian B (1993), Liu S (2009), Ciarallo S (2002), Wolthuis R (2008), Vicent GP (2011), Zhang H (1995), Sayle KL (2003), Jeffrey PD (1995), Davies TG (2001), Cook A (2002), Pevarello P (2006), Levkau B (1998), Poon RY (1996), OConnor PM (1993), Davies TG (2002), Kontopidis G (2003), Andrews MJ (2004), Pevarello P (2004), Pevarello P (2005), Varjosalo M (2013), Varjosalo M (2013), Kikuchi R (2014), Kikuchi R (2014), Mateo F (2009), So J (2015), Okamoto K (2002), Song MS (2011), Huttlin EL (2015), Di Fiore B (2015), Pan ZQ (1993), Pan ZQ (1993), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	43
CDK2	0	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study	Ruffner H (1999), Ruffner H (1999), Ruffner H (1999), Wang H (1997), Chen Y (1996)	5
NFYA	2	APPBP2	3	two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009)	2
BRCA1	7	ESR1	0	imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Zheng L (2001), Fan S (2001), Fan S (2001), Kawai H (2002), Fan S (2002), Fan S (2002), Nakuci E (2006), Wang C (2005), Wang C (2005), Dizin E (2010), Dizin E (2010), Ma Y (2010), Ma Y (2010), Fan S (2001), Ma YX (2005), Ma YX (2005), Ma YX (2005), Ma Y (2007), Ma Y (2007), Kawai H (2002), Jung YS (2014), Kawai H (2002), Kawai H (2002)	23
NFYA	2	ZC3H10	1	two hybrid	Yu H (2011)	1
NFYA	2	PAPOLG	3	two hybrid	Ravasi T (2010)	1
NFYA	2	ATF2	1	affinity chromatography technology	Ahn J (2011)	1
POGZ	49	APP	1	pull down	Olah J (2011)	1
NFYA	2	TES	1	affinity chromatography technology	Huttlin EL (2017)	1
TP53	0	HMGA1	0	affinity chromatography technology, affinity chromatography technology	Aiello A (2010), Aiello A (2010)	2
NFYA	2	UAP1	1	affinity chromatography technology	Huttlin EL (2017)	1
HMGA1	0	SP1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Foti D (2003), Foti D (2003), Aiello A (2010), Aiello A (2010)	4
NFYB	2	TAF12	0	pull down	Frontini M (2002)	1
SP1	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Di Padova M (2003), Singh J (2002), Zhang Y (2002), Sun JM (2002), Gao J (2009), Shon JK (2009), Mottet D (2009), Goto T (2006), Hung JJ (2006), Lagger G (2003), Choi HS (2002), Choi HS (2002), Kang JE (2005), Kang JE (2005), Kang JE (2005), Gan Y (2005), Gan Y (2005), Duan H (2005), Varshochi R (2005), Varshochi R (2005), Plaisance V (2005), Walker GE (2001), Walker GE (2001), Ammanamanchi S (2004), Doetzlhofer A (1999), Sekhavat A (2007), Liu T (2007), Enya K (2008), Liu S (2010), Leclerc GJ (2010), Leclerc GJ (2010), Wong CY (2011), Schnur N (2007)	33
CDK2	0	TES	1	affinity chromatography technology	Hein MY (2015)	1
SERPINB1	0	TES	1	biochemical	Wan C (2015)	1
NFYB	2	HDAC1	4	affinity chromatography technology	Leclerc GJ (2010)	1
EP300	36	CDK2	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Felzien LK (1999), Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	4
CSNK2A1	15	HMGA1	0	enzymatic study, enzymatic study	Zhang M (2011), Piekielko A (2001)	2
EP300	36	JUN	0	pull down, biochemical, x-ray crystallography, affinity chromatography technology, pull down, enzymatic study, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Campbell KM (2002), Campbell KM (2002), Campbell KM (2002), Subbaramaiah K (2002), Duyndam MC (1999), Wang WM (2011), Deng WG (2004), Deng WG (2004), Cheng SE (2011), Cheng SE (2011), Kim BK (2014), Vries RG (2001), Deng WG (2003), Liu L (2017), Liu L (2017)	15
CDK2	0	NFYB	2	affinity chromatography technology, affinity chromatography technology	Yun J (2003), Yun J (2003)	2
SHMT2	3	GTF2A1	1	affinity chromatography technology	Castello A (2012)	1
SP1	0	SREBF2	5	pull down, two hybrid	Gunther M (2000), Bandyopadhyay S (2010)	2
CDC25A	2	APP	1	pull down	Olah J (2011)	1
CREBBP	29	JUN	0	pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, far western blotting	Sano Y (1998), Sano Y (1998), Merika M (1998), Duyndam MC (1999), Johnson J (2007), Yamaguchi K (2005), Tsai LN (2008), Arias J (1994)	8
EP300	36	ATF2	1	biochemical	Duyndam MC (1999)	1
NFYA	2	POGZ	49	two hybrid	Rolland T (2014)	1
NFYA	2	TAF11	0	pull down	Frontini M (2002)	1
BRCA1	7	TP63	0	affinity chromatography technology, imaging technique	Buckley NE (2011), Buckley NE (2014)	2