PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HNRNPL	3	UBE2E3	0	affinity chromatography technology	Fei T (2017)	1
UBE2E3	0	RNF165	0	two hybrid	van Wijk SJ (2009)	1
UBE2E3	0	UBC	7	enzymatic study	Sheng Y (2012)	1
UBC	7	HNRNPL	3	affinity chromatography technology	Matsumoto M (2005)	1
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
UBE2D4	0	RNF165	0	two hybrid	van Wijk SJ (2009)	1
UBE2D1	0	RNF165	0	two hybrid	van Wijk SJ (2009)	1
HNRNPL	3	RNF165	0	affinity chromatography technology	Fei T (2017)	1
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
UBC	7	UBE2N	1	affinity chromatography technology, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Matsumoto M (2005), Scheper J (2010), Wu PY (2003), McKenna S (2003), Wiener R (2012), Ye Y (2003), Bish RA (2007), Juang YC (2012), Pastushok L (2007), Singh RK (2012), McKenna S (2001), McKenna S (2001)	12
RNF165	0	UBC	7	enzymatic study, x-ray crystallography, pull down	Wright JD (2016), Wright JD (2016), Wright JD (2016)	3
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
UBE2D2	0	RNF165	0	two hybrid, pull down, x-ray crystallography	van Wijk SJ (2009), Wright JD (2016), Wright JD (2016)	3
UBE2D3	1	RNF165	0	two hybrid	van Wijk SJ (2009)	1
UBE2E1	1	RNF165	0	two hybrid	van Wijk SJ (2009)	1
UBE2W	0	RNF165	0	two hybrid	van Wijk SJ (2009)	1
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
UBE2N	1	RNF165	0	two hybrid, pull down	van Wijk SJ (2009), Wright JD (2016)	2