PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
USP5	2	UCHL3	1	biochemical	Havugimana PC (2012)	1
PLA2G2A	1	ITGAV	7	pull down	Saegusa J (2008)	1
PLA2G1B	0	PLA2G2A	1	pull down	Ancian P (1995)	1
PLA2G2A	1	CEP70	1	two hybrid	Vinayagam A (2011)	1
SENP8	0	PLA2G2A	1	enzymatic study	Altun M (2011)	1
ITGB3	6	ITGAV	7	x-ray crystallography, imaging technique, affinity chromatography technology	Xiong JP (2002), Moon HE (2015), Ward CM (2000)	3
UCHL1	1	PLA2G2A	1	enzymatic study	Altun M (2011)	1
USP15	4	USP7	14	enzymatic study	Loch CM (2012)	1
USP28	3	UCHL3	1	enzymatic study	Loch CM (2012)	1
USP2	0	PLA2G2A	1	enzymatic study	Altun M (2011)	1
USP15	4	PLA2G2A	1	enzymatic study	Altun M (2011)	1
PLA2G2A	1	VIM	0	affinity chromatography technology, affinity chromatography technology, pull down	Boilard E (2003), Boilard E (2003), Boilard E (2003)	3
USP20	3	UCHL3	1	affinity chromatography technology	Sowa ME (2009)	1
USP28	3	USP4	3	enzymatic study	Loch CM (2012)	1
USP4	3	USP15	4	affinity chromatography technology, enzymatic study, affinity chromatography technology	Zhang L (2012), Loch CM (2012), Das T (2017)	3
PLA2G2A	1	ALOX12	5	affinity chromatography technology	Coffey MJ (2004)	1
USP15	4	UCHL3	1	enzymatic study	Loch CM (2012)	1
USP4	3	PLA2G2A	1	enzymatic study	Altun M (2011)	1
ITGB3	6	VIM	0	affinity chromatography technology	Prevost N (2009)	1
USP28	3	USP15	4	enzymatic study	Loch CM (2012)	1
USP28	3	USP20	3	enzymatic study	Loch CM (2012)	1
USP28	3	USP5	2	enzymatic study	Loch CM (2012)	1
KRAS	1	PLA2G2A	1	genetic interference	Luo J (2009)	1
PLA2G2A	1	TGM2	2	affinity chromatography technology	Curro M (2014)	1
USP28	3	USP7	14	enzymatic study	Loch CM (2012)	1
BAG6	2	USP15	4	affinity chromatography technology	Hein MY (2015)	1
USP15	4	SENP8	0	enzymatic study	Loch CM (2012)	1
PLA2G2A	1	DCN	0	pull down	Sartipy P (2000)	1
UCHL3	1	PLA2G2A	1	enzymatic study	Altun M (2011)	1
SENP6	2	PLA2G2A	1	enzymatic study	Altun M (2011)	1
USP28	3	PLA2G2A	1	enzymatic study	Altun M (2011)	1
PLA2G2A	1	PLA2G2A	1	x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography	Oh BH (1995), Scott DL (1991), Cha SS (1996), Hansford KA (2003)	4
USP28	3	USP8	7	enzymatic study	Loch CM (2012)	1
PLA2G2A	1	BAG6	2	two hybrid	Vinayagam A (2011)	1
USP15	4	UCHL1	1	enzymatic study	Loch CM (2012)	1
USP15	4	USP20	3	enzymatic study	Loch CM (2012)	1
USP15	4	USP8	7	enzymatic study	Loch CM (2012)	1
USP5	2	PLA2G2A	1	enzymatic study	Altun M (2011)	1
USP28	3	UCHL1	1	enzymatic study	Loch CM (2012)	1
USP8	7	PLA2G2A	1	enzymatic study	Altun M (2011)	1
USP28	3	UCHL5	1	enzymatic study	Loch CM (2012)	1
PLA2G2A	1	ITGB3	6	pull down	Saegusa J (2008)	1
UCHL5	1	PLA2G2A	1	enzymatic study	Altun M (2011)	1
USP47	4	PLA2G2A	1	enzymatic study	Altun M (2011)	1
JOSD2	0	PLA2G2A	1	enzymatic study	Altun M (2011)	1
USP28	3	SENP8	0	enzymatic study	Loch CM (2012)	1
USP20	3	PLA2G2A	1	enzymatic study	Altun M (2011)	1
USP7	14	PLA2G2A	1	enzymatic study	Altun M (2011)	1