PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
YOD1	0	RIPK1	2	enzymatic study	Mevissen TE (2013)	1
AMFR	2	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Morito D (2008), Ballar P (2007), Ye Y (2005), Zhong Y (2011)	4
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
TRIM54	1	YOD1	0	enzymatic study	Loch CM (2012)	1
CCDC51	0	YOD1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM63	0	YOD1	0	enzymatic study	Loch CM (2012)	1
YOD1	0	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down	Ernst R (2009), Locke M (2014), Locke M (2014), Ernst R (2009), Ernst R (2009), Schimmack G (2017), Schimmack G (2017)	7
AMFR	2	UBC	7	pull down, pull down, imaging technique, affinity chromatography technology, enzymatic study, x-ray crystallography, pull down, x-ray crystallography, pull down, enzymatic study, enzymatic study, pull down, affinity chromatography technology	Zhong X (2004), Yang H (2010), Ying Z (2009), Jo Y (2011), Ye Y (2003), Xu Y (2012), Liu S (2012), Liu S (2012), Xu Y (2012), Morito D (2008), Flierman D (2006), Liu W (2014), Fang S (2001)	13
VCP	6	UFD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Wang Q (2008), Ballar P (2007), Alexandru G (2008), Zhong X (2006), Fernandez-Saiz V (2010), Nagahama M (2009), Noguchi M (2005), Bruderer RM (2004), Bruderer RM (2004), Bruderer RM (2004), Erzurumlu Y (2013), Li JM (2013), Fogeron ML (2013), Haenzelmann P (2016), Haenzelmann P (2016), Haenzelmann P (2016), Raman M (2015), Raman M (2015), Mountassif D (2015), Wang T (2016), Guo X (2017)	21
FAF2	4	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Lee JN (2008), Alexandru G (2008), Alexandru G (2008), Mueller B (2008), Alexandru G (2012), Xu Y (2013), Christianson JC (2012), Besten Wd (2012), Madsen L (2014), Raman M (2015)	10
YOD1	0	DERL1	2	affinity chromatography technology	Ernst R (2009)	1
POLD1	5	YOD1	0	affinity chromatography technology	Hein MY (2015)	1
UBC	7	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhong X (2006), Dai RM (2001), Bish RA (2007), Lim JJ (2016), Zhang X (2017)	6
USP15	4	TRAF6	0	enzymatic study	Bremm A (2010)	1
AMFR	2	FAF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee JN (2008), Lee JN (2008), Alexandru G (2008), Wang Q (2011), Xu Y (2013), Wang Q (2011), Christianson JC (2012), Christianson JC (2012), Zhang T (2015)	9
YOD1	0	FAM98B	2	biochemical	Wan C (2015)	1
SYVN1	2	DERL1	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Schulze A (2005), Schulze A (2005), Ye Y (2005), Bernardi KM (2010), Huang CH (2013), van de Weijer ML (2014), Hosokawa N (2016)	7
TRIM63	0	TRIM54	1	two hybrid, pull down	Centner T (2001), Centner T (2001)	2
ELAVL1	0	UBE2J1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
YOD1	0	THOC3	1	affinity chromatography technology	Sowa ME (2009)	1
UBC	7	FAF2	4	affinity chromatography technology, affinity chromatography technology	Bish RA (2007), Alexandru G (2008)	2
NEDD4	2	UBC	7	x-ray crystallography, pull down, unspecified method, enzymatic study, x-ray crystallography, enzymatic study, pull down, pull down	Maspero E (2011), Maspero E (2011), Ernst A (2013), Maspero E (2013), Mari S (2014), Mari S (2014), Mari S (2014), Kathman SG (2015)	8
UBC	7	NPLOC4	4	affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Wang B (2003), Bish RA (2007), Kristariyanto YA (2015), Zhang X (2017)	5
AMFR	2	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, two hybrid, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhong X (2004), Zhong X (2004), Lee JN (2008), Cao J (2007), Ballar P (2007), Ballar P (2007), Ye Y (2005), Ye Y (2005), Zhong X (2004), Yang H (2010), Yang H (2010), Ballar P (2010), Jo Y (2011), St-Pierre P (2012), Grelle G (2006), Scheich C (2007), Ballar P (2006), Haenzelmann P (2011), Haenzelmann P (2011), Haenzelmann P (2011), Wang Q (2011), Yu CC (2013), Erzurumlu Y (2013), Liu S (2013), Wang Q (2011), Grelle G (2006), Grelle G (2006), Grelle G (2006), Grelle G (2006), Christianson JC (2012), Zhang T (2015), Khodayari N (2017)	32
TRAF6	0	YOD1	0	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Schimmack G (2017), Schimmack G (2017), Schimmack G (2017), Schimmack G (2017), Schimmack G (2017)	5
USP15	4	YOD1	0	enzymatic study	Loch CM (2012)	1
RIPK1	2	BIRC3	1	affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Bertrand MJ (2008), Bertrand MJ (2008), Dynek JN (2010), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011), Puliyappadamba VT (2013), Wu CJ (2006)	8
YOD1	0	FAF2	4	affinity chromatography technology	Ernst R (2009)	1
UBE2J1	1	TRIM63	0	two hybrid	van Wijk SJ (2009)	1
TRAF6	0	BIRC3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Goncharov T (2013), Harikumar KB (2014), Harikumar KB (2014)	4
UFD1	1	NPLOC4	4	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, x-ray crystallography, biochemical, affinity chromatography technology, affinity chromatography technology	Botta A (2001), Lass A (2008), Vong QP (2005), Bruderer RM (2004), Havugimana PC (2012), Li JM (2013), Pye VE (2007), Wan C (2015), Raman M (2015), Raman M (2015)	10
FCF1	0	YOD1	0	affinity chromatography technology	Huttlin EL (2017)	1
TRIM54	1	USP15	4	enzymatic study	Loch CM (2012)	1
ELAVL1	0	FAF2	4	affinity chromatography technology, affinity chromatography technology, pull down	Abdelmohsen K (2009), Zhou HL (2013), Zhou HL (2013)	3
UBE3A	4	UFD1	1	biochemical	Havugimana PC (2012)	1
YOD1	0	NEDD4	2	enzymatic study	Mevissen TE (2013)	1
VCP	6	SYVN1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, affinity chromatography technology, biochemical	Ballar P (2007), Schulze A (2005), Schulze A (2005), Schulze A (2005), Ye Y (2005), Ye Y (2005), Zhong X (2006), Fernandez-Saiz V (2010), Liu S (2013), Liu S (2013), Liu S (2013), Liu S (2013), Zhang T (2015), Hosokawa N (2016)	14
UBE2J1	1	DERL1	2	affinity chromatography technology	Claessen JH (2010)	1
USP21	2	TRAF6	0	enzymatic study	Bremm A (2010)	1
USP21	2	RIPK1	2	affinity chromatography technology, affinity chromatography technology	Xu G (2010), Xu G (2010)	2
USP21	2	USP15	4	enzymatic study, enzymatic study	Loch CM (2012), Loch CM (2012)	2
ELAVL1	0	VCP	6	affinity chromatography technology, pull down	Zhou HL (2013), Zhou HL (2013)	2
UBE3A	4	UBC	7	enzymatic study, enzymatic study, pull down	Schwarz SE (1998), Ronchi VP (2013), Zhang X (2017)	3
YOD1	0	BIRC3	1	two hybrid	Schimmack G (2017)	1
UBE2J1	1	SYVN1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	van Wijk SJ (2009), Christianson JC (2012), Christianson JC (2012), Schulz J (2017)	4
FAF2	4	NPLOC4	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Raman M (2015), Raman M (2015)	4
BIRC3	1	USP15	4	affinity chromatography technology	Goncharov T (2013)	1
UBE2J1	1	VCP	6	affinity chromatography technology	Claessen JH (2010)	1
NPLOC4	4	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Lass A (2008), Ballar P (2007), Alexandru G (2008), Alexandru G (2008), Fernandez-Saiz V (2010), Noguchi M (2005), Bruderer RM (2004), Bruderer RM (2004), Lee JJ (2013), Erzurumlu Y (2013), Raman M (2015), Raman M (2015), Mountassif D (2015), Wang T (2016), Guo X (2017)	15
YOD1	0	UBC	7	pull down, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study	Ernst R (2009), Mevissen TE (2013), Mevissen TE (2013), Ernst R (2009), Flierman D (2016)	5
AMFR	2	UFD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Cao J (2007), Cao J (2007), Cao J (2007), Cao J (2007)	4
FAF2	4	UFD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Raman M (2015), Raman M (2015)	4
NPLOC4	4	UBE3A	4	biochemical	Kristensen AR (2012)	1
UBE2J1	1	FAF2	4	affinity chromatography technology	Claessen JH (2010)	1
TRIM63	0	TRIM55	2	two hybrid, two hybrid	Centner T (2001), Witt CC (2008)	2
YOD1	0	SHARPIN	1	two hybrid	Schimmack G (2017)	1
SYVN1	2	FAF2	4	affinity chromatography technology	Zhang T (2015)	1
USP15	4	UBC	7	pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Hetfeld BK (2005), Bremm A (2010), Komander D (2009), Loch CM (2012), Herhaus L (2014), Wauer T (2015), Das T (2017), Zhang X (2017), Kwasna D (2018)	9
TRAF6	0	VCP	6	affinity chromatography technology	Ewing RM (2007)	1
ELAVL1	0	AMFR	2	affinity chromatography technology	Abdelmohsen K (2009)	1
UBC	7	UFD1	1	pull down, x-ray crystallography, affinity chromatography technology, pull down	Nathan JA (2013), Park S (2005), Bish RA (2007), Zhang X (2017)	4
6955	0	SYVN1	2	affinity chromatography technology	Cattaneo M (2008)	1
TRIM54	1	USP21	2	enzymatic study	Loch CM (2012)	1
ELAVL1	0	YOD1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
DERL1	2	FAF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Greenblatt EJ (2011), Suzuki M (2012), Suzuki M (2012), Xu Y (2013), Christianson JC (2012), Christianson JC (2012)	6
AMFR	2	SYVN1	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Zhong Y (2011), Ballar P (2010), Zhang T (2015), Zhang T (2015), Zhang T (2015)	5
USP21	2	YOD1	0	enzymatic study	Loch CM (2012)	1
6955	0	VCP	6	affinity chromatography technology	Wang Q (2011)	1
VCP	6	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography	Wang Q (2008), Ballar P (2007), Schulze A (2005), Schulze A (2005), Ye Y (2005), Lilley BN (2005), Greenblatt EJ (2011), Younger JM (2006), Christianson JC (2012), You H (2017), Lim JJ (2016), Lim JJ (2016)	12
UBE2J1	1	YOD1	0	affinity chromatography technology	Claessen JH (2010)	1
TRIM63	0	USP15	4	enzymatic study	Loch CM (2012)	1
TRIM63	0	USP21	2	enzymatic study	Loch CM (2012)	1
YOD1	0	UBE3A	4	enzymatic study	Mevissen TE (2013)	1
PFKM	4	YOD1	0	biochemical	Wan C (2015)	1
TRIM55	2	YOD1	0	enzymatic study	Loch CM (2012)	1
BIRC3	1	UBC	7	pull down, pull down, enzymatic study	Gyrd-Hansen M (2008), Nakatani Y (2012), Sakamoto H (2015)	3
AMFR	2	NPLOC4	4	affinity chromatography technology, affinity chromatography technology	Wang Q (2011), Wang Q (2011)	2
YOD1	0	SYVN1	2	affinity chromatography technology	Bernardi KM (2013)	1
FAF2	4	UBE3A	4	affinity chromatography technology	Alexandru G (2008)	1
UBC	7	SHARPIN	1	pull down	Zhang X (2017)	1
ELAVL1	0	NPLOC4	4	affinity chromatography technology	Abdelmohsen K (2009)	1
RIPK1	2	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao L (2015), Ding Z (2015), Varfolomeev E (2015)	3
YOD1	0	UFD1	1	affinity chromatography technology	Ernst R (2009)	1
YOD1	0	6955	0	affinity chromatography technology	Bernardi KM (2013)	1
YOD1	0	BLOC1S5	1	affinity chromatography technology	Sowa ME (2009)	1
YOD1	0	NPLOC4	4	affinity chromatography technology	Ernst R (2009)	1
YOD1	0	AMFR	2	affinity chromatography technology	Bernardi KM (2013)	1
USP21	2	UBC	7	enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, unspecified method, enzymatic study, enzymatic study, pull down, enzymatic study	Bremm A (2010), Faesen AC (2011), Ye Y (2011), Urbe S (2012), Loch CM (2012), Ernst A (2013), Ye Y (2011), Wauer T (2015), Leung I (2016), Michel MA (2017)	10