PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
KLHL9	1	UBE2D1	0	pull down	Sumara I (2007)	1
HNRNPL	3	KLHL29	1	affinity chromatography technology	Fei T (2017)	1
COPS5	0	HNRNPL	3	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Fei T (2017)	2
CUL3	17	AURKB	2	affinity chromatography technology, affinity chromatography technology	Sumara I (2007), Krupina K (2016)	2
AURKB	2	CEP170	4	affinity chromatography technology	Fogeron ML (2013)	1
COPS6	0	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Birol M (2014)	5
HNRNPL	3	CEP170	4	affinity chromatography technology	Fei T (2017)	1
CUL4A	2	DCUN1D1	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Monda JK (2013), Keuss MJ (2016), Keuss MJ (2016)	9
AURKB	2	KLHL21	3	affinity chromatography technology, pull down, enzymatic study	Maerki S (2009), Maerki S (2009), Maerki S (2009)	3
DCUN1D1	0	COPS6	0	affinity chromatography technology	Bennett EJ (2010)	1
KLHL21	3	KLHL9	1	affinity chromatography technology, affinity chromatography technology	Maerki S (2009), Maerki S (2009)	2
CUL4A	2	CUL3	17	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	KLHL9	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Maerki S (2009), Sumara I (2007), Sumara I (2007), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Maerki S (2009)	7
COPS6	0	KLHL13	0	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
COPS6	0	KLHL9	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
CUL3	17	KLHL13	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Maerki S (2009), Sumara I (2007), Sumara I (2007), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Maerki S (2009)	7
DCUN1D1	0	AURKB	2	pull down	Huang G (2014)	1
COPS5	0	KLHL22	3	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
USP25	0	NEDD8	0	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Xu D (2017)	2
COPS5	0	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Angers S (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Olma MH (2009), Rao F (2014), Pick E (2012), Groisman R (2003), Groisman R (2003), Huttlin EL (2015), Cavadini S (2016), Scherer PC (2016), Scherer PC (2016), Huttlin EL (2017)	19
KLHL22	3	PLK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Beck J (2013), Beck J (2013), Metzger T (2013), Metzger T (2013), Beck J (2013)	5
PLK1	0	KLHL9	1	affinity chromatography technology, affinity chromatography technology	Beck J (2013), Beck J (2013)	2
DCUN1D1	0	NUDCD3	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	USP25	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Xu D (2017)	2
NUDCD3	0	KLHL9	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
COPS5	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	8
KLHL22	3	NUDCD3	0	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPL	3	CUL4A	2	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	NUDCD3	0	affinity chromatography technology	Fei T (2017)	1
KLHL21	3	KLHL13	0	affinity chromatography technology, affinity chromatography technology	Maerki S (2009), Maerki S (2009)	2
KLHL13	0	UBE2D1	0	pull down	Sumara I (2007)	1
KLHL13	0	AURKB	2	enzymatic study, affinity chromatography technology, pull down, enzymatic study	Maerki S (2009), Sumara I (2007), Sumara I (2007), Sumara I (2007)	4
KLHL29	1	KLHL21	3	affinity chromatography technology, affinity chromatography technology	Li S (2014), Huttlin EL (2017)	2
KLHL29	1	KLHL9	1	affinity chromatography technology	Li S (2014)	1
DCUN1D1	0	KLHL9	1	affinity chromatography technology	Bennett EJ (2010)	1
DCUN1D1	0	COPS5	0	affinity chromatography technology	Bennett EJ (2010)	1
KLHL13	0	USP25	0	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Xu D (2017)	2
KLHL13	0	KLHL22	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Maerki S (2009), Huttlin EL (2017)	3
KLHL13	0	NUDCD3	0	affinity chromatography technology	Sowa ME (2009)	1
COPS6	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	6
DCUN1D1	0	CUL3	17	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Kim AY (2008), Kim AY (2008), Bennett EJ (2010), Bennett EJ (2010), Monda JK (2013), Bommelje CC (2013), Meyer-Schaller N (2009), Meyer-Schaller N (2009), Kim AY (2008), Kim AY (2008), Huang G (2014), Huang G (2014), Monda JK (2013), Wan C (2015), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016), Keuss MJ (2016), Huttlin EL (2017)	19
HNRNPL	3	KLHL9	1	affinity chromatography technology	Fei T (2017)	1
DCUN1D1	0	NEDD8	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	KLHL22	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sumara I (2007), Bennett EJ (2010), Olma MH (2009), Maerki S (2009), Huttlin EL (2017), Ferretti LP (2016)	6
CEP170	4	KLHL9	1	bioid	Gupta GD (2015)	1
COPS5	0	PLK1	0	affinity chromatography technology	Bennett EJ (2010)	1
DCUN1D1	0	KLHL13	0	affinity chromatography technology	Bennett EJ (2010)	1
CUL4A	2	KLHL9	1	affinity chromatography technology	Bennett EJ (2010)	1
COPS6	0	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Angers S (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	12
COPS5	0	KLHL21	3	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	NUDCD3	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
AURKB	2	KLHL9	1	affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, pull down	Maerki S (2009), Maerki S (2009), Maerki S (2009), Sumara I (2007), Sumara I (2007), Sumara I (2007)	6
COPS6	0	KLHL22	3	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
COPS5	0	COPS6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, pull down, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Fang L (2008), Sharon M (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Choi HH (2011), Kristensen AR (2012), Birol M (2014), Birol M (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	18
KLHL13	0	KLHL9	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sumara I (2007), Sumara I (2007), Maerki S (2009), Maerki S (2009)	5
KLHL9	1	KLHL22	3	affinity chromatography technology, affinity chromatography technology	Maerki S (2009), Huttlin EL (2017)	2
CUL3	17	UBE2D1	0	pull down	Sumara I (2007)	1
COPS5	0	KLHL13	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Bennett EJ (2010)	3
NEDD8	0	KLHL22	3	affinity chromatography technology	Bennett EJ (2010)	1
USP25	0	KLHL9	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Xu D (2017)	2
NEDD8	0	KLHL9	1	affinity chromatography technology	Bennett EJ (2010)	1
KLHL21	3	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Maerki S (2009), Maerki S (2009), Bennett EJ (2010), Mei ZZ (2016), Huttlin EL (2017)	5
PLK1	0	KLHL21	3	affinity chromatography technology, affinity chromatography technology	Beck J (2013), Beck J (2013)	2
CUL3	17	HNRNPL	3	affinity chromatography technology	Bennett EJ (2010)	1
KLHL29	1	NUDCD3	0	affinity chromatography technology	Huttlin EL (2017)	1
DCUN1D1	0	KLHL22	3	affinity chromatography technology	Bennett EJ (2010)	1
CUL4A	2	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Angers S (2006), Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009)	7
COPS5	0	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Birol M (2014)	5
NEDD8	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Wimuttisuk W (2007)	4
COPS5	0	KLHL9	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2