PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAP2K1	8	BLM	2	genetic interference	Srivas R (2016)	1
BRD4	8	ATAD5	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rahman S (2011), Rahman S (2011), Rahman S (2011), Rahman S (2011)	4
BRAF	12	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
KRAS	1	RAF1	3	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, genetic interference, affinity chromatography technology, fluorescent resonance energy transfe	Li W (2000), Kiyono M (2000), Sui X (2009), Lito P (2012), Rajalingam K (2005), Zhu J (2005), Blaukat A (2000), So J (2015), Ji H (2016), Hart T (2015), Wang T (2017), Saito T (2004), Ivanov AA (2017)	13
YWHAB	1	KSR1	0	affinity chromatography technology	Couzens AL (2013)	1
VCP	6	YWHAE	0	affinity chromatography technology	Yu CC (2013)	1
YWHAE	0	KSR1	0	affinity chromatography technology	Gloeckner CJ (2007)	1
VCP	6	IQGAP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Fogeron ML (2013), Itoh N (2017), Itoh N (2017), Itoh N (2017)	4
MAP2K1	8	ING5	3	genetic interference	Srivas R (2016)	1
TRIM25	5	RBM33	8	affinity chromatography technology	Choudhury NR (2017)	1
HSPA1A	0	HSPA8	4	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
PPARG	0	MAP2K1	8	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down	Burgermeister E (2011), Burgermeister E (2011), Burgermeister E (2007), Burgermeister E (2007), Burgermeister E (2007)	5
MAP3K4	1	YWHAZ	1	two hybrid	Bandyopadhyay S (2010)	1
BTRC	1	HNRNPD	3	affinity chromatography technology, affinity chromatography technology	Coyaud E (2015), Li ML (2013)	2
VCP	6	CHEK1	2	affinity chromatography technology	Yu CC (2013)	1
BLM	2	UBE2I	0	two hybrid, affinity chromatography technology	Eladad S (2005), Eladad S (2005)	2
TRIM25	5	MYC	2	affinity chromatography technology	Choudhury NR (2017)	1
VAV1	2	CHEK1	2	affinity chromatography technology	Huttlin EL (2017)	1
RAF1	3	HSPA8	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Giommarelli C (2010), Zhu J (2005), Zhu J (2005), Zhu J (2005)	4
BTRC	1	DCP1A	1	bioid	Coyaud E (2015)	1
MAP2K1	8	TUSC3	1	genetic interference	Srivas R (2016)	1
VCP	6	RAF1	3	affinity chromatography technology	Yu CC (2013)	1
ARRB2	5	VCP	6	affinity chromatography technology	Xiao K (2007)	1
YWHAE	0	BRD4	8	imaging technique	Zippo A (2009)	1
VCP	6	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li JM (2013), Riemer A (2014), Zhang Z (2015)	3
MAPK1	1	FH	0	genetic interference	Srivas R (2016)	1
HNRNPD	3	UBE2I	0	two hybrid, pull down	Moraes KC (2003), Moraes KC (2003)	2
UBE2I	0	MAP2K1	8	enzymatic study	Kubota Y (2011)	1
HRAS	2	MAPK8	3	genetic interference	Spain BH (1996)	1
ELAVL1	0	RBM33	8	affinity chromatography technology	Abdelmohsen K (2009)	1
BRAF	12	IQGAP1	1	pull down, affinity chromatography technology, affinity chromatography technology	Ren JG (2008), Ren JG (2008), Eisenhardt AE (2016)	3
MAP2K1	8	GRB10	4	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Nantel A (1998), Nantel A (1998), Nantel A (1998), Nantel A (1998)	4
TRIM25	5	MAPK1	1	affinity chromatography technology	Choudhury NR (2017)	1
ELAVL1	0	VHL	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Abdelmohsen K (2009), Datta K (2005), Datta K (2005), Yuen JS (2007)	4
VAV1	2	RAF1	3	affinity chromatography technology	Song JS (1996)	1
BRD4	8	MAP2K1	8	genetic interference	Shen JP (2017)	1
KSR1	0	MAP2K1	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen C (2008), Harrison RE (2004), Gloeckner CJ (2007), Hein MY (2015)	4
BRAF	12	MAPK1	1	enzymatic study, genetic interference, enzymatic study	Ren JG (2008), Hart T (2015), Smith BD (2015)	3
MAP2K1	8	ARAF	0	affinity chromatography technology, enzymatic study, affinity chromatography technology	Gloeckner CJ (2007), Gan X (2013), Hein MY (2015)	3
TRIM25	5	ING5	3	affinity chromatography technology	Choudhury NR (2017)	1
POC5	5	MAP2K1	8	bioid	Gupta GD (2015)	1
PLAU	1	MAP2K1	8	genetic interference	Nguyen DH (1999)	1
KRAS	1	UBE2I	0	genetic interference	Luo J (2009)	1
BRAF	12	HDAC2	1	genetic interference	Shen JP (2017)	1
MAPK8IP3	9	RAF1	3	affinity chromatography technology, pull down, affinity chromatography technology	Kuboki Y (2000), Kuboki Y (2000), Ito M (1999)	3
TRIM25	5	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
GRB10	4	YWHAE	0	pull down, affinity chromatography technology, affinity chromatography technology	Urschel S (2005), Urschel S (2005), Urschel S (2005)	3
FGB	2	MAP2K1	8	affinity chromatography technology	Huttlin EL (2017)	1
MAPK1	1	KRAS	1	affinity chromatography technology, genetic interference	Blaukat A (2000), Hart T (2015)	2
MAPK1	1	RAF1	3	affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Lin YL (2000), Dougherty MK (2005), Zhu J (2005), Blaukat A (2000), Wang J (2009), Wang J (2009), Wang J (2009)	7
THOC2	4	MAP2K1	8	affinity chromatography technology	Hein MY (2015)	1
MAPK1	1	MTOR	14	genetic interference	Srivas R (2016)	1
HNRNPD	3	MAP2K1	8	two hybrid	Lehner B (2004)	1
YWHAB	1	MAP2K2	2	affinity chromatography technology, affinity chromatography technology	Stewart S (1999), Couzens AL (2013)	2
PSMD10	1	MAP2K1	8	affinity chromatography technology	Nanaware PP (2014)	1
CHEK1	2	ATAD5	5	genetic interference	Srivas R (2016)	1
MAPK8	3	YWHAZ	1	enzymatic study	Yoshida K (2005)	1
MYC	2	HDAC2	1	affinity chromatography technology, affinity chromatography technology	Koch HB (2007), Hwang IY (2012)	2
ARAF	0	YWHAE	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bandyopadhyay S (2010), Gloeckner CJ (2007), Choudhary C (2009), So J (2015)	4
RAF1	3	MAP3K1	4	affinity chromatography technology, affinity chromatography technology, pull down	Karandikar M (2000), Karandikar M (2000), Karandikar M (2000)	3
VCP	6	MTOR	14	affinity chromatography technology	Yu CC (2013)	1
ARRB2	5	MAP3K1	4	affinity chromatography technology, imaging technique	Xiao K (2007), Chen TC (2014)	2
CHEK1	2	TUSC3	1	genetic interference	Srivas R (2016)	1
YAP1	0	YWHAB	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Hauri S (2013), Enzo E (2015)	3
HRAS	2	BRAF	12	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Stang S (1997), Reuter CW (1995), Huttlin EL (2017), Eisenhardt AE (2016), Ivanov AA (2017)	5
KRAS	1	MAP2K1	8	genetic interference	Vizeacoumar FJ (2013)	1
BANP	1	MAPK8	3	affinity chromatography technology	Paul D (2017)	1
ELAVL1	0	YAP1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
MAPK3	4	RAF1	3	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Lin YL (2000), Wang J (2009), Wang J (2009), Wang J (2009)	4
ARAF	0	KRAS	1	two hybrid, affinity chromatography technology, fluorescent resonance energy transfe	Rolland T (2014), So J (2015), Ivanov AA (2017)	3
MAP2K1	8	WDR83	1	affinity chromatography technology	Vomastek T (2004)	1
MAP2K1	8	HSPA8	4	affinity chromatography technology	Gloeckner CJ (2007)	1
NFE2L2	1	HDAC2	1	affinity chromatography technology	Lee DY (2012)	1
YWHAB	1	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Couzens AL (2013), Wan C (2015), Hein MY (2015)	3
ELAVL1	0	PLAU	1	unspecified method, unspecified method	Tran H (2003), Tran H (2003)	2
VAV1	2	MAPK1	1	affinity chromatography technology, affinity chromatography technology	Song JS (1996), Lee IS (1997)	2
MAP2K1	8	ZNF277	1	affinity chromatography technology	Hein MY (2015)	1
HRAS	2	RAF1	3	two hybrid, two hybrid, pull down, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Stang S (1997), Germani A (2003), Mitin NY (2004), Vargiu P (2004), Yuryev A (2003), Li W (2000), Li W (2000), Kiyono M (2000), Janoueix-Lerosey I (1998), Boettner B (2000), Karbowniczek M (2006), Han L (1995), Jelinek T (1994), Romero F (1999), Morcos P (1996), Hu CD (1995), Hu CD (1995), Rodriguez-Viciana P (1997), Huang YZ (2003), Stang S (1997), Dougherty MK (2005), Ji H (2016), Fridman M (2000), Ivanov AA (2017)	24
MAP2K1	8	MAP2K1	8	enzymatic study, affinity chromatography technology	Zheng CF (1993), Gloeckner CJ (2007)	2
MYC	2	RAF1	3	pull down, affinity chromatography technology, fluorescent resonance energy transfe	Alexandrov I (1997), Koch HB (2007), Ivanov AA (2017)	3
ARAF	0	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
BTRC	1	PDLIM5	0	bioid	Coyaud E (2015)	1
YWHAE	0	WNK1	7	two hybrid	Bandyopadhyay S (2010)	1
IQGAP1	1	MAP2K1	8	affinity chromatography technology	Carmon KS (2014)	1
MAPK8	3	DCP1A	1	imaging technique	Wasserman T (2010)	1
KSR1	0	CHEK1	2	affinity chromatography technology	Boldt K (2016)	1
PLIN3	3	MAP2K1	8	biochemical	Wan C (2015)	1
HRAS	2	BTRC	1	pull down, affinity chromatography technology, affinity chromatography technology	Kim SE (2009), Kim SE (2009), Kim SE (2009)	3
GRB10	4	RAF1	3	biochemical, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Nantel A (1999), Nantel A (1999), Nantel A (1999), Nantel A (1998), Nantel A (1998), Nantel A (1998), Nantel A (1998)	7
MTOR	14	YWHAZ	1	affinity chromatography technology, genetic interference	Vander Haar E (2007), Srivas R (2016)	2
HRAS	2	MAP2K1	8	affinity chromatography technology	Jelinek T (1994)	1
RPE	3	MAP2K2	2	biochemical	Wan C (2015)	1
MYC	2	UBE2I	0	genetic interference	Toyoshima M (2012)	1
ELAVL1	0	MAP2K1	8	affinity chromatography technology	Abdelmohsen K (2009)	1
UBE2I	0	WNK1	7	enzymatic study	Gocke CB (2005)	1
YWHAZ	1	RAF1	3	pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Clark GJ (1997), Tzivion G (2000), Tzivion G (2000), Koyama S (1995), Koyama S (1995), Van Der Hoeven PC (2000), Chow CW (2000), Andersen SD (2012), Subramanian RR (2001), Wang H (1998), Wang H (1998), Wang H (1998), Dougherty MK (2005), Rajalingam K (2005), Zhu J (2005), So J (2015), Powell DW (2003), Ivanov AA (2017)	18
MAPK1	1	MAP3K1	4	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study	Karandikar M (2000), Karandikar M (2000), Gallagher ED (2004), Tu Z (2003), Loke J (2014)	5
MAPK3	4	BRAF	12	genetic interference, imaging technique	Guan KL (2000), Chen TC (2014)	2
MAP2K1	8	MAPK3	4	two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, enzymatic study, enzymatic study, pull down, affinity chromatography technology	Marti A (1997), Butch ER (1996), Schaeffer HJ (1998), Yung Y (2000), Yung Y (2000), Zheng CF (1993), Zheng CF (1993), Zheng CF (1993), Wang J (2009)	9
TRIM25	5	BANP	1	affinity chromatography technology	Choudhury NR (2017)	1
BRAF	12	HSPA8	4	affinity chromatography technology	Gloeckner CJ (2007)	1
TRIM25	5	HSPA8	4	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
LAMTOR2	0	MTOR	14	affinity chromatography technology	Sancak Y (2010)	1
MAP2K2	2	WDR83	1	affinity chromatography technology	Vomastek T (2004)	1
IQGAP1	1	MAPK3	4	biochemical	Bourguignon LY (2005)	1
UBE2I	0	MAP3K1	4	two hybrid, pull down, affinity chromatography technology	Saltzman A (1998), Saltzman A (1998), Kubota Y (2011)	3
BLM	2	VCP	6	genetic interference	Vizeacoumar FJ (2013)	1
VHL	0	HSPA1A	0	biochemical	Feldman DE (2003)	1
TRIM25	5	PTPN11	20	affinity chromatography technology	Choudhury NR (2017)	1
645455	0	MAP2K1	8	affinity chromatography technology	Hein MY (2015)	1
YWHAZ	1	BRAF	12	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Ewing RM (2007), Jin J (2004), Gloeckner CJ (2007), Hein MY (2015), Huttlin EL (2017), Eisenhardt AE (2016), Ivanov AA (2017)	7
PEBP1	0	MAPK1	1	pull down, pull down	Yeung K (2000), Yeung K (2000)	2
CHEK1	2	BLM	2	affinity chromatography technology, imaging technique, genetic interference	Sengupta S (2004), Sengupta S (2004), Srivas R (2016)	3
BRAF	12	YWHAE	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gloeckner CJ (2007), Gloeckner CJ (2007), Huttlin EL (2017), Eisenhardt AE (2016)	4
TRIM25	5	ZNF277	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	RAF1	3	affinity chromatography technology	Choudhury NR (2017)	1
KSR1	0	LSP1	3	affinity chromatography technology	Harrison RE (2004)	1
SKA3	3	MAP2K1	8	affinity chromatography technology	Hein MY (2015)	1
MYC	2	HSPA1A	0	affinity chromatography technology	Agrawal P (2010)	1
ARRB2	5	YWHAE	0	affinity chromatography technology	Xiao K (2007)	1
TRIM25	5	MTOR	14	affinity chromatography technology	Choudhury NR (2017)	1
ELAVL1	0	GRB10	4	affinity chromatography technology	Abdelmohsen K (2009)	1
MAPK1	1	CHEK1	2	biochemical	Wan C (2015)	1
MAPK3	4	WDR83	1	affinity chromatography technology	Vomastek T (2004)	1
YWHAE	0	MAP3K1	4	pull down	Fanger GR (1998)	1
PEBP4	1	MAP2K1	8	affinity chromatography technology, pull down	Wang X (2004), Wang X (2004)	2
MAP2K1	8	YWHAE	0	affinity chromatography technology	Gloeckner CJ (2007)	1
MAP2K1	8	WNK1	7	two hybrid	Bandyopadhyay S (2010)	1
ARRB2	5	MAPK3	4	affinity chromatography technology, imaging technique	Tohgo A (2003), Chen TC (2014)	2
MAP2K1	8	MAP2K2	2	biochemical, affinity chromatography technology	Stewart S (1999), Huttlin EL (2017)	2
HSPA8	4	WNK1	7	affinity chromatography technology	Huttlin EL (2017)	1
BRAP	0	BRAF	12	affinity chromatography technology	Chen C (2008)	1
BLM	2	MYC	2	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Chandra S (2013), Chandra S (2013), Chandra S (2013), Chandra S (2013)	4
MAP2K1	8	LSP1	3	affinity chromatography technology	Harrison RE (2004)	1
VCP	6	TRIM25	5	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Choudhury NR (2017)	2
ARRB2	5	HNRNPD	3	affinity chromatography technology	Xiao K (2007)	1
TRIM25	5	HSPA1A	0	affinity chromatography technology, affinity chromatography technology	Pauli EK (2014), Choudhury NR (2017)	2
MAP2K1	8	PTPN11	20	biochemical	Wan C (2015)	1
NFE2L2	1	MAPK8	3	affinity chromatography technology	Qin S (2014)	1
MAPK1	1	LAMTOR3	0	pull down	Wunderlich W (2001)	1
YWHAB	1	BRAF	12	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Qiu W (2000), Jin J (2004), Couzens AL (2013), Huttlin EL (2017), Eisenhardt AE (2016)	6
MAPK8	3	HSPA8	4	two hybrid	Vinayagam A (2011)	1
PLIN3	3	PDLIM5	0	biochemical	Kristensen AR (2012)	1
MAPK8IP3	9	MAP3K1	4	affinity chromatography technology	Ito M (1999)	1
ELAVL1	0	BTRC	1	affinity chromatography technology, affinity chromatography technology	Chu PC (2012), Chu PC (2012)	2
MAPK8IP3	9	MAP2K1	8	affinity chromatography technology, pull down, affinity chromatography technology	Kuboki Y (2000), Kuboki Y (2000), Ito M (1999)	3
MAPK3	4	DCP1A	1	two hybrid	Corominas R (2014)	1
NUFIP1	0	MAP2K1	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MYC	2	PLIN3	3	affinity chromatography technology	Hein MY (2015)	1
LSP1	3	BTRC	1	affinity chromatography technology	Huttlin EL (2017)	1
MYC	2	MAPK1	1	pull down, pull down	Jin Z (2004), Gupta S (1994)	2
ELAVL1	0	HDAC2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
PDLIM5	0	MAP2K2	2	biochemical	Wan C (2015)	1
BRAF	12	KRAS	1	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Huttlin EL (2017), Eisenhardt AE (2016), Ivanov AA (2017)	3
CHEK1	2	MAP2K1	8	genetic interference	Shen JP (2017)	1
ELAVL1	0	VCP	6	affinity chromatography technology, pull down	Zhou HL (2013), Zhou HL (2013)	2
BRAP	0	MAP2K1	8	affinity chromatography technology	Chen C (2008)	1
MAP2K1	8	KSR2	6	affinity chromatography technology	Channavajhala PL (2003)	1
YWHAB	1	PPARG	0	affinity chromatography technology, affinity chromatography technology	Park S (2015), Park S (2015)	2
RAF1	3	YWHAB	1	two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yuryev A (2003), Truong AB (2002), Van Der Hoeven PC (2000), Yuryev A (2000), Vincenz C (1996), Conklin DS (1995), Subramanian RR (2001), Rajalingam K (2005), Zhu J (2005), Couzens AL (2013), So J (2015)	11
ELAVL1	0	YWHAB	1	affinity chromatography technology	Abdelmohsen K (2009)	1
YWHAE	0	HSPA8	4	affinity chromatography technology	Gloeckner CJ (2007)	1
LAMTOR2	0	LAMTOR3	0	two hybrid, pull down, affinity chromatography technology, biochemical, two hybrid, two hybrid, affinity chromatography technology, two hybrid	Wunderlich W (2001), Wunderlich W (2001), Wunderlich W (2001), Havugimana PC (2012), Wang J (2011), Rolland T (2014), Sancak Y (2010), Yu H (2011)	8
ELAVL1	0	LAMTOR3	0	affinity chromatography technology	Abdelmohsen K (2009)	1
BRAF	12	RAF1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Weber CK (2001), Weber CK (2001), Kilili GK (2010), Chen C (2008), Chen C (2008), Lito P (2012), Huttlin EL (2017)	7
MAPK3	4	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Wang J (2009), Wang J (2009), Wan C (2015), Hu B (2006)	6
YAP1	0	MAP2K1	8	affinity chromatography technology	Li L (2013)	1
NFE2L2	1	MAP2K1	8	affinity chromatography technology	Qin S (2014)	1
MAP2K1	8	YWHAZ	1	affinity chromatography technology	Gloeckner CJ (2007)	1
MAP2K1	8	BANP	1	two hybrid	Rolland T (2014)	1
ARRB2	5	YWHAB	1	affinity chromatography technology	Xiao K (2007)	1
TRIM25	5	MAP2K1	8	affinity chromatography technology	Choudhury NR (2017)	1
MAP2K2	2	ARAF	0	two hybrid, pull down, two hybrid, affinity chromatography technology	Yin XL (2002), Yin XL (2002), Wang J (2011), So J (2015)	4
YWHAZ	1	WNK1	7	two hybrid	Bandyopadhyay S (2010)	1
DCP1A	1	MAP2K1	8	affinity chromatography technology	Hein MY (2015)	1
TRIM25	5	YWHAZ	1	affinity chromatography technology	Choudhury NR (2017)	1
ELAVL1	0	BRD4	8	affinity chromatography technology	Abdelmohsen K (2009)	1
WDR83	1	LAMTOR3	0	affinity chromatography technology	Vomastek T (2004)	1
YAP1	0	YWHAZ	1	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, fluorescent resonance energy transfe	Couzens AL (2013), Mo XL (2015), Zhang B (2017), Ivanov AA (2017)	4
YAP1	0	BTRC	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Zhao B (2010), Zhao B (2010), Vinayagam A (2011), Huttlin EL (2017)	4
MAP3K1	4	MAPK8	3	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, imaging technique	Xu S (1997), Xu S (1997), Xu S (1997), Xu S (1997), Ryoo K (2004), Tu Z (2003), Sun BK (2011), Gallagher ED (2002), Chen TC (2014)	9
MAPK1	1	MAP2K1	8	affinity chromatography technology, enzymatic study, two hybrid, pull down, pull down, pull down, enzymatic study, affinity chromatography technology, enzymatic study, protein complementation assay, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Sanz-Moreno V (2003), Sanz-Moreno V (2003), Robinson FL (2002), Yeung K (2000), Yeung K (2000), Wunderlich W (2001), Xu Be (2001), Xu Be (2001), Chen Z (2001), Srivastav RK (2011), Kubota Y (2011), Ho DT (2003), Wang J (2009), Jahrling JB (2014)	14
MAP3K8	2	KSR2	6	affinity chromatography technology, affinity chromatography technology	Channavajhala PL (2003), Channavajhala PL (2003)	2
TRIM25	5	IQGAP1	1	affinity chromatography technology	Choudhury NR (2017)	1
HNRNPD	3	CHEK1	2	biochemical	Wan C (2015)	1
YAP1	0	HDAC2	1	affinity chromatography technology	Enzo E (2015)	1
TCTN1	2	MAP2K1	8	bioid	Gupta GD (2015)	1
MAP3K1	4	MAPK3	4	enzymatic study, imaging technique	Loke J (2014), Chen TC (2014)	2
TRIM25	5	DCP1A	1	affinity chromatography technology	Choudhury NR (2017)	1
UBE2I	0	PPARG	0	enzymatic study, fluorescent resonance energy transfe, affinity chromatography technology	Ogawa H (2009), Hartig SM (2015), Hartig SM (2015)	3
MAPK1	1	PPARG	0	affinity chromatography technology, affinity chromatography technology	Jahrling JB (2014), Chen F (2003)	2
HDAC2	1	VHL	0	pull down, affinity chromatography technology, genetic interference	Mahon PC (2001), Hwang IY (2012), Shen JP (2017)	3
TRIM25	5	YWHAB	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	WNK1	7	affinity chromatography technology	Choudhury NR (2017)	1
RAF1	3	WDR83	1	affinity chromatography technology	Vomastek T (2004)	1
YWHAE	0	YWHAB	1	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Couzens AL (2013), Wan C (2015)	4
YWHAB	1	MAP2K1	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stewart S (1999), Gloeckner CJ (2007), Couzens AL (2013)	3
CHEK1	2	TTN	102	genetic interference	Srivas R (2016)	1
MYC	2	YWHAB	1	affinity chromatography technology	Koch HB (2007)	1
TRIM25	5	YWHAE	0	affinity chromatography technology	Choudhury NR (2017)	1
VHL	0	HSPA8	4	affinity chromatography technology, pull down	Lai Y (2011), Lai Y (2012)	2
HNRNPD	3	HSPA8	4	affinity chromatography technology, affinity chromatography technology, biochemical	Sinsimer KS (2008), Laroia G (1999), Wan C (2015)	3
MAP2K1	8	MTOR	14	genetic interference	Srivas R (2016)	1
MAP2K1	8	BRAF	12	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, genetic interference, affinity chromatography technology	Loewenberg M (2006), Kilili GK (2010), Chen C (2008), Pardo OE (2006), Gloeckner CJ (2007), Gloeckner CJ (2007), Hein MY (2015), Huttlin EL (2017), Xie P (2009), Xie P (2009), Hart T (2015), Eisenhardt AE (2016)	12
MAPK8IP3	9	MAPK8	3	pull down, pull down, enzymatic study	Ito M (1999), Kelkar N (2000), Kelkar N (2000)	3
DGUOK	1	MAP2K1	8	affinity chromatography technology	Huttlin EL (2015)	1
RAF1	3	YWHAE	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vincenz C (1996), Conklin DS (1995), Subramanian RR (2001), Gloeckner CJ (2007), Rajalingam K (2005), Zhu J (2005), Choudhary C (2009), Choudhary C (2009), So J (2015)	9
LAMTOR3	0	MAPK3	4	affinity chromatography technology	Schaeffer HJ (1998)	1
MAPK1	1	BANP	1	enzymatic study	Nakka KK (2015)	1
HNRNPD	3	MAP3K4	1	affinity chromatography technology	Hein MY (2015)	1
VCP	6	MAPK1	1	affinity chromatography technology	Yu CC (2013)	1
TRIM25	5	MAP2K2	2	affinity chromatography technology	Choudhury NR (2017)	1
BRAF	12	ARAF	0	affinity chromatography technology, imaging technique, affinity chromatography technology, fluorescent resonance energy transfe	Gloeckner CJ (2007), Chen TC (2014), Huttlin EL (2017), Ivanov AA (2017)	4
PEBP4	1	RAF1	3	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Wang X (2004), Wang X (2004), Garcia R (2009), Garcia R (2009)	4
ARAF	0	HRAS	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
STK11	2	TRIM25	5	two hybrid	Arroyo R (2015)	1
MAP3K4	1	MAPK8	3	enzymatic study, affinity chromatography technology	Sun BK (2011), Hein MY (2015)	2
IQGAP1	1	MAP2K2	2	affinity chromatography technology	Carmon KS (2014)	1
HNRNPD	3	MTOR	14	affinity chromatography technology	Hein MY (2015)	1
STK11	2	HSPA1A	0	affinity chromatography technology	Brajenovic M (2004)	1
MAPK8	3	MAP2K2	2	unspecified method	Ho DT (2006)	1
ARAF	0	MYC	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ARAF	0	WNK1	7	two hybrid	Wang J (2011)	1
MAP2K1	8	ATAD5	5	genetic interference	Srivas R (2016)	1
MAP2K1	8	PEBP1	0	pull down, pull down	Yeung K (2000), Yeung K (2000)	2
VCP	6	MAPK3	4	affinity chromatography technology	Yu CC (2013)	1
ELAVL1	0	MYC	2	affinity chromatography technology	Abdelmohsen K (2009)	1
BRAF	12	VHL	0	genetic interference	Shen JP (2017)	1
YWHAB	1	WNK1	7	affinity chromatography technology	Couzens AL (2013)	1
VCP	6	MAP2K1	8	affinity chromatography technology	Yu CC (2013)	1
MYC	2	BTRC	1	affinity chromatography technology, enzymatic study	Popov N (2010), Popov N (2010)	2
CHEK1	2	VHL	0	genetic interference	Shen JP (2017)	1
ELAVL1	0	KRAS	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ARAF	0	YWHAZ	1	two hybrid, affinity chromatography technology, fluorescent resonance energy transfe	Bandyopadhyay S (2010), So J (2015), Ivanov AA (2017)	3
YWHAZ	1	YWHAE	0	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, biochemical, biochemical, affinity chromatography technology, pull down	Bandyopadhyay S (2010), Zippo A (2009), Zippo A (2009), Havugimana PC (2012), Gloeckner CJ (2007), Wang J (2011), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Gu YM (2006)	10
KAT7	3	ING5	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Doyon Y (2006), Doyon Y (2006), Doyon Y (2006), Iizuka M (2008), Huttlin EL (2017)	6
IQGAP1	1	MAPK1	1	biochemical, affinity chromatography technology	Bourguignon LY (2005), Bourguignon LY (2005)	2
MAPK1	1	WDR83	1	affinity chromatography technology	Vomastek T (2004)	1
VHL	0	HNRNPD	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down	Lai Y (2011), Xin H (2011), Xin H (2011), Xin H (2011), Xin H (2011), Xin H (2011)	6
HSPA8	4	VCP	6	affinity chromatography technology, biochemical, affinity chromatography technology	Vij N (2006), Havugimana PC (2012), Yu CC (2013)	3
TRIM25	5	HNRNPD	3	affinity chromatography technology	Choudhury NR (2017)	1
CHEK1	2	MTOR	14	genetic interference, genetic interference, genetic interference	Shen JP (2017), Srivas R (2016), Srivas R (2016)	3
RAF1	3	BRAP	0	affinity chromatography technology	Chen C (2008)	1
MAPK8	3	MYC	2	enzymatic study, pull down, affinity chromatography technology	Noguchi K (1999), Noguchi K (1999), Noguchi K (1999)	3
ARRB2	5	HDAC2	1	affinity chromatography technology	Xiao K (2007)	1
BRAP	0	KSR1	0	affinity chromatography technology	Chen C (2008)	1
VCP	6	HSPA1A	0	affinity chromatography technology	Yu CC (2013)	1
MYC	2	WNK1	7	genetic interference	Toyoshima M (2012)	1
MAP2K2	2	MAPK1	1	two hybrid, protein complementation assay, pull down, enzymatic study	Robinson FL (2002), Srivastav RK (2011), Ho DT (2003), Ho DT (2003)	4
TRIM25	5	BTRC	1	affinity chromatography technology	Choudhury NR (2017)	1
MAP2K2	2	RAF1	3	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid	Xia Y (1998), Wang J (2011), Wang J (2009), Johnson SE (2006)	4
YAP1	0	YWHAE	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), Hauri S (2013), Enzo E (2015)	3
MAP2K1	8	RBM33	8	affinity chromatography technology	Hein MY (2015)	1
MYC	2	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MAP2K1	8	STK11	2	genetic interference	Srivas R (2016)	1
BTRC	1	YWHAZ	1	affinity chromatography technology	Coyaud E (2015)	1
MYC	2	NFE2L2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Levy S (2010), Levy S (2010), Ramani K (2012)	3
MAP2K1	8	TTN	102	genetic interference	Srivas R (2016)	1
MYC	2	BRD4	8	genetic interference	Toyoshima M (2012)	1
BTRC	1	MAP2K1	8	affinity chromatography technology, affinity chromatography technology	Li L (2013), Li L (2013)	2
MAP2K2	2	MAPK3	4	two hybrid, enzymatic study, enzymatic study, enzymatic study, pull down	Marti A (1997), Butch ER (1996), Zheng CF (1993), Zheng CF (1993), Zheng CF (1993)	5
YAP1	0	VCP	6	affinity chromatography technology	Enzo E (2015)	1
MAPK8	3	RAF1	3	two hybrid	Wang J (2011)	1
PDLIM5	0	MAP2K1	8	biochemical	Wan C (2015)	1
VCP	6	YWHAB	1	affinity chromatography technology	Yu CC (2013)	1
BTRC	1	NFE2L2	1	affinity chromatography technology, bioid	Loveless TB (2015), Coyaud E (2015)	2
MYC	2	YWHAE	0	affinity chromatography technology	Koch HB (2007)	1
BRAF	12	MAP2K2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gloeckner CJ (2007), Huttlin EL (2017), Eisenhardt AE (2016)	3
HRAS	2	BRAP	0	affinity chromatography technology	Matheny SA (2004)	1
ARRB2	5	MAP2K1	8	affinity chromatography technology	Luttrell LM (2001)	1
MAP2K1	8	LAMTOR2	0	affinity chromatography technology	Wunderlich W (2001)	1
HNRNPD	3	MYC	2	unspecified method	Lu M (2013)	1
KSR1	0	BRAF	12	affinity chromatography technology	Chen C (2008)	1
KSR1	0	RAF1	3	enzymatic study	Mueller J (2001)	1
RNASE9	1	MAP2K1	8	affinity chromatography technology	Huttlin EL (2017)	1
MAPK1	1	TTN	102	enzymatic study, genetic interference	Raskin A (2012), Srivas R (2016)	2
FGB	2	PTPN11	20	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	PTPN11	20	affinity chromatography technology	Abdelmohsen K (2009)	1
CHEK1	2	BRD4	8	genetic interference	Srivas R (2016)	1
MAP3K8	2	MAP2K1	8	enzymatic study, enzymatic study	Salmeron A (1996), Eliopoulos AG (2006)	2
MAPK8	3	MAP2K1	8	unspecified method	Ho DT (2006)	1
PLAU	1	HRAS	2	genetic interference	Nguyen DH (1999)	1
UBE2I	0	IQGAP1	1	enzymatic study	Matafora V (2009)	1
BTRC	1	YWHAE	0	affinity chromatography technology	Coyaud E (2015)	1
MYC	2	VHL	0	affinity chromatography technology, affinity chromatography technology	Hwang IY (2012), Hwang IY (2012)	2
HDAC2	1	MAP2K1	8	genetic interference	Shen JP (2017)	1
ARRB2	5	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Shenoy SK (2005), Luttrell LM (2001), Xiao K (2007), Chen TC (2014)	4
MAPK8	3	MTOR	14	affinity chromatography technology	Kwak D (2012)	1
KRAS	1	BTRC	1	affinity chromatography technology	Shukla S (2014)	1
MYC	2	MAP2K1	8	affinity chromatography technology	Hein MY (2015)	1
YWHAZ	1	BRD4	8	imaging technique	Zippo A (2009)	1
KRAS	1	WDR83	1	genetic interference	Luo J (2009)	1
MAP3K4	1	MAP2K1	8	enzymatic study	Chan-Hui PY (1998)	1
MAP2K1	8	HSPA1A	0	affinity chromatography technology	Gloeckner CJ (2007)	1
VCP	6	YWHAZ	1	affinity chromatography technology, two hybrid	Yu CC (2013), Wang J (2011)	2
MAP2K1	8	LAMTOR3	0	affinity chromatography technology, two hybrid, affinity chromatography technology	Wunderlich W (2001), Schaeffer HJ (1998), Schaeffer HJ (1998)	3
BRAF	12	HSPA1A	0	affinity chromatography technology	Gloeckner CJ (2007)	1
YWHAE	0	HSPA1A	0	affinity chromatography technology	Gloeckner CJ (2007)	1
ARRB2	5	RAF1	3	affinity chromatography technology	Luttrell LM (2001)	1
HNRNPD	3	WNK1	7	biochemical	Kristensen AR (2012)	1
NFE2L2	1	MAP2K2	2	affinity chromatography technology	Qin S (2014)	1
MAP2K1	8	FH	0	genetic interference	Srivas R (2016)	1
MAP2K1	8	RAF1	3	pull down, pull down, pull down, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Yeung K (2000), Yeung K (2000), Dasgupta P (2004), Dasgupta P (2004), Dasgupta P (2004), Boussiotis VA (1997), Kilili GK (2010), Kubota Y (2011), Madonna S (2008), Takekawa M (2005), Gloeckner CJ (2007), Zhu J (2005), Zhu J (2005), Blaukat A (2000), Wang J (2009), Hein MY (2015), Mitra S (2016)	17
PEBP1	0	RAF1	3	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yeung K (2000), Yeung K (2000), Yeung K (2000), Lorenz K (2003), Zhao J (2011), Zhao J (2011)	6
HSPA8	4	MAP2K2	2	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	BRD4	8	affinity chromatography technology	Choudhury NR (2017)	1
MYC	2	MAPK3	4	pull down	Jin Z (2004)	1
MAP2K1	8	KAT7	3	enzymatic study	Zou C (2013)	1
VAV1	2	MAP2K1	8	affinity chromatography technology	Song JS (1996)	1
MAP2K1	8	MAP3K1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Karandikar M (2000), Karandikar M (2000), Tu Z (2003)	3
RPE	3	MAP2K1	8	biochemical	Wan C (2015)	1
MAP3K1	4	VHL	0	genetic interference	Shen JP (2017)	1
VCP	6	WNK1	7	affinity chromatography technology	Yu CC (2013)	1
YWHAB	1	ARAF	0	affinity chromatography technology, affinity chromatography technology	Couzens AL (2013), So J (2015)	2
MAP2K1	8	VHL	0	genetic interference	Shen JP (2017)	1
ARRB2	5	HSPA8	4	affinity chromatography technology, affinity chromatography technology	Xiao K (2007), Xiao K (2007)	2
BTRC	1	YWHAB	1	affinity chromatography technology	Coyaud E (2015)	1
MYC	2	PLAU	1	two hybrid	Wang J (2011)	1