Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
PTEN 5728 AZD-8186 CHEMBL3545424 OncoKB, CKB, CIViC 26469692, 22588880, 24658109, 25544636, 25673820, 22261591, 20166697, 18594509, 23769634, 25398829, 21325073, 16647110, 25177151, 24823695, 25514658
PTEN 5728 LY-3023414 CHEMBL3544999 OncoKB, CKB 26469692, 22588880, 24658109, 25544636, 25673820, 22261591, 20166697, 18594509, 23769634, 25398829, 21325073, 16647110, 25177151, 24823695, 21575859, 27439478
PTEN 5728 GEDATOLISIB CHEMBL592445 ClearityFoundationBiomarkers, OncoKB, CKB 26469692, 22588880, 24658109, 25544636, 25673820, 22261591, 20166697, 18594509, 23769634, 25398829, 21325073, 16647110, 25177151, 24823695, 17314276, 14737113
PTEN 5728 PANITUMUMAB CHEMBL1201827 ClearityFoundationBiomarkers, CGI
PTEN 5728 COPANLISIB CHEMBL3218576 ClearityFoundationBiomarkers, CKB 27672108
PTEN 5728 CETUXIMAB CHEMBL1201577 ClearityFoundationBiomarkers, CGI, CIViC 21163703
PTEN 5728 ZSTK-474 CHEMBL586701 ClearityFoundationBiomarkers
PTEN 5728 DS-7423 CHEMBL3545248 ClearityFoundationBiomarkers, CKB 24504419
PTEN 5728 VOXTALISIB CHEMBL3545366 ClearityFoundationBiomarkers, CKB 24634413
PTEN 5728 TRASTUZUMAB CHEMBL1201585 CKB, CGI, CIViC 20813970, 15324695, 16404430, 24470511, 17936563, 21676217
PTEN 5728 BUPARLISIB CHEMBL2017974 CKB, CIViC 24470511, 28119489, 26098748, 25672916
PTEN 5728 CARBOPLATIN CHEMBL1351 CIViC 25672916
PTEN 5728 MK-2206 CHEMBL1079175 CKB, CIViC 24504448, 21289267, 24265152, 22025163, 26187616, 28178345
PTEN 5728 BAY-1125976 CHEMBL3545049 CKB 27699769
PTEN 5728 METFORMIN CHEMBL1431 CKB 24077915, 26921394
PTEN 5728 ARQ-092 CHEMBL3545422 CKB 26469692
PTEN 5728 AEW-541 CHEMBL551064 CKB 26577700
PTEN 5728 INK-128 CHEMBL3545056 CKB 26272063, 27974663, 25261369
PTEN 5728 TALAZOPARIB CHEMBL3137320 CKB 23881923
PTEN 5728 VENETOCLAX CHEMBL3137309 CKB 27974663
PTEN 5728 VELIPARIB CHEMBL506871 CKB
PTEN 5728 NIRAPARIB CHEMBL1094636 CKB
PTEN 5728 ABIRATERONE CHEMBL254328 CKB
PTEN 5728 OLAPARIB CHEMBL521686 OncoKB, CKB 20944090, 20049735, 20530668, 26187614, 21468130, 26469692, 22588880, 24658109, 25544636, 25673820, 22261591, 20166697, 18594509, 23769634, 25398829, 21325073, 16647110, 25177151, 24823695
PTEN 5728 PALBOCICLIB CHEMBL189963 OncoKB, CKB 26469692, 22588880, 24658109, 25544636, 25673820, 22261591, 20166697, 18594509, 23769634, 25398829, 21325073, 16647110, 25177151, 24823695, 27020857
PTEN 5728 AZD-5363 CHEMBL2178577 OncoKB, CKB, CIViC 26469692, 22588880, 24658109, 25544636, 25673820, 22261591, 20166697, 18594509, 23769634, 25398829, 21325073, 16647110, 25177151, 24823695, 22294718, 26910118
PTEN 5728 TEMSIROLIMUS CHEMBL1201182 ClearityFoundationBiomarkers, CKB, CIViC 11504908, 23674493, 27016228
PTEN 5728 OMIPALISIB CHEMBL1236962 ClearityFoundationBiomarkers
PTEN 5728 PF-04691502 CHEMBL1234354 ClearityFoundationBiomarkers, CKB 21750219
PTEN 5728 SIROLIMUS CHEMBL413 CGI
PTEN 5728 PACLITAXEL CHEMBL428647 CKB, CIViC 25672916, 25833835, 25637314
PTEN 5728 VEMURAFENIB CHEMBL1229517 CKB 24265152, 24265153, 27196754, 27048951
PTEN 5728 AZD-6482 CHEMBL2165191 CKB 26504226, 26577700, 23674493
PTEN 5728 BINIMETINIB CHEMBL3187723 CKB 26577700, 26206338
PTEN 5728 INFIGRATINIB CHEMBL1852688 CKB 28119489
PTEN 5728 SAR-260301 CHEMBL3545008 CKB 24387221, 27196754
PTEN 5728 PKI-179 CHEMBL1258517 CKB 20797855
PTEN 5728 RUCAPARIB CHEMBL1173055 CKB 23565244
PTEN 5728 MSC-2363318A CHEMBL3545003 CKB 27186432
PTEN 5728 IDELALISIB CHEMBL2216870 CKB 28178345
PTEN 5728 PLX-4720 CHEMBL1230020 CKB 24265153
PTEN 5728 ALPELISIB CHEMBL2396661 ClearityFoundationBiomarkers, CKB, CGI 26504226, 28119489, 26577700, 27604488, 25544636
PTEN 5728 KX2-391 CHEMBL571546 CKB 24100628
PTEN 5728 OXALIPLATIN CHEMBL414804 CKB 24100628
PTEN 5728 ENCORAFENIB CHEMBL3301612 CKB 26577700
PTEN 5728 PICTILISIB CHEMBL521851 CKB 26058079, 28119489, 26733612, 26577700, 27020857, 24322983, 23136191, 24265153, 19276360, 22693356, 9661880
PTEN 5728 TASELISIB CHEMBL2387080 CKB 26589432
PTEN 5728 PD-0325901 CHEMBL507361 CKB 26272063
PTEN 5728 SF-1126 CHEMBL2326966 CKB 18172313, 24634413
PTEN 5728 UPROSERTIB CHEMBL3137336 CKB 24265152
PTEN 5728 CHEMBL376408 CHEMBL376408 CKB 27974663
PTEN 5728 BENZONATATE CHEMBL1374379 CKB
PTEN 5728 OSI-027 CHEMBL3120215 CKB 21673091
PTEN 5728 VS-5584 CHEMBL1079593 CKB 23270925
PTEN 5728 GSK-2636771 CHEMBL3188551 inhibitor OncoKB, CKB, MyCancerGenomeClinicalTrial 26469692, 22588880, 24658109, 25544636, 25673820, 22261591, 20166697, 18594509, 23769634, 25398829, 21325073, 16647110, 25177151, 24823695, 26577700, 23674493, 26645196, 26117819
PTEN 5728 ENZALUTAMIDE CHEMBL1082407 OncoKB, CKB, CIViC 21575859, 25544636
PTEN 5728 EVEROLIMUS CHEMBL1908360 ClearityFoundationBiomarkers, CKB, CGI, CIViC 23582881, 23989949, 27091708, 21358673, 22662154, 26951309, 28330462, 22473592, 20664174, 20664172
PTEN 5728 DACTOLISIB CHEMBL1879463 ClearityFoundationBiomarkers, CKB 26232337, 22662154, 26206338, 27974663, 28446642
PTEN 5728 IPATASERTIB CHEMBL2177390 CKB, CIViC 27872130, 24141624, 23287563
PTEN 5728 CI-1040 CHEMBL105442 CIViC 24504448
PTEN 5728 GSK-2256098 CHEMBL3544967 CKB 25833835
PTEN 5728 TOPOTECAN CHEMBL84 CKB 25833835
PTEN 5728 APITOLISIB CHEMBL1922094 CKB 26951309
PTEN 5728 CUDC-907 CHEMBL3545052 CKB 22693356
PTEN 5728 DACOMITINIB CHEMBL2110732 CKB 26561558, 25939761
PTEN 5728 CHEMBL589258 CHEMBL589258 CKB 20371716
PTEN 5728 Panulisib CHEMBL3545322 CKB 25700704
PTEN 5728 CHEMBL263664 CHEMBL263664 CKB 21191045
PTEN 5728 RG-7666 CHEMBL3545324 CKB 27638506
PTEN 5728 RIGOSERTIB CHEMBL1241855 CKB
PTEN 5728 Acalisib CHEMBL3545397 CKB
PTEN 5728 CHEMBL1765740 CHEMBL1765740 CKB 28178345
PTEN 5728 KU-55933 CHEMBL222102 CKB 25870146
PTEN 5728 CC-223 CHEMBL3545151 CKB 26177599
PTEN 5728 VORINOSTAT CHEMBL98 CKB 22693356, 9661880
PTEN 5728 PROGESTERONE CHEMBL103 NCI 14557489
PTEN 5728 CHEMBL387187 CHEMBL387187 CIViC 16282176
PTEN 5728 NIVOLUMAB CHEMBL2108738 CKB 26645196
PTEN 5728 Refametinib CHEMBL2138601 CKB 23434733
PTEN 5728 E-6201 CHEMBL1097999 CKB 23039341
PTEN 5728 LINSITINIB CHEMBL1091644 CKB 26561558
PTEN 5728 PEMETREXED (CHEMBL1201258) CHEMBL1201258 CKB 27213589
PTEN 5728 CANDICIDIN CHEMBL1200647 CKB 26839307
PTEN 5728 AT-13148 CHEMBL3544960 CKB 22781553
PTEN 5728 GEMCITABINE CHEMBL888 CKB 28750271
PTEN 5728 AZD-8055 CHEMBL1801204 CKB 28446642
PTEN 5728 VANDETANIB CHEMBL24828 ClearityFoundationBiomarkers, CKB 25910950
PTEN 5728 TEMOZOLOMIDE CHEMBL810 CKB 25910950
PTEN 5728 U-0126 CHEMBL100473 CKB 21358673
PTEN 5728 PA-799 CHEMBL1684984 CKB 21558396
PTEN 5728 CHEMBL525191 CHEMBL525191 CKB 19276360
PTEN 5728 LY-294002 CHEMBL98350 CIViC 15324695
PTEN 5728 PEMBROLIZUMAB CHEMBL3137343 CKB 26645196
PTEN 5728 NAVITOCLAX CHEMBL443684 CKB 26474387
PTEN 5728 FULVESTRANT CHEMBL1358 CKB 26733612
PTEN 5728 LY-2780301 CHEMBL3545134 CKB 28750271
PTEN 5728 ERLOTINIB CHEMBL553 ClearityFoundationBiomarkers, CIViC 16282176
PTEN 5728 GEFITINIB CHEMBL939 ClearityFoundationBiomarkers, CKB, CIViC 16282176, 26561558
PTEN 5728 SELUMETINIB CHEMBL1614701 CKB 26232337, 21358673, 27196754
PTEN 5728 2-METHOXYESTRADIOL CHEMBL299613 CKB 24162827
PTEN 5728 PHENMETRAZINE CHEMBL1201208 CKB 23674493, 21668414
PTEN 5728 PILARALISIB (CHEMBL3218575) CHEMBL3218575 CKB 25637314
PTEN 5728 BMS-754807 CHEMBL575448 CKB 26561558
PTEN 5728 SORAFENIB CHEMBL1336 CKB 27213589

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
PTEN rs17431184 C capecitabine efficacy not stated pfSNP identified 2800 SNPS associated with key-words: 5-FU, capecitabine and oxilaplatin and colorectal cancer. Various criteria were used to determine 1536 SNPs to genotype. These SNPs were genotyped in a discovery cohort (N=62) and tested in a validation cohort (N=27). Both cohorts consisted of patients with colorectal cancer metastasis in liver. Five SNPs (rs2289310 G>T; rs1047840 G>A; rs17431184 T>C; rs17160359 G>T; rs2236722 A>G) were identified as distinguishing the "non-responder" phenotype from the "responder" phenotype when using a logistic regression multivariate model. The AUC for the receiver operating characteristic curve of the 5 SNPs is 0.875. This logistic-based multivariate model is said to be able to identify 39.1% of non-responders. Allele C is associated with increased response to capecitabine and fluorouracil in people with Neoplasm Metastasis as compared to allele T. 25372392 1185002474