PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PLK1	0	CTNNB1	30	affinity chromatography technology, affinity chromatography technology	Lin DC (2011), Lin DC (2011)	2
TP53	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Wang C (2003), Akakura S (2001), Peng Y (2001), Nagata Y (1999), Wang J (2011), Burch L (2004), Taipale M (2012), Fogeron ML (2013), Walerych D (2004)	9
USP13	2	UBC	7	enzymatic study, pull down, pull down, pull down, pull down	Zhang YH (2012), Nathan JA (2013), Zhang YH (2012), Zhang X (2017), Kwasna D (2018)	5
CSNK2A2	1	CSNK2A1	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), So J (2015), Huttlin EL (2015), Wan C (2015), Gao Z (2014), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	9
PTEN	24	CASP8	1	affinity chromatography technology, affinity chromatography technology	Crockett DK (2005), Crockett DK (2005)	2
USP7	14	WWP2	7	two hybrid, affinity chromatography technology	Lim J (2006), Chaudhary N (2014)	2
RNF146	4	TNKS	12	pull down	DaRosa PA (2014)	1
WWP2	7	WWP1	3	affinity chromatography technology, affinity chromatography technology	Chaudhary N (2014), Chaudhary N (2014)	2
PTK2	2	TP53	0	affinity chromatography technology, pull down, imaging technique	Lim ST (2008), Lim ST (2008), Chen TC (2014)	3
ANAPC4	0	ANAPC5	2	biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Havugimana PC (2012), Zhang Z (2012), Chang L (2014), Vodermaier HC (2003), Vodermaier HC (2003), Chang L (2015), Yamaguchi M (2015), Wan C (2015)	8
FZR1	1	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
USP13	2	PTEN	24	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, imaging technique, affinity chromatography technology, enzymatic study	Zhang J (2013), Zhang J (2013), Zhang J (2013), Zhang J (2013), Geng J (2015), Geng J (2015), Geng J (2015), Yuan L (2015)	8
CASP8	1	PARK7	0	pull down	Fu K (2012)	1
NDFIP1	0	PTEN	24	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay	Mund T (2010), Howitt J (2012), Howitt J (2012), Li Y (2014)	4
TP53	0	PARK7	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fan J (2008), Fan J (2008), Kim SJ (2012)	3
BMI1	0	AR	3	affinity chromatography technology	Cao Q (2014)	1
AKT1	1	AR	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin HK (2001), Lin HK (2001), Deep G (2008), Deep G (2008), Steely AM (2017)	5
CBL	7	PIK3R2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Lin H (2001), Hartley D (1995), Feshchenko EA (2004), Alcazar I (2009), Brehme M (2009), Brehme M (2009), Grossmann A (2015)	7
SHARPIN	1	PTEN	24	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	He L (2010), He L (2010), De Melo J (2014), De Melo J (2014)	4
CDC27	2	ANAPC5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Koloteva-Levine N (2004), Gmachl M (2000), Kraft C (2003), Lara-Gonzalez P (2011), Dube P (2005), Fehr AR (2012), Holzmann J (2011), Havugimana PC (2012), Song MS (2011), Vodermaier HC (2003), Tran K (2010), Kelly A (2014), Craney A (2016), Qiao R (2016)	15
CTNNB1	30	KAT2B	2	pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ge X (2009), Ge X (2009), Ge X (2009), Ge X (2009), Ge X (2009)	5
PTEN	24	HSPA8	4	affinity chromatography technology, pull down	Maddika S (2011), Verrastro I (2015)	2
BMI1	0	TP53	0	affinity chromatography technology, affinity chromatography technology	Calao M (2012), Yin J (2013)	2
SLC9A3R1	2	AKT1	1	affinity chromatography technology, enzymatic study	Song GJ (2015), Song GJ (2015)	2
KAT2B	2	AKT1	1	enzymatic study, affinity chromatography technology	Sundaresan NR (2011), Sundaresan NR (2011)	2
XIAP	0	STUB1	4	pull down	Dogan T (2008)	1
PLK1	0	TP53	0	enzymatic study	Dias SS (2009)	1
PTEN	24	UBC	7	protein complementation assay, affinity chromatography technology	Li Y (2014), Li Y (2014)	2
PTEN	24	IRS4	2	affinity chromatography technology, affinity chromatography technology	Crockett DK (2005), Crockett DK (2005)	2
UBC	7	STUB1	4	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Connell P (2001), Connell P (2001), Windheim M (2008), Zhang M (2005)	4
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
WWP2	7	UBC	7	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Sheng Y (2012), Maspero E (2013), Soond SM (2013), Kristariyanto YA (2015)	4
AKT1	1	PTK2	2	imaging technique	Moon HE (2015)	1
HSP90AA1	7	FZR1	1	genetic interference	Srivas R (2016)	1
HSP90AA1	7	EPHB1	9	affinity chromatography technology	Taipale M (2012)	1
XIAP	0	AKT1	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique	Dan HC (2004), Dan HC (2004), Pramanik KC (2013), Pramanik KC (2013), Chen TC (2014)	5
IRS4	2	PIK3R2	3	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
CCNE2	2	FBXW7	2	affinity chromatography technology, enzymatic study	Klotz K (2009), Klotz K (2009)	2
HSP90AA1	7	PTK2	2	affinity chromatography technology	Taipale M (2012)	1
AR	3	UBE2I	0	two hybrid, affinity chromatography technology, genetic interference, enzymatic study	Poukka H (1999), Poukka H (1999), Poukka H (1999), Ogawa H (2009)	4
CSNK2A1	15	AKT1	1	enzymatic study	Di Maira G (2005)	1
CBL	7	HSPA8	4	affinity chromatography technology	Brehme M (2009)	1
NEDD4	2	UBC	7	x-ray crystallography, pull down, unspecified method, enzymatic study, x-ray crystallography, enzymatic study, pull down, pull down	Maspero E (2011), Maspero E (2011), Ernst A (2013), Maspero E (2013), Mari S (2014), Mari S (2014), Mari S (2014), Kathman SG (2015)	8
DLC1	11	PTEN	24	affinity chromatography technology, pull down, affinity chromatography technology	Heering J (2009), Heering J (2009), Heering J (2009)	3
HSP90AA1	7	TUBB4B	6	affinity chromatography technology	Skarra DV (2011)	1
FBXW7	2	DLC1	11	genetic interference	Bailey ML (2015)	1
USP8	7	UBC	7	enzymatic study, unspecified method, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, pull down	Faesen AC (2011), Ernst A (2013), Row PE (2007), Ernst A (2013), Wauer T (2015), Reincke M (2015), Kwasna D (2018)	7
CDC27	2	CTNNB1	30	pull down	Gomes NP (2006)	1
HSP90AB1	2	MVP	1	biochemical	Kristensen AR (2012)	1
UBC	7	RHOA	0	affinity chromatography technology	Huang G (2014)	1
PTEN	24	RPL14	2	affinity chromatography technology, pull down	Crockett DK (2005), Verrastro I (2015)	2
PTEN	24	KAT2B	2	affinity chromatography technology, affinity chromatography technology	Okumura K (2006), Okumura K (2006)	2
CASP8	1	XIAP	0	genetic interference, affinity chromatography technology, affinity chromatography technology	Guo Y (2002), Lee JS (2012), McDonald ER (2004)	3
CTNNB1	30	SLC9A3R1	2	affinity chromatography technology, pull down	Shibata T (2003), Shibata T (2003)	2
PARK7	0	STUB1	4	affinity chromatography technology	Moore DJ (2005)	1
USP10	2	UBC	7	enzymatic study, unspecified method, pull down	Bomberger JM (2009), Ernst A (2013), Kwasna D (2018)	3
TP53	0	STUB1	4	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Muller P (2008), Stankiewicz M (2010), Tripathi V (2007), Tripathi V (2007), Esser C (2005), Lim JH (2011), Wang J (2011), Burch L (2004), Landre V (2013), Horikawa I (2014), Horikawa I (2014), Horikawa I (2014), Fraser JA (2015), Narayan V (2015), Yue X (2016), Parrales A (2016), Parrales A (2016)	17
PBK	0	PTEN	24	affinity chromatography technology, enzymatic study	Shinde SR (2013), Shinde SR (2013)	2
TP53	0	HSP90AB1	2	affinity chromatography technology	Fogeron ML (2013)	1
CBL	7	EPHB1	9	affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology	Fasen K (2008), Fasen K (2008), Fasen K (2008), Fasen K (2008), Rodriguez S (2013), Rodriguez S (2013)	6
BMI1	0	USP7	14	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Maertens GN (2010), Maertens GN (2010), Maertens GN (2010), de Bie P (2010), Lecona E (2015), Lecona E (2015)	6
HSP90AA1	7	AKT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Haendeler J (2003), Kawauchi K (2005), Sato S (2000), Basso AD (2002), Su CH (2011), Klein JB (2005), Sun L (2012)	7
NCOA3	3	FBXW7	2	affinity chromatography technology	Yang C (2013)	1
KAT2B	2	NCOA3	3	two hybrid, pull down	Korzus E (1998), Takeshita A (1997)	2
RHOA	0	CASP8	1	biochemical	Gajate C (2005)	1
PTEN	24	HSP90AB1	2	affinity chromatography technology, pull down	Maddika S (2011), Verrastro I (2015)	2
FZR1	1	PLK1	0	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Fukushima H (2013), Fukushima H (2013), Sedgwick GG (2012), Lee SB (2015), Williamson A (2011)	5
AKT1	1	CTNNB1	30	enzymatic study, enzymatic study	Tian Q (2004), Fang D (2007)	2
FZR1	1	PTEN	24	affinity chromatography technology, pull down, affinity chromatography technology	Song MS (2011), Song MS (2011), Choi BH (2014)	3
HSP90AB1	2	HSPA8	4	biochemical, affinity chromatography technology	Wan C (2015), Reidy M (2018)	2
CBL	7	TUBB4B	6	affinity chromatography technology	Brehme M (2009)	1
TP53	0	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li M (2002), Li M (2002), Li M (2002), Li M (2002), Brooks CL (2007), Brooks CL (2007), Becker K (2007), Hu M (2006), Hu M (2006), Sarkari F (2010), Marchenko ND (2007), Epping MT (2011), Qing P (2011), Tang J (2006), Ma J (2010), Dai C (2011), Holowaty MN (2003), Sheng Y (2006), Sheng Y (2006), Sheng Y (2006), Yi P (2013), Yi P (2013), Zhang J (2014), Fang Z (2013), Ye M (2015), Lim KH (2015), Lim KH (2015), Reddy BA (2014), Reddy BA (2014)	29
UBC	7	ANAPC7	2	affinity chromatography technology, pull down	Matsumoto M (2005), Nathan JA (2013)	2
PTEN	24	RHOA	0	affinity chromatography technology, affinity chromatography technology	Chang CC (2012), Chang CC (2012)	2
PTEN	24	PIK3R2	3	enzymatic study, affinity chromatography technology	He J (2010), He J (2010)	2
PTEN	24	FRK	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yim EK (2009), Yim EK (2009), Yim EK (2009)	3
NEDD4	2	PTEN	24	enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Wang X (2008), Wang X (2008), Yim EK (2009), Chung S (2011), Wu Y (2013), Hong SW (2013), Hong SW (2013), Li N (2015), Li Z (2014), Chen Z (2016), Ahn Y (2008)	11
FBXW7	2	CTNNB1	30	affinity chromatography technology, affinity chromatography technology	Jiang JX (2016), Jiang JX (2016)	2
HSPA8	4	UBC	7	two hybrid	Stelzl U (2005)	1
AR	3	NCOA3	3	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tan JA (2000), Gnanapragasam VJ (2001), Tan JA (2000), Wang Q (2004), Axlund SD (2010)	5
PTEN	24	RNF146	4	affinity chromatography technology, affinity chromatography technology	Li N (2015), Li N (2015)	2
AKT1	1	HSP90AB1	2	affinity chromatography technology	Sato S (2000)	1
NDFIP1	0	NEDD4	2	affinity chromatography technology	Xing LF (2016)	1
PTEN	24	ANAPC4	0	affinity chromatography technology, affinity chromatography technology	Song MS (2011), Song MS (2011)	2
IRS4	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Sano H (2002), Skarra DV (2011)	2
PTEN	24	CDC27	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Song MS (2011), Song MS (2011), Song MS (2011), Song MS (2011)	4
UBE2I	0	BMI1	0	two hybrid	Markson G (2009)	1
STUB1	4	HSP90AA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, enzymatic study, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down	Zhang L (2007), Zhang M (2005), Tateishi Y (2004), Tateishi Y (2004), Connell P (2001), Ko HS (2009), Kumar P (2007), Kumar P (2007), Wang L (2011), Stankiewicz M (2010), Graf C (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Kundrat L (2010), Morishima Y (2008), Zhou P (2003), Zhang M (2008), Grelle G (2006), Kim SA (2005), Arndt V (2005), Muller P (2012), Burch L (2004), Burch L (2004), Jang KW (2011), Schuelke JP (2010), Wang Q (2012), Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013), Gano JJ (2010), Skarra DV (2011), Yang SW (2013), Grelle G (2006), Grelle G (2006), Narayan V (2015)	36
KAT2B	2	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid, enzymatic study, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study	Jin Y (2002), Wang H (2008), Zhao Y (2006), Roe JS (2006), Perez RE (2010), Tang Y (2006), Zhao LY (2003), Liu L (1999), Liu L (1999), Sakaguchi K (1998), Harrod R (2003), Harrod R (2003), MacPartlin M (2005), Chen H (1999), Kang H (2009)	15
FZR1	1	CDC27	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhou Y (2003), Kramer ER (1998), Farhana L (2002), Cen B (2010), Sorensen CS (2001), Binne UK (2007), Wang X (2008), Tran K (2008), Wang LY (2012), Wang LY (2012), Ban KH (2007), Lv XB (2010), Huang KT (2012), Song MS (2011), Fukushima H (2013), Lau AW (2013), Cotto-Rios XM (2011), Vodermaier HC (2003), Vodermaier HC (2003), Vodermaier HC (2003), Choi BH (2014), Jeganathan KB (2006), Fang G (1998), Sedgwick GG (2012), Kelly A (2014), Listovsky T (2013), Pavlides SC (2016), Huttlin EL (2017)	28
TP53	0	USP10	2	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology	Yuan J (2010), Yuan J (2010), Yuan J (2010), Yuan J (2010), Oi N (2014), Oi N (2014), Oi N (2014)	7
PARK7	0	AR	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Tillman JE (2007), Tillman JE (2007), Tillman JE (2007)	3
MVP	1	HSPA8	4	affinity chromatography technology	Huttlin EL (2017)	1
CSNK2A1	15	USP7	14	enzymatic study, enzymatic study	Carra G (2017), Khoronenkova SV (2012)	2
ANAPC4	0	FZR1	1	biochemical, biochemical, unspecified method, biochemical, affinity chromatography technology, affinity chromatography technology	Zhang Z (2012), Chang L (2014), Vodermaier HC (2003), Chang L (2015), Boekhout M (2015), Huttlin EL (2017)	6
TP53	0	IRS4	2	affinity chromatography technology	Fogeron ML (2013)	1
CTNNB1	30	HSP90AB1	2	affinity chromatography technology	Tian Q (2004)	1
PTEN	24	AKT1	1	affinity chromatography technology, fluorescent resonance energy transfe	Mistafa O (2010), Ivanov AA (2017)	2
UBC	7	MVP	1	pull down	Zhang X (2017)	1
TP53	0	HSPA8	4	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Akakura S (2001), Kaur J (1996), Fogeron ML (2013), Horikawa I (2014), Matsumoto H (1994), Matsumoto H (1994), Karras GI (2017)	7
STUB1	4	HSPA8	4	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, x-ray crystallography, pull down, pull down, pull down, pull down, affinity chromatography technology, enzymatic study, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, unspecified method, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study	Ballinger CA (1999), Ballinger CA (1999), Ballinger CA (1999), Tateishi Y (2004), Tateishi Y (2004), Jiang J (2001), Wang L (2011), Wang L (2011), Wang L (2011), Stankiewicz M (2010), Yang M (2011), Yang M (2011), Urushitani M (2004), Grelle G (2006), Kim SA (2005), Arndt V (2005), Alberti S (2004), Meacham GC (2001), Smith MC (2013), Smith MC (2013), Matsumura Y (2013), Spooner RA (2008), Taipale M (2014), Taipale M (2014), Heimdal K (2014), Grelle G (2006), Grelle G (2006), Kamynina E (2007), Zhang H (2015), Zhang H (2015), Zhang H (2015), Li P (2015), Guo Y (2016), Zhang H (2017), Pakdaman Y (2017)	35
PTEN	24	OTUD3	2	affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Yuan L (2015), Yuan L (2015), Yuan L (2015), Yuan L (2015)	4
AKT1	1	STUB1	4	affinity chromatography technology, affinity chromatography technology	Dickey CA (2008), Su CH (2011)	2
PTEN	24	PLK1	0	affinity chromatography technology, enzymatic study	Li Z (2014), Li Z (2014)	2
TP53	0	TUBB4B	6	affinity chromatography technology	Fogeron ML (2013)	1
PTEN	24	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Wu Y (2013), Zhang J (2013), Zhang J (2013), Yuan L (2015)	4
CBL	7	PTEN	24	affinity chromatography technology, affinity chromatography technology	Rodriguez S (2013), Rodriguez S (2013)	2
PTEN	24	CCNE2	2	affinity chromatography technology, affinity chromatography technology	Crockett DK (2005), Crockett DK (2005)	2
CTNNB1	30	AR	3	pull down, two hybrid, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Yang F (2002), Yang F (2002), Masiello D (2004), Song LN (2004), Amir AL (2003), Amir AL (2003), Mulholland DJ (2003), Mulholland DJ (2003), Pawlowski JE (2002), Mulholland DJ (2003), Levy L (2004)	11
HSP90AA1	7	FBXW7	2	affinity chromatography technology	Taipale M (2012)	1
OTUD3	2	UBC	7	enzymatic study, enzymatic study, pull down	Mevissen TE (2013), Flierman D (2016), Kwasna D (2018)	3
UBE2I	0	WWP2	7	enzymatic study	Bawa-Khalfe T (2016)	1
PTEN	24	TUBB4B	6	affinity chromatography technology, pull down	Maddika S (2011), Verrastro I (2015)	2
AKT1	1	HSPA8	4	affinity chromatography technology	Klein JB (2005)	1
PTEN	24	EPHB1	9	affinity chromatography technology, affinity chromatography technology	Rodriguez S (2013), Rodriguez S (2013)	2
XIAP	0	UBC	7	x-ray crystallography, pull down, pull down, pull down	Tse MK (2011), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Nakatani Y (2012)	4
CDC27	2	ANAPC4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Gmachl M (2000), Kraft C (2003), Mansfeld J (2011), Lara-Gonzalez P (2011), Mansfeld J (2011), Izawa D (2011), Ma HT (2011), Ma HT (2011), Ma HT (2011), Dube P (2005), Holzmann J (2011), Wolthuis R (2008), Havugimana PC (2012), Uzunova K (2012), Song MS (2011), Zhang Z (2012), Chang L (2014), Hein JB (2014), Vodermaier HC (2003), Vodermaier HC (2003), Vodermaier HC (2003), Tran K (2010), Chang L (2015), Yamaguchi M (2015), Wan C (2015), Hein MY (2015), Voets E (2015), Masuda K (2015), Boekhout M (2015), Craney A (2016), Qiao R (2016), Izawa D (2012), Hein JB (2016)	34
CDC27	2	ANAPC7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Gmachl M (2000), Kraft C (2003), Lara-Gonzalez P (2011), Tran K (2008), Dube P (2005), Holzmann J (2011), Havugimana PC (2012), Sedgwick GG (2012), Song MS (2011), Vodermaier HC (2003), Tran K (2010), Yamaguchi M (2015), Yamaguchi M (2015), Wan C (2015), Kelly A (2014), Craney A (2016), Qiao R (2016), Boldt K (2016)	19
AR	3	USP10	2	affinity chromatography technology, pull down	Faus H (2005), Faus H (2005)	2
PTEN	24	BMI1	0	affinity chromatography technology, affinity chromatography technology	Fan C (2009), Fan C (2009)	2
PLK1	0	FBXW7	2	affinity chromatography technology, enzymatic study	Xiao D (2016), Xiao D (2016)	2
PTEN	24	ANAPC5	2	affinity chromatography technology, affinity chromatography technology	Song MS (2011), Song MS (2011)	2
FZR1	1	ANAPC5	2	unspecified method, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Sedgwick GG (2012), Huttlin EL (2017)	3
CSNK2A1	15	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, enzymatic study	Uhle S (2003), Fogeron ML (2013), Bhansali M (2014), Chen TC (2014), Walerych D (2004), Walerych D (2004)	6
XIAP	0	UBE2I	0	two hybrid, two hybrid	Dynek JN (2010), Dynek JN (2010)	2
HSPA8	4	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down	Polanowska-Grabowska R (1997), Giommarelli C (2010), Gano JJ (2010), Skarra DV (2011), Wan C (2015), Sun L (2012)	6
ANAPC5	2	ANAPC7	2	biochemical, affinity chromatography technology	Havugimana PC (2012), Sedgwick GG (2012)	2
UBC	7	HSP90AB1	2	affinity chromatography technology	Bish RA (2007)	1
PTEN	24	WWP2	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study	Crockett DK (2005), Ahmed SF (2012), Wu Y (2013), Maddika S (2011), Maddika S (2011), Maddika S (2011), Bawa-Khalfe T (2016), Bawa-Khalfe T (2016), Bawa-Khalfe T (2016), Chen Z (2016), Chen Z (2016), Chen Z (2017)	12
PARK7	0	UBE2I	0	two hybrid	Junn E (2005)	1
CBL	7	PTK2	2	imaging technique, affinity chromatography technology, affinity chromatography technology	Rafiq K (2011), Schmidt MH (2003), Sekine Y (2007)	3
FZR1	1	ANAPC7	2	unspecified method, affinity chromatography technology	Vodermaier HC (2003), Sedgwick GG (2012)	2
PTEN	24	ANAPC7	2	affinity chromatography technology, affinity chromatography technology	Song MS (2011), Song MS (2011)	2
USP10	2	PTEN	24	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang J (2013), Zhang J (2013), Sun J (2017), Sun J (2017)	4
WWP1	3	UBC	7	enzymatic study	Kristariyanto YA (2015)	1
PTEN	24	WWP1	3	affinity chromatography technology, affinity chromatography technology	Li N (2015), Maddika S (2011)	2
AR	3	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Chen ST (2015), Chen ST (2015), Chen ST (2015), Chen ST (2015)	4
MVP	1	TP53	0	two hybrid	Corominas R (2014)	1
UBC	7	CSNK2A2	1	affinity chromatography technology	Matsumoto M (2005)	1
PTEN	24	PTK2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study	Tamura M (1999), Haier J (2002), Crockett DK (2005), Tamura M (1999), Tamura M (1999), Tamura M (1999)	6
PTEN	24	UBE2I	0	affinity chromatography technology, affinity chromatography technology	Waite KA (2003), Huang J (2012)	2
HSP90AA1	7	AR	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Veldscholte J (1992), Nemoto T (1992), Zoubeidi A (2007), DaSilva J (2009), Chymkowitch P (2011), Gibbs A (2009), Wolf SS (2007), Luo J (2015), Kwegyir-Afful AK (2015), Ni L (2010), McClurg UL (2016)	11
FZR1	1	TP53	0	enzymatic study	Gmachl M (2000)	1
CSNK2A1	15	HSP90AB1	2	enzymatic study	Zhang M (2011)	1
HSP90AB1	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Cheng MB (2010), Gano JJ (2010), Skarra DV (2011), Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Wan C (2015), Hein MY (2015)	8
NEDD4	2	PLK1	0	pull down, enzymatic study	Persaud A (2009), Li Z (2014)	2
PIK3R2	3	HSPA8	4	affinity chromatography technology	Brehme M (2009)	1
HSP90AB1	2	RPL14	2	biochemical	Havugimana PC (2012)	1
TP53	0	RPL14	2	affinity chromatography technology	Fogeron ML (2013)	1
PTEN	24	TNKS2	6	affinity chromatography technology, enzymatic study	Li N (2015), Li N (2015)	2
AR	3	TP53	0	genetic interference	Shenk JL (2001)	1
CBL	7	UBC	7	x-ray crystallography, pull down, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, x-ray crystallography, pull down, pull down, enzymatic study	Peschard P (2007), Peschard P (2007), Davies GC (2004), Davies GC (2004), Kassenbrock CK (2004), Zhou ZR (2008), Kim M (2004), Dou H (2013), Liu N (2015), Buetow L (2016), Kliza K (2017)	11
PTEN	24	STUB1	4	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ahmed SF (2012), Ahmed SF (2012), Ahmed SF (2012), Yuan L (2015)	4
CTNNB1	30	CBL	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Chitalia V (2013), Chitalia V (2013), Chitalia V (2013), Shivanna S (2015)	4
AR	3	STUB1	4	affinity chromatography technology, pull down, enzymatic study, unspecified method, two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology	DaSilva J (2009), Chymkowitch P (2011), Chymkowitch P (2011), Rees I (2006), He B (2004), He B (2004), Schuelke JP (2010), McClurg UL (2016), Wang J (2016), Wang J (2016), Wang J (2016)	11
HSP90AA1	7	WWP1	3	affinity chromatography technology	Taipale M (2012)	1
CTNNB1	30	USP7	14	affinity chromatography technology, affinity chromatography technology, enzymatic study, unspecified method	Novellasdemunt L (2017), Novellasdemunt L (2017), Novellasdemunt L (2017), Novellasdemunt L (2017)	4
UBC	7	CSNK2A1	15	affinity chromatography technology	Matsumoto M (2005)	1
UBE2I	0	USP8	7	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
ANAPC4	0	ANAPC7	2	affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Mansfeld J (2011), Havugimana PC (2012), Zhang Z (2012), Chang L (2014), Sedgwick GG (2013), Vodermaier HC (2003), Chang L (2015), Yamaguchi M (2015), Wan C (2015), Sedgwick GG (2016)	10
PTEN	24	MCRS1	1	affinity chromatography technology, affinity chromatography technology, far western blotting, pull down	Okumura K (2005), Okumura K (2005), Okumura K (2005), Okumura K (2005)	4
MAGI3	1	PTEN	24	two hybrid, pull down, affinity chromatography technology	Wu Y (2000), Wu Y (2000), Wu Y (2000)	3
HSP90AA1	7	FRK	1	affinity chromatography technology	Taipale M (2012)	1
PTEN	24	TNKS	12	affinity chromatography technology, affinity chromatography technology, enzymatic study	Li N (2015), Li N (2015), Li N (2015)	3
AKT1	1	DLC1	11	enzymatic study	Hers I (2006)	1
CASP8	1	UBC	7	pull down	Bellail AC (2012)	1
CSNK2A1	15	PTEN	24	enzymatic study, pull down, affinity chromatography technology, enzymatic study	Miller SJ (2002), Miller SJ (2002), Crockett DK (2005), Li Z (2014)	4
CTNNB1	30	HSPA8	4	affinity chromatography technology	Tian Q (2004)	1
TP53	0	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PTK2	2	STUB1	4	affinity chromatography technology	Lim ST (2012)	1
TP53	0	NCOA3	3	pull down	Lee SK (1999)	1
UBE2I	0	TP53	0	two hybrid, two hybrid, two hybrid, enzymatic study, two hybrid, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Minty A (2000), Gallagher WM (1999), Shen Z (1996), Bernier-Villamor V (2002), Wang J (2008), Spektor TM (2011), Jakobs A (2007), Mohideen F (2009), Lin JY (2004), Bennett RL (2012), Heo KS (2013), Morimoto M (2003), Rodriguez MS (1999), Muller S (2000), Fernandez-Lloris R (2006), Mohan RD (2007), Brandt M (2013), Weger S (2005)	18
NEDD4	2	AKT1	1	enzymatic study, enzymatic study, affinity chromatography technology	Persaud A (2009), Fan CD (2013), Fan CD (2013)	3
USP8	7	PTEN	24	affinity chromatography technology, affinity chromatography technology	Zhang J (2013), Zhang J (2013)	2
FBXW7	2	PTEN	24	affinity chromatography technology, affinity chromatography technology	Yang C (2013), Yang C (2013)	2
AR	3	KAT2B	2	pull down, enzymatic study	Fu M (2000), Fu M (2000)	2
USP7	14	UBC	7	enzymatic study, enzymatic study, unspecified method, enzymatic study, pull down	Bremm A (2010), Faesen AC (2011), Ernst A (2013), Holowaty MN (2003), Kwasna D (2018)	5
PTEN	24	HSP90AA1	7	affinity chromatography technology, genetic interference	Maddika S (2011), Shen JP (2017)	2
CSNK2A2	1	PTEN	24	enzymatic study, pull down	Miller SJ (2002), Miller SJ (2002)	2
PTEN	24	AR	3	pull down, affinity chromatography technology	Lin HK (2004), Lin HK (2004)	2
CASP8	1	TP53	0	affinity chromatography technology, affinity chromatography technology	Yao Z (2007), Yao Z (2007)	2
NCOA3	3	PTEN	24	affinity chromatography technology, affinity chromatography technology	Yang C (2013), Yang C (2013)	2
HSP90AA1	7	CSNK2A1	15	pull down, enzymatic study, enzymatic study, affinity chromatography technology	Miyata Y (1995), Muller P (2012), Zhang M (2011), Woo SH (2009)	4
USP8	7	AKT1	1	affinity chromatography technology	Cao Z (2007)	1
SLC9A3R1	2	EPHB1	9	affinity chromatography technology, affinity chromatography technology	Rodriguez S (2013), Rodriguez S (2013)	2
HSP90AB1	2	STUB1	4	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
PTEN	24	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Freeman DJ (2003), Freeman DJ (2003), Zhou M (2003), Zhou M (2003), Hong SW (2013), Li Y (2008)	6
UBC	7	SHARPIN	1	pull down	Zhang X (2017)	1
FBXW7	2	TP53	0	affinity chromatography technology	Huttlin EL (2017)	1
PARK7	0	PTEN	24	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Das F (2011), Das F (2011), Kim YC (2009), Kim YC (2009)	4
WWP2	7	NDFIP1	0	affinity chromatography technology	Huttlin EL (2015)	1
PTEN	24	CTNNB1	30	affinity chromatography technology, affinity chromatography technology	Li A (2010), Li A (2010)	2
PTEN	24	XIAP	0	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Van Themsche C (2009), Van Themsche C (2009), Van Themsche C (2009), Ahmed SF (2012)	4
PTEN	24	SLC9A3R1	2	affinity chromatography technology, pull down, affinity chromatography technology, genetic interference, pull down, affinity chromatography technology	Yang L (2011), Yang L (2011), Rodriguez S (2013), Molina JR (2012), Molina JR (2012), Zheng J (2016)	6
PTEN	24	MVP	1	two hybrid, affinity chromatography technology, pull down	Yu Z (2002), Yu Z (2002), Yu Z (2002)	3
HSP90AA1	7	CSNK2A2	1	pull down	Miyata Y (1995)	1