PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
G3BP1	4	PCNA	0	affinity chromatography technology	Jain S (2016)	1
EWSR1	2	SRRM1	2	bioid	Elzi DJ (2014)	1
SMC1A	15	RAD21	3	affinity chromatography technology, imaging technique, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gregson HC (2001), Austin C (2009), Gandhi R (2006), Panigrahi AK (2011), Panigrahi AK (2011), Panigrahi AK (2011), Holzmann J (2011), Hauf S (2005), Havugimana PC (2012), Wan C (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	13
G3BP1	4	MCM7	5	affinity chromatography technology	Jain S (2016)	1
RAD21	3	CCAR2	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Panigrahi AK (2011), Panigrahi AK (2011), Panigrahi AK (2011)	3
NSMCE2	0	PDS5A	5	biochemical	Wu N (2012)	1
PSMC2	2	RAD21	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PDS5A	5	STAG1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sumara I (2000), Kueng S (2006), Kueng S (2006), Losada A (2005)	4
PRKDC	12	TPR	5	biochemical	Havugimana PC (2012)	1
AIRE	3	SMC1A	15	affinity chromatography technology, affinity chromatography technology	Abramson J (2010), Abramson J (2010)	2
MCM4	3	SMC3	16	affinity chromatography technology	Boldt K (2016)	1
SMC3	16	PDS5A	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Bauerschmidt C (2010), Kueng S (2006), Kueng S (2006), Kueng S (2006), Schmitz J (2007), Losada A (2005), Losada A (2005), Nishiyama T (2010), Wan C (2015)	9
SRRM1	2	SNW1	0	affinity chromatography technology	McCracken S (2005)	1
RAD21	3	EWSR1	2	affinity chromatography technology, affinity chromatography technology	Panigrahi AK (2011), Panigrahi AK (2011)	2
EWSR1	2	NSMCE2	0	bioid	Elzi DJ (2014)	1
SMC3	16	PDS5B	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Kueng S (2006), Kueng S (2006), Schmitz J (2007), Schmitz J (2007), Losada A (2005), Losada A (2005), Brough R (2012), Wan C (2015), Hein MY (2015)	9
AIRE	3	RAD21	3	affinity chromatography technology, affinity chromatography technology	Abramson J (2010), Abramson J (2010)	2
STAG2	6	SMC1B	1	biochemical	Wan C (2015)	1
PDS5B	3	SMC1A	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Kueng S (2006), Gandhi R (2006), Losada A (2005), Wan C (2015), Hein MY (2015)	5
STAG2	6	PDS5B	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kueng S (2006), Kueng S (2006), Losada A (2005)	3
USP37	1	SMC3	16	bioid, affinity chromatography technology	Yeh C (2015), Yeh C (2015)	2
WAPL	1	SMC1A	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hutchins JR (2010), Kueng S (2006), Hein MY (2015), Hein MY (2015)	4
EWSR1	2	DDB1	6	bioid	Elzi DJ (2014)	1
AIRE	3	SMC3	16	affinity chromatography technology, affinity chromatography technology	Abramson J (2010), Shao W (2016)	2
PDS5B	3	PCNA	0	affinity chromatography technology	Brough R (2012)	1
MCM4	3	MCM7	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, biochemical, affinity chromatography technology	Yabuta N (2003), Fujita M (1997), Ishimi Y (1996), You Z (2002), Havugimana PC (2012), Ramachandran N (2004), Kristensen AR (2012), Wan C (2015), Boldt K (2016)	9
PPM1D	11	PSMC2	2	affinity chromatography technology	Yadav L (2017)	1
CDCA5	0	RAD21	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rankin S (2005), Rankin S (2005), Nishiyama T (2010), Zhang N (2011), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	7
RAD21	3	MCM7	5	affinity chromatography technology, biochemical	Panigrahi AK (2011), Wan C (2015)	2
WAPL	1	STAG1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hutchins JR (2010), Kueng S (2006), Kueng S (2006), Hein MY (2015)	4
EWSR1	2	CDCA5	0	bioid	Elzi DJ (2014)	1
SRRM1	2	PDS5A	5	affinity chromatography technology	McCracken S (2005)	1
PDS5A	5	SMC1A	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Kueng S (2006), Gandhi R (2006), Losada A (2005), Wan C (2015), Hein MY (2015)	5
RAD21	3	PCNA	0	affinity chromatography technology, biochemical, biochemical	Panigrahi AK (2011), Havugimana PC (2012), Wan C (2015)	3
SRRM1	2	SMC1A	15	affinity chromatography technology, biochemical, affinity chromatography technology	McCracken S (2005), McCracken S (2005), McCracken S (2005)	3
RAD21	3	DAPK3	5	two hybrid, affinity chromatography technology	Panigrahi AK (2011), Panigrahi AK (2011)	2
PPM1D	11	G3BP1	4	affinity chromatography technology	Yadav L (2017)	1
RAD21	3	SMC3	16	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim HS (2010), Kueng S (2006), Kueng S (2006), Kueng S (2006), Schmitz J (2007), Schmitz J (2007), Losada A (2005), Losada A (2000), Panigrahi AK (2011), Panigrahi AK (2011), Kang H (2011), Holzmann J (2011), Hauf S (2005), Havugimana PC (2012), Seitan VC (2006), Nishiyama T (2010), Wan C (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	20
CDCA5	0	SMC1B	1	affinity chromatography technology	Huttlin EL (2015)	1
SNW1	0	WAPL	1	affinity chromatography technology	Lleres D (2010)	1
PRKDC	12	SMARCA5	4	biochemical	Havugimana PC (2012)	1
RAD21	3	UBA1	1	affinity chromatography technology, affinity chromatography technology	Panigrahi AK (2011), Panigrahi AK (2011)	2
SMC3	16	WAPL	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schmitz J (2007), Hutchins JR (2010), Nishiyama T (2010), Kueng S (2006), Kueng S (2006), Kueng S (2006), Kueng S (2006), Hein MY (2015), Hein MY (2015)	9
PDS5A	5	PDS5B	3	affinity chromatography technology, biochemical	Gandhi R (2006), Wan C (2015)	2
DDB1	6	PCNA	0	affinity chromatography technology	Angers S (2006)	1
PCNA	0	MCM4	3	affinity chromatography technology	Han J (2014)	1
AIRE	3	PRKDC	12	affinity chromatography technology, affinity chromatography technology	Abramson J (2010), Abramson J (2010)	2
CDCA5	0	STAG1	7	affinity chromatography technology	Hein MY (2015)	1
G3BP1	4	UBA1	1	affinity chromatography technology	Jain S (2016)	1
CDCA5	0	PDS5B	3	pull down, affinity chromatography technology, affinity chromatography technology	Rankin S (2005), Nishiyama T (2010), Hein MY (2015)	3
RAD21	3	CDC34	3	two hybrid, affinity chromatography technology	Panigrahi AK (2011), Panigrahi AK (2011)	2
SNW1	0	SMC1A	15	affinity chromatography technology	Lleres D (2010)	1
STAG1	7	RAD21	3	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sumara I (2000), Kueng S (2006), Gandhi R (2006), Canudas S (2007), Losada A (2000), Panigrahi AK (2011), Panigrahi AK (2011), Holzmann J (2011), Hauf S (2005), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	12
USP37	1	STAG1	7	bioid	Yeh C (2015)	1
EWSR1	2	PCNA	0	bioid	Elzi DJ (2014)	1
DDB1	6	TPR	5	biochemical	Havugimana PC (2012)	1
FHL3	0	SNW1	0	affinity chromatography technology	Huttlin EL (2015)	1
RAD21	3	PPP1R15A	2	two hybrid, affinity chromatography technology	Panigrahi AK (2011), Panigrahi AK (2011)	2
STAG1	7	SMC1B	1	biochemical	Wan C (2015)	1
SRRM1	2	STAG2	6	affinity chromatography technology	McCracken S (2005)	1
RAD21	3	G3BP1	4	affinity chromatography technology, affinity chromatography technology	Panigrahi AK (2011), Jain S (2016)	2
CDCA5	0	SMC3	16	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rankin S (2005), Rankin S (2005), Schmitz J (2007), Schmitz J (2007), Nishiyama T (2010), Nishiyama T (2010), Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	10
SMC1B	1	RAD21	3	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
STAG2	6	SMC1A	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Kueng S (2006), Gandhi R (2006), Losada A (2000), Wan C (2015), Hein MY (2015)	5
NSMCE2	0	SMC3	16	biochemical	Wu N (2012)	1
SNW1	0	PRKDC	12	affinity chromatography technology	Lleres D (2010)	1
RAD21	3	DDB1	6	affinity chromatography technology, affinity chromatography technology	Panigrahi AK (2011), Panigrahi AK (2011)	2
SNW1	0	DDB1	6	affinity chromatography technology	Zhang C (2003)	1
SMARCA5	4	SMC3	16	biochemical	Hakimi MA (2002)	1
SMARCA5	4	SMC1A	15	biochemical	Hakimi MA (2002)	1
G3BP1	4	MCM4	3	affinity chromatography technology	Jain S (2016)	1
SRRM1	2	WAPL	1	affinity chromatography technology	McCracken S (2005)	1
RAD21	3	PPM1D	11	affinity chromatography technology, affinity chromatography technology	Panigrahi AK (2011), Panigrahi AK (2011)	2
PSMC2	2	SMC1A	15	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PCNA	0	PRKDC	12	affinity chromatography technology	Ohta S (2002)	1
SNW1	0	STAG1	7	affinity chromatography technology	Lleres D (2010)	1
NSMCE2	0	PDS5B	3	biochemical	Wu N (2012)	1
USP37	1	STAG2	6	bioid, affinity chromatography technology	Yeh C (2015), Yeh C (2015)	2
SMARCA5	4	RAD21	3	biochemical, biochemical	Hakimi MA (2002), Hakimi MA (2002)	2
SSU72	0	STAG2	6	affinity chromatography technology, pull down, enzymatic study	Kim HS (2010), Kim HS (2010), Kim HS (2010)	3
MCM7	5	SMC1A	15	biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, pull down	Havugimana PC (2012), Ryu MJ (2006), Ryu MJ (2006), Ryu MJ (2006), Ryu MJ (2006), Ryu MJ (2006)	6
PDS5B	3	RAD21	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gandhi R (2006), Losada A (2005), Panigrahi AK (2011), Brough R (2012), Hein MY (2015), Huttlin EL (2017)	6
SMC1A	15	SMC3	16	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim ST (2002), Lee J (2003), Lee J (2003), Schmiesing JA (1998), Gregson HC (2001), Kueng S (2006), Schmitz J (2007), Schmitz J (2007), Losada A (2000), Kang H (2011), Havugimana PC (2012), Wan C (2015), Hein MY (2015), Hein MY (2015), Boldt K (2016)	15
CDCA5	0	WAPL	1	affinity chromatography technology	Hein MY (2015)	1
WAPL	1	STAG2	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hutchins JR (2010), Kueng S (2006), Kueng S (2006), Kueng S (2006), Hein MY (2015)	5
PDS5A	5	STAG2	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Sumara I (2000), Kueng S (2006), Kueng S (2006), Losada A (2005), Wan C (2015)	5
PIP5K1A	2	RAD21	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RAD21	3	TPR	5	affinity chromatography technology, affinity chromatography technology	Panigrahi AK (2011), Panigrahi AK (2011)	2
STAG1	7	SMC1A	15	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology	Sumara I (2000), Kueng S (2006), Gandhi R (2006), Losada A (2000), Wan C (2015), Hein MY (2015)	6
STAG1	7	PDS5B	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Kueng S (2006), Kueng S (2006), Losada A (2005), Wan C (2015)	4
SSU72	0	SMC1A	15	affinity chromatography technology	Kim HS (2010)	1
SSU72	0	SMC3	16	affinity chromatography technology	Kim HS (2010)	1
RAD21	3	APOB	8	affinity chromatography technology, affinity chromatography technology	Panigrahi AK (2011), Hein MY (2015)	2
NSMCE2	0	RAD21	3	enzymatic study, affinity chromatography technology, biochemical	Wu N (2012), Wu N (2012), Wu N (2012)	3
PIP5K1A	2	STAG2	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DDB1	6	UBA1	1	affinity chromatography technology, affinity chromatography technology	Panigrahi AK (2011), Panigrahi AK (2011)	2
WAPL	1	PDS5A	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Hutchins JR (2010), Nishiyama T (2010), Kueng S (2006), Kueng S (2006), Kueng S (2006), Kueng S (2006), Hein MY (2015)	7
MCM4	3	SMC1A	15	affinity chromatography technology	Boldt K (2016)	1
AIRE	3	PCNA	0	affinity chromatography technology	Abramson J (2010)	1
NSMCE2	0	STAG2	6	biochemical	Wu N (2012)	1
SNW1	0	SMARCA5	4	affinity chromatography technology	Lleres D (2010)	1
RAD21	3	CAPN1	3	affinity chromatography technology, enzymatic study	Panigrahi AK (2011), Panigrahi AK (2011)	2
USP37	1	MCM4	3	bioid	Yeh C (2015)	1
CDCA5	0	PDS5A	5	pull down, affinity chromatography technology, affinity chromatography technology	Rankin S (2005), Nishiyama T (2010), Hein MY (2015)	3
WAPL	1	RAD21	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hutchins JR (2010), Panigrahi AK (2011), Panigrahi AK (2011), Kueng S (2006), Kueng S (2006), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	8
STAG2	6	SMC3	16	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Kueng S (2006), Kueng S (2006), Kueng S (2006), Schmitz J (2007), Losada A (2005), Canudas S (2007), Losada A (2000), Losada A (2000), Wan C (2015), Hein MY (2015)	10
USP37	1	RAD21	3	bioid, affinity chromatography technology	Yeh C (2015), Yeh C (2015)	2
NSMCE2	0	WAPL	1	biochemical	Wu N (2012)	1
RAD21	3	FHL3	0	two hybrid, affinity chromatography technology, two hybrid	Panigrahi AK (2011), Panigrahi AK (2011), Rolland T (2014)	3
RAD21	3	SNW1	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Lleres D (2010)	2
SSU72	0	RAD21	3	affinity chromatography technology, pull down, affinity chromatography technology	Kim HS (2010), Kim HS (2010), Kim HS (2010)	3
RAD21	3	STAG2	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Kim HS (2010), Kueng S (2006), Canudas S (2007), Losada A (2000), Panigrahi AK (2011), Panigrahi AK (2011), Holzmann J (2011), Wu N (2012), Hauf S (2005), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	12
SRRM1	2	RAD21	3	affinity chromatography technology, biochemical, affinity chromatography technology	McCracken S (2005), McCracken S (2005), McCracken S (2005)	3
RAD21	3	MCM4	3	affinity chromatography technology, biochemical	Panigrahi AK (2011), Wan C (2015)	2
G3BP1	4	PDS5B	3	affinity chromatography technology	Jain S (2016)	1
USP37	1	WAPL	1	bioid, affinity chromatography technology, affinity chromatography technology	Yeh C (2015), Yeh C (2015), Yeh C (2015)	3
RAD21	3	PRKDC	12	affinity chromatography technology, biochemical	Panigrahi AK (2011), Havugimana PC (2012)	2
SNW1	0	SMC3	16	affinity chromatography technology	Lleres D (2010)	1
STAG1	7	SMC3	16	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Sumara I (2000), Kueng S (2006), Kueng S (2006), Kueng S (2006), Gandhi R (2006), Schmitz J (2007), Losada A (2005), Canudas S (2007), Losada A (2000), Losada A (2000), Wan C (2015), Hein MY (2015)	12
UBA1	1	CDC34	3	enzymatic study, pull down, enzymatic study, pull down, enzymatic study	Tokgoez Z (2012), Jin J (2007), Chong RA (2014), Chong RA (2014), Wauer T (2015)	5
CDCA5	0	SMC1A	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Huttlin EL (2015), Hein MY (2015), Hein MY (2015), Elbatsh AM (2016)	4
SNW1	0	PSMC2	2	affinity chromatography technology	Lleres D (2010)	1
SMC1B	1	SMC3	16	biochemical, affinity chromatography technology	Wan C (2015), Lee J (2003)	2
PDS5A	5	RAD21	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kueng S (2006), Gandhi R (2006), Losada A (2005), Panigrahi AK (2011), Panigrahi AK (2011), Hein MY (2015), Huttlin EL (2017)	7
PSMC2	2	SMC3	16	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PCNA	0	MCM7	5	affinity chromatography technology	Han J (2014)	1
SRRM1	2	SMC3	16	biochemical, affinity chromatography technology	McCracken S (2005), McCracken S (2005)	2
USP37	1	SMC1A	15	bioid	Yeh C (2015)	1
WAPL	1	PDS5B	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hutchins JR (2010), Kueng S (2006), Kueng S (2006), Kueng S (2006), Hein MY (2015)	5
NSMCE2	0	SMC1A	15	biochemical	Wu N (2012)	1
CDCA5	0	STAG2	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang N (2011), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	4
THBS3	3	RAD21	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2