PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HIST1H3A	3	DDB1	6	affinity chromatography technology, pull down	Higa LA (2006), Higa LA (2006)	2
UBC	7	UBE2C	1	affinity chromatography technology	Matsumoto M (2005)	1
HIST2H2AC	1	HIST2H2BE	1	pull down	Long L (2014)	1
DCAF1	5	CUL4A	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ahn J (2010), Belzile JP (2007), He YJ (2006), McCall CM (2008), McCall CM (2008), McCall CM (2008), McCall CM (2008), Hrecka K (2007), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Olma MH (2009), Jin J (2006), Kyei GB (2015)	14
RAG1	1	KPNA1	5	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Cortes P (1994), Cortes P (1994), Cortes P (1994), Spanopoulou E (1995), Spanopoulou E (1995)	5
HMGB1	0	HMGB2	2	affinity chromatography technology, biochemical	Krynetski EY (2003), Wan C (2015)	2
RBX1	2	UBE2D2	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Pick E (2007), Lan L (2012), Tsai WB (2010), Hrecka K (2007), Okuda H (2001), Tai T (2006), Ahn J (2011), Gong B (2010), Lu Y (2012), Ohta A (2013), da Silva Almeida AC (2013), Delucia M (2013), Scott DC (2014), Camp ND (2012), Kim S (2014), Theurillat JP (2014), Kigoshi Y (2011), Pashkova N (2010), Beck J (2013), Pierce WK (2015), Wu K (2016), Parameswaran B (2015), Simo S (2013), Groisman R (2006), Marzahn MR (2016), Courtheoux T (2016), Hasanov E (2017), Ferretti LP (2016), Zhou X (2017), Kroenke J (2014), Mulvaney KM (2016)	31
DDB1	6	UBC	7	affinity chromatography technology, affinity chromatography technology	Angers S (2006), Matsumoto M (2005)	2
RAG1	1	UBC	7	enzymatic study	Yurchenko V (2003)	1
FBXW7	2	RBX1	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Busino L (2012), Matsumoto A (2011), Strohmaier H (2001), Ye M (2017)	4
HSP90AA1	7	APP	1	affinity chromatography technology	Kumar P (2007)	1
HIST2H2AC	1	HIST1H3A	3	pull down, pull down, pull down	Hoffmann A (1996), Hoffmann A (1996), Boenisch C (2012)	3
RAG1	1	HIST2H2AC	1	far western blotting	Grazini U (2010)	1
RAG1	1	MDC1	8	affinity chromatography technology, affinity chromatography technology	Coster G (2012), Coster G (2012)	2
HIST2H2AC	1	UBC	7	pull down, pull down	Long L (2014), Zhang X (2017)	2
APP	1	HIST2H2AC	1	pull down	Virok DP (2011)	1
DCAF1	5	RBX1	2	pull down	Ahn J (2010)	1
RAG1	1	DCAF1	5	biochemical, pull down, affinity chromatography technology	Kassmeier MD (2011), Kassmeier MD (2011), Kassmeier MD (2011)	3
HIST1H3A	3	CUL4A	2	affinity chromatography technology, pull down	Higa LA (2006), Higa LA (2006)	2
RBX1	2	APP	1	pull down	Olah J (2011)	1
RAG1	1	HIST4H4	1	far western blotting	Grazini U (2010)	1
RAG1	1	HIST1H3A	3	enzymatic study	Jones JM (2011)	1
RAG1	1	RBX1	2	affinity chromatography technology	Kassmeier MD (2011)	1
RAG1	1	UBE2H	3	pull down	Jones JM (2011)	1
RAG2	0	DCAF1	5	biochemical	Kassmeier MD (2011)	1
HIST3H3	0	HSP90AA1	7	biochemical, affinity chromatography technology	Campos EI (2010), Campos EI (2010)	2
DDB1	6	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down	Wang H (2006), Kapetanaki MG (2006), Hu J (2004), Ahn J (2010), Fischer ES (2011), Groisman R (2006)	6
HIST2H2BE	1	UBC	7	pull down	Long L (2014)	1
DCAF1	5	HIST1H3A	3	pull down, pull down	Kim K (2012), Kim K (2012)	2
KPNA2	0	KPNA1	5	biochemical	Wan C (2015)	1
HMGB2	2	RAG1	1	pull down, pull down	Aidinis V (1999), Aidinis V (1999)	2
CUL4A	2	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Angers S (2006), Jin J (2006), Wang H (2006), Kapetanaki MG (2006), Matsuda N (2005), Hu J (2004), Hu J (2004), Hu J (2004), Ahn J (2010), Maddika S (2009), Fischer ES (2011), Tan L (2007), He YJ (2006), He YJ (2006), He YJ (2006), McCall CM (2008), McCall CM (2008), Shiyanov P (1999), Bennett EJ (2010), Gastaldello S (2012), Kanei-Ishii C (2012), Hodgson AJ (2012), Kulaksiz G (2005), Wu Z (2012), Wu Z (2012), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Rao F (2014), Wan C (2015), Liu Y (2015), Zha Z (2015), Mouysset J (2015), Gao J (2015), Yang Y (2016), Yang Y (2016), Scherer PC (2016), Eichner R (2016), Mo Y (2017), Mo Y (2017), Peng Z (2016), Higa LA (2006), Ohtake F (2007)	46
KPNA2	0	APP	1	pull down	Olah J (2011)	1
RBX1	2	UBE2D1	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, unspecified method, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Li Y (2010), Shaik S (2012), Costessi A (2011), Bashir T (2010), Lan L (2012), Welcker M (2011), Wilkins A (2004), Yada M (2004), Li C (2011), Lee DF (2009), Santra MK (2009), Chen BB (2012), Liu J (2002), Duan S (2011), Barbash O (2011), Kamura T (2003), Abbas T (2008), Peschiaroli A (2009), Popov N (2010), Uchida S (2011), Dimitrova YN (2010), Maerki S (2009), Malatesta M (2012), Davis MA (2013), Chen H (2013), Mallampalli RK (2013), Rossi M (2013), Mori Y (2013), Lu A (2013), Fischer ES (2014), Andresen CA (2014), Herrero-Ruiz J (2014), Johansson P (2014), Uchiki T (2009), Min SH (2012), Gao D (2010), Canettieri G (2010), Lin MY (2011), Read MA (2000), Zhang DD (2004), Zhang DD (2005), Fukushima H (2013), Matsumoto S (2015), Ibeawuchi SR (2015), Malonia SK (2015), Liu Y (2015), Liu Y (2015), Gao J (2015), Zhang C (2015), Chu WK (2015), Barbash O (2009), Kershaw NJ (2014), Nam S (2009), Wu HC (2014), Kim JH (2015), Kung YA (2017), Nguyen TV (2016), Shimizu K (2017), Gschweitl M (2016), Terai K (2013), Chandra S (2013), Dai X (2017), Qie S (2017), Chen BB (2013), Kroenke J (2014)	65
HMGB2	2	APP	1	pull down	Olah J (2011)	1
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
RAG1	1	HIST3H3	0	affinity chromatography technology, pull down, far western blotting, enzymatic study	Grazini U (2010), Grazini U (2010), Grazini U (2010), Grazini U (2010)	4
RAG1	1	RAG1	1	enzymatic study	Singh SK (2015)	1
CUL4A	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Bennett EJ (2010), Taipale M (2012)	3
HSP90AA1	7	FBXW7	2	affinity chromatography technology	Taipale M (2012)	1
HSP90AA1	7	RAG1	1	affinity chromatography technology	Taipale M (2012)	1
RAG1	1	UBE2D1	0	pull down	Singh SK (2015)	1
DCAF1	5	HIST3H3	0	enzymatic study	Kim K (2013)	1
CUL4A	2	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Angers S (2006), Bennett EJ (2010), Olma MH (2009), Wu K (2016)	4
RAG1	1	KPNA2	0	two hybrid, two hybrid	Cuomo CA (1994), Spanopoulou E (1995)	2
RAG1	1	UBE2D2	0	pull down, pull down, pull down	Grazini U (2010), Yurchenko V (2003), Singh SK (2015)	3
APP	1	RAG1	1	pull down	Virok DP (2011)	1
DCAF1	5	UBE2D2	0	pull down	Ahn J (2010)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
HIST3H3	0	HIST4H4	1	biochemical, affinity chromatography technology	Campos EI (2010), Campos EI (2010)	2
FBXW7	2	RAG1	1	genetic interference	Bailey ML (2015)	1
RAG1	1	CUL4A	2	affinity chromatography technology	Kassmeier MD (2011)	1
HMGB1	0	RAG1	1	pull down, pull down	Aidinis V (1999), Aidinis V (1999)	2
RAG1	1	RUNX1	0	affinity chromatography technology, affinity chromatography technology	Cieslak A (2014), Cieslak A (2014)	2
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
RAG1	1	RAG2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical	McMahan CJ (1997), Villa A (1998), Villa A (1998), Spanopoulou E (1995), Spanopoulou E (1995), Ko JE (2004), Zhang YH (2015), Zhang YH (2015), Singh SK (2015)	9
RAG1	1	DDB1	6	biochemical, affinity chromatography technology	Kassmeier MD (2011), Kassmeier MD (2011)	2
RBX1	2	CUL4A	2	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, biochemical, enzymatic study, pull down, biochemical	Dias DC (2002), Ohta T (1999), Guerrero-Santoro J (2008), Hu J (2004), Furukawa M (2002), Maddika S (2009), Tron AE (2012), Tron AE (2012), He YJ (2006), Gastaldello S (2012), Olma MH (2009), Kristensen AR (2012), Huang DT (2009), Pick E (2007), Yang Y (2016), Scherer PC (2016), Nguyen TV (2016)	17
RAG1	1	UBE2C	1	pull down	Yurchenko V (2003)	1
DCAF1	5	UBC	7	affinity chromatography technology	Li W (2010)	1
RAG1	1	HIST2H2BE	1	far western blotting	Grazini U (2010)	1
DDB1	6	DCAF1	5	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Jin J (2006), Jin J (2006), Ahn J (2010), Maddika S (2009), Maddika S (2009), McCall CM (2008), McCall CM (2008), Hrecka K (2007), Hrecka K (2007), Le Rouzic E (2007), Le Rouzic E (2007), Olma MH (2009), Pham TN (2011), Gerard FC (2014), Nakagawa T (2015), Wan C (2015), Kyei GB (2015), Cassiday PA (2015), Gao J (2015), Gao J (2015), Wu Y (2016), Wu Y (2016), Wang H (2017), Zhou X (2016), Zhou X (2016), Wang X (2017)	26
RAG2	0	DDB1	6	biochemical	Kassmeier MD (2011)	1