Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
RYR1 6261 cA2 CHEMBL2109588 antagonist, activator GuideToPharmacologyInteractions
RYR1 6261 DANTROLENE CHEMBL1201288 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, TEND
RYR1 6261 RUTHENIUM RED CHEMBL2068405 channel blocker GuideToPharmacologyInteractions
RYR1 6261 SURAMIN CHEMBL265502 agonist, activator GuideToPharmacologyInteractions, DrugBank 16056233
RYR1 6261 ADENOSINE TRIPHOSPHATE CHEMBL14249 activator GuideToPharmacologyInteractions
RYR1 6261 MAGNESIUM CHEMBL2146125 antagonist GuideToPharmacologyInteractions
RYR1 6261 DANTROLENE SODIUM CHEMBL928 antagonist ChemblInteractions
RYR1 6261 RYANODINE CHEMBL2112186 activator, channel blocker GuideToPharmacologyInteractions
RYR1 6261 PROCAINE CHEMBL569 channel blocker GuideToPharmacologyInteractions
RYR1 6261 CAFFEINE CHEMBL113 activator GuideToPharmacologyInteractions

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
RYR1 rs118192161 T halothane other yes Wild-type (WT) or mice with a knock in of the malignant hyperthermia causative variant (Arg163Cys; c.487C>T) were exposed to 1.5% halothane. Mice with the Arg163Cys variant had much greater elevations in calcium and sodium in "vastus lateralis" muscle when exposed to halothane in vivo as compared to the WT mice. Allele T is associated with increased response to halothane as compared to allele C. 23159934 1444698070